Case report
Clinical challenges of persistent pulmonary air-leaks—Case report
Desafios clínicos de fugas de ar pulmonares persistentes—relato de caso
Read
16887
Timeswas read the article
2942
Total PDF
13945
Total HTML
Share statistics
array:25 [ "pii" => "S0873215913001050" "issn" => "08732159" "doi" => "10.1016/j.rppneu.2013.07.004" "estado" => "S300" "fechaPublicacion" => "2014-05-01" "aid" => "175" "copyright" => "Sociedade Portuguesa de Pneumologia" "copyrightAnyo" => "2013" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Rev Port Pneumol. 2014;20:162-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 10734 "formatos" => array:3 [ "EPUB" => 273 "HTML" => 9222 "PDF" => 1239 ] ] "Traduccion" => array:1 [ "en" => array:20 [ "pii" => "S2173511514000414" "issn" => "21735115" "doi" => "10.1016/j.rppnen.2013.07.008" "estado" => "S300" "fechaPublicacion" => "2014-05-01" "aid" => "175" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/" "subdocumento" => "sco" "cita" => "Rev Port Pneumol. 2014;20:162-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3337 "formatos" => array:3 [ "EPUB" => 274 "HTML" => 2176 "PDF" => 887 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Clinical challenges of persistent pulmonary air-leaks—Case report" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "162" "paginaFinal" => "166" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Desafios clínicos de fugas de ar pulmonares persistentes—relato de caso" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 650 "Ancho" => 828 "Tamanyo" => 83935 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Thoracic CT scan showing pleural cavity with a chest tube inside and pleural thickening.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. van Zeller, P. Bastos, G. Fernandes, A. Magalhães" "autores" => array:4 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "van Zeller" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Bastos" ] 2 => array:2 [ "nombre" => "G." "apellidos" => "Fernandes" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Magalhães" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0873215913001050" "doi" => "10.1016/j.rppneu.2013.07.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215913001050?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511514000414?idApp=UINPBA00004E" "url" => "/21735115/0000002000000003/v3_201610140056/S2173511514000414/v3_201610140056/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0873215913001396" "issn" => "08732159" "doi" => "10.1016/j.rppneu.2013.08.004" "estado" => "S300" "fechaPublicacion" => "2014-05-01" "aid" => "191" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "Rev Port Pneumol. 2014;20:167-71" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 9009 "formatos" => array:3 [ "EPUB" => 269 "HTML" => 7403 "PDF" => 1337 ] ] "pt" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Caso clínico</span>" "titulo" => "Fístula arterio-arterial entre a artéria pulmonar e artérias intercostais – a propósito de um caso clínico de «unilateral rib notching»" "tienePdf" => "pt" "tieneTextoCompleto" => "pt" "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "167" "paginaFinal" => "171" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Arterio-arterial fistula between pulmonary and intercostal arteries – Case report of “unilateral rib notching”" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "pt" => true ] "contienePdf" => array:1 [ "pt" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0055" "etiqueta" => "Figura 11" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr11.jpeg" "Alto" => 926 "Ancho" => 950 "Tamanyo" => 90974 ] ] "descripcion" => array:1 [ "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Angiografia seletiva da 7<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSup">a</span> artéria intercostal esquerda revela anastomose exclusivamente arterial com artéria pulmonar homolateral.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Morais, T. Almeida, P. Campos" "autores" => array:3 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Morais" ] 1 => array:2 [ "nombre" => "T." "apellidos" => "Almeida" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Campos" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215913001396?idApp=UINPBA00004E" "url" => "/08732159/0000002000000003/v2_201509041437/S0873215913001396/v2_201509041437/pt/main.assets" ] "itemAnterior" => array:20 [ "pii" => "S0873215914000051" "issn" => "08732159" "doi" => "10.1016/j.rppneu.2014.01.002" "estado" => "S300" "fechaPublicacion" => "2014-05-01" "aid" => "206" "copyright" => "Sociedade Portuguesa de Pneumologia" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "ssu" "cita" => "Rev Port Pneumol. 