Case report
Exogenous lipoid pneumonia caused by chronic improper use of baby body oil in adult patient
Pneumonia lipoide exógena provocada pela utilização crónica indevida de óleo corporal para bebés num paciente adulto
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TC da face: marcada modificação da trabeculação óssea do corpo da mandíbula direita, com cerca de 3,5<span class="elsevierStyleHsp" style=""></span>cm de comprimento. B. Ortopantomografia mostrando alterações na mandíbula direita.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Inês Neves, António Morais, Adriana Magalhães" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Inês" "apellidos" => "Neves" ] 1 => array:2 [ "nombre" => "António" "apellidos" => "Morais" ] 2 => array:2 [ "nombre" => "Adriana" "apellidos" => "Magalhães" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173511513000663" "doi" => "10.1016/j.rppnen.2013.09.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511513000663?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087321591300055X?idApp=UINPBA00004E" "url" => "/08732159/0000001900000005/v3_201509041357/S087321591300055X/v3_201509041357/pt/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Exogenous lipoid pneumonia caused by chronic improper use of baby body oil in adult patient" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "233" "paginaFinal" => "236" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Doubková, M. Doubek, M. Moulis, J. Sk¿iĿková" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "Doubková" "email" => array:1 [ 0 => "doubkovamartina@seznam.cz" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">⿿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Doubek" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Moulis" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Sk¿iĿková" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Pneumology and Phthiseology, Faculty of Medicine and University Hospital, Brno, Czech Republic" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Central European Institute of Technology, Masaryk University, Brno, Czech Republic" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Pathology, Faculty of Medicine and University Hospital, Brno, Czech Republic" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⿿" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Pneumonia lipoide exógena provocada pela utilização crónica indevida de óleo corporal para bebés num paciente adulto" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 900 "Ancho" => 2333 "Tamanyo" => 275143 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Chest high-resolution computed tomography (HRCT) at diagnosis (A) and two years after diagnosis (B). Bilateral lung infiltration in the lower lobes, particularly on the right side in the area of segment S6, with the following dimensions: 85<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>ÿ<span class="elsevierStyleHsp" style=""></span>38<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>ÿ<span class="elsevierStyleHsp" style=""></span>70<span class="elsevierStyleHsp" style=""></span>mm. The surrounding tissue shows ground-glass opacities, thickened interlobular septa, and a craving paving picture with air bronchogram (A). Partial regression of pulmonary infiltration after discontinuation of ⿿baby body oil therapy⿿ (B).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Lipoid pneumonia can be classified as endogenous, idiopathic, or exogenous.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Endogenous lipoid pneumonia is the least frequent and is generally observed in patients with chronic bronchial obstruction of the airways by tumors, bronchiolitis obliterans, and lipid storage diseases such as Gaucher's disease and Niemann⿿Pick disease. Idiopathic lipoid pneumonia is a rare disorder and has been associated with smoking in healthy individuals. Exogenous lipoid pneumonia (ELP) is an uncommon condition resulting from aspirating or inhaling fat-like material.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> These substances elicit a foreign body reaction and proliferative fibrosis in the lung. Symptoms can vary significantly among individuals, ranging from asymptomatic to severe, life-threatening disease. The radiological findings have variable patterns and distribution. For this reason, lipoid pneumonia may mimic many other diseases.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The diagnosis of ELP is based on a history of exposure to oil, characteristic radiological findings, and the presence of lipid-laden macrophages in sputum or BAL analysis. There are currently no studies in literature that define the best therapeutic option; however, there is a consensus that the key measure is identifying and discontinuing exposure to the offending agent.