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and long-term HD therapy via an arteriovenous &#40;AV&#41; access to the pathogenesis of PAH in these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> On the other hand&#44; the prevalence of PAH in patients on peritoneal dialysis &#40;PD&#41; is still a matter of debate&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The information in the literature regarding unexplained or primary PAH in ESRD patients especially PD patients is limited&#46; Therefore&#44; the aim of the present study was to compare the prevalence of unexplained PAH in HD and PD patients&#46; In addition&#44; we aimed to compare laboratory parameters between patients with unexplained PAH and those with normal pulmonary artery pressure &#40;PAP&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Materials and methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">We retrospectively reviewed the medical records of 278 chronic HD and 145 chronic PD patients treated at the hospitals affiliated to the university in Tabriz&#44; Iran between May 2008 and January 2010&#46; The patients&#8217; data including age&#44; sex&#44; co-morbidities&#44; medications&#44; tobacco use&#44; etiology of renal failure&#44; vascular access type&#44; and duration of dialysis therapy were recorded&#46; Laboratory findings including hemoglobin&#44; calcium&#44; phosphorus&#44; alkaline phosphatase&#44; albumin&#44; parathyroid hormone &#40;PTH&#41; level&#44; serum iron&#44; total iron binding capacity&#44; ferritin&#44; creatinine and blood urea nitrogen were documented&#46; The results of transthoracic Doppler echocardiography were used to determine the pulmonary artery pressure&#44; expiratory and inspiratory inferior vena cava &#40;IVC&#41; diameters and percent collapse&#44; left ventricular ejection fraction&#44; presence of valvular diseases&#44; etc&#46; PAH was defined as a systolic pulmonary artery pressure &#40;SPAP&#41; &#8805;35<span class="elsevierStyleHsp" style=""></span>mmHg&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Patients with cardiac disease&#44; pulmonary disease&#44; collagen vascular disease&#44; volume overload at the time of echocardiography &#40;&#60;50&#37; collapsibility in IVC diameter&#41; and positive human immunodeficiency virus &#40;HIV&#41; test were excluded&#46; Additionally&#44; patients treated with dialysis &#60;3 months or &#62;7 years were not included in the present study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Data were presented as median &#40;interquartile range&#41;&#46; All statistical analyses were performed with Statistical Package of Social Science &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#41; for Windows version 16&#46; The Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#44; chi-square test and Fisher&#39;s exact test were used wherever appropriate&#46; A <span class="elsevierStyleItalic">P</span>-value &#60;0&#46;05 was considered statistically significant&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0025" class="elsevierStylePara elsevierViewall">Data from 66 patients were analyzed&#58; 34 in group HD and 32 in group PD &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The median age of the study population was 57 &#40;45&#8211;68&#41; years&#46; The median duration of dialysis was 102 &#40;54&#46;25&#8211;161&#41; weeks in HD group and 44 &#40;24&#46;5&#8211;82&#41; weeks in PD group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#44; Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#41;&#46; Among HD group&#44; 18 patients &#40;53&#37;&#41; had proximal and 16 patients &#40;47&#37;&#41; had distal arteriovenous fistula &#40;AVF&#41;&#46; However&#44; none of the patients in PD group had functional AVF&#59; 28 patients were primarily in PD group and 4 patients had primary nonfunctional AVF&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The median SPAP value in patients with PAH was 37&#46;5 &#40;35&#8211;45&#41;<span class="elsevierStyleHsp" style=""></span>mmHg&#46; According to the echocardiographic findings&#44; PAH was detected in 20 &#40;30&#46;3&#37;&#41; patients&#58; 14 &#40;41&#46;1&#37;&#41; patients in HD group and 6 &#40;18&#46;7&#37;&#41; patients in PD group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#44; Fisher&#39;s exact test&#41;&#46; Among HD patients with PAH&#44; vascular access type was proximal and distal AVF in 8 &#40;57&#46;1&#37;&#41; and 6 &#40;42&#46;9&#37;&#41; patients&#44; respectively&#46; None of the PD patients with PAH had vascular access&#46; There were no differences in gender&#44; age&#44; weight&#44; duration of dialysis&#44; calcium&#44; phosphorus&#44; alkaline phosphatase&#44; albumin&#44; parathyroid hormone level&#44; total iron binding capacity&#44; ferritin&#44; creatinine and blood urea nitrogen between the patients with PAH and those with normal PAP &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; The median serum iron was significantly lower in patients with PAH &#40;47<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41; compared to that in patients with normal PAP &#40;71&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#44; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The median hemoglobin of patients with normal PAP was not comparable to that of PAH patients &#40;11&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL vs&#46; 9&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#44; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">The present study revealed that PAH was more frequent in patients undergoing HD &#40;41&#46;1&#37;&#41; than in patients of PD group &#40;18&#46;7&#37;&#41;&#46; Previous studies have mostly reported the prevalence of PAH in HD patients&#44; but not in PD patients&#46; Amin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Yigla et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and Tarrass et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> concluded that there was a high prevalence of PAH among patients with ESRD receiving long-term HD with surgical AV access&#46; The two latter studies differed with regard to the type of PAH&#59; primary and secondary PAH in the former and primary PAH in the latter&#46; Nakhoul and colleagues<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and Havlucu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> found PAH in approximately half of the HD patients&#46; Nakhoul et al&#46; noted a significant decrease in PAP following successful kidney transplants and temporary closure of AV access in some PAH patients&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Kumbar et al&#46; detected PAH &#40;primary and secondary&#41; in 42&#37; of patients on PD&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In a recent study on HD and PD patients&#44; Bozbas and co-workers found a higher PAH ratio in HD compared to that in the PD group &#40;18&#46;8&#37; vs&#46; 5&#46;9&#37;&#41;&#46; Patients with secondary PAH were not excluded in their study&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Furthermore&#44; the duration of dialysis in the HD group was longer than that in the PD group&#46; This may account for the differing incidence of PAH between the two groups&#46; However&#44; previous studies have highlighted no difference in the duration of HD therapy between patients with PAH and those without PAH&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;11</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In recent studies numerous parameters have been compared between patients with PAH and those with normal PAP&#46; In a study on HD patients&#44; Abassi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> and Yigla et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> found that those with elevated PAP had significantly lower hemoglobin and hematocrit levels&#46; Similarly&#44; we observed significantly lower hemoglobin levels in PAH patients in the present study&#46; In contrast&#44; other researchers have failed to detect any difference in hemoglobin and hematocrit levels between the two groups&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6&#44;9&#44;10</span></a> In addition&#44; we found lower serum iron levels in patients with PAH compared to those in normal PAP group&#46; This finding has not been previously reported in patients undergoing HD and&#47;or PD&#46; In a recent study&#44; Ruiter et al&#46; interestingly revealed that iron deficiency was common in idiopathic PAH&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> The present study&#39;s findings are consistent with previous studies which found that PTH level and calcium&#8211;phosphorus product did not differ&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5&#44;7&#44;9&#44;12</span></a> However&#44; Havlucu and colleagues reported higher calcium&#8211;phosphorus production and PTH levels in patients with PAH&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Although we failed to find a significant difference in ferritin levels between PAH and normal PAP groups&#44; Kumbar et al&#46; disclosed lower ferritin levels in patients with PAH&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">There is not yet a clear explanation for the high prevalence of PAH in ESRD&#46; In HD patients&#44; numerous hormonal and metabolic disorders have been attributed to vasoconstriction of pulmonary vessels and pulmonary artery calcification&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;12&#44;14</span></a> However&#44; Amin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and Yigla