2014;20:152-61" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 14200 "formatos" => array:3 [ "EPUB" => 295 "HTML" => 11583 "PDF" => 2322 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Prevention of ventilator-associated pneumonia" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "152" "paginaFinal" => "161" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Prevenção de pneumonia associada ao uso do ventilador" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1537 "Ancho" => 2167 "Tamanyo" => 182659 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Routes of colonization/infection in mechanically ventilated patients<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> A – oral and pharyngeal colonization; B – gastric colonization; C – infected patients; D – handling of respiratory equipment; E – use of respiratory devices; and F – aerosols from contaminated air.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Oliveira, C. Zagalo, P. Cavaco-Silva" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Oliveira" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Zagalo" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Cavaco-Silva" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173511514000463" "doi" => "10.1016/j.rppnen.2014.01.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511514000463?idApp=UINPBA00004E" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215914000051?idApp=UINPBA00004E" "url" => "/08732159/0000002000000003/v2_201509041437/S0873215914000051/v2_201509041437/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>" "titulo" => "Clinical challenges of persistent pulmonary air-leaks—Case report" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "162" "paginaFinal" => "166" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. van Zeller, P. Bastos, G. Fernandes, A. Magalhães" "autores" => array:4 [ 0 => array:4 [ "nombre" => "M." "apellidos" => "van Zeller" "email" => array:2 [ 0 => "vanzeller.mafalda@gmail.com" 1 => "mafalda_vanzeller@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "P." "apellidos" => "Bastos" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "G." "apellidos" => "Fernandes" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Magalhães" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Serviço de Pneumologia, Centro Hospitalar de São João, Porto, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Serviço de Cirurgia Cardio-Torácica, Centro Hospitalar de São João, Porto, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Faculdade de Medicina, Universidade do Porto, Porto, Portugal" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Desafios clínicos de fugas de ar pulmonares persistentes—relato de caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1054 "Ancho" => 1193 "Tamanyo" => 100159 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray on 12th day after right midle lobectomy and 24<span class="elsevierStyleHsp" style=""></span>h after chest tube remotion.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Prolonged pulmonary air leaks are common and may cause a high level of morbidity, prolonged hospital stays, infectious and cardiopulmonary complications.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Although there is variation among different authors in their definition of air-leaks, recent studies of pulmonary lobectomy have established an approximate average length of hospital stay of 5 days; and so it has been proposed that a persistent air-leak should be defined as an air leak lasting beyond the postoperative fifth day.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In fact, this is consistent with The Society of Thoracic Surgeons database definition, which refers to persistent air-leaks as those that typically present when the patient would otherwise be discharged if it were not for the continued air-leak.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The vast majority of postoperative air-leaks are alveolar air-leaks; this is relevant since the management of these is very different from the management of bronchopleural fistula which often require immediate surgical intervention.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The most consistently identified risk factor for prolonged air leak is chronic obstructive lung disease,<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> a low forced expiratory volume on 1st second and low maximum voluntary ventilation percentage.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Treatment options of prolonged air leaks include watchful waiting with continuous drainage through a thoracostomy tube,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> pleurodesis, surgical procedures,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> as well as the use of endoscopic techniques.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Endobronchial approaches include the application of gelfoam, the use of fibrin glue, coils or endobronchial valves.