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Vol. 13. Issue 1.
Pages 53-70 (January - February 2007)
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Vol. 13. Issue 1.
Pages 53-70 (January - February 2007)
Artigo Original / Original Article
Open Access
Derrame pleural complicado na criança – Abordagem terapêutica
Complicated pleural effusion in children – Therapeutical approach
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Sara Martins1, Sandra Valente1, Teresa Nunes David2, Luísa Pereira2, Celeste Barreto3, Teresa Bandeira3,
Corresponding author
teresa.bandeira@hsm.min-saude.pt

Correspondência/Correspondence to: Teresa Bandeira, Unidade de Pneumologia Pediátrica (UPP), Clínica Universitária de Pediatria, Director de Serviço: Prof. Doutor J. Gomes Pedro, Hospital de Santa Maria, Avenida Professor Egas Moniz, 1649-035 LISBOA
1 Interna de Internato Complementar de Pediatria / Resident of Paediatrics
2 Assistente Hospitalar de Pediatria / Hospital Assistant, Paediatrics
3 Assistente Hospitalar Graduada de Pediatria / Hospital Assistant, Consultant Paediatrics
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Resumo

A abordagem do derrame pleural parapneumónico complicado, em idade pediátrica, permanece controversa. As opções terapêuticas incluem antibioticoterapia e drenagem pleural contínua, instilação intrapleural de fibrinolíticos, videotoracoscopia e toracotomia com descorticação. O objectivo deste estudo foi rever, avaliar e actualizar a abordagem ao derrame pleural complicado. Procedeu-se à revisão retrospectiva dos processos clínicos das crianças internadas na UPP por derrame pleural complicado entre 1992 e 2003. Foram incluídos 25 doentes, com idade média (±DP): 37,4 (± 37,0) meses, sendo 15/25 (60%) do sexo masculino. A identificação do agente foi possível em 17/25 (68%) casos [S. aureus6/17 (35%), St. pneumoniae 5/17 (29%)], no líquido pleural em 16/17 (94%) casos. Todos os doentes realizaram toracocentese e antibioticoterapia sistémica. A drenagem pleural contínua foi instituída em 22/25 (88%) casos com duração média (±DP): 14,2 (± 7,8) dias; em 1 caso houve instilação de fibrinolíticos intrapleurais e em 11/25 (44%) realizou-se toracotomia com descorticação. Um doente foi submetido a videotoracoscopia primária. A duração média de internamento (±DP) foi de 30,4 (± 15,1) dias e não ocorreram óbitos. A experiência do centro é determinante na abordagem escolhida e na rapidez de actuação. Provavelmente ambas influenciam o prognóstico imediato.

Rev Port Pneumol 2007; XIII (1): 53-70

Palavras-chave:
Derrame pleural
empiema pleural
criança
Abstract

Pediatric management of complicated pleural effusion (CPE) remains controversial. Different approaches include antibiotics and chest tube drainage alone or the use of fibrinolitics, videothorascoscopy (VTC) and surgical decortication through thoracotomy.

The aim of the present study was to review, evaluate and update technical approach to CPE. We retrospectively reviewed the clinical files of children admitted to the Pediatric Respiratory Ward between 1992 and 2003 with the diagnosis of CPE. Twenty-five patients were included [15 male (60%)]. Mean (±SD) age was 37,4 (±37,0) months. Bacteria were identified in 17/25 (68%) [S. aureus in 6/17 (35%), St. pneumoniae in 5/17 (29%)], 16/17 (94%)in the pleural fluid. Twenty-five children were treated with antibiotics and thoracocentesis (100%). Chest tube drainage was required in 22/25 (88%) with mean (±DP) duration of 14,2 (±7,8) days. Fibrinolitics were employed in 1 only case and surgical decortication in 11/25 (44%). One patient (4%) was submitted to primary VTC. Median length of stay was 30,4 (±15,1) days and no deaths were recorded. Center skills in CPE management are critical on the choice of the technique and the timing of approach. This seems to influence immediate prognosis.

