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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A esperan&#231;a de vida dos doentes com fibrose qu&#237;stica &#40;FQ&#41; tem vindo a aumentar&#44; sendo mais frequente a identifica&#231;&#227;o de osteoporose&#46; A patog&#233;nese de uma baixa densidade mineral &#243;ssea &#40;DMO&#41; na FQ parece ser multifactorial e o objectivo deste trabalho foi avaliar a preval&#234;ncia de baixa DMO num grupo de doentes com FQ e a sua correla&#231;&#227;o com outros par&#226;metros avaliados&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">O estudo incluiu 22 doentes com FQ com idades compreendidas entre os 14 e os 45 anos &#40;m&#233;dia 26&#44;3&#41;&#44; dois dos quais transplantados pulmonares&#46; A DMO foi avaliada por densitometria &#243;ssea ao n&#237;vel da coluna lombar e do colo do f&#233;mur&#46; Estes dados foram correlacionados com os valores s&#233;ricos de 25-hydroxivi-tamina D&#44; o IMC e o volume expirat&#243;rio m&#225;ximo for&#231;ado no primeiro segundo &#40;VEM&#41;&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Os valores da DMO &#40;<span class="elsevierStyleItalic">Z-score</span> e <span class="elsevierStyleItalic">T-scor</span>e&#41; variaram entre 0&#44;6 e -6 e entre 0&#44;5 e -6&#44;7&#44; respectivamente&#44; a n&#237;vel da coluna lombar e entre 0&#44;6 e -3&#44;9 e 0&#44;6 e -4&#44;1 a n&#237;vel do colo do f&#233;mur&#46; A m&#233;dia das concentra&#231;&#245;es s&#233;ricas de 25-&#40;OH&#41;D &#40;12&#44;57<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; encontrava-se no limite inferior da normalidade &#40;10-60<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; Em m&#233;dia os doentes n&#227;o apresentavam malnutri&#231;&#227;o mas os valores de IMC variam entre 15&#44;2 e 33&#44;7<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Relativamente &#224; fun&#231;&#227;o pulmonar&#44; 64&#37; dos doentes apresentavam VEM inferior a 80&#37; e&#44; destes&#44; quatro tinham valores inferiores a 40&#37;&#46; Foi encontrada uma correla&#231;&#227;o positiva entre valores baixos de DMO e VEM&#44; assim como entre valores de DMO e 25-OHD&#46; N&#227;o houve correla&#231;&#227;o linear entre IMC e DMO&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;5&#41;&#58; 625-634</span></p></span>"
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        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Patients with cystic fibrosis &#40;CF&#41; have an increasing life span and osteoporosis has become a more recognised problem in these patients&#46; The pathogenesis of low bone mineral density &#40;BMD&#41; in CF seems to be multifactorial and the aim of this study was to assess the prevalence of low BMD in a group of CF outpatients and to relate the findings with the variables studied&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">The study included 22 patients aged between 14 and 45 years &#40;mean age 26&#46;3&#41;&#46; Two of the subjects were lung transplant patients&#46; BMD was assessed by dualenergy X-ray absorptiometry &#40;DEXA&#41; at the lumbar spine &#40;LS&#41; and femoral neck &#40;FN&#41;&#46; This data was correlated with serum 25-hydroxy vitamin D &#40;25-OHD&#41; levels&#44; BMI and the forced expiratory volume in one second &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">BMD &#40;Z-score and T-score&#41; ranged from 0&#46;6 to -6 and from 0&#46;5 to -6&#46;7 at LS&#59; at FN the scores ranged from 0&#46;6 to -3&#46;9 and from 0&#46;6 to -4&#46;1&#46; The mean serum 25-OHD concentration &#40;12&#44;57<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; was at the low end of the normal range &#40;10-60<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; On average patients did not present with malnutrition&#44; however BMI ranged from 15&#46;2 to 33&#46;7<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Lung function status was assessed by FEV<span class="elsevierStyleInf">1</span>&#59; 64&#37; of patients had FEV<span class="elsevierStyleInf">1</span> below 80&#37; and within this group four patients had a FEV<span class="elsevierStyleInf">1</span> under 40&#37;&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">There was a positive correlation between low BMD and 25-OHD concentrations and also between BMD and FEV<span class="elsevierStyleInf">1</span>&#46; There was no linear correlation between BMD and BMI&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;5&#41;&#58; 625-634</span></p></span>"
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Artigo Original/Original Article
Avaliação da densidade mineral óssea em doentes com fibrose quística
Evaluation of bone mineral density in cystic fibrosis patients
Jessica Cemlyn-Jones1, Fernanda Gamboa2, Mário Loureiro3, M. Fontes Baganha4
1 Interna Complementar de Pneumologia / Resident, specialist training in Pulmonology
2 Assistente Hospitalar de Pneumologia / Pulmonolgy consultant
