Article information
RESUMO
Os autores apresentam um caso clinico de carcinoma timico, num bomem de 57 anos, préviamente saudável, que foi enviado á consulta externa de Pneumologia do Hospital de S. João. O doente foi referenciado para estudo de imagem hipotransparenre pulmonar, parahilar esquerda, detectada em telerradiografia de torax efectuada por rotina.
A propósito do caso clinico fazem-se algumas consideraçães sobre neoplasias tímicas, nomeadamente o carcinoma tímico, no que diz respeito à sua raridade, diagnóstico, evolução, terapêutica e prognóstico.
REV PORT PNEUMOL 2000; VI (2): 145-153
Palavras-chave:
Carcmoma tirnico
Caso clinico
Neoplasias tímicas
ABSTRACT
The authors present a case report of thymic carcinoma in a previously healthy 57 years old man, who after the detection of a left parahilar lung opacity on a routine chest X-Ray, was refered to the Pneumology Department of Hospital S. João.
The article focuses on several aspects of thymic neoplasms, particulary on thouse related to thymic carcinoma concerning, its rarity, diagnose, clinical course, therapeutics and prognosis.
REV PORT PNELIMOL 2000; VI (2): 145-153
Key-words:
Thymic carcinoma
Case report
Thymic neoplasms
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BIBLIOGRAFIA
[1.]
T.I. Morgenthaler, L.R. Brown, T.V. Colby, C.M. Harper, D.T. Coles.
Thymoma:symposium on intrathoracic neoplasms – part IX.
Mayo-Clin-Proc, 68 (1993 Nov), pp. 1110-1123
[3.]
B. Mullen, J.D. Richardson.
Primary anterior mediastinal tumours in children and adults.
Ann Thorac Surg, 42 (1986), pp. 338-348
[4.]
second edition, pp. 891-962
[5.]
Third edition, pp. 1469-1506
[6.]
F. Nogueira.
Tumores do timo Oncologia Pneumológica.
R.Sotto-MayorE.TetxeiraJ.Maçanita. Temas de actualização, (1999),
[7.]
GIACCONE G, ARDIZZONI A, KIRKPATRICK A, CLERICO M, SAHMOUD T, ZANDWIJK N. Cisplatin and Etoposide Combination Chemotherapy for Locally Advanced or Metastatic Thymoma a Phase II Study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.
[8.]
P.N. Lara, P.D. Bonomi, L.P. Faber.
Retreatment of recurrent invasive thymoma with platinum. doxorubicin and cyclophosphamtde.
Chest, 110 (1996), pp. 1115-1117
[9.]
M. Godinho.
Tumores invastvos do mediastino anterior – abordagem diagnóstica e orientação terapêutica.
Rev Pon Pneumol, 3 (1999), pp. 267-311
[10.]
L.G. Weide, T.M. Ulbright, P.J. Loehrer, S.D. Williams.
Thymic carcinoma - a distinct clinical entity responsive to chemotherapy.
Cancer, 71 (1993), pp. 1219-1223
[11.]
J. Rosai, G.D. Levine.
Tumors of the thymus Atlas of Tumor Pathology Fasc 13 Ser 2, pp. 167-181
[12.]
G.D. Levine, J. Rosai.
Thymic hiperplasia and neoplasia review ofcurrent concepts.
Hum Pathol., 9 (1978), pp. 495-515
[13.]
E. Pescarmona, E.A. Rendina, F. Venuta, C. Riccj, C.D. Baroni.
Recurrent thymoma evidence for htstological progression.
Histopathology, 27 (1995), pp. 445-449
[14.]
Y. Yamakawa, A. Masaoka, T. Hashimoto, H. Niwa, T. Mizuno, Y. Fujii, K.A. Nakahara.
Tentative Tumor Node Metastasis Classification of Thymoma.
Cancer, 68 (1991), pp. 984-1987
[15.]
H.R. Dib, B. Friedman, H.I. Khouli, D.R. Gerber, R.L. Weiss.
Malignant Thymoma – a complicated triad of SVC syndrome, cardiac tamponade and DIC.
Chest, (1994), pp. 941-942
[16.]
A.M. Egea, J.L. Albasini, P.P. Paricio, J.S. Perez, F.G. Lax, A.J. Bascuñana.
Prognostic factors of thymomas.
European Journal of Surgical Oncology, 21 (1995), pp. 482-485
[17.]
J.M. Verley, K.H. Hollmann.
Thymoma – A comparativ study of clinical stages histological features and survival in 200 cases.
Cancer, 55 (1985), pp. 1074-1086
[18.]
A. Masaoka, Y. Monden, K. Nakahara, T. Tanioka.
Follow up study of thymomas with special reference 10 their clinical stages.
Cancer, 48 (1981), pp. 2485-2492
[19.]
J.F. Regnard, P. Magdeleinat, C. Dromer, E. Dulmet, V. De Montpreville, J.F. Levi, P. Levasseur.
