Journal Information
Vol. 15. Issue 2.
Pages 319-324 (March - April 2009)
Share
Share
Download PDF
More article options
Vol. 15. Issue 2.
Pages 319-324 (March - April 2009)
Caso Clínico/Case Report
Open Access
Abcessos cerebrais múltiplos – Uma complicação rara de bronquiectasias
Multiple brain abscesses – A rare complication of bronchiectasis
Visits
6182
Natália Melo1,
Corresponding author
nataliafmelo@hotmail.com

Natália Melo, Serviço de Pneumologia, Hospital de S. João, Alameda Professor Hernâni Monteiro, 4202-451 Porto, Telefone: 919371855.
, Vicens Diaz-Brito2, Clara Chamadoira3, Isabel Gomes4, Adelina Amorim5
1 Interna Complementar de Pneumologia – Serviço de Pneumologia – Director de Serviço: Prof. Dr. Venceslau Hespanhol
2 Assistente Hospitalar de Doenças Infecciosas – Serviço de Doenças Infecciosas – Director de Serviço: Prof. Dr. António Sarmento
3 Interna Complementar de Neurocirurgia – Serviço de Neurocirurgia – Director de Serviço: Prof. Dr. Rui Vaz
4 Assistente Hospitalar Graduada de Pneumologia – Serviço de Pneumologia
5 Assistente Hospitalar de Pneumologia – Serviço de Pneumologia Hospital de S. João, Porto
This item has received

Under a Creative Commons license
Article information
Resumo

Introdução: O abcesso cerebral (AC) pode surgir como complicação de uma grande variedade de infec-ções, traumatismos ou cirurgias. Os microrganismos podem atingir o cérebro por contiguidade ou por dis-seminação hematogénea. Os AC estão descritos como uma complicação rara de bronquiectasias (BQ).

Caso clínico: Mulher de 44 anos com história de tuberculose pulmonar na infância e com diagnóstico de BQ bilaterais extensas que apresentou alterações do comportamento e posteriormente paresia do 6.º ner-vo craniano esquerdo, tendo sido diagnosticados AC múltiplos. O estudo microbiológico exaustivo foi negativo. A pesquisa de focos de infecção primária revelou apenas a presença de BQ infectadas. Efectuou tratamento antibiótico empírico e antiedematoso, com melhoria clínica progressiva. Contudo, por persistência das lesões cerebrais, foi submetida a excisão cirúrgica dos AC. Teve alta com diplopia, sem outras alterações neurológicas.

Conclusão: No presente caso clínico, as BQ foram o único foco de infecção detectado, motivo pelo qual, nos doentes com esta patologia e com alterações neurológicas de novo, deverá ser pesquisada a existência de lesões infecciosas do sistema nervoso central.

Rev Port Pneumol 2009; XV (2): 319-324

Palavras-chave:
Bronquiectasias
abcesso cerebral
Abstract

Background: Brain abscess can arise as a complication of a variety of infections, trauma or surgery. Bac-teria can invade the brain by direct spread or through haematogenous seeding. Brain abscesses are described as a rare complication of bronchiectasis.

Case description: A 44-year-old woman with pul-monary tuberculosis in childhood and with the diagnosis of bilateral extensive bronchiectasis who presented behaviour alterations and later, paresis of the sixth cranial nerve, was diagnosed multiple brain abscesses. The microbiological exams were negative. The study of the primary focus of infection could only identify infected bronchiectasis. Empiric antibiotics and anti-oedematous treatment were prescribed with progressive clinical improvement. Because of inadequate response she was submitted to surgery. She was discharged with diplopia, without any other neurological alterations.

Conclusion: In the present clinical case, the infected bronchiectasis were the only focal infection detected, so in patients with this disease and with new neurological manifestations, infected lesions in the central nervous system should be excluded.