et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> did not confirm the role of secondary hyperparathyroidism and pulmonary calcification as the etiology of PAH in ESRD patients&#46; Later&#44; Nakhoul et al&#46; studied the role of two endothelial-derived molecules&#44; endothelin-1 and nitric oxide &#40;NO&#41;&#44; in the pathogenesis of PAH in HD patients via AV access&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Although impaired NO production and reduced sensitivity to NO have already been described in patients with chronic renal failure&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Nakhoul et al&#46; first demonstrated a link between impaired NO production and PAH in uremic patients receiving chronic HD therapy via AV access&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> This finding may be also generalized to the patients on PD therapy&#59; NO deficiency has been described in PD patients&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Along with high cardiac output resulting from the AV access&#44; such an endothelial dysfunction may reduce the capability of the pulmonary vasculature to maintain the raised cardiac output and may subsequently contribute to the development of PAH in ESRD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;18</span></a> An increase in the cardiac output and pulmonary blood flow due to the AV access may change shear stress&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> This may alter endothelial function or release of mediators through induction of gene expression patterns&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Moreover&#44; a venous torrent of microbubbles stemming from tubing or dialyzer has been proposed as a potential etiological factor in the development of PAH in this population&#46; These microbubbles obstruct capillaries in the lungs&#44; which may cause tissue ischemia&#44; an inflammatory response and complement activation&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">This study has certain limitations&#46; The retrospective observational design of the study might be considered a weakness in this work&#46; Moreover&#44; PAP was measured by a non-invasive method&#44; Doppler echocardiography&#44; without obtaining direct invasive measurements &#40;e&#46;g&#46; right heart catheterization&#41;&#46; However&#44; measurements of PAP by the applied Doppler echocardiographic method have been reported to have a good correlation with measurements obtained by invasive methods in some studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;21&#44;22</span></a> This method of PAP measurement has been widely applied in previous studies on PAH in patients on HD or PD&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#8211;11&#44;15</span></a> In addition&#44; doses of erythropoiesis-stimulating agent &#40;ESA&#41; were not available in either group&#46; Higher doses of ESA in either group might be a confounding factor and interesting to observe&#46; Furthermore&#44; the effect of the duration of dialysis on the incidence of PAH was not addressed in the present study&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; unexplained PAH seems to be more frequent in patients undergoing HD than patients in the PD group&#46; Moreover&#44; among numerous laboratory parameters&#44; hemoglobin and serum iron levels are lower in patients with PAH compared to those in normal PAP group&#46; Due to the high importance of PAH in ESRD patients receiving both HD and PD therapy&#44; the present findings need to be further explored in larger studies&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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          "identificador" => "xres547614"
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            3 => "Results"
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          "identificador" => "xpalclavsec565495"
          "titulo" => "Keywords"
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            0 => "Resumo"
            1 => "Objetivos"
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            3 => "Resultados"
            4 => "Conclus&#227;o"
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          "titulo" => "Introduction"
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          "titulo" => "Materials and methods"
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          "titulo" => "Results"
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          "identificador" => "sec0020"
          "titulo" => "Discussion"
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        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicts of interest"
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          "titulo" => "References"
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    "fechaRecibido" => "2010-01-29"
    "fechaAceptado" => "2011-07-06"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec565495"
          "palabras" => array:3 [
            0 => "Unexplained pulmonary hypertension"
            1 => "Peritoneal dialysis"
            2 => "Hemodialysis"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec565494"
          "palabras" => array:3 [
            0 => "Hipertens&#227;o arterial pulmonar inexplic&#225;vel"
            1 => "Di&#225;lise peritoneal"
            2 => "Hemodi&#225;lise"
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    "resumen" => array:2 [
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        "titulo" => "Abstract"
        "resumen" => "<span><span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To compare the prevalence of unexplained pulmonary artery hypertension &#40;PAH&#41; in hemodialysis &#40;HD&#41; and peritoneal dialysis &#40;PD&#41; patients and to compare laboratory parameters between patients with unexplained PAH and those with normal pulmonary artery pressure &#40;PAP&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We retrospectively reviewed the medical records of 278 chronic HD and 145 chronic PD patients&#46; Laboratory findings including hemoglobin&#44; calcium&#44; phosphorus&#44; alkaline phosphatase&#44; albumin&#44; parathyroid hormone level&#44; serum iron&#44; total iron binding capacity&#44; ferritin&#44; creatinine and blood urea nitrogen were documented&#46; The results of transthoracic Doppler echocardiography were used to determine the pulmonary artery pressure &#40;PAP&#41;&#46; PAH was defined as a systolic pulmonary artery pressure &#40;SPAP&#41; &#8805;35<span class="elsevierStyleHsp" style=""></span>mmHg&#46; To rule out secondary PAH&#44; patients with cardiac disease&#44; pulmonary disease&#44; collagen vascular disease&#44; volume overload at the time of echocardiography and positive human immunodeficiency virus test were excluded&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Data from 34 patients in group HD and 32 individuals in group PD were analyzed&#46; The median age of the study population was 57 &#40;45&#8211;68&#41; years&#46; The median SPAP value in patients with PAH was 37&#46;5 &#40;35&#8211;45&#41;<span class="elsevierStyleHsp" style=""></span>mmHg&#46; According to the echocardiographic findings&#44; PAH was found in 14 &#40;41&#46;1&#37;&#41; patients of HD group and in 6 &#40;18&#46;7&#37;&#41; patients of PD group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46; The median serum iron and hemoglobin was significantly lower in patients with PAH compared to those in patients with normal PAP &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Unexplained PAH seems to be more frequent in patients undergoing HD than patients in PD group&#46; Moreover&#44; hemoglobin and serum iron levels are lower in patients with PAH compared to those in normal PAP group&#46;</p></span>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span><span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Comparar a preval&#234;ncia de hipertens&#227;o arterial pulmonar &#40;PAH&#41; inexplic&#225;vel em doentes sob hemodi&#225;lise &#40;HD&#41; e di&#225;lise peritoneal &#40;PD&#41; e comparar os par&#226;metros laboratoriais entre doentes com PAH inexplic&#225;vel e aqueles com press&#227;o arterial pulmonar normal &#40;PAP&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Revimos&#44; de forma retrospetiva&#44; os registos m&#233;dicos de 278 doentes com HD cr&#243;nica e 145 com PD cr&#243;nica&#46; Dos dados laboratoriais foram registadas hemoglobina&#44; c&#225;lcio&#44; f&#243;sforo&#44; fosfatase alcalina&#44; albumina&#44; n&#237;vel de paratormona&#44; ferro s&#233;rico&#44; capacidade total de liga&#231;&#227;o de ferro&#44; ferritina&#44; creatinina e nitrog&#233;nio ureico no sangue&#46; Os resultados do ecocardiograma doppler <span class="elsevierStyleItalic">transtor&#225;cico</span> foram utilizados para determinar a press&#227;o arterial pulmonar &#40;PAP&#41;&#46; A PAH foi definida como uma press&#227;o arterial pulmonar sist&#243;lica &#40;SPAP&#41; &#8805;35<span class="elsevierStyleHsp" style=""></span>mmHg&#46; Para excluir a PAH secund&#225;ria&#44; foram exclu&#237;dos os pacientes com problemas card&#237;acos&#44; doen&#231;as pulmonares&#44; doen&#231;as vasculares do colag&#233;nio&#44; excesso de volume na altura do ecocardiograma e v&#237;rus de imunodefici&#234;ncia humana positivo&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Foram analisados dados de 34 pacientes no HD e 32 indiv&#237;duos no grupo PD&#46; A mediana de idade da popula&#231;&#227;o estudada foi de 57 &#40;45&#8211;68&#41; anos&#46; O valor m&#233;dio de SPAP em doentes