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 38-year-old woman was referred to our department for bilateral pulmonary infiltration. The infiltration was found coincidentally during the pre-operation examination before leg varices surgery. Nothing was bothering the patient. She was a non-smoker and did not take any regular medication. The pulmonary function test proved a mild impairment of diffusing capacity (61% diffusing capacity for carbon monoxide ⿿ DL<span class="elsevierStyleInf">CO</span>). Nevertheless, her chest X-ray disclosed extensive infiltration in both lungs (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). A chest computed tomography (CT) scan revealed bilateral lung consolidation, particularly in the S6 area on the right side (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). In differential diagnosis according to findings of high-resolution CT (HRCT) of thorax, we considered pulmonary alveolar proteinosis, alveolar hemorrhage, or bronchioloalveolar carcinoma. However, the clear right predominance of lesions gave primary support to the aspiration etiology of lesions. Laboratory blood findings (hematology, biochemistry, antibody, tumor markers) were normal. By auscultation, we found sporadic crackles over the right lung. The bronchoalveolar fluid had a greasy appearance. Lymphocytic alveolitis was also found (lymphocytes 21%). The transthoracic lung biopsy revealed vacuolated macrophages, giant cells, optically empty spots, a foreign body reaction with granulomatous process. All vacuolated macrophages contained lipids (lipophages) and represented 35% of all cells in the biopsy. This finding raised the suspicion of oil substance aspiration ⿿ ELP (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Subsequently, the patient confessed to daily nasal application of baby body oil drops (with azulene and medicinal liquid paraffin) over a period of five years to treat the dryness of her nasal mucosa. The otorhinolaryngologic examination was normal. The patient refused glucocorticoid therapy. Regular controls of the pulmonary function test, chest X-ray (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B) and HRCT of thorax were performed in the patient. Two years after discontinuing ⿿baby body oil therapy⿿, a chest CT scan revealed partial improvement (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B). We proposed additional corticosteroid therapy due to persisting lesions on CT. However, this therapy was refused by the patient.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">ELP is a rare disease resulting from the micro-aspiration of lipid formulations. These substances elicit a foreign body reaction and proliferative fibrosis in the lung. Acute, sometimes fatal, cases can occur, but the disease is usually indolent. The diagnosis of ELP is often difficult as symptoms, signs, and radiographic findings can be non-specific.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> On HRCT, alveolar filling causes a ground-glass pattern of a crazy paving appearance, which stays at some distance from the pleura and exhibits low attenuation numbers. On the other hand, in unenhanced HRCT, pulmonary vessels may spontaneously be visible within the areas of parenchymal filling, a sign known as the ⿿spontaneous angiogram⿿.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3⿿5</span></a> The most characteristic computed tomography of finding of ELP is the presence of low-density space consolidation (⿿30 to ⿿150 Hounsfield units) in the lungs.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> As illustrated by our case, there should be a clear right predominance of lesions supporting an aspiration etiology of pneumonia. A lung biopsy is not always indicated for diagnosis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Diagnosis of ELP is suggested at history taking, and is confirmed by the examination of sputum or BAL, which show lipid laden cells and free-floating oil.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Our case was caused by improper use of baby body oil containing paraffin. So far, paraffin has been described as a cause of ELP in fire-eaters,<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7⿿9</span></a> and in children.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In differential diagnosis of ELP in adults, mainly lipoid pneumonia caused by amiodarone must be taken into consideration.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Treatment of LP is not well-studied. Treatment in patients without clinical symptoms remains controversial, but in patients with diffuse pulmonary damage, therapies have been reported. Avoiding ongoing exposure and providing supportive care is the mainstay of treatment. Not every patient with exogenous lipoid pneumonia will improve after the withdrawal of lipid-containing material or corticosteroid therapy. Gondouin et al., in a retrospective multicenter study, found that corticosteroid therapy had not been very effective for every cases of lipoid pneumonia.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The use of systemic corticosteroids in patients without clinical symptoms remains controversial; however, whole lung lavages, and systemic corticosteroids have been used in patients with diffuse pulmonary damage.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,12</span></a> In our case, however, corticosteroid therapy has been refused by the patient. Complications of this disease include recurrent bronchopneumonia, superinfection, pulmonary fibrosis, and lung cancer.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusion</span><p id="par0030" class="elsevierStylePara elsevierViewall">The diagnosis of ELP is often difficult as symptoms, signs, and radiographic findings can be non-specific. Chronic improper use of miscellaneous oil substances can cause this very rare disorder and we would like to emphasize the role of precise case history in better identification of interstitial lung disorders. Correct HRCT description avoids the misdiagnosis of ELP.