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,7</span></a> Generally balloon catheter inflation is used to identify the segmental or sub-segmental airway or airways responsible for the air leak.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Schweigert et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> reported a different method using methylene blue via the chest tubes. We describe a case of a persistent air-leak treated with endobronchial valves placement in segments identified using methylene blue via the chest tube.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0035" class="elsevierStylePara elsevierViewall">A 68-year-old male presented with cough, weight loss and a lung mass in the right middle lobe (ML).</p><p id="par0040" class="elsevierStylePara elsevierViewall">He was an ex-smoker with a 45 pack-year smoking history, and during his professional life he had been exposed to asbestos for many years. His previous medical history included a prostatectomy due to prostate cancer 6 years earlier with no evidence of recurrence.</p><p id="par0045" class="elsevierStylePara elsevierViewall">A pulmonary adenocarcinoma was diagnosed by transthoracic needle aspiration biopsy of the ML lesion and the positron emission tomography–computed tomography (PET/CT) scan performed for staging, revealed fluorodeoxyglucose (FDG) uptake not only on the ML mass (maximum standardized uptake value (SUVmax)-11) but also on the right pleura which led to further pleural investigations with multiple biopsies which were negative for malignant cells. He was staged T2N0M0 and was submitted to surgery</p><p id="par0050" class="elsevierStylePara elsevierViewall">A thoracotomy with a right middle lobectomy, which included division of the triangular ligament plus a systematic lymphadenectomy was performed and, since pleural plaques were found during the procedure they were removed and a lower right lobe pleural decortication was carried out.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Pathology confirmed a pT1bN0R0 adenocarcinoma, with no evidence of pleural malignant involvement but a chronic fibrinous pleuritis was also diagnosed.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Patient extubation was possible soon after the surgery and there was no need for postoperative mechanical ventilation. Kinesiotherapy which is a routine and widely recognized intervention aimed at enhancing lung expansion was started as soon as possible.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Although lung expansion was achieved within 2 days, an air leak was identified and the suction necessary to maintain the lung expansion was continued for ten more days until there was no visible air-leak during normal tidal breathing. At this point, the suction was stopped and the tubes were clamped after 2 days. Since there was no clinical compromise, no worsening pneumothorax nor any increase in subcutaneous air, the chest tube was removed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), and the patient was discharged from hospital within 48<span class="elsevierStyleHsp" style=""></span>h.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Two weeks after hospital discharge – 1 month after surgery – he was re-admitted with the clinical symptoms of chest infection. A thorax CT scan showed a right large anterior hidropneumothorax, pleural thickness and subcutaneous emphysema. An empyema and a postoperative air-leak were diagnosed. Large spectrum antibiotics were initiated, a chest tube was immediately put in place and a bronchofibroscopy used to assess the stump integrity and the absence of other endobronchial complications. Despite these measures, the patient underwent pleuro-pulmonary decortication, which was complicated by dense pleural adhesions. During the procedure suture of pulmonary lacerations was performed and Tissucol<span class="elsevierStyleSup">®</span> spray used to control the air-leaks. Although the clinical health status and infection parameters initially improved the patient had a persistent air leak with a stable asymptomatic pneumothorax on water seal that increased whenever negative suction was suspended and the chest drain was left in free drainage.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Watchful waiting with continuous drainage through a chest tube was kept up for 2 months, during that period, until the air-leak seemed to be resolved and the patient could tolerate the drain being clamped; a talc pleurodesis through the chest tube was attempted without satisfactory results.