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1&#41; high probability ventilation&#47;perfusion lung scan&#44; 2&#41; intermediate or low probability ventilation&#47;perfusion lung scan with signs suggestive of arterial thrombosis as revealed by pulmonary angiography with or without signs of venous thrombosis in lower limbs through ultrasound scan or venography&#46; 3&#41; Intraluminal filling defect observed in pulmonary angiography or consecutive sections of the vessels or more than 2&#46;5<span class="elsevierStyleHsp" style=""></span>mm in diameter as revealed by pulmonary angiography&#46; 4&#41; Intraluminal filling defect in segmentary branches or in more proximal branches as observed in helical CT scan&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Data collection strategy during the initial PE episode</span><p id="par0050" class="elsevierStylePara elsevierViewall">Patients were enrolled in the study through periodical visits to the Emergency Unit&#44; Internal Medicine Unit&#44; Pneumology&#44; Nuclear Medicine and Radiology Units&#46; A series of variables were noted down in a form designed for the purpose and were subsequently converted into computer format&#46; Periodical visit were made to the units where the patients were admitted in order to confirm the correct completion of the form&#46; We also revised in the Computer System for the Management of Clinical and Analytical Documentation &#40;SIDCA&#41; &#40;Sistema Inform&#225;tico de Documentaci&#243;n Cl&#237;nica y Anal&#237;tica&#41; the list of patients with the EP code &#40;CIE9&#41; throughout the study period&#46; This work has been approved for Ethical Committee in our hospital&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The variables collected during the acute episode were divided into&#58; epidemiological data &#40;gender and age&#41;&#44; risk factors &#40;family history of VTE&#44; hormone therapy&#44; previous trauma&#44; previous surgery&#44; previous neoplasm &#40;except for non-melanoma skin cancer&#41;&#44; baseline disease &#40;previous history of VTE&#44; arterial hypertension&#44; congestive heart failure&#44; acute coronary syndrome&#44; respiratory insufficiency&#44; chronic airway obstruction&#44; acute cerebrovascular accident&#44; dementia&#44; dyslipidemia and varicose syndrome&#41; and prognostic and clinical characteristics &#40;shock rate&#44; partial oxygen pressure&#44; heart rate&#44; systolic arterial tension&#44; creatinine&#41;&#46; Dyslipidemia was defined as&#58; hypertriglyceremia &#62; 150<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;1&#46;69 mmol&#47;L&#41; or HDL cholesterol &#40;high-density lipoprotein&#41; &#60; 40<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; &#40;1&#46;04 mmol&#47;L&#41; in males and &#60; 50<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;1&#46;29 mmol&#47;L&#41; in females&#46; Congestive heart insufficiency was defined taking into account the NYHA functional class I-IV classification&#46; Dementia was defined according to DSM-IV criteria &#40;memory impairment and at least one of the following cognitive alterations&#58; aphasia&#44; apraxia&#44; agnosia&#44; alteration of cognitive functions&#46; Also&#44; these factors must be intense enough to interfere with the occupational or social activities of the patients&#46; The alterations indicate a deterioration of such functions in comparison to the previous situation of the patient&#46; These symptoms are not exclusive of an embarrassment state&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Follow up of patients&#58;</span> In order to analyse survival rates and long term complications we followed up all patients who did not die during admission&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">All patients were followed up in a monographic visit of thromboembolic disease at months 1&#44; 3&#44; 6&#44; 12&#44; 18 and 24&#46; We noted down the date and cause of death of all the patients who died during the follow-up period&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Strategy to capture losses was divided into&#58;</span> 1&#41; telephone contact with the patients who did not attend the follow-up visits&#44; 2&#41; Computer System for the Management of Clinical and Analytical Documentation &#40;SIDCA&#41; of the University Hospital Virgen del Roc&#237;o to identify episodes requiring admission or referral to other units&#44; 3&#41; Review of clinical histories&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical analysis</span><p id="par0075" class="elsevierStylePara elsevierViewall">In the statistical analysis of the results obtained we indicate both absolute and relative frequency for qualitative variables&#44; and mean and standard deviation for quantitative variables&#46; In case of asymmetrical distribution of the variables&#44; we analysed median values and interquartile range&#46; We compared the groups &#40;deceased and non deceased&#41; using the chi-square test &#40;qualitative variables&#41; considering a p value &#60; 0&#46;05 as statistically significant&#46; The comparison of time free from episodes has been performed by means of the Kaplan-Meier test together with the log rank test and multivariate analysis in order to control possible confusing variables&#44; according to the Cox regression model&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0080" class="elsevierStylePara elsevierViewall">The sample obtained in our cohort was 148 patients&#46; Half of the patients &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>74&#41; were male&#46; Mean age of patients was 64&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;2 yrs&#46; During the two-year follow-up period 34 patients died &#40;23&#37;&#41;&#46; The causes of death were&#58; cancer &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&#44; acute coronary syndrome &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41;&#44; sudden death with dyspnoea &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#41;&#44; major bleeding in the digestive tract &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; non hemorrhagic acute cerebrovascular stroke &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41; and unknown causes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41;&#46; Accumulated mortality rate reached 19&#46;2&#37; after one year and 29&#46;6&#37; after two years&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Patients &#40;272 patients&#47;year&#41; were followed up for a