Rev Port Pneumol 2007; XIII (1): 53-70

Key-words:
Pleural effusion
pleural empyema
child
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Bibliografia / Bibliography
[1.]
I.C. Michelow, K. Olsen, J. Lozano, et al.
Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children.
Pediatrics, 113 (2004), pp. 701-707
[2.]
BTS Guidelines for the management of community-acquired pneumonia in childhood.
Thorax, 57 (2002), pp. 1-24
[3.]
American Thoracic Society.
Management of nontuberculous empyema.
Am Rev Respir Dis, 85 (1962), pp. 935-936
[4.]
D. Shoseyov, H. Bibi, G. Shatzberg, et al.
Short-term course and outcome of treatments of pleural empyema in pediatric patients.
Chest, 121 (2002), pp. 836-840
[5.]
B. Satish, M. Bunker, P. Seddon.
Management of thoracic empyema in childhood: does the pleural thickening matter?.
Arch Dis Child, 88 (2003), pp. 918-921
[6.]
A. Barbato, C. Panizzolo, C. Monciotti, et al.
Use of urokinase in childhood pleural empyema.
Pediatr Pulmonol, 35 (2003), pp. 50-55
[7.]
C.T. Yao, J.M. Wu, C.C. Liu, et al.
Treatment of complicated parapneumonic pleural effusion with intrapleural streptokinase in children.
Chest, 125 (2004), pp. 566-571
[8.]
L.E. Chen, J.C. Langer, P.A. Dillom, et al.
Management of late-stage parapneumonic empyema.
J Pediatr Surg, 37 (2002), pp. 371-374
[9.]
J.E. Heffner, L.K. Brown, C. Barbieri, et al.
Pleural fluid chemical analysis in parapneumonic effusions: a metaanalysis.
Am J Respir Crit Care Med, 151 (1995), pp. 1700-1708
[10.]
G.L. Colice, A. Curtis, J. Deslauriers, et al.
Medical and surgical treatment of parapneumonic effusions: an evidence-based guideline.
Chest, 18 (2000), pp. 1158-1171
[11.]
L.F. Donnelly.
Maximizing the usefulness of imaging in children with community-acquired pneumonia.
[12.]
R.R. Ramnath, R.M. Heller, T. Ben-Ami, et al.
Implications of early sonographic evaluation of parapneumonic effusions in children with pneumonia.
Pediatrics, 101 (1998), pp. 68-71
[13.]
P. Kumar, M.C. McKean.
Evidence based paediatrics: review of BTS guidelines for the management of community-acquired pneumonia in children.
J Infect, 48 (2004), pp. 134-138
[14.]
G.A. Khakoo, P. Goldtraw, D.M. Hansell, et al.
Surgical treatment of parapneumonic empyema.
[15.]
N. Coote.
Surgical versus nonsurgical management of pleural empyema.
Cochrane Database Syst Rev, 2 (2002),
[16.]
A.H. Meier, B. Smith, A. Raghavan.
Rational treatment of empyema in children.
Arch Surg, 135 (2000), pp. 907-912
[17.]
R.G. Wells, P.L. Havens.
Intrapleural fibrinolysis for parapneumonic effusion and empyema in children.
Radiology, 228 (2003), pp. 370-378
[18.]
N.B. Bishop, S. Pon, H.M. Ushay, et al.
Alteplase in the treatment of complicated parapneumonic effusion: a case report.
Pediatrics, 111 (2003), pp. e188-e190
[19.]
K.W. Kercher, R.J. Attorri, D. Hoover, et al.
Thoracoscopic decortication as first-line therapy for pediatric parapneumonic empyema.
Chest, 118 (2000), pp. 24-27
[20.]
H.P. Liu, M.J. Hsieh, H.I. Lu, et al.
Thoracoscopic-assisted management of postpneumonic empyema in children refractory to medical response.
Surg Endosc, 16 (2002), pp. 1612-1614
[21.]
S.J. Hoff, W.W. Neblett, R.M. Heller, et al.
Postpneumonic empyema in childhood: selecting appropriate therapy.
J Pediatr Surg, 24 (1989), pp. 659-664
[22.]
K.R. Shankar, S.E. Kenny, B.O. Okoye, et al.
Evolving experience in the management of empyema thoracis.
Acta Paediatr, 89 (2000), pp. 417-420
[23.]
R.W. Light, R.M. Rodriguez.
Management of parapneumonic effusions.
Clin Chest Med, 19 (1998), pp. 373-382
[24.]
I.M. Balfour-Lynn.
Some consensus but little evidence: guidelines on management of pleural infection in children.
Thorax, 60 (2005), pp. 94-96
