Journal Information
Vol. 10. Issue 4.
Pages 355-364 (July - August 2004)
Share
Share
Download PDF
More article options
Vol. 10. Issue 4.
Pages 355-364 (July - August 2004)
CASO CLÍNICO/CLINICAL CASE
Open Access
Pneumonia eosinofílica aguda com evolução para síndroma de dificuldade respiratória aguda: caso clínico
Acute eosinophilic pneumonia associated with acute respiratoty distress syndrome: case report
Visits
5286
J.P.F. Baptista1, P.C. Casanova1, J.P.A. Sousa2, P.J. Martins2, A. Simões2, V. Fernandes2, J. Souto2, J.J. Costa3, A. Rebelo3, L. Carvalho4, J. Pimentel5
1 Assistente Hospitalar de Medicina Intensiva, Serviço de Medicina Intensiva dos Hospitais da Universidade de Coimbra Av. Bissaya Barreto e Praceta Prof. Mota Pinto, 3000-075 Coimbra
2 Assistente Hospitalar Graduado de Medicina Intensiva, Serviço de Medicina Intensiva dos Hospitais da Universidade de Coimbra Av. Bissaya Barreto e Praceta Prof. Mota Pinto, 3000-075 Coimbra
3 Chefe de Serviço de Medicina Intensiva, dos Hospitais da Universidade de Coimbra Av. Bissaya Barreto e Praceta Prof. Mota Pinto, 3000-075 Coimbra
4 Professora Associada de Anatomia Patológica, Serviço de Medicina Intensiva dos Hospitais da Universidade de Coimbra Av. Bissaya Barreto e Praceta Prof. Mota Pinto, 3000-075 Coimbra
5 Director do Serviço de Medicina Intensiva, Serviço de Medicina Intensiva dos Hospitais da Universidade de Coimbra Av. Bissaya Barreto e Praceta Prof. Mota Pinto, 3000-075 Coimbra
This item has received

Under a Creative Commons license
Article information
RESUMO

Os autores apresentam um caso de pneumonia eosinofílica aguda (PEA) associada a síndroma de dificuldade respiratória aguda grave num adolescente previamente saudável, medicado com nitrofurantoína. A PEA deve ser incluída no diagnóstico diferencial da pneumonia adquirida na comunidade, bem como na lista das patologias causadoras de síndroma de dificuldade respiratória aguda, e o seu diagnóstico deve ser sugerido pela presença de alveolite eosinofílica no líquido de lavagem broncoalveolar. O reconhecimento precoce da PEA e a terapêutica com corticóides pode ser lifesaving.

REV PORT PNEUMOL 2004; X (4): 355-364

Palavras chave:
eosinophilic pneumonia
acute eosinophilic pneumonia
acute respiratory distress syndrome
bronchoalveolar lavage fluid
comunity adquired pneumonia
iatrogeny
nitrofurantoin
Palavras chave:
pneumonia eosinofílica
pneumonia eosinofílica aguda
síndroma de dificuldade respiratória agudo
lavagem broncoalveolar
pneumonia adquirida na comunidade
iatrogenia
nitrofurantoína
ABSTRACT

The Authors present a case of acute eosinophilic pneumonia (AEP) associated with severe acute respiratory distress syndrome in a previously healthy young adult, medicated with nitrofurantoin. AEP must be included in the diferential diagnosis of comunity adquired pneumonia, as well as a cause of acute respiratory distress syndrome; its diagnosis is sugested by the presence of eosinophilic alveolitis in bronchoalveolar lavage fluid. The early diagnosis of AEP and corticosteroid therapy may be lifesaving.

