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Vol. 12. Issue 1.
Pages 61-70 (January - February 2006)
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Vol. 12. Issue 1.
Pages 61-70 (January - February 2006)
Artigo de Revisão\Revision Article
Open Access
Testes de função pulmonar no transplante de medula óssea: Revisão sistemática
Pulmonary function testing in bone marrow transplantation: A systematic review
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Eliane Viana Mancuso1, Nilton Alves de Rezende2,
Corresponding author
narezende@terra.com.br

Endereço para correspondência: Professor Nilton Alves de Rezende. Departamento de Clínica Médica, Faculdade de Medicina da UFMG Al. Alfredo Balena 190 CEP-30130-100 Belo Horizonte, Brasil.
1 Mestranda do Programa de Pós-Graduação em Clínica Médica da Universidade Federal de Minas Gerais, Brasil.
2 Professor Adjunto do Departamento de Clínica Médica da Faculdade de Medicina da Universidade Federal de Minas Gerais, Brasil. Doutor em Medicina. Pós-Doutorado, Emory University, Atlanta, USA
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Resumo

As complicações pulmonares constituem causa importante de morbidade e mortalidade em doentes submetidos a transplante de medula óssea. Os testes de função pulmonar são utilizados rotineiramente na avaliação antes e no acompanhamento após o transplante. A revisão sistemática da literatura mostrou que a presença de alterações nos testes de função pulmonar antes do transplante de medula não esteve relacionada com maior incidência de complicações pulmonares pós-transplante. Entretanto, alterações destes testes após o transplante estiveram relacionadas com maior incidência de complicações respiratórias. Desta forma, embora as alterações dos testes de função pulmonar pré-transplante não tenham sido de valor preditivo positivo na detecção precoce de complicações respiratórias pós-transplante, os mesmos podem ser úteis na comparação com os testes realizados após o transplante e devem fazer parte da avaliação de doentes candidatos ao transplante de medula óssea.

Rev Port Pneumol 2006; XII (1): 61-69

Palavras-chave:
Transplante de medula óssea
testes de função pulmonar
revisão sistemática
Abstract

The pulmonary function test plays an important role in the management of pulmonary complications after bone marrow transplantation. Although its utility in helping to predict the likelihood of developing post transplant pulmonary complications and mortality is not well established, current data indicate that pre-transplant pulmonary function tests are important as a reference for the interpretation of post transplant pulmonary function tests and for identifying patients at high risk of developing pulmonary complications and/or mortality after bone marrow transplantation.

Rev Port Pneumol 2006; XII (1): 61-69

Key-words:
Bone marrow transplantation
respiratory function tests
systematic review
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Copyright © 2006. Sociedade Portuguesa de Pneumologia/SPP
Pulmonology
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