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"apellidos" => "Barros-Dios" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173511513000493" "doi" => "10.1016/j.rppnen.2013.02.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511513000493?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215913000263?idApp=UINPBA00004E" "url" => "/08732159/0000001900000004/v2_201509041415/S0873215913000263/v2_201509041415/pt/main.assets" ] "asociados" => array:1 [ 0 => array:19 [ "pii" => "S0873215913000767" "issn" => "08732159" "doi" => "10.1016/j.rppneu.2013.06.003" "estado" => "S300" "fechaPublicacion" => "2013-07-01" "aid" => "163" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "dis" "cita" => "Rev Port Pneumol. 2013;19:184-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 6817 "formatos" => array:3 [ "EPUB" => 270 "HTML" => 5349 "PDF" => 1198 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Comment</span>" "titulo" => "Mechanically Assisted Invasive Ventilation for ALS patients: Is it the Ultimate Strategy To Improve Survival?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "184" "paginaFinal" => "185" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "A Ventilação Mecânica Invasiva na Esclerose Lateral Amiotrófica: a derradeira estratégia?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Anabela C. Pinto" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Anabela C." "apellidos" => "Pinto" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215913000767?idApp=UINPBA00004E" "url" => "/08732159/0000001900000004/v2_201509041415/S0873215913000767/v2_201509041415/en/main.assets" ] ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Unexpected death of a ventilator-dependent amyotrophic lateral sclerosis patient" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "175" "paginaFinal" => "178" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. di Paolo, L. Evangelisti, N. Ambrosino" "autores" => array:3 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "di Paolo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Evangelisti" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:4 [ "nombre" => "N." "apellidos" => "Ambrosino" "email" => array:1 [ 0 => "nico.ambrosino@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Legal Medicine – Neuroscience Department, University of Pisa, Pisa, Italy" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Pulmonary Unit, Cardio-Thoracic Department, Pulmonary Rehabilitation and Weaning Center, University Hospital, Auxilium Vitae, Volterra, Pisa, Italy" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Morte inesperada de um doente com Esclerose Lateral Amiotrófica dependente de ventilador" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 667 "Ancho" => 1000 "Tamanyo" => 223838 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Pulmonary histological examination.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Amyotrophic lateral sclerosis (ALS) is a devastating disease involving both upper and lower motor neurons. It is the most common form of motor neuron disease, affecting approximately 1.2 to 1.8/100,000 individuals. Clinically, ALS is characterised by progressive muscular weakness leading to loss of the ability to move and speak and, in almost all patients, causes death between 3 and 5 years from diagnosis. Cortical and cognitive functions remain essentially unchanged.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Respiratory failure is the most common cause of morbidity and mortality in these patients. Reduction in respiratory muscle strength with ineffective alveolar ventilation and difficult airway secretions clearance may lead to chronic respiratory insufficiency (CRI) and potentially life-threatening problems. Long term mechanical ventilation (LTMV) delivered either invasively or non invasively is the main therapeutic intervention to support the respiratory muscle function and to increase life expectancy and health-related quality of life (QOL).<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Literature evaluating survival of ALS patients receiving LTMV via tracheostomy is scarce and contains conflicting reports, with considerable variation among studies as to the time between starting this treatment and death.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Quality control of the equipment used and risk management are important aspects of LTMV in order to ensure that patients receive the prescribed ventilatory support safely and accurately.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,5</span></a> Deaths due to malfunction of mechanical ventilators are reported but forensic autopsy records are rare.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> We report the case of a 69-year-old trachostomised, ventilator-dependent ALS female patient, found dead by her husband.