com PAH foi de 37&#44;5 &#40;35&#8211;45&#41; mmHg&#46; De acordo com os resultados do ecocardiograma&#44; a PAH foi registada em 14 &#40;41&#44;1&#37;&#41; pacientes do grupo HD e em 6 &#40;18&#44;7&#37;&#41; pacientes do grupo PD &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41;&#46; A mediana do ferro s&#233;rico m&#233;dio e da hemoglobina estavam significativamente mais baixos em pacientes com PAH em compara&#231;&#227;o com os pacientes com PAP normal &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A PAH inexplic&#225;vel parece ser mais frequente em pacientes com HD do que em pacientes no grupo de PD&#46; Al&#233;m disso&#44; os n&#237;veis de hemoglobina e ferro s&#233;rico s&#227;o inferiores em pacientes com PAH comparando com os do grupo de PAP normal&#46;</p></span>"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">PAP&#44; pulmonary artery pressure&#59; TIBC&#44; total iron binding capacity&#59; BUN&#44; blood urea nitrogen&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Normal PAP &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Elevated PAP &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Gender &#40;male&#58;female&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#58;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#58;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;5 &#40;39&#46;75&#8211;68&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 &#40;53&#46;75&#8211;67&#46;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Weight &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;5 &#40;54&#8211;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&#46;5 &#40;53&#46;25&#8211;69&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Duration of dialysis &#40;weeks&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57 &#40;27&#46;75&#8211;140&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77 &#40;44&#46;5&#8211;171&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemoglobin &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;3 &#40;9&#46;95&#8211;12&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;9 &#40;9&#46;5&#8211;10&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;004<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Calcium &#40;Ca&#41; &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">249 &#40;193&#46;75&#8211;297&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">215 &#40;174&#8211;312&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;72&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;77&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;09&nbsp;\t\t\t\t\t\t\n
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                    0 => array:2 [
                      "titulo" => "The long-term effects of arteriovenous fistula creation on the development of pulmonary hypertension in hemodialysis patients"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            2 => "S&#46; Oymak"
                            3 => "M&#46; Duran"
                            4 => "I&#46; Kocyigit"
                            5 => "F&#46; Oguz"
                          ]
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                    0 => array:2 [
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                        "tituloSerie" => "Hemodial Int"
                        "fecha" => "2010"
                        "volumen" => "14"
                        "paginaInicial" => "398"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20854331"
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                          ]
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                      ]
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                  ]
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              "etiqueta" => "2"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary arterial hypertension"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;W&#46; Farber"
                            1 => "J&#46; Loscalzo"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1056/NEJMra035488"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "351"
                        "paginaInicial" => "1655"
                        "paginaFinal" => "1665"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15483284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
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              "etiqueta" => "3"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Background diseases in 671 patients with moderate to severe pulmonary hypertension"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Yigla"
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                            2 => "Z&#46;S&#46; Azzam"
                            3 => "A&#46;H&#46; Rubin"
                            4 => "S&#46;A&#46; Reisner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Isr Med Assoc J"
                        "fecha" => "2000"
                        "volumen" => "2"
                        "paginaInicial" => "684"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11062769"
                            "web" => "Medline"
                          ]
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                      "titulo" => "Pulmonary hypertension in patients with end-stage renal disease"
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                          "autores" => array:6 [
                            0 => "M&#46; Yigla"
                            1 => "F&#46; Nakhoul"
                            2 => "A&#46; Sabag"
                            3 => "N&#46; Tov"
                            4 => "B&#46; Gorevich"
                            5 => "Z&#46; Abassi"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
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                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "123"
                        "paginaInicial" => "1577"
                        "paginaFinal" => "1582"
                        "link" => array:1 [
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                      "titulo" => "Pulmonary hypertension in peritoneal dialysis patients"
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                            0 => "L&#46; Kumbar"
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                            2 => "M&#46;A&#46; Rafiq"
                            3 => "C&#46; Borawski"
                            4 => "J&#46; Chattopadhyay"
                            5 => "M&#46;M&#46; Avram"
                          ]
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                      ]
                    ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Perit Dial"
                        "fecha" => "2007"
                        "volumen" => "23"
                        "paginaInicial" => "127"
                        "paginaFinal" => "131"
                        "link" => array:1 [
                          0 => array:2 [
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                          "autores" => array:6 [
                            0 => "S&#46;S Bozbas"
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                            3 => "H&#46; Bozbas"
                            4 => "E&#46; Karacaglar"
                            5 => "S&#46; Kanyilmaz"
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                        "fecha" => "2009"
                        "volumen" => "41"
                        "paginaInicial" => "2753"
                        "paginaFinal" => "2756"
                        "link" => array:1 [
                          0 => array:2 [
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              "etiqueta" => "7"
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                          "autores" => array:4 [
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                            2 => "M&#46;A&#46; Hamid"
                            3 => "A&#46; Elhendy"
                          ]
                        ]
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                    ]
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                        "fecha" => "2003"
                        "volumen" => "124"
                        "paginaInicial" => "2093"
                        "paginaFinal" => "2097"
                        "link" => array:1 [
                          0 => array:2 [
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                            4 => "M&#46;G&#46; Benghanem"
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                        "tituloSerie" => "Hemodial Int"
                        "fecha" => "2006"
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                        "paginaInicial" => "356"
                        "paginaFinal" => "359"
                        "link" => array:1 [
                          0 => array:2 [
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                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "paginaInicial" => "1686"
                        "paginaFinal" => "1692"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15840664"
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                        "paginaInicial" => "189"
                        "paginaFinal" => "193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18310865"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension in chronic dialysis patients with arteriovenous fistula&#58; pathogenesis and therapeutic prospective"