REV PORT PNEUMOL 2004; X (4): 355-364

Full text is only aviable in PDF
BIBLIOGRAFIA
[1.]
J.N. Allen, W.B. Davis.
State of the art: the eosinophilic lung diseases.
Am j Respir Crit Care Med, 150 (1994), pp. 1423-1438
[2.]
J.N. Allen, E.R. Pacht, J.E. Gadek, W.B. Davis.
AEP as a reversible cause of noninfectious respiratory failure.
N Engl J Med, 321 (1989), pp. 569-574
[3.]
D.B. Badesh, T.E. King, M.I. Schwarz.
AEP: A hypersensitivity phenomenom?.
Am Rev Respi Dis, 139 (1989), pp. 249-252
[4.]
V.L. Buddharaju, J.L. Saraceno, J.M. Rosen, S.D. Spivack, T.C. Smith, R. Ilves, D.A. Killam.
AEP associated with shock.
Crit Care Med, 27 (1999), pp. 2014-2016
[5.]
G.U. Meduri.
The standardization of bronchoscopic techniques for ventilator associated pneumonia.
Chest, 102 (1992), pp. 557S
[6.]
S. Umeki.
Reevaluation of eosinophilic pneumonia and its diagnostic significance.
Arch Int Med, 152 (1992), pp. 1913-1919
[7.]
D.C. Grootendorst, J.K. Sont, L.N. Willems, J.C. Kluin-Nelemans, J.H. Van Krieken, M. Veselic-Charvat, P.J. Sterk.
Comparison of inflammatory cell counts in asthma: induced sputum vs bronchoalveolar lavage and bronchial biopsies.
Clin Exp Allergy, 27 (1997 Jul), pp. 769-779
[8.]
H.Y. Reynolds.
Bronchoalveolar lavage.
Am Rev Respir Dis, 135 (1987 Jan), pp. 250-263
[9.]
J.N. Allen, J.B. Davis, E.R. Pacht.
Diagnostic significance of increased BAL fluid eosinophils.
Am Rev Respir Dis, 142 (1990), pp. 642-647
[10.]
J.F. Tomashefsky.
Pulmonary pathology of ARDS in Clinics in Chest Medicine.
ARDS, 21 (2000), pp. 3435-3490
[11.]
W.N. Rom, R. Garcia, T.A. Yie, D.B. Tse, G. Mcguiness, V. Roggli, D. Prezant.
AEP in a New York City firefighter exposed to World Trade Center dust.
Am J Resp Crit Care Med, 15 (2002), pp. 785-786
[12.]
K. Watanabe, N. Fujimura, K. Kasahara, M. Yasui, S. Myou, T. Kita, A. Watanabe, S. Nakao.
AEP following cigarrette smoking challenge test.
Intern Med, 41 (2002), pp. 1016-1020
[13.]
E.K. Talmadge.
Idiopathic AEP.
[14.]
T. Weng, A. Yuan, K.C. Tsai, W.J. Chen.
A patient with ARDS present initially with peripheral infiltration on chest radiographs and pulmonary eosinophilia.
Am J Emerg Med, 19 (2001 Sep), pp. 457-458
[15.]
G.N. Giacoppe, D.A. Degler.
Rapid evolving ARDS with eosinophilia of unknow cause in previously healthy active duty soldiers at an army training center: report of two cases.
Mil Med, 164 (1999 Dec), pp. 911-916
[16.]
H. Alp, R.S. Daum, C. Abrahams, M.E. Wylam.
AEP: a cause of reversible, severe, noninfectious respiratory failure.
J Pediatr, 132 (1998), pp. 540-543
[17.]
Harman A.L. Pope, E.D. Allen, A.J. Christoforidis.
AEP: a summary of 15 cases and review of the literature.
Medicine (Baltimore), 75 (1996), pp. 334-342
[18.]
E. Miyazaki, S. Katsunori, T. Shigenaga, T. Matsumoto, S. Kita, Y. Inobe, T. Tsuda.
A case of AEP caused by inalation of trichosporon terrestre.
Am J Crit Care Med, 151 (1995), pp. 541-543
[19.]
H.J. Israel, P. Diamond.
Recurrent pulmonary infiltration and pleural effusion due to nitrofurantoín sensivity.
N Engl J Med, 266 (1962), pp. 1024-1026
[20.]
B.N. Liubov.
Drug-induced respiratory disorders.
Drug Safety, 23 (2000), pp. 143-164
[21.]
C.R. Chudnofsky, E.J. Otten.
Acute pulmonar toxicity to nitrofurantoin.
