TY - JOUR T1 - Comparative survival analysis between idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis JO - Pulmonology T2 - AU - Alberti,Maria Laura AU - Malet Ruiz,Jose María AU - Fernández,Martin Eduardo AU - Fassola,Leandro AU - Caro,Fabián AU - Roldán,Ivette Buendía AU - Paulin,Francisco SN - 25310437 M3 - 10.1016/j.pulmoe.2019.08.007 DO - 10.1016/j.pulmoe.2019.08.007 UR - https://journalpulmonology.org/en-comparative-survival-analysis-between-idiopathic-articulo-S2531043719301801 AB - IntroductionChronic hypersensitivity pneumonitis (CHP) is an interstitial lung disease with limited treatment response and bad prognosis. Sometimes it is indistinguishable from idiopathic pulmonary fibrosis (IPF) becoming one of the main differential diagnosis. The aim of our study is to compare survival and functional decline between these two entities. MethodsSurvival and functional decline more than 10% in FVC were compared using Kaplan Meier (KM) method between patients with CHP and IPF. Cox proportional hazard analysis was used to identify independent predictors of survival and functional decline. Results146 patients were included, 54 with CHP and 92 with IPF. KM rate for 2 years survival was 0.71 (CI 95% 0,6–0,8) for CHP group and 0,83 (CI 95% 0,66 - 0,92) for IPF (p=0,027). Nevertheless this difference disappeared using Cox proportional hazard analysis, the adjusted HR for survival among CHP patients was 0,53 (CI 95% 0,25–1,15) (p=0,11). There was no difference in functional evolution between the two groups. KM rate for a decline more than or equal to 10% was 0,64 for CHP (CI 95% 0,43–0,79) and 0,78 for IPF (IC 95% 0,6–0,88) (p=0,22). This observation did not change after using Cox proportional hazard analysis. ConclusionsOur study shows that both IPF and CHP are fibrosing interstitial diseases with a similar evolution and survival. It might be possible that therapeutic approach in patients with CHP should change in the light of these observations. ER -