period of 24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#46;8 &#40;median<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>range&#41;&#46; 73&#46;6&#37; of the sample &#40;23&#37; dead and 3&#46;4&#37; lost&#41; was followed up for 24 months&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Table <a class="elsevierStyleCrossRef" href="#tbl0005">&#40;table 1&#41;</a> shows those variables whose possible association with less survival rate at two years has been analysed&#46; Independent variables associated to less survival rate were&#58; creatinine levels &#62; 2 &#40;OR&#44; 8&#46;8&#59; 95&#37; CI&#44; 1&#46;1 &#8211; 70&#46;87&#41;&#44; previous neoplasm &#40;OR&#44; 8&#46;8&#59; 95&#37; CI&#44; 3&#46;69 &#8211; 20&#46;98&#41;&#44; dementia &#40;OR&#44; 6&#46;85&#59; 95&#37; CI&#44; 2&#46;1 &#8211; 22&#46;33&#41; and dyslipidemia &#40;OR&#44; 5&#46;07&#59; 95&#37; CI&#44; 1&#46;92 &#8211; 13&#46;44&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">The 44&#46;45&#37; of patients with dyslipidemia died vs&#46; 20&#46;8&#37; of patients who did not show such condition &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; No significant differences were observed in relation to mean age &#40;63&#46;8 vs&#46; 68&#46;7&#41; or gender between patients with and without dyslipidemia&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">One of the most relevant data obtained in the present study&#44; and which contributes to its seriousness and external accuracy&#44; is the appropriate two-year follow-up of 97&#37; of the sample made up only of patients with PE who were consecutively and prospectively enrolled in the study&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The sample of patients was homogeneous and its distribution between genders was similar to that observed in other studies<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;14</span></a>&#46; Patient age was similar to that reported by different series in the United States<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#44; Spain<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and other European studies<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;17</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Reported survival rate after VTE varies widely<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;18</span></a>&#46; Such variability is probably the result of the shortcomings observed in study design&#58; patients with negative clinical evolution<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#8211;21</span></a>&#44; patients diagnosed in residences<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;22</span></a>&#44; age &#62; 65<span class="elsevierStyleHsp" style=""></span>years<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;22</span></a>&#44; patients admitted to tertiary level hospitals<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;24</span></a> or patients from clinical trials<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#44;26</span></a>&#46; As a result&#44; an accurate estimate of global survival rate associated to VTE cannot be obtained&#46; Anyway mortality observed in our study is similar to other series<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The factors associated to a lower survival rate mentioned in our study had already been analysed in previous studies&#44; as in the case of neoplasm&#44; dementia and renal insufficiency<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#8211;29</span></a>&#46; Dementia is considered a negative prognostic factor in new prognostic scales<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29&#44;30</span></a>&#44; but at present dyslipidemia is not included in any scale&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">High serum cholesterol and LDL cholesterol levels&#44; and low HDL cholesterol levels are considered risk factors for atherothrombosis<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a>&#46; Despite their potent effect on atherogenesis&#44; lipids and lipoproteins could affect haemostasis by modulating the procoagulant and fibrinolytic expression and function<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a>&#46; Doggen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> have shown that elevated triglycerides levels pose a higher risk &#40;twofold&#41; for venous thrombosis&#46; A case-control study<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> also reported the fact that hypercholesterolemia is associated with a higher risk of DVT&#46; As regards hypertriglyceridemia&#44; results are controversial&#58; some studies associate it with venous thrombosis<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;12</span></a>&#44; but others do not report such interplay<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a>&#46; It is important to carry out the measurements prior to the onset of therapy&#44; because it is known that lipid levels diminish in the event of an acute vascular episode<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a>&#46; Finally&#44; Tsai et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#44; in their analysis of cardiovascular risk factors and incidence of a first episode of VTE&#44; concluded that some arterial risk factors&#44; including dyslipidemia&#44; were not associated with VTE&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">All the above mentioned studies establish the association of dyslipidemia with a first episode of VTE&#44; but we report the association of dyslipidemia&#44; as an independent risk factor&#44; with lower long-term survival rate in patients with PE&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The interplay between dylipidemia and PE in this sense has not been thoroughly analysed yet&#46; In our series&#44; long-term mortality rate due to vascular reasons in patients with dyslipidemia who have suffered PE is sevenfold greater than mortality in untreated dyslipidemic patients<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; Moreover&#44; the mortality rate observed in our patients with PE is more than twofold greater in patients with dylipidemia than in those without this condition&#46; We do not know for sure whether the fact of having suffered an episode of PE boosts the effect of dyslipidemia as a prognostic factor for lower survival&#46; Nor do we know whether patients with dyslipidemia who suffer PE are those with a more advanced or difficult to manage metabolic disease&#46; Other questions