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        "titulo" => "Abstract"
        "resumen" => "<span><span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Not every individual exposed to <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> becomes infected&#46; One host genetic factor&#44; involved in modulating the immune response that has been studied in many ethnic groups is the association of human leukocyte antigens &#40;HLA&#41; with susceptibility to tuberculosis &#40;TB&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To investigate the association between TB&#44; HLA-DRB1 and HLA-DQB1 alleles in a Portuguese population&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">HLA-DRB1 and HLA-DQB1 gene polymorphisms were analyzed by PCR-SSP in 92 TB patients&#44; and 82 healthcare professionals without TB but exposed on a daily basis to infectious patients for more than two years &#40;healthy exposed - HE&#41;&#46; Tuberculin skin test reaction &#40;TST&#41;&#44; was positive in 69 individuals &#40;all over 15<span class="elsevierStyleHsp" style=""></span>mm&#41; in the HE group &#40;HE&#43;&#41; and negative in thirteen &#40;HE&#8212;&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">HLA-DRB1&#42;14 frequency is higher in the TB patients group &#40;7&#37; vs&#46; 0&#59; p &#61; 0&#46;038&#41; than in HE&#43;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">No genetic marker clearly indicative of disease susceptibility or resistance was identified in this study&#46; However&#44; HLA-DRB1&#42;14 was more frequent in TB patients suggesting that it may be involved in the evolution infection towards active TB in our population&#46;</p></span>"
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        "resumen" => "<span><span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Nem todos os indiv&#237;duos expostos ao <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> ficam infectados&#46; Um dos factores gen&#233;ticos envolvidos na modula&#231;&#227;o da resposta imune e estudado em muitos grupos &#233;tnicos &#233; a associa&#231;&#227;o entre mol&#233;culas HLA <span class="elsevierStyleItalic">&#40;human leukocyte antigens&#41;</span> e a susceptibilidade &#224; tuberculose &#40;TB&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Objectivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Investigar a rela&#231;&#227;o entre TB e os alelos HLA-DRB1&#44; DQB1 numa popula&#231;&#227;o Portuguesa&#46;</p></span> <span><span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Os polimorfismos dos genes HLA-DRB1 e HLA-DQB1 foram analisados por PCR-SSP em 92 doentes com TB e 82 profissionais de sa&#250;de saud&#225;veis&#44; expostos diariamente a doentes baciliferos por um per&#237;odo superior a 2 anos &#40;expostos saud&#225;veis&#58; ES&#41;&#46; Neste grupo de ES&#44; o teste tubercul&#237;nico foi positivo &#40;TST &#8805; 10<span class="elsevierStyleHsp" style=""></span>mm&#41; em 69 indiv&#237;duos &#40;todos com valor superior a 15<span class="elsevierStyleHsp" style=""></span>mm&#41; &#40;ES&#43;&#41; e negativo &#40;TST &#60; 10<span class="elsevierStyleHsp" style=""></span>mm&#41; em 13 &#40;ES&#8212;&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A frequ&#234;ncia do alelo HLA-DRB1&#42;14 &#233; superior no grupo de doentes com tuberculose em rela&#231;&#227;o ao grupo de ES&#43; &#40;7&#37; vs&#46; 0&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;038&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclus&#245;es</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">N&#227;o foi identificado neste estudo&#44; nenhum marcador gen&#233;tico de susceptibilidade&#47;resist&#234;ncia &#224; doen&#231;a&#46; No entanto&#44; o alelo HLA-DRB1&#42;14 foi mais frequente nos doentes com tuberculose&#44; sugerindo que possa estar envolvido na evolu&#231;&#227;o da infec&#231;&#227;o para tuberculose activa na nossa popula&#231;&#227;o&#46;</p></span>"
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HLA class II alleles as markers of tuberculosis susceptibility and resistance
O papel do HLA classe II na susceptibilidade/resistência à tuberculose
R. Duartea,b,c,
Corresponding author
rdmelo@med.up.pt

Corresponding author.
