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In obesity&#44; the deposition of periluminal fat and the reduction of lung volume contribute to an altered compliance of the upper airway thus promoting its collapse&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> During sleep there is a physiological decrease in the tone of the pharynx muscles that induce a slight narrowing of the upper airway<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> which&#44; in the case of obese individuals&#44; contributes to a further reduction of the pharynx lumen leading to OSA symptoms&#46; One of the most important symptoms is the excessive daytime sleepiness<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> which is believed to be caused by sleep fragmentation&#46; This characteristic of OSA patients can contribute to a reduced level of physical activity and energetic metabolism predisposing to obesity&#46; Moreover&#44; studies suggest that genetic polymorphisms of the leptin receptor may influence both sleep apnea and obesity&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> contributing to metabolic dysregulation in these patients&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The treatment of obese patients with OSA involves behavioral changes&#44; positive airway pressure and bariatric procedures&#58; intragastric balloon and bariatric surgery&#46; This is the more effective current treatment for morbidly obese<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> and produces a sustained weight loss&#44; being associated with a better possibility of cure of OSA&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">To assess the impact of weight loss on OSA in obese patients who underwent bariatric procedure&#44; a retrospective study was conducted in Santa Maria Hospital &#40;HSM&#41;&#44; North Lisbon Hospital Center &#40;CHLN&#41;&#46; Data was collected on patients with a BMI &#8805;35<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> who underwent bariatric procedure &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Thirty-six patients were included&#44; 30 &#40;83&#37;&#41; were female&#59; the mean age was 43&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years and the mean BMI was 46&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;2<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Males had a higher BMI than females&#46; Of the twenty-nine patients tested with polysomnography before surgery due to symptoms associated with OSA&#44; 20 were identified with OSA&#46; Of these&#44; 10 repeated the polysomnography 12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7 months after bariatric surgery&#46; Seven patients were female and the mean age was 46&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;5 years&#46; The mean BMI fell from 48&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;5<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> to 32&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;3<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> with a mean loss of excess weight of 56&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#46;8&#37;&#46; Six patients lost more than 50&#37; of excess weight&#46; There was a resolution of OSA in seven patients and a significant improvement was noted in the other three&#46; A significant reduction of apnea hypopnea index &#40;AHI&#41; was noted from a median value of 31&#46;9&#47;h to 3&#47;h&#46; There was a significant improvement in minimal peripheric oxygen saturation with a rise in the mean value from 73<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#37; to 86<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#37;&#46; There was an improvement in the median value of total time of oxygen saturation below 90&#37; &#40;T90&#41; from 32&#46;5 to 1&#46;2<span class="elsevierStyleHsp" style=""></span>min&#46; A significant reduction was noted in the median value of Oxygen Desaturation Index &#40;ODI&#41; from 45&#46;5<span class="elsevierStyleHsp" style=""></span>events&#47;hour to 4&#46;2<span class="elsevierStyleHsp" style=""></span>events&#47;hour&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Regarding the other 10 patients who did not repeat the sleep study&#44; three abandoned the medical follow-up and two gained weight therefore it was assumed that there had been no improvement in the disease&#46; Two patients failed to lose 15&#37; of body weight after the bariatric procedure and considering they had moderate OSA and associated comorbidities it was assumed they would not benefit from repeating the sleep study&#46; Three patients lost more than 15&#37; body weight after bariatric procedure and presented mild OSA in the pre-operative polysomnography with an AHI in the limit of normality &#40;AHI 7&#46;2&#47;h&#59; 5&#46;6&#47;h e 9&#46;7&#47;h&#41;&#44; so there was no clinical need to repeat the sleep study&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Weight loss associated with bariatric procedure is beneficial for obese patients with OSA as shown by the significant reduction of AHI and other indexes related to OSA one year after the bariatric procedure&#46; Besides behavioral treatment&#44; which should be offered to every patient&#44; long-term treatment with positive airway pressure is the treatment of choice for OSA&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> However&#44; for morbid obesity&#44; bariatric procedure should be considered as it produces effective results in weight loss which has a beneficial impact on OSA&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Research letter
Impact of bariatric surgery in obstructive sleep apnea in obese patients
I.M. Guerreiroa,
Corresponding author
ines.m.guerreiro@gmail.com

Corresponding author.