</p><p id="par0080" class="elsevierStylePara elsevierViewall">An endoscopic approach was tried out to manage the air-leak. A balloon catheter introduced through the bronchoscope was inflated on different segments while observation of the chest drainage system assessed the air leak. A reduction of the air-leak seemed to be achieved when B7 and B8 segments of the lower right lobe were occluded and valves (Zephyr EBV) were placed in these segments. The endobronchial valves were put in position using a flexible catheter. The valves were compressed into the distal tip of the delivery catheter using a valve loader supplied with the system. The delivery catheter was then passed through the working channel of a standard adult bronchoscope (>2.8<span class="elsevierStyleHsp" style=""></span>mm inner diameter) and guided to the target airways. Once in place the valve was deployed. However, this only achieved a reduction in the air-leak.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Three weeks later (4 months after initial surgery) a thoracomyoplasty using a rectus abdominis flap to obliterate the pleural space was performed, and the endobronchial valves were removed. Three weeks after this later surgery it was possible to clamp and remove the chest tube without clinical or radiological worsening.</p><p id="par0090" class="elsevierStylePara elsevierViewall">Unfortunately two weeks later the patient was re-admitted with respiratory distress and a pneumothorax so a chest tube was put back and kept under suction (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The patient was not clinically fit for surgery, so an endoscopic approach was attempted again.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">This time, instillation of methylene blue (1 ampoule diluted in 1 liter saline solution) via chest tube was used to locate the bronchial segment leading to the fistula. While the blue solution was being instilled another clinician looked through the bronchoscope and watched the blue solution appearing on the segments leading to the fistula. Segments B6 and B7 were visually identified (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) and endobronchial valves were put in place as described above.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">After the procedure the size of the air leak seemed to be reduced and clamping was attempted. As there was no evidence of worsening pneumothorax, progressive subcutaneous air development or dyspnea, the chest tube was removed.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Patient heath status slowly improved and he was discharged from hospital. On follow up, metastasis were found on both lungs and the patient died 8 months later.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors describe a case of a persistent air-leak after pulmonary resection. Air leaks are a common problem often associated with prolonged hospital stays, infectious and cardiopulmonary complications, and they occasionally require reoperation<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and/or bronchoscopic techniques.</p><p id="par0115" class="elsevierStylePara elsevierViewall">The patient presented had several risk factors for the development of an air-leak since he had chronic obstructive pulmonary disease,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and of particular relevance in this case, the presence of significant pleural adhesions.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,11</span></a> It is most likely that the pleural adhesions were related to his known asbestos exposure during adulthood.</p><p id="par0120" class="elsevierStylePara elsevierViewall">Treatment options of air-leaks include watchful waiting, surgical procedures as well as medical therapy like pleurodesis, and in particular the use of different bronchoscopy techniques such as glues, coils and sealants. Success has been variable and there does not seem to be an optimal therapy. The current possible interventions seem to be complementary and treatment should be individualized.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> There are no controlled studies comparing the different approaches.</p><p id="par0125" class="elsevierStylePara elsevierViewall">In the present case, the first option was a surgical procedure because a thoracotomy was needed to control infection that was unresponsive to antibiotics and for drainage through chest tube. During surgery an attempt was made to close the site of the air-leak and Tissucol<span class="elsevierStyleSup">®</span> spray was used, however it persisted even after a waiting period of several weeks.</p><p id="par0130" class="elsevierStylePara elsevierViewall">A chemical pleurodesis was then attempted. The instillation of a sclerosing agent into the pleural space through the thoracostomy tube promotes the pleural symphysis, which might lead to leak closure,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> but as shown in the literature has not been very effective.