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 69-year-old female had been diagnosed as having had ALS for 2 years. She had been 24/24<span class="elsevierStyleHsp" style=""></span>h ventilator-dependent, under tracheostomy LTMV for 18 month after a previous 9-month period of mask ventilation. Lung function test at initiation of NIV showed mild restriction (slow vital capacity (SVC): 61% pred, forced expiratory volume at 1<span class="elsevierStyleHsp" style=""></span>s (FEV1): 60% pred, FEV1/SVC:99%). Tracheostomy had been electively performed after progressive worsening of gas exchanges (PaCO2 59<span class="elsevierStyleHsp" style=""></span>mmHg) symptoms and lack of compliance to NIV. In fact, the patient had not tolerated NIV for more than 2<span class="elsevierStyleHsp" style=""></span>h per night. She was also on enteral nutrition (EN) through percutaneous gastrostomy (PEG). In the last 12 months the patients underwent two admissions to the emergency department for non-respiratory causes, and had no major problem in the last four months before she was found dead in her bed by her husband. No resuscitation maneuver was performed.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The night before, her husband had checked ventilator and EN pump and had found nothing unusual. Early in the morning he was woken up by the alarm of the EN pump: he realized that his wife was not breathing and pulseless. The ventilator was in “stand- by” mode.</p><p id="par0030" class="elsevierStylePara elsevierViewall">At autopsy, gross examination did not reveal any trauma sign but showed brain oedema and congestion and lung congestion. Pulmonary histological examination revealed a slightly thickening of peribronchial interstitial space, alveolar overdistension with alveolar rupture and diffuse alveolar haemorrhage, alveolar capillary congestion (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 1</a>). Focal microhemorrhages were detected also in lungs, kidneys, liver, heart, brain and adrenal glands tissue (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 2</a>). Oxicological examination was negative.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Analysis of the internal memory of the ventilator, showed that during the night, several voltage drops had happened. Specific technical tests revealed malfunction of the ventilator internal battery, unable to provide the necessary voltage had caused the ventilator stop. Battery malfunction also reduced the alarm volume which was not heard by caregiver.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Respiratory failure is the most common cause of death in ALS patients. In this case, cause of death was attributed to ventilator pump failure related to acute asphyxia. Asphyxia is a broad term including a variety of conditions resulting in interference with oxygen uptake or utilization,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> particularly in the brain. In the forensic context, death typically results from mechanically induced cerebral hypoxia.</p><p id="par0045" class="elsevierStylePara elsevierViewall">All ventilators provided with an expiratory valve allow the patient to breath in room air in case of ventilator malfunctioning. The valve always remains open when the ventilator stops. Only a severe valve malfunctioning can explain asphyxia in a patient still actively breathing. However the likelihood of this valve malfunctioning is very low because in case of valve membrane rupture (so called mushroom valve) the valve leaks still allow the patients to breath in room air. But in this case it is not likely that our 24/24 hour ventilatory-dependent patient would still have the residual strength for breathing activity and this would explain the acute asphyxia.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Pulmonary histological examination revealed thickening of peribronchial interstitial space, alveolar over-distension, break of inter-alveolar walls and diffuse alveolar haemorrhages that can also go along with the hypothesis of barotraumas in a long term ventilated patient. In the present case histological pattern showed high grade of acute pulmonary emphysema allowing us to hypothesize long-term barotrauma effect.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Ventilator-dependent patient management, including periodic check and maintenance of the ventilator, is crucial. A survey covering 16 European countries showed that: (1) ventilator servicing was mainly carried out by external companies, with a servicing frequency ranging 3–12 months; (2) interaction between servicing companies and prescribers was limited; (3) participation of centres in equipment quality control was poor; and (4) centres were insufficiently aware of vigilance systems.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Chatwin et al.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> examined the nature of calls to a home support helpline to identify patient/equipment problems and strategies to minimise risk for patients, healthcare teams and manufacturers. From adult and paediatric patients with neuromuscular disease, chronic obstructive pulmonary disease or chest wall disease receiving LTMV, and all calls to a dedicated respiratory support telephone hotline in a six-month period were analysed. Out of 1211 patients 1119 received non-invasive ventilation, 12 tracheostomy ventilation; 149 had two ventilators for 24-h ventilator dependency. There was a mean of 528 daytime calls per month and 14 calls a month at night. Following 188 calls, a home visit was performed; these identified a technical problem that could either be solved in the patient's home in 64% or required replacement or new parts in 22% of cases. In 25 calls in which no mechanical fault was identified, 13 patients were either found to be unwell or required hospital admission. Authors conclude that patients using LTMV have a substantial need for assistance, with most technical problems being resolved simply. Where no fault was found during an equipment check, the patient themselves may be unwell and should receive early clinical evaluation. The patient may have mistaken clinical deterioration for an equipment problem.