Prognostic factors and long term results after thymoma resection a series of 307 patients.
J. Thorac. Cardiovasc Surg, 112 (1996), pp. 376-384
[20.]
C. Ricci, E.A. Rendina, E.O. Pescarmona, F. Venuta, R. Di Tolla, L.P. Ruco, C.D. Baroni.
Correlations between histological type, clinical behaviour and prognosis in thymoma.
Thorax, 44 (1989), pp. 455-460
[21.]
G. Maggi, C. Casadio, A. Cavallo, R. Cianci, M. Molinatti, E. Ruffini.
Thymoma results of 241 operated cases.
Ann. Thorac Surg, 51 (1991), pp. 152-156
[22.]
Y. Levy, A. Afek, Y. Sherer, Bar-Dayany, R. Shibi, J. Kopolovic, Y. Shoenfeld.
Malignant thymoma associated with autoimmune diseases: a retrospective study and review of the literature.
Seminars in Arthritis & Rheumatism, 28 (1998), pp. 73-79
[23.]
M. Wick, P. Bernatz, J. Carney, L. Brown.
Primary mediastinal carcinoid tumours.
Am J Surg Pathol, 6 (1982), pp. 195-205
[24.]
L.A. Gartner, M.L. Voorhess.
Adrenocorticotroptc hormone – producing thymic carcinoid in a teenager.
Cancer, 71 (1993 Jan 1), pp. 106-111
[25.]
M. Dusmet, M.F. Mckneally.
Bronchial and thymic carcinotd tumors a review.
Digestton, 55 (1994),
[26.]
L.D. Truong, D.R. Mody, P.T. Cagle, G.L. Jackson York, Schwartzmr, T.M. Wheeler.
Thymic carcinoma -a clinicopathologic study of 13 cases.
Am. J. Surg. Pathol, 14 (1990), pp. 151-166
[27.]
Y.M. Sirpal, S.K. Chadha, A.K. Benarjee.
Thymohpoma – a rare mediastinaltumot – repon of two cases and review of literature.
Indian J. Cancer, 32 (1995 Mar), pp. 23-26
[28.]
Y. Kitano, K. Yokomori, M. Ohkura, T. Kataoka.
Giant thymolipoma in a child.
M.NarjtaT.Takemura. J Pediatr Surg, 28 (1993 Dec), pp. 1622-1625
[29.]
S. Suster, J. Rosaj.
Thymic carcinoma – a clinicopathologic studyof 60cases.
Cancer, 67 (1991), pp. 1025-1032
[30.]
P.V. Quagliano.
Thymtc carcinoma case reports and review J.
Thorac Imaging, 11 (1996 Winter), pp. 66-74
[31.]
M. Wick, L. Weiland, B. Scheithaner, P. Bernatz.
Primary thymic carcinomas.
Am J. Surg. Pathol, 6 (1982), pp. 613-630
[32.]
J.E. Lewis, M.R. Wick, B.W. Schelthauer, P.E. Bernatz, W.F. Taylor.
Thymoma a clinicopathologic review.
Cancer, 60 (1987), pp. 2777-2843
[33.]
J. Rosai.
Ackennan’s surgical pathology, 7th ed, pp. 348-365
[34.]
C.P. Hsu, C.Y. Chen, C.L. Chen, et al.
Thymic carcinoma tern years experience in twenty patients.
J Thorac Cardiovasc. Surg, 107 (1994), pp. 615-620
[35.]
S. Suster, C.A. Moran.
Primary thymic ephitelial neoplasms showing combined features of thymomas and thymic carcinoma A clinicopathological study of 22 cases.
Am J Surg Pathol, 20 (1996 Dec), pp. 1469-1480
[36.]
L.S. Wang, M.H. Huang, T.S. Lin, B.S. Huang, K.Y. Chien.
Malignant thymoma.
Cancer, 70 (1992), pp. 443-450
[37.]
R. Hohlfeld, H. Wekerle.
The thymus in myasthenia gravis.
Neurol Clin, 12 (1994 May), pp. 331-342
[38.]
D.C. Snover, G.O. Levine, J. Rosai.
Thymic carcinoma five distinctive histological variants.
AM J Surg Pathol, 6 (1982), pp. 451-470
[39.]
K. Kondo, Y. Yamakawa, H. Niwa, M. Kiriyama, I. Fukai.
Clinical study of nineteen thymic carcinomas Nippon Kyobu Geka Gakkai Zasshi.
Journal of the Japanese Association for Thoracic Surgery, 44 (1996), pp. 169-174
[40.]
T. Kushihashi, H. Fujisawa, H. Munechica.
Magnetic resonance imaging of thymic epithelial tumors.
Central Review in Diagnostic imaging, 37 (1996), pp. 191-259
[41.]