, M. Brancoa, S. Moreirab, J. Valençab
a Faculdade de Medicina da Universidade de Lisboa (FML), Portugal
b Serviço de Pneumologia do Hospital de Santa Maria (HSM), Centro Hospitalar Lisboa Norte (CHLN)/Faculdade de Medicina da Universidade de Lisboa, Portugal
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studies suggest that genetic polymorphisms of the leptin receptor may influence both sleep apnea and obesity&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> contributing to metabolic dysregulation in these patients&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The treatment of obese patients with OSA involves behavioral changes&#44; positive airway pressure and bariatric procedures&#58; intragastric balloon and bariatric surgery&#46; This is the more effective current treatment for morbidly obese<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> and produces a sustained weight loss&#44; being associated with a better possibility of cure of OSA&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">To assess the impact of weight loss on OSA in obese patients who underwent bariatric procedure&#44; a retrospective study was conducted in Santa Maria Hospital &#40;HSM&#41;&#44; North Lisbon Hospital Center &#40;CHLN&#41;&#46; Data was collected on patients with a BMI &#8805;35<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> who underwent bariatric procedure &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Thirty-six patients were included&#44; 30 &#40;83&#37;&#41; were female&#59; the mean age was 43&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years and the mean BMI was 46&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;2<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span>&#46; Males had a higher BMI than females&#46; Of the twenty-nine patients tested with polysomnography before surgery due to symptoms associated with OSA&#44; 20 were identified with OSA&#46; Of these&#44; 10 repeated the polysomnography 12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7 months after bariatric surgery&#46; Seven patients were female and the mean age was 46&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;5 years&#46; The mean BMI fell from 48&#46;3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;5<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> to 32&#46;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;3<span class="elsevierStyleHsp" style=""></span>kg&#47;m<span class="elsevierStyleSup">2</span> with a mean loss of excess weight of 56&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#46;8&#37;&#46; Six patients lost more than 50&#37; of excess weight&#46; There was a resolution of OSA in seven patients and a significant improvement was noted in the other three&#46; A significant reduction of apnea hypopnea index &#40;AHI&#41; was noted from a median value of 31&#46;9&#47;h to 3&#47;h&#46; There was a significant improvement in minimal peripheric oxygen saturation with a rise in the mean value from 73<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#37; to 86<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#37;&#46; There was an improvement in the median value of total time of oxygen saturation below 90&#37; &#40;T90&#41; from 32&#46;5 to 1&#46;2<span class="elsevierStyleHsp" style=""></span>min&#46; A significant reduction was noted in the median value of Oxygen Desaturation Index &#40;ODI&#41; from 45&#46;5<span class="elsevierStyleHsp" style=""></span>events&#47;hour to 4&#46;2<span class="elsevierStyleHsp" style=""></span>events&#47;hour&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Regarding the other 10 patients who did not repeat the sleep study&#44; three abandoned the medical follow-up and two gained weight therefore it was assumed that there had been no improvement in the disease&#46; Two patients failed to lose 15&#37; of body weight after the bariatric procedure and considering they had moderate OSA and associated comorbidities it was assumed they would not benefit from repeating the sleep study&#46; Three patients lost more than 15&#37; body weight after bariatric procedure and presented mild OSA in the pre-operative polysomnography with an AHI in the limit of normality &#40;AHI 7&#46;2&#47;h&#59; 5&#46;6&#47;h e 9&#46;7&#47;h&#41;&#44; so there was no clinical need to repeat the sleep study&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Weight loss associated with bariatric procedure is beneficial for obese patients with OSA as shown by the significant reduction of AHI and other indexes related to OSA one year after the bariatric procedure&#46; Besides behavioral treatment&#44; which should be offered to every patient&#44; long-term treatment with positive airway pressure is the treatment of choice for OSA&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> However&#44; for morbid obesity&#44; bariatric procedure should be considered as it produces effective results in weight loss which has a beneficial impact on OSA&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Original language: English
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