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                            4 => "M&#46; Yigla"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.mnh.0000232874.27846.37"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Nephrol Hypertens"
                        "fecha" => "2006"
                        "volumen" => "15"
                        "paginaInicial" => "353"
                        "paginaFinal" => "360"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16775448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Iron deficiency is common in idiopathic pulmonary arterial hypertension&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Ruiter"
                            1 => "S&#46; Lankhorst"
                            2 => "A&#46; Boonstra"
                            3 => "P&#46;E&#46; Postmus"
                            4 => "S&#46; Zweegman"
                            5 => "N&#46; Westerhof"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00100510"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2011"
                        "volumen" => "37"
                        "paginaInicial" => "1386"
                        "paginaFinal" => "1391"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20884742"
                            "web" => "Medline"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                      "titulo" => "Excess PTH in CRF induces pulmonary calcification&#44; pulmonary hypertension and right ventricular hypertrophy"
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                          "etal" => false
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                            3 => "J&#46;G&#46; Mohler"
                            4 => "S&#46;G&#46; Massry"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "paginaInicial" => "158"
                        "paginaFinal" => "163"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7731141"
                            "web" => "Medline"
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                      ]
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                ]
              ]
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                0 => array:2 [
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                    0 => array:2 [
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                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:6 [
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                            2 => "I&#46; Safadi"
                            3 => "N&#46; Tov"
                            4 => "S&#46;A&#46; Reisner"
                            5 => "F&#46; Nakhoul"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                        "paginaFinal" => "810"
                        "link" => array:1 [
                          0 => array:2 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of chronic renal failure on nitric oxide metabolism"
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                      ]
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                        "paginaInicial" => "S74"
                        "paginaFinal" => "S79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11576927"
                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
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                            4 => "C&#46; Baylis"
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                      ]
                    ]
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                    0 => array:1 [
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                        "paginaInicial" => "F794"
                        "paginaFinal" => "F797"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10330062"
                            "web" => "Medline"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0090"
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension in hemodialysis patients&#58; an unrecognized threat"
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                        "tituloSerie" => "Semin Dial"
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                        "paginaInicial" => "353"
                        "paginaFinal" => "357"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Flow-induced pressure differentially regulates endothelin-1&#44; urotensin II&#44; adrenomedullin&#44; and relaxin in pulmonary vascular endothelium"
                      "autores" => array:1 [
                        0 => array:2 [
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                            3 => "C&#46; B&#246;hme"
                            4 => "D&#46; Heinze"
                            5 => "F&#46; Ott"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1006/bbrc.2001.5946"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem Biophys Res Commun"
                        "fecha" => "2001"
                        "volumen" => "289"
                        "paginaInicial" => "245"
                        "paginaFinal" => "251"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11708807"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microbubbles&#58; pathophysiology and clinical implications"
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                        0 => array:2 [
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                            0 => "M&#46; Barak"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Chest"
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                        "volumen" => "128"
                        "paginaInicial" => "2918"
                        "paginaFinal" => "2932"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                  ]
                ]
              ]
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Original article
Unexplained pulmonary hypertension in peritoneal dialysis and hemodialysis patients
Hipertensão pulmonar inexplicável em doentes com diálise peritoneal e hemodiálise
J. Etemadia, H. Zolfagharib, R. Firoozic, M.R. Ardalana, M. Toufanc, M.M. Shojad, K. Ghabilie,
Corresponding author
kghabili@gmail.com

Corresponding author.
a Department of Nephrology, Dialysis and Transplantation, Tabriz University of Medical Sciences, Tabriz, Iran
b Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
c Department of Cardiology, Tabriz University of Medical Sciences, Tabriz, Iran
d Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
e Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Pulmonary arterial hypertension &#40;PAH&#41; is a newly recognized disease in patients with renal disease&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In clinical practice&#44; shunting of blood from the left to the right side of the heart and increased cardiac output and pulmonary blood flow are common medical conditions resulting in PAH&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> However&#44; Yigla et al&#46; first noted unexplained PAH in some long-term hemodialysis &#40;HD&#41; patients during an epidemiologic study&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> They attributed both end stage renal disease &#40;ESRD&#41; and long-term HD therapy via an arteriovenous &#40;AV&#41; access to the pathogenesis of PAH in these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> On the other hand&#44; the prevalence of PAH in patients on peritoneal dialysis &#40;PD&#41; is still a matter of debate&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> The information in the literature regarding unexplained or primary PAH in ESRD patients especially PD patients is limited&#46; Therefore&#44; the aim of the present study was to compare the prevalence of unexplained PAH in HD and PD patients&#46; In addition&#44; we aimed to compare laboratory parameters between patients with unexplained PAH and those with normal pulmonary artery pressure &#40;PAP&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Materials and methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">We retrospectively reviewed the medical records of 278 chronic HD and 145 chronic PD patients treated at the hospitals affiliated to the university in Tabriz&#44; Iran between May 2008 and January 2010&#46; The patients&#8217; data including age&#44; sex&#44; co-morbidities&#44; medications&#44; tobacco use&#44; etiology of renal failure&#44; vascular access type&#44; and duration of dialysis therapy were recorded&#46; Laboratory findings including hemoglobin&#44; calcium&#44; phosphorus&#44; alkaline phosphatase&#44; albumin&#44; parathyroid hormone &#40;PTH&#41; level&#44; serum iron&#44; total iron binding capacity&#44; ferritin&#44; creatinine and blood urea nitrogen were documented&#46; The results of transthoracic Doppler echocardiography were used to determine the pulmonary artery pressure&#44; expiratory and inspiratory inferior vena cava &#40;IVC&#41; diameters and percent collapse&#44; left ventricular ejection fraction&#44; presence of valvular diseases&#44; etc&#46; PAH was defined as a systolic pulmonary artery pressure &#40;SPAP&#41; &#8805;35<span class="elsevierStyleHsp" style=""></span>mmHg&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Patients with cardiac disease&#44; pulmonary disease&#44; collagen vascular disease&#44; volume overload at the time of echocardiography &#40;&#60;50&#37; collapsibility in IVC diameter&#41; and positive human immunodeficiency virus &#40;HIV&#41; test were excluded&#46; Additionally&#44; patients treated with dialysis &#60;3 months