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Ethical disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Protection of human and animal subjects</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Confidentiality of data</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Right to privacy and informed consent</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicts of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres547672" "titulo" => "Abstract" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Case report" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec565553" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres547673" "titulo" => "Resumo" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Introdução" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Caso clínico" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusões" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec565552" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conclusion" ] 8 => array:3 [ "identificador" => "sec0025" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflicts of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-12-03" "fechaAceptado" => "2013-05-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec565553" "palabras" => array:3 [ 0 => "Aspiration" 1 => "Exogenous lipoid pneumonia" 2 => "Baby body oil" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec565552" "palabras" => array:3 [ 0 => "Aspiração" 1 => "Pneumonia lipoide exógena" 2 => "ÿleo corporal para bebés" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Exogenous lipoid pneumonia (ELP) is an uncommon condition resulting from aspirating or inhaling fatlike material. These substances elicit a foreign body reaction and proliferative fibrosis in the lung.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Case report</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We report a case of a 38-year-old woman with bilateral pulmonary infiltration. There were no clinical symptoms of this infiltration at diagnosis. The infiltration was found coincidentally during the pre-operation examination before surgery. A chest computed tomography scan revealed bilateral lung consolidation, particularly in the S6 area on the right side. The transthoracic lung biopsy led to suspicion of ELP. Precise anamnesis confirms the diagnosis of ELP caused by chronic improper use of baby body oil. Two years after discontinuing ⿿baby body oil therapy⿿, a chest CT scan revealed partial regression of pulmonary infiltration.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conclusion</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The diagnosis of exogenous lipoid pneumonia is often difficult as symptoms, signs, and radiographic findings are all rather non-specific. We would like to emphasize the role of precise case history in better identification of ELP.</p></span>" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Case report" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Conclusion" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "<span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introdução</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A pneumonia lipoide exógena (ELP) é uma condição incomum resultante da aspiração ou inalação de material gorduroso. Estas substâncias provocam uma reação a corpo estranho que pode resultar em fibrose pulmonar proliferativa.</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Caso clínico</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Neste trabalho relatamos o caso de uma doente de 38 anos com infiltrado pulmonar bilateral. Não houve sintomas resultantes desta infiltração infiltração no momento do diagnóstico. Esta alteração imagiológica foi encontrada, por acaso, durante o exame pré-operatório. A tomografia computadorizada do tórax revelou consolidação pulmonar bilateral, particularmente na área S6 do lado direito. A biópsia transtorácica pulmonar conduziu a uma suspeita de ELP. Uma análise precisa do histórico da paciente confirmou o diagnóstico de ELP provocada por uma utilização continuada e desapropriada de óleo corporal para bebés. Dois anos após a descontinuação da exposição ao óleo corporal para bebés, uma tomografia computorizada de tórax revelou uma regressão parcial do infiltrado pulmonar.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusões</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">O diagnóstico de pneumonia lipoide exógena é muitas vezes difícil, já que os sintomas, sinais e imagens radiológicas são bastante inespecíficos. Gostaríamos de destacar a importância da análise precisa do histórico dos pacientes para uma melhor identificação de ELP.</p></span>" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "abst0020" "titulo" => "Introdução" ] 1 => array:2 [ "identificador" => "abst0025" "titulo" => "Caso clínico" ] 2 => array:2 [ "identificador" => "abst0030" "titulo" => "Conclusões" ] ] ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1244 "Ancho" => 2333 "Tamanyo" => 167211 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Chest X-rays at diagnosis (A) and six months after diagnosis (B). Extensive and intense infiltration with maximum intensity on the right side, in the area of segment S6 at diagnosis, and partial regression of pulmonary infiltration six months later.