we should answer would be&#58; which parameters defined as dyslipidemia are considered more determinant and whether the prognosis of these patients may improve with statin therapy&#46; This last question would have significant practical implications as we already know that statin therapy in dyslipidemic patients reduces mortality in 12&#46;37&#37; a year&#44; disregard of the cause of death<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;This work has several limitations&#46; Firstly&#44; the sample of patients included in our study is not large but the results get at hypothetical new factor related to a poor survival&#46; Further studies with larger samples and primarily focused on this issue could answer many of the above mentioned questions&#46; Secondly&#44; other data not available and would be interesting to contrast with the results obtained are quantitative results of total cholesterol&#44; LDL-cholesterol&#44; HDL cholesterol&#44; triglycerides&#44; duplication of tests and if the analytical was fasting or not&#44; and whether the patient was taking statins&#46; Individuals treated with lipid-lowering drugs should be excluded or taking into account&#44; because treatment could affect lipid levels&#46; Several studies&#44; including ours&#44; did not make such exclusion<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;35</span></a>&#46; These data were not considered when designing the study&#46; The development of prospective studies should collect these data&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">We think that this finding also becomes more important due mainly to two recently published papers&#46; Khemasuwan et al&#46; suggest that the use of statins is associated with a significant reduction in the occurrence of venous thromboembolism in patients with cancer<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&#46; Glynn et al&#46; in a randomized trial of apparently healthy persons found that rosuvastatin significantly reduced the occurrence of symptomatic venous thromboembolism<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a>&#46; These previous results in addition to our work open a field of research on whether this type of Venous Thromboembolism patients may benefit from treatment with statins&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusion</span><p id="par0145" class="elsevierStylePara elsevierViewall">We could summarize that in our study&#44; patients with dyslipidemia who suffered PE showed worse survival rate&#46; The role dyslipidemia may have as a vascular risk factor especially in patients with PE and the possibility to improve survival rates warrants further investigation&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interests</span><p id="par0150" class="elsevierStylePara elsevierViewall">Authors declare that they don&#8217;t have any conflict of interests&#46;</p></span></span>"
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    "fechaRecibido" => "2010-12-16"
    "fechaAceptado" => "2011-03-10"
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            0 => "Dyslipidemia"
            1 => "Lipid metabolic disorders"
            2 => "Pulmonary embolism"
            3 => "Survival analysis"
            4 => "Venous thromboembolism"
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        "titulo" => "Abstract"
        "resumen" => "<span><span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyse survival rate after 24 months in consecutive patients with a diagnosis of PE as well as associated factors&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective cohort study during a follow-up period of two years in a series of consecutive patients with PE&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">During the follow-up period&#44; 34 out of 148 patients died &#40;23&#37;&#41;&#46; Factors independently associated with reduced survival rate were&#58; creatinine levels &#62; 2 &#40;OR&#44; 8&#46;8&#59; 95&#37; CI&#44; 1&#46;1 - 70&#46;87&#41;&#44; previous neoplasm &#40;OR&#44; 8&#46;8&#59; 95&#37; CI&#44; 3&#46;69 - 20&#46;98&#41;&#44; dementia &#40;OR&#44; 6&#46;85&#59; 95&#37; CI&#44; 2&#46;1 - 22&#46;33&#41; and dyslipidemia &#40;OR&#44; 5&#46;07&#59; 95&#37; CI&#44; 1&#46;92 - 13&#46;44&#41;&#46; Forty four percent of the patients with dyslipidemia died vs&#46; 20&#46;8&#37; of patients without this condition&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In our study dyslipidemia shows as a long-term negative prognostic marker for survival in patients with EP&#46;</p></span>"
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        "resumen" => "<span><span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analisar a taxa de sobreviv&#234;ncia ap&#243;s 24 meses&#44; em pacientes consecutivos com diagn&#243;stico de PE&#44; bem como fatores associados&#46;</p></span> <span><span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudo prospectivo durante um per&#237;odo de seguimento de dois anos em uma s&#233;rie consecutiva de pacientes com PE&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Durante o per&#237;odo de acompanhamento&#44; 34 dos 148 pacientes morreram &#40;23&#37;&#41;&#46; Fatores independentemente associados &#224; reduzida taxa de sobreviv&#234;ncia foram&#58; os n&#237;veis de creatinina&#62; 2 &#40;OR&#44; 8&#44;8&#59; 95&#37; CI&#44; 1&#44;1-70&#44;87&#41;&#44; neoplasia anterior &#40;OR&#44; 8&#44;8&#59; IC 95&#37;&#44; 3&#44;69-20&#44;98&#41;&#44; dem&#234;ncia &#40;OR&#44; 6&#44;85&#59; 95&#37; CI&#44; 2&#44;1-22&#44;33&#41; e dislipidemia &#40;OR&#44; 5&#44;07&#59; IC 95&#37;&#44; 1&#44;92-13&#44;44&#41;&#46; Quarenta e quatro por cento dos pacientes com dislipidemia morreram contra 20&#44;8&#37; dos pacientes sem essa condi&#231;&#227;o&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclus&#245;es</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">No nosso estudo&#44; a dislipidemia mostra-se um marcador progn&#243;stico negativo de longo prazo na sobrevida de pacientes com EP&#46;</p></span>"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Cumulative survival in patients with and without dyslipidemia&#46;</p>"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">CI&#58; Confidence interval&#59; VTE&#58; Venous thromboembolic disease&#59; CHF&#58; Congestive heart failure&#59; ACS&#58; Acute coronary syndrome&#59; ACVA&#58; Acute cerebrovascular accident&#59; pO2&#58; Partial oxygen pressure&#59; HR&#58; Heart rate&#59; p&#58; p &#60; 0&#46;05 is considered as