or &#62;7 years were not included in the present study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Data were presented as median &#40;interquartile range&#41;&#46; All statistical analyses were performed with Statistical Package of Social Science &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#41; for Windows version 16&#46; The Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#44; chi-square test and Fisher&#39;s exact test were used wherever appropriate&#46; A <span class="elsevierStyleItalic">P</span>-value &#60;0&#46;05 was considered statistically significant&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Results</span><p id="par0025" class="elsevierStylePara elsevierViewall">Data from 66 patients were analyzed&#58; 34 in group HD and 32 in group PD &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The median age of the study population was 57 &#40;45&#8211;68&#41; years&#46; The median duration of dialysis was 102 &#40;54&#46;25&#8211;161&#41; weeks in HD group and 44 &#40;24&#46;5&#8211;82&#41; weeks in PD group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#44; Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test&#41;&#46; Among HD group&#44; 18 patients &#40;53&#37;&#41; had proximal and 16 patients &#40;47&#37;&#41; had distal arteriovenous fistula &#40;AVF&#41;&#46; However&#44; none of the patients in PD group had functional AVF&#59; 28 patients were primarily in PD group and 4 patients had primary nonfunctional AVF&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The median SPAP value in patients with PAH was 37&#46;5 &#40;35&#8211;45&#41;<span class="elsevierStyleHsp" style=""></span>mmHg&#46; According to the echocardiographic findings&#44; PAH was detected in 20 &#40;30&#46;3&#37;&#41; patients&#58; 14 &#40;41&#46;1&#37;&#41; patients in HD group and 6 &#40;18&#46;7&#37;&#41; patients in PD group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#44; Fisher&#39;s exact test&#41;&#46; Among HD patients with PAH&#44; vascular access type was proximal and distal AVF in 8 &#40;57&#46;1&#37;&#41; and 6 &#40;42&#46;9&#37;&#41; patients&#44; respectively&#46; None of the PD patients with PAH had vascular access&#46; There were no differences in gender&#44; age&#44; weight&#44; duration of dialysis&#44; calcium&#44; phosphorus&#44; alkaline phosphatase&#44; albumin&#44; parathyroid hormone level&#44; total iron binding capacity&#44; ferritin&#44; creatinine and blood urea nitrogen between the patients with PAH and those with normal PAP &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; The median serum iron was significantly lower in patients with PAH &#40;47<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#41; compared to that in patients with normal PAP &#40;71&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;dL&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#44; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The median hemoglobin of patients with normal PAP was not comparable to that of PAH patients &#40;11&#46;3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL vs&#46; 9&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#44; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">The present study revealed that PAH was more frequent in patients undergoing HD &#40;41&#46;1&#37;&#41; than in patients of PD group &#40;18&#46;7&#37;&#41;&#46; Previous studies have mostly reported the prevalence of PAH in HD patients&#44; but not in PD patients&#46; Amin et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Yigla et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and Tarrass et al&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> concluded that there was a high prevalence of PAH among patients with ESRD receiving long-term HD with surgical AV access&#46; The two latter studies differed with regard to the type of PAH&#59; primary and secondary PAH in the former and primary PAH in the latter&#46; Nakhoul and colleagues<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and Havlucu et al&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> found PAH in approximately half of the HD patients&#46; Nakhoul et al&#46; noted a significant decrease in PAP following successful kidney transplants and temporary closure of AV access in some PAH patients&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Kumbar et al&#46; detected PAH &#40;primary and secondary&#41; in 42&#37; of patients on PD&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In a recent study on HD and PD patients&#44; Bozbas and co-workers found a higher PAH ratio in HD compared to that in the PD group &#40;18&#46;8&#37; vs&#46; 5&#46;9&#37;&#41;&#46; Patients with secondary PAH were not excluded in their study&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Furthermore&#44; the duration of dialysis in the HD group was longer than that in the PD group&#46; This may account for the differing incidence of PAH between the two groups&#46; However&#44; previous studies have highlighted no difference in the duration of HD therapy between patients with PAH and those without PAH&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;11</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In recent studies numerous parameters have been compared between patients with PAH and those with normal PAP&#46; In a study on HD patients&#44; Abassi et al&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> and Yigla et al&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> found that those with elevated PAP had significantly lower hemoglobin and hematocrit levels&#46; Similarly&#44; we observed significantly lower hemoglobin levels in PAH patients in the present study&#46; In contrast&#44; other researchers have failed to detect any difference in hemoglobin and hematocrit levels between the two groups&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6&#44;9&#44;10</span></a> In addition&#44; we found lower serum iron levels in patients with PAH compared to those in normal PAP group&#46; This finding has not been previously reported in patients undergoing HD and&#47;or PD&#46; In a recent study&#44; Ruiter et al&#46; interestingly revealed that iron deficiency was common in idiopathic PAH&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> The present study&#39;s findings are consistent with previous studies which found that PTH level and calcium&#8211;phosphorus product did not differ&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5&#44;7&#44;9&#44;12</span></a> However&#44; Havlucu and colleagues reported higher calcium&#8211;phosphorus production and PTH levels in patients with PAH&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Although we failed to find a significant difference in ferritin levels between PAH and normal PAP groups&#44; Kumbar et al&#46; disclosed lower ferritin levels in patients with PAH&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">There is not yet a clear explanation for the high prevalence of PAH in ESRD&#46; In HD patients&#44; numerous hormonal and metabolic disorders have been attributed to vasoconstriction of pulmonary vessels and pulmonary artery calcification&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10&#44;12&#44;14</span></a> However&#44; Amin et al&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and Yigla et al&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> did not confirm the role of secondary hyperparathyroidism and pulmonary calcification as the etiology of PAH in ESRD patients&#46; Later&#44; Nakhoul et al&#46; studied the role of two endothelial-derived molecules&#44; endothelin-1 and nitric oxide &#40;NO&#41;&#44; in the pathogenesis of PAH in HD patients via AV access&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Although impaired NO production and reduced sensitivity to NO have already been described in patients with chronic renal failure&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Nakhoul et al&#46; first demonstrated a link between impaired NO production and PAH in uremic patients receiving chronic HD therapy via AV access&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> This finding may be also generalized to the patients on PD therapy&#59; NO deficiency has been described in PD patients&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Along with high cardiac output resulting from the AV access&#44; such an endothelial dysfunction may reduce the capability of the pulmonary vasculature to maintain the raised cardiac output and may subsequently contribute to the development of PAH in ESRD patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;18</span></a> An increase in the cardiac output and pulmonary blood flow due to the AV access may change shear stress&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> This may alter endothelial function or release of mediators through induction of gene expression patterns&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Moreover&#44; a venous torrent of microbubbles stemming from tubing or dialyzer has been proposed as a potential etiological factor in the development of PAH in this population&#46; These microbubbles obstruct capillaries in the lungs&#44; which may cause tissue ischemia&#44; an inflammatory response and complement activation&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">This study has certain limitations&#46; The retrospective observational design of the study might be considered a weakness in this work&#46; Moreover&#44; PAP was measured by a non-invasive method&#44; Doppler echocardiography&#44; without obtaining direct invasive