, C. Carvalhoa,d, C. Pereirad, A. Bettencourtd, A. Carvalhoa,c, M. Villare, A. Domingosf, H. Barrosb, J.A. Marquesb, P. Pinho Costag, D. Mendonçah, B. Martinsd,g
a Centro de Diagnóstico Pneumológico (CDP) de Vila Nova de Gaia, Vila Nova de Gaia, Portugal
b Faculdade de Medicina, Universidade do Porto, Portugal
c Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal
d Laboratório de Imunogenética, Instituto de Ciências Biomédicas Abe Salazar (ICBAS), Universidade do Porto, Porto, Portugal
e Centro de Diagnóstico Pneumológico (CDP) de Venda Nova, Lisboa, Portugal
f Centro Hospitalar Torres Vedras, Torres Vedras, Portugal
g Laboratório de Imunogenética, Instituto Nacional da Saúde (NSA) Dr. Ricardo Jorge, Porto, Portugal
h Departamento de Estudo de Populações, Instituto de Ciências Biomédicas Abe Salazar (ICBAS), Universidade do Porto, Porto, Portugal
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        "titulo" => "Abstract"
        "resumen" => "<span><span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Not every individual exposed to <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> becomes infected&#46; One host genetic factor&#44; involved in modulating the immune response that has been studied in many ethnic groups is the association of human leukocyte antigens &#40;HLA&#41; with susceptibility to tuberculosis &#40;TB&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To investigate the association between TB&#44; HLA-DRB1 and HLA-DQB1 alleles in a Portuguese population&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">HLA-DRB1 and HLA-DQB1 gene polymorphisms were analyzed by PCR-SSP in 92 TB patients&#44; and 82 healthcare professionals without TB but exposed on a daily basis to infectious patients for more than two years &#40;healthy exposed - HE&#41;&#46; Tuberculin skin test reaction &#40;TST&#41;&#44; was positive in 69 individuals &#40;all over 15<span class="elsevierStyleHsp" style=""></span>mm&#41; in the HE group &#40;HE&#43;&#41; and negative in thirteen &#40;HE&#8212;&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">HLA-DRB1&#42;14 frequency is higher in the TB patients group &#40;7&#37; vs&#46; 0&#59; p &#61; 0&#46;038&#41; than in HE&#43;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">No genetic marker clearly indicative of disease susceptibility or resistance was identified in this study&#46; However&#44; HLA-DRB1&#42;14 was more frequent in TB patients suggesting that it may be involved in the evolution infection towards active TB in our population&#46;</p></span>"
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        "resumen" => "<span><span class="elsevierStyleSectionTitle">Introdu&#231;&#227;o</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Nem todos os indiv&#237;duos expostos ao <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> ficam infectados&#46; Um dos factores gen&#233;ticos envolvidos na modula&#231;&#227;o da resposta imune e estudado em muitos grupos &#233;tnicos &#233; a associa&#231;&#227;o entre mol&#233;culas HLA <span class="elsevierStyleItalic">&#40;human leukocyte antigens&#41;</span> e a susceptibilidade &#224; tuberculose &#40;TB&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Objectivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Investigar a rela&#231;&#227;o entre TB e os alelos HLA-DRB1&#44; DQB1 numa popula&#231;&#227;o Portuguesa&#46;</p></span> <span><span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Os polimorfismos dos genes HLA-DRB1 e HLA-DQB1 foram analisados por PCR-SSP em 92 doentes com TB e 82 profissionais de sa&#250;de saud&#225;veis&#44; expostos diariamente a doentes baciliferos por um per&#237;odo superior a 2 anos &#40;expostos saud&#225;veis&#58; ES&#41;&#46; Neste grupo de ES&#44; o teste tubercul&#237;nico foi positivo &#40;TST &#8805; 10<span class="elsevierStyleHsp" style=""></span>mm&#41; em 69 indiv&#237;duos &#40;todos com valor superior a 15<span class="elsevierStyleHsp" style=""></span>mm&#41; &#40;ES&#43;&#41; e negativo &#40;TST &#60; 10<span class="elsevierStyleHsp" style=""></span>mm&#41; em 13 &#40;ES&#8212;&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A frequ&#234;ncia do alelo HLA-DRB1&#42;14 &#233; superior no grupo de doentes com tuberculose em rela&#231;&#227;o ao grupo de ES&#43; &#40;7&#37; vs&#46; 0&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;038&#41;&#46;</p></span> <span><span class="elsevierStyleSectionTitle">Conclus&#245;es</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">N&#227;o foi identificado neste estudo&#44; nenhum marcador gen&#233;tico de susceptibilidade&#47;resist&#234;ncia &#224; doen&#231;a&#46; No entanto&#44; o alelo HLA-DRB1&#42;14 foi mais frequente nos doentes com tuberculose&#44; sugerindo que possa estar envolvido na evolu&#231;&#227;o da infec&#231;&#227;o para tuberculose activa na nossa popula&#231;&#227;o&#46;</p></span>"
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Article information
ISSN: 08732159
Original language: English
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