Clinical studyRepeat Radiofrequency Ablation for Local Progression of Lung Tumors: Does It Have a Role in Local Tumor Control?
Section snippets
Materials and Methods
Institutional review board approval and patient informed consent were obtained to perform RF ablation of lung tumors. The institutional review board also approved the reporting of this retrospective study.
Results
Although all 56 tumors should have undergone every scheduled follow-up CT examination after the repeat RF ablation, 15, seven, five, and three tumors did not undergo CT at 1, 3, 6, and 9 months, respectively. The mean follow-up period for the 56 tumors was 8.5 months after the repeat RF ablation (median, 6.4 months; range, 0.0−32.5 months). After the repeat RF ablation, local progression was again observed in 17 of the 56 tumors (30%). In seven of the 17 tumors, local progression was diagnosed
Discussion
In our study, the overall secondary TERs for all 797 tumors were significantly higher than the overall primary TERs; that is, repeat RF ablation offered a significant benefit in local control for the entire population. However, the TERs after repeat RF ablation were significantly lower than the overall primary TERs after the first RF ablation. This indicates that tumors that showed local progression after the first RF ablation were associated with a higher risk of local progression even after
References (16)
- et al.
Radiofrequency ablation for the treatment of non-small cell lung cancer in marginal surgical candidates
J Thorac Cardiovasc Surg
(2005) - et al.
Evaluation of microscopic tumor extension in non-small-cell lung cancer for three-dimensional conformal radiotherapy planning
Int J Radiat Oncol Biol Phys
(2000) - et al.
Image-guided tumor ablation: standardization of terminology and reporting criteria
J Vasc Interv Radiol
(2005) - et al.
Percutaneous radiofrequency ablation of lung neoplasms: initial therapeutic response
J Vasc Interv Radiol
(2004) - et al.
Effect of vessel diameter on the creation of ovine lung radiofrequency lesions in vivo: preliminary results
J Surg Res
(2005) - et al.
Lung radiofrequency ablation with and without bronchial occlusion: experimental study in porcine lungs
J Vasc Interv Radiol
(2004) - et al.
Local recurrence after hepatic radiofrequency coagulation: multivariate meta-analysis and review of contributing factors
Ann Surg
(2005) - et al.
Factors for early tumor recurrence of single small hepatocellular carcinoma after percutaneous radiofrequency ablation therapy
World J Gastroenterol
(2005)
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None of the authors have identified a conflict of interest.