statistically significant&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Survive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Die&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Relative Risk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">CI&#160;95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleBold">Demographic characteristics</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Males</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55 &#40;74&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;25&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;66-2&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;44 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Age &#62;70 yrs</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52 &#40;78&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;21&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;43-1&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;65 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Risk factors</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Hormonal therapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;72&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;27&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;50-2&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;68 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Trauma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;92&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;7&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;03-1&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;17 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31 &#40;83&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;16&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;25-1&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;27 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Previous neoplasm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;45&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;54&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;58-9&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;000<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleBold">Baseline disease</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Previous history of VTE</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;86&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;13&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;17-1&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;31 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hypertension</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;73&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;26&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;70-2&#46;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;35 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">CHF</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;73&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;26&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;51-2&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;72 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ACS</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;58&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;41&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;94-4&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Chronic air-flow obstruction</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;65&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;35&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;76-4&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;19&#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Asthma</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;90&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;9&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;05-2&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;31 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ACVA</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;75&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;25&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;43-2&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;84 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dementia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;11-8&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dislypidemia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;55&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;44&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;19-5&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Varicose syndrome</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;88&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;11&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;13-1&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;15 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleBold">Prognostic and evolutive characteristics</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Shock rate &#8805;1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21 &#40;72&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;58-2&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;53 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">pO2 &#60; 60 mmHg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25 &#40;73&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;26&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;50-2&#46;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;82 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">HR &#62; 90 spm</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">74 &#40;77&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21 &#40;22&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;44-1&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;70 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Systolic arterial pressure &#60;100 mmHg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;77&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;22&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;39-2&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;99 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Creatinine &#62;2 mg&#47;dL</span>&nbsp;\t\t\t\t\t\t\n
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Dyslipidemia as a long-term marker for survival in pulmonary embolism
L. Jara-Palomaresa,
Corresponding author
luisoneumo@hotmail.com

Autor para correspondencia.
