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RESUMO
A inflamação, componente importante da patogenia da asma, tem sido desde há muito referenciada nesta doença, existindo múltiplos trabalhos que demonstram a implicação de várias células e mediadores.
No presente artigo é efectuada uma revisão dos diversos protagonistas do processo inflamatório na asma brônquica, acentuando-se particularmente o papel dos leucotrienos na perpetuação da resposta inflamatória. Foca-se, de forma breve, a possível acção dos anti-leucotrienos e sua importância na modulação da resposta inflamatória das vias aéreas dos doentes com asma.
REV PORT PNEUMOL 1999: V (5): 487-497
ABSTRACT
Inflammation is a very important component of bronchial asthma and, during the last decades, several cells and mediators have been implicated in its pathogenesis.
In this paper, the role of these protagonists on the inflammatory process is reviewed with an emphasis on the role of leukotriens perpetuating inflammation. Leukotrien antagonists and their role on the modulation of airway inflammation are briefly commented.
REV PORT PNEUMOL 1999; V (5): 487-497
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