</p><p id="par0135" class="elsevierStylePara elsevierViewall">The presence of postoperative empyema where decortication has failed and the presence of bronchial fistulae are currently considered indications for thoracomyoplasty procedures.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> It allows complete and definitive obliteration of the infected pleural space by a combination of thoracoplasty and the use of neighborhood muscle flaps (latissimus dorsi, serratus anterior, pectoralis, rectus abdominis, etc.).</p><p id="par0140" class="elsevierStylePara elsevierViewall">This happened in this case but, although recent publications show an overall success rate of 90%, with a quick and definitive healing, it was only effective in controlling the infection not the fistula.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Bronchoscopic approaches to the management of pulmonary air-leaks have become more popular not only as diagnostic tools but also as therapeutic ones.</p><p id="par0150" class="elsevierStylePara elsevierViewall">In order to successfully manage a fistula with bronchoscopic techniques, the fistula must be directly visualized (proximal fistulas) and there should be evidence that occlusion has significantly decreased or the air leak stopped. The most commonly used technique to locate the bronchial segment leading to the distal fistulas is the use of balloons, like Swan-Ganz catheter, to systematically occlude the bronchial segments<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> with simultaneous observation of the chest drainage system to assess the air leak. This method may prove challenging in patients with small air leaks which are only present when they cough and not during normal tidal volume breathing.</p><p id="par0155" class="elsevierStylePara elsevierViewall">Although methylene blue has been used to diagnose the presence of fistulas for many years, by instillation through the stump and if detected in the chest tube it can confirm a brochopleural fistula, its use to locate the bronchial segment leading to the fistula was only described in 2011.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Methylene blue was used via the chest tube and immediately after the instillation, if a fistula was present; the methylene blue could be seen by the bronchoscopist on the bronchial segment leading to the fistula.</p><p id="par0160" class="elsevierStylePara elsevierViewall">In our patient the use of methylene blue enabled identification of two bronchial segments involved in the air-leak, one common to that identified by the balloon method but also a different one unsuspected by the previous technique.</p><p id="par0165" class="elsevierStylePara elsevierViewall">After identification of the bronchial segment, multiple approaches might be considered including the application of gelfoam, the use of fibrin glue, coil placement, stents and endobronchial valves.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> There are no controlled studies to determine which of these is the most effective or safest. Travaline et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> showed that the implantation of endobronchial one-way valves (Zephyr EBV) was effective for a large number of patients with prolonged air-leaks. Complete cessation of air-leak was achieved in 48% of patients and diminution of magnitude in 45%.</p><p id="par0170" class="elsevierStylePara elsevierViewall">In this case the implantation of a Zephyr valve on segment B6 and B7, in association with pleural healing and thickening, decreased the magnitude of the air leak enough for the chest tube to be removed. These nonsurgical approaches appear promising and, for some patients may be the only treatment option. The authors would like to emphasize the use of methylene blue via the chest tube to identify the segments of the persistent air-leak and to guide the endobronchial valves placement.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical disclosures</span><p id="par0175" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Protection of human and animal subjects</span>. The authors declare that no experiments were performed on humans or animals for this study.</p><p id="par0180" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Confidentiality of data</span>. The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study received sufficient information and gave their written informed consent to participate in the study.