measurements &#40;e&#46;g&#46; right heart catheterization&#41;&#46; However&#44; measurements of PAP by the applied Doppler echocardiographic method have been reported to have a good correlation with measurements obtained by invasive methods in some studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;21&#44;22</span></a> This method of PAP measurement has been widely applied in previous studies on PAH in patients on HD or PD&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;4&#8211;11&#44;15</span></a> In addition&#44; doses of erythropoiesis-stimulating agent &#40;ESA&#41; were not available in either group&#46; Higher doses of ESA in either group might be a confounding factor and interesting to observe&#46; Furthermore&#44; the effect of the duration of dialysis on the incidence of PAH was not addressed in the present study&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; unexplained PAH seems to be more frequent in patients undergoing HD than patients in the PD group&#46; Moreover&#44; among numerous laboratory parameters&#44; hemoglobin and serum iron levels are lower in patients with PAH compared to those in normal PAP group&#46; Due to the high importance of PAH in ESRD patients receiving both HD and PD therapy&#44; the present findings need to be further explored in larger studies&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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          "identificador" => "xres547614"
          "titulo" => array:5 [
            0 => "Abstract"
            1 => "Objectives"
            2 => "Methods"
            3 => "Results"
            4 => "Conclusion"
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          "identificador" => "xpalclavsec565495"
          "titulo" => "Keywords"
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          "identificador" => "xres547615"
          "titulo" => array:5 [
            0 => "Resumo"
            1 => "Objetivos"
            2 => "M&#233;todos"
            3 => "Resultados"
            4 => "Conclus&#227;o"
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          "identificador" => "xpalclavsec565494"
          "titulo" => "Palavras-chave"
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        4 => array:2 [
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          "titulo" => "Introduction"
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        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
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        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
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          "identificador" => "sec0020"
          "titulo" => "Discussion"
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        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflicts of interest"
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          "titulo" => "References"
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2010-01-29"
    "fechaAceptado" => "2011-07-06"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec565495"
          "palabras" => array:3 [
            0 => "Unexplained pulmonary hypertension"
            1 => "Peritoneal dialysis"
            2 => "Hemodialysis"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec565494"
          "palabras" => array:3 [
            0 => "Hipertens&#227;o arterial pulmonar inexplic&#225;vel"
            1 => "Di&#225;lise peritoneal"
            2 => "Hemodi&#225;lise"
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      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span><span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To compare the prevalence of unexplained pulmonary artery hypertension &#40;PAH&#41; in hemodialysis &#40;HD&#41; and peritoneal dialysis &#40;PD&#41; patients and to compare laboratory parameters between patients with unexplained PAH and those with normal pulmonary artery pressure &#40;PAP&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We retrospectively reviewed the medical records of 278 chronic HD and 145 chronic PD patients&#46; Laboratory findings including hemoglobin&#44; calcium&#44; phosphorus&#44; alkaline phosphatase&#44; albumin&#44; parathyroid hormone level&#44; serum iron&#44; total iron binding capacity&#44; ferritin&#44; creatinine and blood urea nitrogen were documented&#46; The results of transthoracic Doppler echocardiography were used to determine the pulmonary artery pressure &#40;PAP&#41;&#46; PAH was defined as a systolic pulmonary artery pressure &#40;SPAP&#41; &#8805;35<span class="elsevierStyleHsp" style=""></span>mmHg&#46; To rule out secondary PAH&#44; patients with cardiac disease&#44; pulmonary disease&#44; collagen vascular disease&#44; volume overload at the time of echocardiography and positive human immunodeficiency virus test were excluded&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Data from 34 patients in group HD and 32 individuals in group PD were analyzed&#46; The median age of the study population was 57 &#40;45&#8211;68&#41; years&#46; The median SPAP value in patients with PAH was 37&#46;5 &#40;35&#8211;45&#41;<span class="elsevierStyleHsp" style=""></span>mmHg&#46; According to the echocardiographic findings&#44; PAH was found in 14 &#40;41&#46;1&#37;&#41; patients of HD group and in 6 &#40;18&#46;7&#37;&#41; patients of PD group &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#41;&#46; The median serum iron and hemoglobin was significantly lower in patients with PAH compared to those in patients with normal PAP &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Unexplained PAH seems to be more frequent in patients undergoing HD than patients in PD group&#46; Moreover&#44; hemoglobin and serum iron levels are lower in patients with PAH compared to those in normal PAP group&#46;</p></span>"
      ]
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span><span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Comparar a preval&#234;ncia de hipertens&#227;o arterial pulmonar &#40;PAH&#41; inexplic&#225;vel em doentes sob hemodi&#225;lise &#40;HD&#41; e di&#225;lise peritoneal &#40;PD&#41; e comparar os par&#226;metros laboratoriais entre doentes com PAH inexplic&#225;vel e aqueles com press&#227;o arterial pulmonar normal &#40;PAP&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Revimos&#44; de forma retrospetiva&#44; os registos m&#233;dicos de 278 doentes com HD cr&#243;nica e 145 com PD cr&#243;nica&#46; Dos dados laboratoriais foram registadas hemoglobina&#44; c&#225;lcio&#44; f&#243;sforo&#44; fosfatase alcalina&#44; albumina&#44; n&#237;vel de paratormona&#44; ferro s&#233;rico&#44; capacidade total de liga&#231;&#227;o de ferro&#44; ferritina&#44; creatinina e nitrog&#233;nio ureico no sangue&#46; Os resultados do ecocardiograma doppler <span class="elsevierStyleItalic">transtor&#225;cico</span> foram utilizados para determinar a press&#227;o arterial pulmonar &#40;PAP&#41;&#46; A PAH foi definida como uma press&#227;o arterial pulmonar sist&#243;lica &#40;SPAP&#41; &#8805;35<span class="elsevierStyleHsp" style=""></span>mmHg&#46; Para excluir a PAH secund&#225;ria&#44; foram exclu&#237;dos os pacientes com problemas card&#237;acos&#44; doen&#231;as pulmonares&#44; doen&#231;as vasculares do colag&#233;nio&#44; excesso de volume na altura do ecocardiograma e v&#237;rus de imunodefici&#234;ncia humana positivo&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Foram analisados dados de 34 pacientes no HD e 32 indiv&#237;duos no grupo PD&#46; A mediana de idade da popula&#231;&#227;o estudada foi de 57 &#40;45&#8211;68&#41; anos&#46; O valor m&#233;dio de SPAP em doentes com PAH foi de 37&#44;5 &#40;35&#8211;45&#41; mmHg&#46; De acordo com os resultados do ecocardiograma&#44; a PAH foi registada em 14 &#40;41&#44;1&#37;&#41; pacientes do grupo HD e em 6 &#40;18&#44;7&#37;&#41; pacientes do grupo PD &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41;&#46; A mediana do ferro s&#233;rico m&#233;dio e da hemoglobina estavam significativamente mais baixos em pacientes com PAH em compara&#231;&#227;o com os pacientes com PAP normal &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A PAH inexplic&#225;vel parece ser mais frequente em pacientes com HD do que em pacientes no grupo de PD&#46; Al&#233;m disso&#44; os n&#237;veis de hemoglobina e ferro s&#233;rico s&#227;o inferiores em pacientes com PAH comparando com os do grupo de PAP normal&#46;</p></span>"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">PAP&#44; pulmonary artery pressure&#59; TIBC&#44; total iron binding capacity&#59; BUN&#44; blood urea nitrogen&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Normal PAP &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Elevated PAP &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Gender &#40;male&#58;female&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22&#58;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#58;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;5 &#40;39&#46;75&#8211;68&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 &#40;53&#46;75&#8211;67&#46;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Weight &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;5 &#40;54&#8211;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">60&#46;5 &#40;53&#46;25&#8211;69&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Duration of dialysis &#40;weeks&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57 &#40;27&#46;75&#8211;140&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">77 &#40;44&#46;5&#8211;171&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Hemoglobin &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;3 &#40;9&#46;95&#8211;12&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;9 &#40;9&#46;5&#8211;10&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;004<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Calcium &#40;Ca&#41; &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;8 &#40;8&#46;17&#8211;9&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;35 &#40;7&#46;82&#8211;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Phosphorus &#40;P&#41; &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;45 &#40;4&#46;37&#8211;6&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;11 &#40;4&#46;57&#8211;7&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Ca&#46;P product&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&#46;2 &#40;39&#46;35&#8211;56&#46;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&#46;13 &#40;38&#46;2&#8211;61&#46;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Alkaline phosphatase &#40;IU&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">249 &#40;193&#46;75&#8211;297&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">215 &#40;174&#8211;312&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Albumin &#40;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;1 &#40;3&#46;6&#8211;4&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;8 &#40;3&#46;62&#8211;4&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Parathyroid hormone &#40;pg&#47;mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">197 &#40;71&#8211;412&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">213 &#40;172&#8211;509&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Serum iron &#40;SI&#41; &#40;&#956;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&#46;5 &#40;58&#46;5&#8211;98&#46;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">47 &#40;31&#46;5&#8211;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;001<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">TIBC &#40;&#956;g&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The long-term effects of arteriovenous fistula creation on the development of pulmonary hypertension in hemodialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Unal"
                            1 => "K&#46; Tasdemir"
                            2 => "S&#46; Oymak"
                            3 => "M&#46; Duran"
                            4 => "I&#46; Kocyigit"
                            5 => "F&#46; Oguz"
                          ]
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                      ]
                    ]
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                    0 => array:2 [
                      "doi" => "10.1111/j.1542-4758.2010.00478.x"
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                        "tituloSerie" => "Hemodial Int"
                        "fecha" => "2010"
                        "volumen" => "14"
                        "paginaInicial" => "398"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20854331"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary arterial hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;W&#46; Farber"
                            1 => "J&#46; Loscalzo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra035488"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2004"
                        "volumen" => "351"
                        "paginaInicial" => "1655"
                        "paginaFinal" => "1665"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15483284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Background diseases in 671 patients with moderate to severe pulmonary hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Yigla"
                            1 => "S&#46; Dabbah"
                            2 => "Z&#46;S&#46; Azzam"
                            3 => "A&#46;H&#46; Rubin"
                            4 => "S&#46;A&#46; Reisner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Isr Med Assoc J"
                        "fecha" => "2000"
                        "volumen" => "2"
                        "paginaInicial" => "684"
                        "paginaFinal" => "689"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11062769"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension in patients with end-stage renal disease"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Yigla"
                            1 => "F&#46; Nakhoul"
                            2 => "A&#46; Sabag"
                            3 => "N&#46; Tov"
                            4 => "B&#46; Gorevich"
                            5 => "Z&#46; Abassi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "123"
                        "paginaInicial" => "1577"
                        "paginaFinal" => "1582"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12740276"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension in peritoneal dialysis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Kumbar"
                            1 => "P&#46;A&#46; Fein"
                            2 => "M&#46;A&#46; Rafiq"
                            3 => "C&#46; Borawski"
                            4 => "J&#46; Chattopadhyay"
                            5 => "M&#46;M&#46; Avram"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Perit Dial"
                        "fecha" => "2007"
                        "volumen" => "23"
                        "paginaInicial" => "127"
                        "paginaFinal" => "131"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17886618"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension in patients with end-stage renal disease undergoing renal transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;S Bozbas"
                            1 => "S&#46; Akcay"
                            2 => "C&#46; Altin"
                            3 => "H&#46; Bozbas"
                            4 => "E&#46; Karacaglar"
                            5 => "S&#46; Kanyilmaz"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.transproceed.2009.07.049"
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                        "tituloSerie" => "Transplant Proc"
                        "fecha" => "2009"
                        "volumen" => "41"
                        "paginaInicial" => "2753"
                        "paginaFinal" => "2756"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19765426"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
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              "identificador" => "bib0035"
              "etiqueta" => "7"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension in patients with chronic renal failure&#58; role of parathyroid hormone and pulmonary artery calcifications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            1 => "A&#46; Fawzy"
                            2 => "M&#46;A&#46; Hamid"
                            3 => "A&#46; Elhendy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "124"
                        "paginaInicial" => "2093"
                        "paginaFinal" => "2097"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14665485"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Doppler echocardiograph evaluation of pulmonary hypertension in patients undergoing hemodialysis"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Tarrass"
                            1 => "M&#46; Benjelloun"
                            2 => "G&#46; Medkouri"
                            3 => "K&#46; Hachim"
                            4 => "M&#46;G&#46; Benghanem"
                            5 => "B&#46; Ramdani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1542-4758.2006.00129.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hemodial Int"
                        "fecha" => "2006"
                        "volumen" => "10"
                        "paginaInicial" => "356"
                        "paginaFinal" => "359"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17014511"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathogenesis of pulmonary hypertension in haemodialysis patients via arterio-venous access"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Nakhoul"
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                            2 => "R&#46; Gilman"
                            3 => "S&#46;A&#46; Reisner"
                            4 => "Z&#46; Abassi"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfh840"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "paginaInicial" => "1686"
                        "paginaFinal" => "1692"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15840664"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension in patients with chronic renal failure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Havlucu"
                            1 => "S&#46; Kursat"
                            2 => "C&#46; Ekmekci"
                            3 => "P&#46; Celik"
                            4 => "S&#46; Serter"
                            5 => "O&#46; Bayturan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000102953"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "2007"
                        "volumen" => "74"
                        "paginaInicial" => "503"
                        "paginaFinal" => "510"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17505128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension in hemodialysis patients"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Mahdavi-Mazdeh"