Rev Port Pneumol 2009; XV (2): 319-324

Key-words:
Bronchiectasis
brain abscess
Full text is only aviable in PDF
Bibliografia
[1.]
K.L. Heilpem, B. Lorber.
Focal intracranial infections.
Infect Dis North Am, 10 (1996), pp. 879-898
[2.]
E. Grigoriadis, W.L. Gold.
Pyogenic brain absecess caused by Streptococcus pneumoniae: case report and review.
Clin Infect Dis, 25 (1997), pp. 1108-1112
[3.]
Y.-H. Ni, K.-M. Yeh, M.-Y. Peng, et al.
Community-acquired brain abscess in Taiwan: etiology and probable source of infection.
J Microbiol Immunol Infect, 37 (2004), pp. 231-235
[4.]
J. Ariza, A. Casanova, P.F. Viladrich, et al.
Etiological agent and primary source of infection in 42 cases of focal intracranial suppuration.
J Clin Microbiol, 24 (1986), pp. 899-902
[5.]
A.I. Mylonas, F.H. Tzerbos, M. Mihalaki, et al.
Cerebral abscess of odontogenic origin.
J Craniomaxillofac Surg, 35 (2007), pp. 63-67
[6.]
R. Bakshi, P.D. Wright, P.R. Kindel, et al.
Cranial magnetic resonance imaging findings in bacterial endocarditis: the neuroimaging spectrum of septic brain embolization demonstrated in twelve patients.
J Neuroimaging, 9 (1999), pp. 78-84
[7.]
S.E. Schliamser, K. Backman, S.R. Norrby.
Intracranial abscesses in adults: an analysis of 54 consecutive cases.
Scand J Infect Dis, 20 (1988), pp. 1-9
[8.]
P.Y. Ng, W.T. Seow, P.L. Ong.
Brain abscesses: review of 30 cases treated with with surgery.
Aust NZ J Surg, 65 (1995), pp. 664-666
[9.]
S.Y. Yang, C.S. Zhao.
Review of 140 patients with brain abscess.
Surg Neurol, 39 (1993), pp. 290-296
[10.]
K.H. Guppy, C. Thomas, K. Thomas, et al.
Cerebral fungal infections in the immunocompromised host: a literature review and a new pathogen: Chaetimium atro-brunneum.
Neurosurgery, 43 (1998), pp. 1463-1469
[11.]
J. Angrill, C. Agustí, R. de Cellis, et al.
Bacterial colonization in patients with bronchiectasis: microbiological pattern and risk factors.
Thorax, 57 (2002), pp. 15-19
[12.]
M.B. Nicotra, M. Rivera, A.M. dale, et al.
Clinical patho-physiologic and microbiologic characterization of bron-chiectasis in an aging cohor.
Chest, 108 (1995), pp. 955-961
[13.]
H.R. Frey, E.W. Russi.
Bronchiectasis – current aspects of an old disease.
Schweiz Med Wochenschr, 127 (1997), pp. 219-230
[14.]
J. Pecker, J.C. Clement.
Acute abscess of the cerebrum indicative of bronchiectasis caused by Fusiformis fusi-formis associated with Corynebacterium parvum; cure by combined surgical and anti-infections treatment.
Bull Men Soc Med Hop Paris, 68 (1952), pp. 153-157
[15.]
G. Lorente.
Acquired bronchiectasis and metastatic cerebral abscess.
Rev Cline sp, 76 (1960), pp. 134-135
[16.]
J. Chomicki.
Metastatic abscess of the brain as complication of bronchiectasis. Case report.
Va Med Mon, 87 (1960), pp. 394-396
[17.]
K.S. Patel, P.V. Marks.
Multiple brain abscesses secondary to bronchiectasis. A case of 34 discrete abscesses in one brain.
Clin Neurol Neurosurg, 91 (1989), pp. 265-267
[18.]
G. Leibovitch, Y. Maaravi, O. Shalev.
Multiple brain abscesses caused by Steptococcus bovis.
J Infect, 23 (1991), pp. 195-196
[19.]
P.K. Duffner, M.E. Cohen.
Cystic fibrosis with brain abscess.
Arch Neurol, 36 (1979), pp. 27-28
[20.]
E.G. Fischer, H. Shwachman, J.G. Wepsic.
Brain abscess and cystic fibrosis.
J Pediatr, 95 (1979), pp. 385-388
[21.]
M.W. Kline.
Brain abscess in a patient with cystic fibrosis.
Pediatr Infect Dis, 4 (1985), pp. 72-73
[22.]
W.M. Gershan, L.S. Rusakow, K.J. Henrickson, et al.
Brain abscess caused by Blastomyces dermatidis in a child with cystic fibrosis.
Chest, 106 (1994), pp. 601-603
[23.]
A. Arivazhagan, P. Pandey, B. Anandh, et al.
An unusual etiology of recurrent cerebral abscesses – a report of 3 cases, (2008),
[24.]
M. Takeshita, M. Kagawa, Yatos, et al.
Current treatment of brain abscess in patients with congenital cyanotic heart disease.
Neurosurgery, 41 (1997), pp. 1270-1278
[25.]
C. Seydoux, P. Francioli.
Bacterial Brain abscesses: factors influencing mortality and sequelae.
Clin Infect Dis, 15 (1992), pp. 394-401
[26.]
P. Tattevin, F. Bruneel, B. Clair, et al.
Bacterial brain abscesses: a retrospective study of 94 patients admitted to an intensive care unit (1980 to 1999).
Am J Med, 115 (2003), pp. 143-146
[27.]
A.K. Jansson, P. Enblad, J. Sjolin.
Efficacy and safety of cefotaxime in combination with metronidazole for empirical treatment of brain abscess in clinical practice: a retrospective study of 66 consecutive cases.
Eur J Clin Microbiol Infect Dis, 23 (2004), pp. 7-14
Copyright © 2009. Sociedade Portuguesa de Pneumologia/SPP
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?