</p><p id="par0185" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Right to privacy and informed consent</span>. The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflicts of interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres547767" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec565646" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres547766" "titulo" => "Resumo" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec565647" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Ethical disclosures" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-04-17" "fechaAceptado" => "2013-07-12" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec565646" "palabras" => array:3 [ 0 => "Pulmonary air-leak" 1 => "Bronchoscopy" 2 => "Methylene blue" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec565647" "palabras" => array:3 [ 0 => "Fístula alveolo-pleural" 1 => "Broncoscopia" 2 => "Azul metileno" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Air leaks are a common problem after pulmonary resection and can be a source of significant morbidity and mortality.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The authors describe the case of a 68-year-old male patient who presented with a persistent air-leak after pulmonary resection. Watchful waiting, surgical procedures, as well as medical therapy like pleurodesis and implantation of endobronchial one-way valves on the bronchial segments identified using systematic occlusion of the bronchial segments, were all tried unsuccessfully. During that time the patient remained hospitalized with a chest tube.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The instillation of methylene blue through the chest tube was used to identify the segments leading to the persistent air-leak; this enabled successful endobronchial valve placement which sufficiently reduced the size of the air-leak so that the chest tube could be removed.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nonsurgical approaches seem promising and, for some patients may be the only treatment option after all conventional treatments have failed or are considered too high risk.</p></span>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">As fístulas pleurais são um problema comum após a ressecção pulmonar e podem condicionar morbidade e mortalidade significativas.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Os autores descrevem o caso de um paciente do sexo masculino com 68 anos que apresentou uma fístula alveolo-pleural persistente após ressecção pulmonar. Foi tentada atitude expectante, procedimentos cirúrgicos, bem como terapêutica médica como pleurodese e colocação de válvulas endobrônquicas nos segmentos brônquios identificados utilizando o método de oclusão sistemática dos segmentos brônquicos, sem sucesso. Durante esse tempo o paciente permaneceu hospitalizado com necessidade de drenagem torácica.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Posteriormente, a instalação de azul de metileno através do dreno torácico foi utilizada para identificar os segmentos envolvidos na fístula, o que permitiu a identificação de diferentes segmentos relativamente ao método prévio, possibilitando a colocação de válvulas endobronquicas que promoveram redução da fistula e consequente remoção do dreno torácico com sucesso.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">As abordagens não-cirúrgicas parecem promissoras e, para alguns pacientes, podem ser a única opção de tratamento depois de todos os tratamentos convencionais falharem ou serem considerados de muito alto risco.</p></span>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1054 "Ancho" => 1193 "Tamanyo" => 100159 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Chest X-ray on 12th day after right midle lobectomy and 24<span class="elsevierStyleHsp" style=""></span>h after chest tube remotion.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 844 "Ancho" => 1105 "Tamanyo" => 129169 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Thoracic CT scan showing pleural cavity with a chest tube inside and pleural thickening.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 592 "Ancho" => 1168 "Tamanyo" => 114394 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Methylene blue on segment B7 (Panel A) and B6 (Panel B) of right lower lobe after instillation through chest tube.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of persistent pulmonary air leaks using endobronchial valves" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.M. Travaline" 1 => "R.J. McKenna Jr." 2 => "T. De Giacomo" 3 => "F. Venuta" 4 => "S.R. Hazelrigg" 5 => "M. Boomer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.08-2389" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2009" "volumen" => "136" "paginaInicial" => "355" "paginaFinal" => "360" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19349382" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A prospective algorithm for the management of air leaks after pulmonary resection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.J. Cerfolio" 1 => "R.P. Tummala" 2 => "W.L. Holman" 3 => "G.L. Zorn" 4 => "J.K. Kirklin" 