, R. Otero-Candeleraa, T. Elias-Hernandeza, A. Cayuela-Dominguezb, M. Ferrer-Galvana, M.J. Alfaroc, E. Monteroc, E. Barrot-Cortesa
a Medical-Surgical Unit of Respiratory Diseases, University Hospital Virgen del Rocio, Seville, Spain
b Research Unit, University Hospital Virgen del Rocío, Seville, Spain
c Emergency Unit, University Hospital Virgen del Rocio, Seville, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Venous thromboembolic disease &#40;VTE&#41; is a complex condition with a multifactor aetiology in which both the clinical history of the patient and the genetic and environmental factors play a role&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Survival rate after VTE is worse than expected and it is even worse after pulmonary embolism &#40;PE&#41; than after deep venous thrombosis &#40;DVT&#41; alone<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#46; Mortality during follow-up of patients with VTE has been the topic of several research studies and it ranges from 12&#46;5&#37;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> to 37&#37;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46; VTE recurrence is so often that&#44; about 30&#37; of patients&#44; present recurrences in the following 10<span class="elsevierStyleHsp" style=""></span>years<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Patients with VTE show several variables associated to a decreased survival rate&#46; From a clinical point of view&#44; it is interesting to which those aspects can be treated&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Patients with non treated dyslipidemia have a global mortality rate a year of 9&#46;7&#37;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; As shown by several double-blind placebo-controlled studies&#44; the use of statins to reduce cholesterol levels significantly decrease cardiovascular risk<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#46; Lower levels of cholesterol achieved by the administration of statins may reduce the incidence of ictus in high risk populations and in patients with ictus or transient ischemic attack<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Although we have found some studies which associate dyslipidemia with a higher risk of VTE<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#8211;12</span></a>&#44; none of these works has documented the prognostic role dyslipidemia may play in this type of patients&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this paper&#44; we present a long-term study of a series of consecutive patients diagnosed with PE aiming to analyse the main complications of such condition and their distribution in time and to establish the factors associated with a lower survival rate&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Material and methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Study design</span><p id="par0035" class="elsevierStylePara elsevierViewall">Prospective cohort study with a follow-up period of two years&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Patients</span><p id="par0040" class="elsevierStylePara elsevierViewall">We analysed a cohort of consecutive patients diagnosed with PE from February 2003 through September 2004 at the University Hospital Virgen del Roc&#237;o in Seville&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Methods</span><p id="par0045" class="elsevierStylePara elsevierViewall">We considered as diagnostic criteria for PE&#58; 1&#41; high probability ventilation&#47;perfusion lung scan&#44; 2&#41; intermediate or low probability ventilation&#47;perfusion lung scan with signs suggestive of arterial thrombosis as revealed by pulmonary angiography with or without signs of venous thrombosis in lower limbs through ultrasound scan or venography&#46; 3&#41; Intraluminal filling defect observed in pulmonary angiography or consecutive sections of the vessels or more than 2&#46;5<span class="elsevierStyleHsp" style=""></span>mm in diameter as revealed by pulmonary angiography&#46; 4&#41; Intraluminal filling defect in segmentary branches or in more proximal branches as observed in helical CT scan&#46;</p><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Data collection strategy during the initial PE episode</span><p id="par0050" class="elsevierStylePara elsevierViewall">Patients were enrolled in the study through periodical visits to the Emergency Unit&#44; Internal Medicine Unit&#44; Pneumology&#44; Nuclear Medicine and Radiology Units&#46; A series of variables were noted down in a form designed for the purpose and were subsequently converted into computer format&#46; Periodical visit were made to the units where the patients were admitted in order to confirm the correct completion of the form&#46; We also revised in the Computer System for the Management of Clinical and Analytical Documentation &#40;SIDCA&#41; &#40;Sistema Inform&#225;tico de Documentaci&#243;n Cl&#237;nica y Anal&#237;tica&#41; the list of patients with the EP code &#40;CIE9&#41; throughout the study period&#46; This work has been approved for Ethical Committee in our hospital&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The variables collected during the acute episode were divided into&#58; epidemiological data &#40;gender and age&#41;&#44; risk factors &#40;family history of VTE&#44; hormone therapy&#44; previous trauma&#44; previous surgery&#44; previous neoplasm &#40;except for non-melanoma skin cancer&#41;&#44; baseline disease &#40;previous history of VTE&#44; arterial hypertension&#44; congestive heart failure&#44; acute coronary syndrome&#44; respiratory insufficiency&#44; chronic airway obstruction&#44; acute cerebrovascular accident&#44; dementia&#44; dyslipidemia and varicose syndrome&#41; and prognostic and clinical characteristics &#40;shock rate&#44; partial oxygen pressure&#44; heart rate&#44; systolic arterial tension&#44; creatinine&#41;&#46; Dyslipidemia was defined as&#58; hypertriglyceremia &#62; 150<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;1&#46;69 mmol&#47;L&#41; or HDL cholesterol &#40;high-density lipoprotein&#41; &#60; 40<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; &#40;1&#46;04 mmol&#47;L&#41; in males and &#60; 50<span class="elsevierStyleHsp" style=""></span>mg&#47;dL &#40;1&#46;29 mmol&#47;L&#41; in females&#46; Congestive heart insufficiency was defined taking into account the NYHA functional class I-IV classification&#46; Dementia was defined according to DSM-IV criteria &#40;memory impairment and at least one of the following cognitive alterations&#58; aphasia&#44; apraxia&#44; agnosia&#44; alteration of cognitive functions&#46; Also&#44; these factors must be intense enough to interfere with the occupational or social activities of the patients&#46; The alterations indicate a deterioration of such functions in comparison to the previous situation of the patient&#46; These symptoms are not exclusive of an embarrassment state&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Follow up of patients&#58;</span> In order to analyse survival rates and long term complications we followed up all patients who did not die during admission&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">All patients were followed up in a monographic visit of thromboembolic disease at