3 Director do Serviço de Pneumologia dos HUC / Head, Pulmonologu Unit, HUC
4 Director do Departamento de Ciências Pneumológicas e Alergológicas dos HUC / Director, Department of Pulmonology and Allergology Sciences, HUC
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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A esperan&#231;a de vida dos doentes com fibrose qu&#237;stica &#40;FQ&#41; tem vindo a aumentar&#44; sendo mais frequente a identifica&#231;&#227;o de osteoporose&#46; A patog&#233;nese de uma baixa densidade mineral &#243;ssea &#40;DMO&#41; na FQ parece ser multifactorial e o objectivo deste trabalho foi avaliar a preval&#234;ncia de baixa DMO num grupo de doentes com FQ e a sua correla&#231;&#227;o com outros par&#226;metros avaliados&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">O estudo incluiu 22 doentes com FQ com idades compreendidas entre os 14 e os 45 anos &#40;m&#233;dia 26&#44;3&#41;&#44; dois dos quais transplantados pulmonares&#46; A DMO foi avaliada por densitometria &#243;ssea ao n&#237;vel da coluna lombar e do colo do f&#233;mur&#46; Estes dados foram correlacionados com os valores s&#233;ricos de 25-hydroxivi-tamina D&#44; o IMC e o volume expirat&#243;rio m&#225;ximo for&#231;ado no primeiro segundo &#40;VEM&#41;&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Os valores da DMO &#40;<span class="elsevierStyleItalic">Z-score</span> e <span class="elsevierStyleItalic">T-scor</span>e&#41; variaram entre 0&#44;6 e -6 e entre 0&#44;5 e -6&#44;7&#44; respectivamente&#44; a n&#237;vel da coluna lombar e entre 0&#44;6 e -3&#44;9 e 0&#44;6 e -4&#44;1 a n&#237;vel do colo do f&#233;mur&#46; A m&#233;dia das concentra&#231;&#245;es s&#233;ricas de 25-&#40;OH&#41;D &#40;12&#44;57<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; encontrava-se no limite inferior da normalidade &#40;10-60<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; Em m&#233;dia os doentes n&#227;o apresentavam malnutri&#231;&#227;o mas os valores de IMC variam entre 15&#44;2 e 33&#44;7<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Relativamente &#224; fun&#231;&#227;o pulmonar&#44; 64&#37; dos doentes apresentavam VEM inferior a 80&#37; e&#44; destes&#44; quatro tinham valores inferiores a 40&#37;&#46; Foi encontrada uma correla&#231;&#227;o positiva entre valores baixos de DMO e VEM&#44; assim como entre valores de DMO e 25-OHD&#46; N&#227;o houve correla&#231;&#227;o linear entre IMC e DMO&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;5&#41;&#58; 625-634</span></p></span>"
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        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Patients with cystic fibrosis &#40;CF&#41; have an increasing life span and osteoporosis has become a more recognised problem in these patients&#46; The pathogenesis of low bone mineral density &#40;BMD&#41; in CF seems to be multifactorial and the aim of this study was to assess the prevalence of low BMD in a group of CF outpatients and to relate the findings with the variables studied&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">The study included 22 patients aged between 14 and 45 years &#40;mean age 26&#46;3&#41;&#46; Two of the subjects were lung transplant patients&#46; BMD was assessed by dualenergy X-ray absorptiometry &#40;DEXA&#41; at the lumbar spine &#40;LS&#41; and femoral neck &#40;FN&#41;&#46; This data was correlated with serum 25-hydroxy vitamin D &#40;25-OHD&#41; levels&#44; BMI and the forced expiratory volume in one second &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">BMD &#40;Z-score and T-score&#41; ranged from 0&#46;6 to -6 and from 0&#46;5 to -6&#46;7 at LS&#59; at FN the scores ranged from 0&#46;6 to -3&#46;9 and from 0&#46;6 to -4&#46;1&#46; The mean serum 25-OHD concentration &#40;12&#44;57<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; was at the low end of the normal range &#40;10-60<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; On average patients did not present with malnutrition&#44; however BMI ranged from 15&#46;2 to 33&#46;7<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Lung function status was assessed by FEV<span class="elsevierStyleInf">1</span>&#59; 64&#37; of patients had FEV<span class="elsevierStyleInf">1</span> below 80&#37; and within this group four patients had a FEV<span class="elsevierStyleInf">1</span> under 40&#37;&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">There was a positive correlation between low BMD and 25-OHD concentrations and also between BMD and FEV<span class="elsevierStyleInf">1</span>&#46; There was no linear correlation between BMD and BMI&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;5&#41;&#58; 625-634</span></p></span>"
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Article information
ISSN: 08732159
Original language: Portuguese
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