5 => "D.C. McGiffin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "1998" "volumen" => "66" "paginaInicial" => "1726" "paginaFinal" => "1731" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9875779" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of alveolar air leaks after pulmonary resection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Singhal" 1 => "V.A. Ferraris" 2 => "C. Bridges" 3 => "E.R. Clough" 4 => "J.D. Mitchell" 5 => "C.H. Fernando" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2009.09.020" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2010" "volumen" => "89" "paginaInicial" => "1327" "paginaFinal" => "1335" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20338378" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of prolonged air leak following pulmonary lobectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.J. Stolz" 1 => "J. Schutzner" 2 => "R. Lischke" 3 => "J. Simonek" 4 => "P. Pafko" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejcts.2004.11.004" "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "2005" "volumen" => "27" "paginaInicial" => "334" "paginaFinal" => "336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15691692" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patient and surgical factors influencing air leak after lung volume reduction surgery: lessons learned from the National Emphysema Treatment Trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.M. DeCamp" 1 => "E.H. Blackstone" 2 => "K.S. Naunheim" 3 => "M.J. Krasna" 4 => "D.E. Wood" 5 => "Y.M. Meli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2006.02.050" "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2006" "volumen" => "82" "paginaInicial" => "197" "paginaFinal" => "206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16798215" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors and treatment of persistent air-leaks" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.J. Cerfolio" 1 => "C.S. Bass" 2 => "A.H. Pask" 3 => "C.R. Katholi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2002" "volumen" => "73" "paginaInicial" => "1727" "paginaFinal" => "1731" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12078760" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchopleural fistulas: an overview of the problem with special focus on endoscopic management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Lois" 1 => "M. Noppen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.128.6.3955" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "paginaInicial" => "3955" "paginaFinal" => "3965" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16354867" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Ellis JH, Sequeira FW, Weber TR, Eigen H, Fitzgerald JF. Balloon catheter occlusion of bronchopleural fistulae. AJR Am J Roentgenol. 1982;138:157–159." ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Closure of persisting air leaks in patients with severe pleural empyema – use of endoscopic one-way endobronchial valve" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Schweigert" 1 => "D. Kraus" 2 => "J.H. Ficker" 3 => "H.J. Stein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejcts.2010.07.004" "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiothorac Surg" "fecha" => "2011" "volumen" => "39" "paginaInicial" => "401" "paginaFinal" => "403" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20709562" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What keeps postpulmonary ressection patients in hospital?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Bardell" 1 => "D. Petsikas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Can Respir J" "fecha" => "2003" "volumen" => "10" "paginaInicial" => "86" "paginaFinal" => "89" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12693389" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of prolonged air leak after pulmonary lobectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Brunelli" 1 => "M. Monteverde" 2 => "A. Borri" 3 => "M. Salati" 4 => "R.D. Marasco" 5 => "A. Fianchini" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2004" "volumen" => "77" "paginaInicial" => "2003" "paginaFinal" => "2010" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A different application method of talc pleurodesis for the treatment of persistent air leak" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Kilic" 1 => "A. Findikcioglu" 2 => "A. Hatipoglu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1445-2197.2006.03850.x" "Revista" => array:6 [ "tituloSerie" => "ANZ J Surg" "fecha" => "2006" "volumen" => "76" "paginaInicial" => "754" "paginaFinal" => "756" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16916401" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thoracomyoplasty in the treatment