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 900 "Ancho" => 2333 "Tamanyo" => 275143 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Chest high-resolution computed tomography (HRCT) at diagnosis (A) and two years after diagnosis (B). Bilateral lung infiltration in the lower lobes, particularly on the right side in the area of segment S6, with the following dimensions: 85<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>ÿ<span class="elsevierStyleHsp" style=""></span>38<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>ÿ<span class="elsevierStyleHsp" style=""></span>70<span class="elsevierStyleHsp" style=""></span>mm. The surrounding tissue shows ground-glass opacities, thickened interlobular septa, and a craving paving picture with air bronchogram (A). Partial regression of pulmonary infiltration after discontinuation of ⿿baby body oil therapy⿿ (B).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1180 "Ancho" => 1583 "Tamanyo" => 532761 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Hematoxylin- and eosin-stained slide (ÿ200) of patient's lung tissue. Instead of normal alveoli in the lung, there are empty spaces of different sizes, lined with partially flattened multinucleated giant cells. Between those empty places, there is fibrous connective tissue, sometimes with infiltration of lymphocytes. In the connective tissue, there are also foreign body granulomas with large multinucleated cells that have vacuoles in the cytoplasm. The lesions do not have a distinct margin from the normal lung.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exogenous lipid pneumonia: a retrospective multicentre study of 44 cases in France" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Gondouin" 1 => "P. Manzoni" 2 => "E. Ranfaing" 3 => "J. Brun" 4 => "J. Cadranel" 5 => "D. 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| Year/Month | Html | Total | |
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| 2024 November | 46 | 12 | 58 |
| 2024 October | 541 | 40 | 581 |
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| 2024 May | 113 | 44 | 157 |
| 2024 April | 188 | 36 | 224 |
| 2024 March | 94 | 27 | 121 |
| 2024 February | 73 | 32 | 105 |
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| 2023 November | 89 | 36 | 125 |
| 2023 October | 105 | 41 | 146 |
| 2023 September | 114 | 34 | 148 |
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| 2023 June | 65 | 18 | 83 |
| 2023 May | 88 | 27 | 115 |
| 2023 April | 94 | 20 | 114 |
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| 2022 September | 115 | 31 | 146 |
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| 2021 March | 378 | 34 | 412 |
| 2021 February | 218 | 24 | 242 |
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| 2020 December | 218 | 28 | 246 |
| 2020 November | 168 | 32 | 200 |
| 2020 October | 144 | 21 | 165 |
| 2020 September | 287 | 25 | 312 |
| 2020 August | 229 | 32 | 261 |
| 2020 July | 252 | 27 | 279 |
| 2020 June | 231 | 31 | 262 |
| 2020 May | 240 | 30 | 270 |
| 2020 April | 304 | 8 | 312 |
| 2020 March | 254 | 16 | 270 |
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| 2020 January | 378 | 24 | 402 |
| 2019 December | 252 | 29 | 281 |
| 2019 November | 345 | 19 | 364 |
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| 2019 July | 287 | 31 | 318 |
| 2019 June | 345 | 24 | 369 |
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| 2019 January | 298 | 16 | 314 |
| 2018 December | 148 | 13 | 161 |
| 2018 November | 62 | 2 | 64 |
| 2018 October | 103 | 9 | 112 |
| 2018 September | 192 | 8 | 200 |
| 2018 August | 434 | 30 | 464 |
| 2018 July | 502 | 21 | 523 |
| 2018 June | 464 | 14 | 478 |
| 2018 May | 558 | 25 | 583 |
| 2018 April | 381 | 29 | 410 |
| 2018 March | 413 | 17 | 430 |
| 2018 February | 349 | 17 | 366 |
| 2018 January | 331 | 13 | 344 |
| 2017 December | 410 | 28 | 438 |
| 2017 November | 327 | 27 | 354 |
| 2017 October | 357 | 23 | 380 |
| 2017 September | 348 | 18 | 366 |
| 2017 August | 347 | 25 | 372 |
| 2017 July | 220 | 22 | 242 |
| 2017 June | 222 | 15 | 237 |
| 2017 May | 336 | 14 | 350 |
| 2017 April | 247 | 9 | 256 |
| 2017 March | 399 | 17 | 416 |
| 2017 February | 540 | 9 | 549 |
| 2017 January | 227 | 13 | 240 |
| 2016 December | 211 | 18 | 229 |
| 2016 November | 389 | 21 | 410 |
| 2016 October | 355 | 25 | 380 |
| 2016 September | 350 | 13 | 363 |
| 2016 August | 264 | 14 | 278 |
| 2016 July | 157 | 26 | 183 |
| 2016 May | 22 | 33 | 55 |
| 2016 April | 366 | 7 | 373 |
| 2016 March | 522 | 26 | 548 |
| 2016 February | 518 | 24 | 542 |
| 2016 January | 596 | 31 | 627 |
| 2015 December | 551 | 26 | 577 |
| 2015 November | 517 | 22 | 539 |
| 2015 October | 509 | 32 | 541 |
| 2015 September | 523 | 32 | 555 |
| 2015 August | 518 | 45 | 563 |
| 2015 July | 544 | 29 | 573 |
| 2015 June | 467 | 18 | 485 |
| 2015 May | 560 | 26 | 586 |
| 2015 April | 641 | 27 | 668 |
| 2015 March | 723 | 25 | 748 |
| 2015 February | 642 | 29 | 671 |
| 2015 January | 666 | 33 | 699 |
| 2014 December | 625 | 24 | 649 |
| 2014 November | 558 | 18 | 576 |
| 2014 October | 644 | 26 | 670 |
| 2014 September | 619 | 32 | 651 |
| 2014 August | 562 | 15 | 577 |
| 2014 July | 473 | 15 | 488 |
| 2014 June | 472 | 16 | 488 |
| 2014 May | 483 | 15 | 498 |
| 2014 April | 435 | 18 | 453 |
| 2014 March | 499 | 14 | 513 |
| 2014 February | 429 | 21 | 450 |
| 2014 January | 409 | 16 | 425 |
| 2013 December | 212 | 28 | 240 |
| 2013 November | 190 | 43 | 233 |
| 2013 October | 115 | 58 | 173 |
| 2013 September | 58 | 21 | 79 |
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