[25.]
S.C. Buckingham, M.D. King, M.L. Miller.
Incidence and etiologies of complicated parapneumonic effusions in children, 1996 to 2001.
Pediatr Infect Dis J, 22 (2003), pp. 499-504
[26.]
T.Q. Tan, E.O. Mason, E.R. Wald, et al.
Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae.
Pediatrics, 110 (2002), pp. 1-6
[27.]
Y.C. Hsieh, P.R. Hsueh, C.Y. Lu, et al.
Clinical manifestations and molecular epidemiology of necrotizing pneumonia and empyema caused by Streptococcus pneumoniae in children in Taiwan.
Clin Infec Dis, 38 (2004), pp. 830-835
[28.]
P.O. Sousa, T. Bandeira, J. Guimaraes, et al.
Empiema pleural – experiência da unidade de pneumologia pediátrica.
Rev Port Pediatr, 24 (1993), pp. 314-318
[29.]
M.J. Pierrepoint, A. Evans, S.J. Morris, et al.
Pigtail catheter drain in the treatment of empyema thoracis.
Arch Dis Child, 87 (2002), pp. 331-332
[30.]
A.E. Balci, S. Eren, R. Ulku, et al.
Management of multiloculated empyema thoracis in children: thoracotomy versus fibrinolytic treatment.
Eur J Cardiothorac Surg, 22 (2002), pp. 595-598
[31.]
J.J. Doski, D. Lou, B.A. Hicks, et al.
Management of parapneumonic collections in infants and children.
J Pediatr Surg, 35 (2000), pp. 265-270
[32.]
G. Cohen, V. Hjortdal, M. Ricci, et al.
Primary thoracoscopic treatment of empyema in children.
J Thorac Cardiovasc Surg, 25 (2003), pp. 79-84
[33.]
T.N. Hilliard, A.J. Henderson, S.C. Hewer.
Management of parapneumonic effusion and empyema.
Arch Dis Child, 88 (2003), pp. 915-917
[34.]
J.D. Campbell, J.P. Nataro.
Pleural empyema.
Pediatr Infect Dis J, 18 (1999), pp. 725-726
[35.]
D.M. Orenstein.
Diseases of the pleura.
Nelson Textbook of Pediatrics, 16, pp. 329-1330
[36.]
N.P. Barnes, J. Hull, A.H. Thomson.
Medical management of parapneumonic pleural disease.
Pediatr Pulmonol, 39 (2005), pp. 127-134
[37.]
S. Quintas, A. Boto, L. Pereira, et al.
Pneumonia aguda da comunidade na criança – decisão terapêutica.
Acta Pediatr Port, 33 (2002), pp. 85-92
[38.]
C. Alexiou, A. Goyal, R. Firmin, et al.
Is open thoracotomy still a good treatment option for the management of empyema in children?.
Ann Thorac Surg, 76 (2003), pp. 1854-1858
[39.]
D. Spencer.
Empyema thoracis: not time to put down the knife.
Arch Dis Child, 88 (2003), pp. 842-843
[40.]
A. Jaffé, G. Cohen.
Thoracic empyema.
Arch Dis Child, 88 (2003), pp. 839-841
[41.]
R.K. Mitri, S.D. Brown, D. Zurakowski, et al.
Outcomes of primary image-guided drainage of parapneumonic effusions in children.
Pediatrics, 110 (2002), pp. 37-42
[42.]
I.M. Balfour-Lynn, E. Abrahamson, G. Cohen, et al.
BTS guidelines for the management of pleural infection in children.
Thorax, 60 (2005), pp. i1-i21
[43.]
A.H. Thomson, J. Hull, M.R. Kumar, et al.
Randomised trial of intrapleural urokinase in the treatment of childhood empyema.
Thorax, 57 (2002), pp. 343-347
[44.]
N.A. Maskell, C.W. Davies, A.J. Nunn, et al.
U.K. Controlled Trial of Intrapleural Streptokinase for Pleural Infection.
[45.]
M. Singh, J.L. Mathew, S. Chandra, et al.
Randomized controlled trial of intrapleural streptokinase in empyema thoracis in children.
Acta Paediatr, 93 (2004), pp. 1443-1445
[46.]
R. Cameron, H.R. Davies.
Intrapleural fibrinolytic therapy versus conservative management in the treatment of parapneumonic effusions and empyema.
Cochrane Database Syst Rev, 2 (2004),
[47.]
M.A. Wait, S. Sharma, J. Hohn, Nogare A. Dal.
A randomized trial of empyema therapy.
Chest, 111 (1997), pp. 1548-1551
[48.]
S. Sonnapa, G. Cohen, C.M. Owens, et al.
Comparison of urokinase and video-assisted thoracoscopic surgery for treatment of childhood empyema.
Am J Respir Crit Care Med, 174 (2006), pp. 221-227
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