of empyema: current indications, basic principles, and results" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.V. Botianu" 1 => "A.M. Botianu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Pulm Med" "fecha" => "2012" "paginaInicial" => "418" "paginaFinal" => "514" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/08732159/0000002000000003/v2_201509041437/S0873215913001050/v2_201509041437/en/main.assets" "Apartado" => array:4 [ "identificador" => "9580" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Casos clínicos" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000002000000003/v2_201509041437/S0873215913001050/v2_201509041437/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215913001050?idApp=UINPBA00004E" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 17 | 10 | 27 |
| 2024 October | 98 | 43 | 141 |
| 2024 September | 111 | 30 | 141 |
| 2024 August | 110 | 34 | 144 |
| 2024 July | 114 | 39 | 153 |
| 2024 June | 99 | 25 | 124 |
| 2024 May | 109 | 29 | 138 |
| 2024 April | 127 | 36 | 163 |
| 2024 March | 93 | 25 | 118 |
| 2024 February | 91 | 36 | 127 |
| 2024 January | 72 | 24 | 96 |
| 2023 December | 120 | 29 | 149 |
| 2023 November | 51 | 34 | 85 |
| 2023 October | 69 | 47 | 116 |
| 2023 September | 55 | 27 | 82 |
| 2023 August | 42 | 23 | 65 |
| 2023 July | 69 | 26 | 95 |
| 2023 June | 38 | 21 | 59 |
| 2023 May | 70 | 34 | 104 |
| 2023 April | 53 | 29 | 82 |
| 2023 March | 118 | 22 | 140 |
| 2023 February | 77 | 23 | 100 |
| 2023 January | 48 | 21 | 69 |
| 2022 December | 48 | 10 | 58 |
| 2022 November | 97 | 32 | 129 |
| 2022 October | 48 | 38 | 86 |
| 2022 September | 41 | 32 | 73 |
| 2022 August | 60 | 52 | 112 |
| 2022 July | 47 | 42 | 89 |
| 2022 June | 53 | 32 | 85 |
| 2022 May | 59 | 43 | 102 |
| 2022 April | 50 | 30 | 80 |
| 2022 March | 52 | 41 | 93 |
| 2022 February | 71 | 37 | 108 |
| 2022 January | 44 | 33 | 77 |
| 2021 December | 47 | 38 | 85 |
| 2021 November | 51 | 33 | 84 |
| 2021 October | 57 | 48 | 105 |
| 2021 September | 44 | 35 | 79 |
| 2021 August | 62 | 32 | 94 |
| 2021 July | 42 | 19 | 61 |
| 2021 June | 73 | 29 | 102 |
| 2021 May | 81 | 25 | 106 |
| 2021 April | 156 | 79 | 235 |
| 2021 March | 129 | 29 | 158 |
| 2021 February | 116 | 21 | 137 |
| 2021 January | 81 | 17 | 98 |
| 2020 December | 82 | 14 | 96 |
| 2020 November | 80 | 23 | 103 |
| 2020 October | 81 | 16 | 97 |
| 2020 September | 106 | 18 | 124 |
| 2020 August | 112 | 27 | 139 |
| 2020 July | 180 | 26 | 206 |
| 2020 June | 135 | 18 | 153 |
| 2020 May | 148 | 30 | 178 |
| 2020 April | 166 | 8 | 174 |
| 2020 March | 121 | 20 | 141 |
| 2020 February | 132 | 22 | 154 |
| 2020 January | 163 | 17 | 180 |
| 2019 December | 117 | 19 | 136 |
| 2019 November | 137 | 17 | 154 |
| 2019 October | 128 | 28 | 156 |
| 2019 September | 144 | 27 | 171 |
| 2019 August | 299 | 13 | 312 |
| 2019 July | 313 | 26 | 339 |
| 2019 June | 309 | 14 | 323 |
| 2019 May | 344 | 22 | 366 |
| 2019 April | 324 | 37 | 361 |
| 2019 March | 462 | 23 | 485 |
| 2019 February | 390 | 12 | 402 |
| 2019 January | 402 | 34 | 436 |
| 2018 December | 283 | 12 | 295 |
| 2018 November | 94 | 3 | 97 |
| 2018 October | 102 | 5 | 107 |
| 2018 September | 69 | 6 | 75 |
| 2018 August | 104 | 41 | 145 |
| 2018 July | 146 | 30 | 176 |
| 2018 June | 81 | 14 | 95 |
| 2018 May | 114 | 19 | 133 |
| 2018 April | 161 | 13 | 174 |
| 2018 March | 156 | 23 | 179 |
| 2018 February | 82 | 14 | 96 |
| 2018 January | 93 | 19 | 112 |
| 2017 December | 98 | 27 | 125 |
| 2017 November | 89 | 20 | 109 |
| 2017 October | 44 | 20 | 64 |
| 2017 September | 67 | 34 | 101 |
| 2017 August | 62 | 14 | 76 |
| 2017 July | 85 | 19 | 104 |
| 2017 June | 104 | 26 | 130 |
| 2017 May | 42 | 24 | 66 |
| 2017 April | 29 | 40 | 69 |
| 2017 March | 142 | 21 | 163 |
| 2017 February | 256 | 9 | 265 |
| 2017 January | 61 | 7 | 68 |
| 2016 December | 117 | 10 | 127 |
| 2016 November | 112 | 9 | 121 |
| 2016 October | 174 | 12 | 186 |
| 2016 September | 262 | 6 | 268 |
| 2016 August | 178 | 5 | 183 |
| 2016 July | 122 | 12 | 134 |
| 2016 May | 0 | 14 | 14 |
| 2016 April | 116 | 3 | 119 |
| 2016 March | 155 | 10 | 165 |
| 2016 February | 127 | 16 | 143 |
| 2016 January | 113 | 15 | 128 |
| 2015 December | 117 | 12 | 129 |
| 2015 November | 102 | 9 | 111 |
| 2015 October | 111 | 9 | 120 |
| 2015 September | 103 | 18 | 121 |
| 2015 August | 100 | 18 | 118 |
| 2015 July | 113 | 8 | 121 |
| 2015 June | 102 | 21 | 123 |
| 2015 May | 86 | 9 | 95 |
| 2015 April | 66 | 17 | 83 |
| 2015 March | 72 | 3 | 75 |
| 2015 February | 67 | 11 | 78 |
| 2015 January | 48 | 12 | 60 |
| 2014 December | 61 | 15 | 76 |
| 2014 November | 53 | 13 | 66 |
| 2014 October | 65 | 20 | 85 |
| 2014 September | 44 | 40 | 84 |
| 2014 August | 49 | 22 | 71 |
| 2014 July | 65 | 21 | 86 |
| 2014 June | 63 | 35 | 98 |
| 2014 May | 83 | 52 | 135 |
Show all