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Ethical disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Protection of human and animal subjects</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Confidentiality of data</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Right to privacy and informed consent</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres547739" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec565619" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres547738" "titulo" => "Resumo" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introdução" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec565618" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "Right to privacy and informed consent" ] ] ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-09-13" "fechaAceptado" => "2012-12-18" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec565619" "palabras" => array:3 [ 0 => "Amyotrophic lateral sclerosis" 1 => "Acute respiratory failure" 2 => "Home mechanical ventilation" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec565618" "palabras" => array:3 [ 0 => "Esclerose lateral amiotrófica" 1 => "Insuficiência respiratória aguda" 2 => "Ventilação mecânica doméstica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Amyotrophic lateral sclerosis (ALS) is a fatal, progressive, neurodegenerative disease and most patients affected die of respiratory compromise and/or pneumonia within 2–3 years of diagnosis. As ALS progresses, ventilator assistance is required. In the end stages of the disease, patients suffer from respiratory failure and may become ventilator-dependent. Deaths due to malfunction of mechanical ventilators are reported but there are very few forensic autopsy records. We report the case of a 69-year-old ALS female ventilator-dependent, trachostomised patient who was found dead by her husband, with the ventilator in “stand-by” mode.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A forensic autopsy was performed. Samples of internal organs were taken for histological and toxicological examination. The ventilator internal memory was also analysed and tested in order to find possible malfunction.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Gross examination did not reveal any sign of trauma but showed brain and lung congestion. Pulmonary histological examination revealed thickening of peribronchial interstitial space, alveolar over-distension, break of inter-alveolar walls and diffuse alveolar haemorrhages. Focal microhemorrhages were also detected in other organs. Analysis of the ventilator internal memory showed that during the night of death, there had been several voltage drops. Specific tests revealed malfunction of the internal battery which was unable to provide the necessary voltage, as a consequence the ventilator switched off, stopping ventilation. Battery malfunction reduced the volume of the ventilator alarm, which was not heard by the caregiver.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Histological pattern, with acute pulmonary emphysema and focal polivisceral haemorrhages, is strongly suggestive of a death due to “acute” asphyxia. The authors also discuss the need for strict supervision and follow up of these ventilatory dependent patients and their devices.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introdução</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A Esclerose Lateral Amiotrófica (ELA) é uma doença fatal, progressiva e neurodegenerativa e a maioria dos doentes afectados morrerão de falha respiratória e/ou pneumonia 2 ou 3 anos após o diagnóstico. À medida que a ELA progride torna-se necessária a assistência ventilatória. Nos estágios finais da doença, os doentes sofrem de insuficiência respiratória e podem tornar-se dependentes do ventilador. São conhecidas mortes devido ao mau funcionamento de ventiladores mecânicos mas existem poucos registos forenses de tal situação. Relatamos o caso de uma doente de 69 anos com ELA, traqueostomizada e dependente do ventilador, que foi encontrada morta pelo seu marido com o ventilador em modo de espera («stand-by»).</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foi realizada uma autópsia forense. Foram recolhidas amostras dos órgãos internos para exame toxicológico e histológico. A memória interna do ventilador foi também analisada e testada de modo a descobrir uma possível avaria.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">O exame macroscópico não revelou qualquer sinal de trauma mas indicou congestão cerebral e pulmonar. O exame pulmonar histológico revelou o espessamento do espaço intersticial peribrônquico, sobredistensão alveolar, quebra de paredes interalveolares e hemorragias alveolares difusas. Foram detetadas micro-hemorragias focais noutros órgãos. A análise da memória interna do ventilador mostrou que, durante a noite da morte, houve diversas quedas de tensão. Testes específicos revelaram o mau funcionamento da bateria interna que não conseguiu fornecer a tensão necessária, consequentemente o ventilador desligou-se, parando a ventilação. O mau funcionamento da bateria reduziu o volume do alarme do ventilador, que não foi ouvido pelo prestador de cuidados.