E. Pescarmona, E. Rendina, F. Venuta, E. Arcangelo, M. Pagani, C. Ricci, L. Ruco, C. Baroni.
Analysis of prognostic factors and clinicopathological staging of thymoma.
Ann Thorac Surg, 50 (1990), pp. 534-535
[42.]
Y. Shimosato.
Controversie surrounding the subclassification of thymomas.
Cancer, Vol 74 (July 15 1994), pp. 542-544
[43.]
D. Blumberg, M.E. Burt, M.S. Bains, R.J. Downey, N. Martini, V. Rusch, R.J. Ginsberg.
Thymic carcinolna current staging does not predict prognosis.
J Thorac Cardiovasc Surg, 115 (1998), pp. 303-309
[44.]
A. Masaoka, Y. Yamakawa, Y. Fujii.
Well differentiated thymic carcinoma is it thymic carcinoma or not? (letter).
Journal of Thoracic & Cardiovasc Surg, 117 (1999), pp. 628-630
[45.]
M. Marino, H.K. Muller-Hermelink.
Thymoma and thymic carcinoma relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus.
Virchows Arch (A), 407 (1985), pp. 119-149
[46.]
H.K. Muller-Hermelink, M. Marino, G. Palestro.
Pathology of thymic epithelial tumours.
The human thymus,
[47.]
H.K. Muller-Hermelink, M. Marino, G. Palestro, V. Schumcher, T. Kirchner.
Immunohistological evidences ofcortical and medullary differentiation in thymoma.
Virchows Arch, 408 (1985), pp. 143-161
[48.]
T. Kirchner, H.K. Muller-Hermelink.
New approaches to the diagnosis of thymic epithehal tumours Prog.
Surg. Pathol., 10 (1989), pp. 167-169
[49.]
E. Pescarmona, E.A. Rendina, F. Venuta, C. Ricci, L.P. Ruco, C.D. Baroni.
The prognostic implication of thymoma histologic subtyping – a study of 80 consecutive cases.
Am J Clin Pathol, 93 (1990), pp. 190-195
[50.]
Y. Shimosato, T. Kameya, K. Nagai, K. Seumasu.
Squamnus cell carcinoma of the thymus. An analysis ofeight cases.
Am. J. Surg Pathol, 1 (1977), pp. 109-121
[51.]
I. Fukai, A. Masaoka, T. Hashimoto, Y. Yamakawa, H. Niwa, M. Kiriyama, T. Eimoto.
Differential diagnosis of thymic carcinoma and lung carcinoma with the use of antibodies to citokeratins.
J Thorac Cardiovasc Surg, 110 (1995), pp. 1670-1675
[52.]
E. Bacha, A.R. Chapelier, P. Macchiarini, E. Fadel, P.G. Dartevelle.
Surgery for invastve primary mediastinal tumors.
Ann. Thorac. Surg, 66 (1998), pp. 234-239
[53.]
R.D. Marks, K.M. Wallace, H.S. Petit.
Radiation therapy control of nine patients wuh malignant thymomas.
Cancer, 41 (1978), pp. 117-119
[54.]
D. Cowen, P. Richard, F. Mornex, T. Bachelot, G.M. Jung, X. Mirabel, C. Marchal, J.L. Lagrange, P. Rambert, G. Chaplain, et al.
Thymoma result of a multicentric retrospective series of 149 non metastatic Irradiated patients and review oft be literature.
Radiother Oncol, 34 (1995 Jan), pp. 9-16
[55.]
W.J. Curran, M.J. Kornstein, J.J. Brooks, A. Turrisi.
Invasive thymoma The role of mediastinal Irradiation following complete or incomplete surgical resection.
J Clin Oncol, 6 (1988), pp. 1722-1727
[56.]
R.P. Loehrer, C. Perz, L. Roth, F. Greco, R. Livingston, L. Einhorn.
Chemotherapy for advanced thymoma.
Ann Intern Med, 113 (1990), pp. 520-524
[57.]
FORNASIERO A, DANIELE O, GHIOTTO C, PIAZZA M, FIORE-DONNATI L, CALABRÓ F, REA F. FIORENTINO MY Chemotherapy for invasive thymoma – a 13 year experience.
[58.]
O.K. Bjerrum, K. Kiss, G. Dangaard.
Combination chemotherapy with a five drug regimen for invasive thymoma.
Acta Oncol, 35 (1996), pp. 71-73
[59.]
F. Oshita, T. Kasai, T. Kurata, M. Fukuda, N. YamaMoto, Y. Ohe, T. Tamura, K. Eguchi, T. Shinkaj, T. Shinkaj, N. Saijo.
Intensive chemotherapy with cisplatin, doxorubicm, cyclophosphamide, etoposide and granulocyte colony-stimulating factor for advanced thymoma or thymic cancer preliminary results.
Jpn J Clin Oncol, 25 (1995 Oct), pp. 208-212
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