months 1&#44; 3&#44; 6&#44; 12&#44; 18 and 24&#46; We noted down the date and cause of death of all the patients who died during the follow-up period&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Strategy to capture losses was divided into&#58;</span> 1&#41; telephone contact with the patients who did not attend the follow-up visits&#44; 2&#41; Computer System for the Management of Clinical and Analytical Documentation &#40;SIDCA&#41; of the University Hospital Virgen del Roc&#237;o to identify episodes requiring admission or referral to other units&#44; 3&#41; Review of clinical histories&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Statistical analysis</span><p id="par0075" class="elsevierStylePara elsevierViewall">In the statistical analysis of the results obtained we indicate both absolute and relative frequency for qualitative variables&#44; and mean and standard deviation for quantitative variables&#46; In case of asymmetrical distribution of the variables&#44; we analysed median values and interquartile range&#46; We compared the groups &#40;deceased and non deceased&#41; using the chi-square test &#40;qualitative variables&#41; considering a p value &#60; 0&#46;05 as statistically significant&#46; The comparison of time free from episodes has been performed by means of the Kaplan-Meier test together with the log rank test and multivariate analysis in order to control possible confusing variables&#44; according to the Cox regression model&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0080" class="elsevierStylePara elsevierViewall">The sample obtained in our cohort was 148 patients&#46; Half of the patients &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>74&#41; were male&#46; Mean age of patients was 64&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;2 yrs&#46; During the two-year follow-up period 34 patients died &#40;23&#37;&#41;&#46; The causes of death were&#58; cancer &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&#44; acute coronary syndrome &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41;&#44; sudden death with dyspnoea &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#41;&#44; major bleeding in the digestive tract &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; non hemorrhagic acute cerebrovascular stroke &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41; and unknown causes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41;&#46; Accumulated mortality rate reached 19&#46;2&#37; after one year and 29&#46;6&#37; after two years&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Patients &#40;272 patients&#47;year&#41; were followed up for a period of 24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>23&#46;8 &#40;median<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>range&#41;&#46; 73&#46;6&#37; of the sample &#40;23&#37; dead and 3&#46;4&#37; lost&#41; was followed up for 24 months&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Table <a class="elsevierStyleCrossRef" href="#tbl0005">&#40;table 1&#41;</a> shows those variables whose possible association with less survival rate at two years has been analysed&#46; Independent variables associated to less survival rate were&#58; creatinine levels &#62; 2 &#40;OR&#44; 8&#46;8&#59; 95&#37; CI&#44; 1&#46;1 &#8211; 70&#46;87&#41;&#44; previous neoplasm &#40;OR&#44; 8&#46;8&#59; 95&#37; CI&#44; 3&#46;69 &#8211; 20&#46;98&#41;&#44; dementia &#40;OR&#44; 6&#46;85&#59; 95&#37; CI&#44; 2&#46;1 &#8211; 22&#46;33&#41; and dyslipidemia &#40;OR&#44; 5&#46;07&#59; 95&#37; CI&#44; 1&#46;92 &#8211; 13&#46;44&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">The 44&#46;45&#37; of patients with dyslipidemia died vs&#46; 20&#46;8&#37; of patients who did not show such condition &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a>&#41;&#46; No significant differences were observed in relation to mean age &#40;63&#46;8 vs&#46; 68&#46;7&#41; or gender between patients with and without dyslipidemia&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0100" class="elsevierStylePara elsevierViewall">One of the most relevant data obtained in the present study&#44; and which contributes to its seriousness and external accuracy&#44; is the appropriate two-year follow-up of 97&#37; of the sample made up only of patients with PE who were consecutively and prospectively enrolled in the study&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The sample of patients was homogeneous and its distribution between genders was similar to that observed in other studies<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13&#44;14</span></a>&#46; Patient age was similar to that reported by different series in the United States<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a>&#44; Spain<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and other European studies<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;17</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Reported survival rate after VTE varies widely<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;18</span></a>&#46; Such variability is probably the result of the shortcomings observed in study design&#58; patients with negative clinical evolution<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19&#8211;21</span></a>&#44; patients diagnosed in residences<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#8211;22</span></a>&#44; age &#62; 65<span class="elsevierStyleHsp" style=""></span>years<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15&#44;22</span></a>&#44; patients admitted to tertiary level hospitals<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;24</span></a> or patients from clinical trials<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">25&#44;26</span></a>&#46; As a result&#44; an accurate estimate of global survival rate associated to VTE cannot be obtained&#46; Anyway mortality observed in our study is similar to other series<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">The factors associated to a lower survival rate mentioned in our study had already been analysed in previous studies&#44; as in the case of neoplasm&#44; dementia and renal insufficiency<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">27&#8211;29</span></a>&#46; Dementia is considered a negative prognostic factor in new prognostic scales<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29&#44;30</span></a>&#44; but at present dyslipidemia is not included in any scale&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">High serum cholesterol and LDL cholesterol levels&#44; and low HDL cholesterol levels are considered risk factors for atherothrombosis<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a>&#46; Despite their potent effect on atherogenesis&#44; lipids and lipoproteins could affect haemostasis by modulating the procoagulant and fibrinolytic expression and function<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a>&#46; Doggen et al&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> have shown that elevated triglycerides levels pose a higher risk &#40;twofold&#41; for venous thrombosis&#46; A case-control study<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> also reported the fact that hypercholesterolemia is associated with