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusão</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">O padrão histológico, com enfisema pulmonar agudo e hemorragias focais poliviscerais, é fortemente indicador de morte devido a asfixia «aguda». Os autores discutem também a necessidade de uma supervisão rigorosa e seguimento destes doentes dependentes do ventilador e dos seus equipamentos.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Introdução" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 667 "Ancho" => 1000 "Tamanyo" => 223838 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Pulmonary histological examination.</p>" ] ] 1 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2195 "Ancho" => 2917 "Tamanyo" => 1313108 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Microscopic polivisceral haemorrhages: (A) lung; (B) heart; (C) kidney; and (D) brain.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Amyotrophic Lateral Sclerosis: a review of current concepts" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. 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Year/Month | Html | Total | |
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2024 November | 12 | 9 | 21 |
2024 October | 112 | 36 | 148 |
2024 September | 288 | 29 | 317 |
2024 August | 255 | 33 | 288 |
2024 July | 259 | 29 | 288 |
2024 June | 199 | 34 | 233 |
2024 May | 188 | 29 | 217 |
2024 April | 152 | 41 | 193 |
2024 March | 158 | 26 | 184 |
2024 February | 113 | 32 | 145 |
2024 January | 110 | 25 | 135 |
2023 December | 120 | 27 | 147 |
2023 November | 119 | 35 | 154 |
2023 October | 155 | 42 | 197 |
2023 September | 118 | 32 | 150 |
2023 August | 86 | 18 | 104 |
2023 July | 111 | 35 | 146 |
2023 June | 150 | 15 | 165 |
2023 May | 125 | 27 | 152 |
2023 April | 105 | 17 | 122 |
2023 March | 110 | 27 | 137 |
2023 February | 110 | 21 | 131 |
2023 January | 82 | 19 | 101 |
2022 December | 95 | 20 | 115 |
2022 November | 96 | 31 | 127 |
2022 October | 106 | 27 | 133 |
2022 September | 68 | 30 | 98 |
2022 August | 82 | 41 | 123 |
2022 July | 82 | 47 | 129 |
2022 June | 75 | 29 | 104 |
2022 May | 101 | 48 | 149 |
2022 April | 66 | 31 | 97 |
2022 March | 75 | 39 | 114 |
2022 February | 78 | 36 | 114 |
2022 January | 72 | 36 | 108 |
2021 December | 53 | 43 | 96 |
2021 November | 71 | 39 | 110 |
2021 October | 81 | 45 | 126 |
2021 September | 61 | 30 | 91 |
2021 August | 58 | 36 | 94 |
2021 July | 53 | 23 | 76 |
2021 June | 99 | 33 | 132 |
2021 May | 133 | 31 | 164 |
2021 April | 313 | 61 | 374 |
2021 March | 261 | 16 | 277 |
2021 February | 157 | 26 | 183 |
2021 January | 124 | 20 | 144 |
2020 December | 116 | 20 | 136 |
2020 November | 150 | 28 | 178 |
2020 October | 102 | 15 | 117 |
2020 September | 155 | 27 | 182 |
2020 August | 161 | 27 | 188 |
2020 July | 182 | 17 | 199 |
2020 June | 196 | 24 | 220 |
2020 May | 198 | 20 | 218 |
2020 April | 227 | 7 | 234 |
2020 March | 199 | 24 | 223 |
2020 February | 182 | 15 | 197 |
2020 January | 227 | 12 | 239 |
2019 December | 181 | 19 | 200 |
2019 November | 165 | 13 | 178 |
2019 October | 166 | 30 | 196 |
2019 September | 140 | 26 | 166 |
2019 August | 213 | 12 | 225 |
2019 July | 244 | 25 | 269 |
2019 June | 258 | 14 | 272 |
2019 May | 284 | 12 | 296 |
2019 April | 291 | 28 | 319 |
2019 March | 345 | 16 | 361 |
2019 February | 280 | 18 | 298 |
2019 January | 302 | 24 | 326 |
2018 December | 161 | 9 | 170 |
2018 November | 76 | 0 | 76 |
2018 October | 106 | 10 | 116 |
2018 September | 62 | 13 | 75 |
2018 August | 47 | 26 | 73 |
2018 July | 71 | 19 | 90 |
2018 June | 69 | 20 | 89 |
2018 May | 97 | 23 | 120 |
2018 April | 117 | 27 | 144 |
2018 March | 113 | 21 | 134 |
2018 February | 86 | 13 | 99 |
2018 January | 81 | 19 | 100 |
2017 December | 138 | 16 | 154 |
2017 November | 55 | 19 | 74 |
2017 October | 58 | 11 | 69 |
2017 September | 82 | 23 | 105 |
2017 August | 89 | 29 | 118 |
2017 July | 65 | 15 | 80 |
2017 June | 65 | 13 | 78 |
2017 May | 60 | 20 | 80 |
2017 April | 46 | 6 | 52 |
2017 March | 38 | 47 | 85 |
2017 February | 28 | 5 | 33 |
2017 January | 18 | 6 | 24 |
2016 December | 32 | 9 | 41 |
2016 November | 33 | 7 | 40 |
2016 October | 29 | 10 | 39 |
2016 September | 46 | 5 | 51 |
2016 August | 16 | 6 | 22 |
2016 July | 10 | 11 | 21 |
2016 June | 2 | 0 | 2 |
2016 May | 27 | 3 | 30 |
2016 April | 128 | 4 | 132 |
2016 March | 156 | 21 | 177 |
2016 February | 166 | 19 | 185 |
2016 January | 156 | 24 | 180 |
2015 December | 139 | 25 | 164 |
2015 November | 109 | 18 | 127 |
2015 October | 149 | 16 | 165 |
2015 September | 151 | 19 | 170 |
2015 August | 129 | 10 | 139 |
2015 July | 166 | 13 | 179 |
2015 June | 134 | 16 | 150 |
2015 May | 140 | 21 | 161 |
2015 April | 199 | 25 | 224 |
2015 March | 232 | 16 | 248 |
2015 February | 197 | 6 | 203 |
2015 January | 191 | 17 | 208 |
2014 December | 198 | 8 | 206 |
2014 November | 232 | 10 | 242 |
2014 October | 250 | 27 | 277 |
2014 September | 232 | 18 | 250 |
2014 August | 256 | 10 | 266 |
2014 July | 171 | 18 | 189 |
2014 June | 165 | 13 | 178 |
2014 May | 166 | 12 | 178 |
2014 April | 187 | 15 | 202 |
2014 March | 200 | 24 | 224 |
2014 February | 187 | 18 | 205 |
2014 January | 184 | 28 | 212 |
2013 December | 150 | 21 | 171 |
2013 November | 143 | 33 | 176 |
2013 October | 110 | 40 | 150 |
2013 September | 100 | 43 | 143 |
2013 August | 118 | 76 | 194 |
2013 July | 85 | 43 | 128 |