The Journal of Emergency Medicine, 7 (1989), pp. 15-19
[22.]
A.E. Mulberg, L.M. Bell.
Fatal cholestatic hepatitis and multisystem failure associated with nitrofurantoin.
J Pediatr Gastroenterol Nutr, 17 (1993), pp. 307-309
[23.]
R.H. Israel, R.A. Gross, P.A. Bomba.
ARDS associated with acute nitrofurantoin toxicity.
Respiration, 39 (1980), pp. 318-322
[24.]
N. Nagaratnam, S. Rajiyah, A.D. Chetiyawarden.
Acute respiratory distress following nitrofurantoin therapy.
Ceylon Med J, 21 (1976), pp. 144-145
[25.]
M.J. Murray, R. Kronenberg.
Pulmonary reactions simulating cardiac pulmonary edema caused by nitrofurantoin.
N Engl J Med, 273 (1965), pp. 1185-1187
[26.]
M. Oddo, L. Liaudet, M. Leporty, A. Broccard, M. Schaller.
Relapsing acute respiratory failure induced by minocline.
Chest, 123 (2003), pp. 2146-2148
[27.]
Y. Valke, R. Pauwels, V. Staeten.
BAL in acute hipersensitivity pneumonitis caused by sulfasalazine.
Chest, 92 (1987), pp. 572-573
[28.]
J. Seebach, R. Speich, J. Fher, P. Tuchmidt, E. Russi.
GM-CSF induced AEP.
Br J Hematol, 90 (1995), pp. 963-965
[29.]
S.M. Salerno, J.S. Strong, B.J. Roth, V. Sakata.
Eosinophilic pneumonia and respiratory failure associated with a trazodone overdose.
Am J Respir Crit Care Med, 152 (1995), pp. 2170-2172
[30.]
B.M. Martinez, P. Domingo.
Eosinophilic pneumonia associated with tenidap.
B Med J, 314 (1997), pp. 349
[31.]
M.T. Barnes, J. Bascunana, B. Garcia, J.L. Alvarez Sala.
AEP associated with antidepressant agents.
Pharm World Sci, 21 (1999), pp. 241-242
[32.]
D. Coetmuer, G. Guivarch, E. Briens, C. Lopes.
PEA: rôle possible de la chloroquine.
Rev Mal Respir, 15 (1998), pp. 657-660
[33.]
K.J. Kelly, R. Ruffing.
AEP following intentional inalation of scotchguard.
Ann Allergy, 71 (1993), pp. 358-361
[34.]
O.H. Pi, M.S. Balter.
Cocaine induced eosinophil lung disease.
Thorax, 47 (1992), pp. 478-479
[35.]
K.A. Bogess, T.J. Benedetti, G. Raghu.
Nitrofuranton-induced pulmonary toxicity during pregnancy: a report of a case and review of the literature.
Obstetrical and Gynecology Survey, 51 (1996), pp. 367-370
[36.]
L. Holmberg, G. Bman.
Pulmonary reactions to nitrofurantoin-447 cases reported to the Swedish Adverse Drug Reaction Committee 1966-1976.
Eur J Respir Dis, 62 (1981), pp. 180-189
[37.]
F. Magee, J.L. Wright, N. Chan, W. Currie, G. Karr, J. Hogg.
Thurlbeck: Two unusual pathological reactions to nitrofurantoin: case reports.
Histopathology, 10 (1986), pp. 701-706
[38.]
M.M. Meyer.
Nitrofurantoin-induced pulmonary hemorrage in a renal transplant recipient receiving imunosupressive therapy: case report and review of the literature.
The Journal of Urology, 152 (1994), pp. 938-940
[39.]
L.W.M. Brutine, W.J. Martin.
Chronic nitrofurantoín reactions reaction associated with T-lymphocyte alveolitis.
Chest, 89 (1986), pp. 150
[40.]
D. Carbonera, A. Angrilli, G.F. Azzone.
Mechanism of nitrofurantoín toxicity and oxidative stress in mitochondria.
Biochim Byophys Acta, 936 (1988), pp. 139
[41.]
W.J. Martin.
Nitrofurantoín: evidence for the oxidant injury of lung parenchymal cells.
Am Rev Respir Dis, 127 (1983), pp. 482
Copyright © 2004. Sociedade Portuguesa de Pneumologia/SPP
Pulmonology
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?