a higher risk of DVT&#46; As regards hypertriglyceridemia&#44; results are controversial&#58; some studies associate it with venous thrombosis<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;12</span></a>&#44; but others do not report such interplay<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a>&#46; It is important to carry out the measurements prior to the onset of therapy&#44; because it is known that lipid levels diminish in the event of an acute vascular episode<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a>&#46; Finally&#44; Tsai et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a>&#44; in their analysis of cardiovascular risk factors and incidence of a first episode of VTE&#44; concluded that some arterial risk factors&#44; including dyslipidemia&#44; were not associated with VTE&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">All the above mentioned studies establish the association of dyslipidemia with a first episode of VTE&#44; but we report the association of dyslipidemia&#44; as an independent risk factor&#44; with lower long-term survival rate in patients with PE&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">The interplay between dylipidemia and PE in this sense has not been thoroughly analysed yet&#46; In our series&#44; long-term mortality rate due to vascular reasons in patients with dyslipidemia who have suffered PE is sevenfold greater than mortality in untreated dyslipidemic patients<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; Moreover&#44; the mortality rate observed in our patients with PE is more than twofold greater in patients with dylipidemia than in those without this condition&#46; We do not know for sure whether the fact of having suffered an episode of PE boosts the effect of dyslipidemia as a prognostic factor for lower survival&#46; Nor do we know whether patients with dyslipidemia who suffer PE are those with a more advanced or difficult to manage metabolic disease&#46; Other questions we should answer would be&#58; which parameters defined as dyslipidemia are considered more determinant and whether the prognosis of these patients may improve with statin therapy&#46; This last question would have significant practical implications as we already know that statin therapy in dyslipidemic patients reduces mortality in 12&#46;37&#37; a year&#44; disregard of the cause of death<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46;This work has several limitations&#46; Firstly&#44; the sample of patients included in our study is not large but the results get at hypothetical new factor related to a poor survival&#46; Further studies with larger samples and primarily focused on this issue could answer many of the above mentioned questions&#46; Secondly&#44; other data not available and would be interesting to contrast with the results obtained are quantitative results of total cholesterol&#44; LDL-cholesterol&#44; HDL cholesterol&#44; triglycerides&#44; duplication of tests and if the analytical was fasting or not&#44; and whether the patient was taking statins&#46; Individuals treated with lipid-lowering drugs should be excluded or taking into account&#44; because treatment could affect lipid levels&#46; Several studies&#44; including ours&#44; did not make such exclusion<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;35</span></a>&#46; These data were not considered when designing the study&#46; The development of prospective studies should collect these data&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">We think that this finding also becomes more important due mainly to two recently published papers&#46; Khemasuwan et al&#46; suggest that the use of statins is associated with a significant reduction in the occurrence of venous thromboembolism in patients with cancer<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a>&#46; Glynn et al&#46; in a randomized trial of apparently healthy persons found that rosuvastatin significantly reduced the occurrence of symptomatic venous thromboembolism<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a>&#46; These previous results in addition to our work open a field of research on whether this type of Venous Thromboembolism patients may benefit from treatment with statins&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusion</span><p id="par0145" class="elsevierStylePara elsevierViewall">We could summarize that in our study&#44; patients with dyslipidemia who suffered PE showed worse survival rate&#46; The role dyslipidemia may have as a vascular risk factor especially in patients with PE and the possibility to improve survival rates warrants further investigation&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interests</span><p id="par0150" class="elsevierStylePara elsevierViewall">Authors declare that they don&#8217;t have any conflict of interests&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span><span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyse survival rate after 24 months in consecutive patients with a diagnosis of PE as well as associated factors&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective cohort study during a follow-up period of two years in a series of consecutive patients with PE&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">During the follow-up period&#44; 34 out of 148 patients died &#40;23&#37;&#41;&#46; Factors independently associated with reduced survival rate were&#58; creatinine levels &#62; 2 &#40;OR&#44; 8&#46;8&#59; 95&#37; CI&#44; 1&#46;1 - 70&#46;87&#41;&#44; previous neoplasm &#40;OR&#44; 8&#46;8&#59; 95&#37; CI&#44; 3&#46;69 - 20&#46;98&#41;&#44; dementia &#40;OR&#44; 6&#46;85&#59; 95&#37; CI&#44; 2&#46;1 - 22&#46;33&#41; and dyslipidemia &#40;OR&#44; 5&#46;07&#59; 95&#37; CI&#44; 1&#46;92 - 13&#46;44&#41;&#46; Forty four percent of the patients with dyslipidemia died vs&#46; 20&#46;8&#37; of patients without this condition&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In our study dyslipidemia shows as a long-term negative prognostic marker for survival in patients with EP&#46;</p></span>"
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        "resumen" => "<span><span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analisar a taxa de sobreviv&#234;ncia ap&#243;s 24 meses&#44; em pacientes consecutivos com diagn&#243;stico de PE&#44; bem como fatores associados&#46;</p></span> <span><span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudo prospectivo durante um per&#237;odo de seguimento de dois anos em uma s&#233;rie consecutiva de pacientes com PE&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Durante o per&#237;odo de acompanhamento&#44; 34 dos 148 pacientes morreram &#40;23&#37;&#41;&#46; Fatores independentemente associados &#224; reduzida taxa de sobreviv&#234;ncia foram&#58; os n&#237;veis de creatinina&#62; 2 &#40;OR&#44; 8&#44;8&#59; 95&#37; CI&#44; 1&#44;1-70&#44;87&#41;&#44; neoplasia anterior &#40;OR&#44; 8&#44;8&#59; IC 95&#37;&#44; 3&#44;69-20&#44;98&#41;&#44; dem&#234;ncia &#40;OR&#44; 6&#44;85&#59; 95&#37; CI&#44; 2&#44;1-22&#44;33&#41; e dislipidemia &#40;OR&#44; 5&#44;07&#59; IC 95&#37;&#44; 1&#44;92-13&#44;44&#41;&#46; Quarenta e quatro por cento dos pacientes com dislipidemia morreram contra 20&#44;8&#37; dos pacientes sem essa condi&#231;&#227;o&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclus&#245;es</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">No nosso estudo&#44; a dislipidemia mostra-se um marcador progn&#243;stico negativo de longo prazo na sobrevida de pacientes com EP&#46;</p></span>"