                            1 => "S&#46; Alijavad-Mousavi"
                            2 => "H&#46; Yahyazadeh"
                            3 => "M&#46; Azadi"
                            4 => "H&#46; Yoosefnejad"
                            5 => "Y&#46; Ataiipoor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Saudi J Kidney Dis Transpl"
                        "fecha" => "2008"
                        "volumen" => "19"
                        "paginaInicial" => "189"
                        "paginaFinal" => "193"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18310865"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension in chronic dialysis patients with arteriovenous fistula&#58; pathogenesis and therapeutic prospective"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Z&#46; Abassi"
                            1 => "F&#46; Nakhoul"
                            2 => "E&#46; Khankin"
                            3 => "S&#46;A&#46; Reisner"
                            4 => "M&#46; Yigla"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.mnh.0000232874.27846.37"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Nephrol Hypertens"
                        "fecha" => "2006"
                        "volumen" => "15"
                        "paginaInicial" => "353"
                        "paginaFinal" => "360"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16775448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Iron deficiency is common in idiopathic pulmonary arterial hypertension&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Ruiter"
                            1 => "S&#46; Lankhorst"
                            2 => "A&#46; Boonstra"
                            3 => "P&#46;E&#46; Postmus"
                            4 => "S&#46; Zweegman"
                            5 => "N&#46; Westerhof"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00100510"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2011"
                        "volumen" => "37"
                        "paginaInicial" => "1386"
                        "paginaFinal" => "1391"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20884742"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Excess PTH in CRF induces pulmonary calcification&#44; pulmonary hypertension and right ventricular hypertrophy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "A&#46;N&#46; Ansari"
                            3 => "J&#46;G&#46; Mohler"
                            4 => "S&#46;G&#46; Massry"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "1995"
                        "volumen" => "47"
                        "paginaInicial" => "158"
                        "paginaFinal" => "163"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7731141"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary calcification in hemodialysis patients&#58; correlation with pulmonary artery pressure values"
                      "autores" => array:1 [
                        0 => array:2 [
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                            1 => "Z&#46; Keidar"
                            2 => "I&#46; Safadi"
                            3 => "N&#46; Tov"
                            4 => "S&#46;A&#46; Reisner"
                            5 => "F&#46; Nakhoul"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1523-1755.2004.00807.x"
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                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2004"
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                        "paginaInicial" => "806"
                        "paginaFinal" => "810"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15253737"
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                ]
              ]
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            15 => array:3 [
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              "etiqueta" => "16"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of chronic renal failure on nitric oxide metabolism"
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                          "autores" => array:1 [
                            0 => "N&#46;D&#46; Vaziri"
                          ]
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                      ]
                    ]
                  ]
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                    0 => array:1 [
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                        "volumen" => "38"
                        "paginaInicial" => "S74"
                        "paginaFinal" => "S79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11576927"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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                    0 => array:2 [
                      "titulo" => "Nitric oxide production is low in end-stage renal disease patients on peritoneal dialysis"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;J&#46; Schmidt"
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                            2 => "T&#46;S&#46; Tracy"
                            3 => "M&#46;I&#46; Sorkin"
                            4 => "C&#46; Baylis"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "tituloSerie" => "Am J Physiol"
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                        "volumen" => "276"
                        "paginaInicial" => "F794"
                        "paginaFinal" => "F797"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10330062"
                            "web" => "Medline"
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                    ]
                  ]
                ]
              ]
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            17 => array:3 [
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension in hemodialysis patients&#58; an unrecognized threat"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Yigla"
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                            2 => "S&#46;A&#46; Reisner"
                            3 => "F&#46; Nakhoul"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Semin Dial"
                        "fecha" => "2006"
                        "volumen" => "19"
                        "paginaInicial" => "353"
                        "paginaFinal" => "357"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16970730"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Flow-induced pressure differentially regulates endothelin-1&#44; urotensin II&#44; adrenomedullin&#44; and relaxin in pulmonary vascular endothelium"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Dschietzig"
                            1 => "C&#46; Richter"
                            2 => "C&#46; Bartsch"
                            3 => "C&#46; B&#246;hme"
                            4 => "D&#46; Heinze"
                            5 => "F&#46; Ott"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1006/bbrc.2001.5946"
                      "Revista" => array:6 [
                        "tituloSerie" => "Biochem Biophys Res Commun"
                        "fecha" => "2001"
                        "volumen" => "289"
                        "paginaInicial" => "245"
                        "paginaFinal" => "251"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11708807"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Microbubbles&#58; pathophysiology and clinical implications"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Barak"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.128.4.2918"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "paginaInicial" => "2918"
                        "paginaFinal" => "2932"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16236969"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "REVEAL registry&#58; correlation of right heart catheterization and echocardiography in patients with pulmonary arterial hypertension"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "D&#46;P&#46; Miller"
                            3 => "M&#46;D&#46; McGoon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1751-7133.2010.00202.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Congest Heart Fail"
                        "fecha" => "2011"
                        "volumen" => "17"
                        "paginaInicial" => "56"
                        "paginaFinal" => "64"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21449993"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Noninvasive assessment of pulmonary hypertension&#58; a simultaneous echo-Doppler hemodynamic study"
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                          "etal" => true
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                            0 => "S&#46; Marangoni"
                            1 => "A&#46; Quadri"
                            2 => "A&#46; Dotti"
                            3 => "S&#46; Scalvini"
                            4 => "M&#46; Volterrani"
                            5 => "M&#46; Schena"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiology"
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                        "paginaInicial" => "401"
                        "paginaFinal" => "408"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3228823"
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Article information
ISSN: 08732159
Original language: English
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