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Cumulative survival in patients with and without dyslipidemia&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">CI&#58; Confidence interval&#59; VTE&#58; Venous thromboembolic disease&#59; CHF&#58; Congestive heart failure&#59; ACS&#58; Acute coronary syndrome&#59; ACVA&#58; Acute cerebrovascular accident&#59; pO2&#58; Partial oxygen pressure&#59; HR&#58; Heart rate&#59; p&#58; p &#60; 0&#46;05 is considered as statistically significant&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Survive&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Die&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Relative Risk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">CI&#160;95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleBold">Demographic characteristics</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Males</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">55 &#40;74&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;25&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;66-2&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;44 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Age &#62;70 yrs</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52 &#40;78&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;21&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;43-1&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;65 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Risk factors</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Hormonal therapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;72&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;27&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;50-2&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;68 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Trauma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;92&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;7&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;03-1&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;17 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31 &#40;83&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;16&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;25-1&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;27 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Previous neoplasm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;45&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;54&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;58-9&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;000<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleBold">Baseline disease</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Previous history of VTE</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;86&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;13&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;17-1&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;31 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Hypertension</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;73&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;26&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;70-2&#46;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;35 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">CHF</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;73&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;26&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;51-2&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;72 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ACS</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;58&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;41&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;94-4&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Chronic air-flow obstruction</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;65&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;35&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;76-4&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;19&#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Asthma</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;90&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;9&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;05-2&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;31 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">ACVA</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;75&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;25&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;43-2&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;84 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dementia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;11-8&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dislypidemia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;55&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;44&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;19-5&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Varicose syndrome</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;88&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;11&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;13-1&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;15 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleBold">Prognostic and evolutive characteristics</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Shock rate &#8805;1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21 &#40;72&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;58-2&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;53 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">pO2 &#60; 60 mmHg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">25 &#40;73&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;26&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;50-2&#46;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;82 &#40;NS&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">HR &#62; 90 spm</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">74 &#40;77&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Systolic arterial pressure &#60;100 mmHg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;77&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5 &#40;22&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;39-2&#46;57&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Creatinine &#62;2 mg&#47;dL</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;33&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;66&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;57-27&#46;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Variables associated to less survival rate&#46;</p>"
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Article information
ISSN: 08732159
Original language: English
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