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Reis, A. Antunes" "autores" => array:2 [ 0 => array:4 [ "nombre" => "R." "apellidos" => "Reis" "email" => array:1 [ 0 => "ricardomcreis@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Antunes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Respiratory Department, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Respiratory Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Volumes pulmonares na patogénese de apneia obstrutiva do sono" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Obstructive sleep apnea (OSA) is a complex disorder characterized by recurrent episodes of upper airway obstruction. Obstructive events occur at the level of the pharynx and there are many factors which contribute to its collapsibility. It has been suggested that reduced end-expiratory lung volumes may play a role.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However it is not clear whether, and to what extent, lung volumes influence obstructive events and oxygen desaturations independently of other factors.</p><p id="par0010" class="elsevierStylePara elsevierViewall">To find answers to this, all patients evaluated in a sleep consultation unit, over a 6-month period, with complaints of snoring and excessive sleepiness, were examined with home or laboratory polysomnography and performed static and dynamic spirometry. Apnea-hypopnea index (AHI), oxygen desaturation index (ODI) and minimal oxygen desaturation (mO2) were evaluated in relation to patient lung volumes.</p><p id="par0015" class="elsevierStylePara elsevierViewall">A total of 75 subjects (47 males, aged 54.4<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>12.3, BMI 30.9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>4.7<span class="elsevierStyleHsp" style=""></span>kg/m<span class="elsevierStyleSup">2</span>) were evaluated, 50 had OSA, 8 severe (AHI<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>30/h) and 14 moderate (AHI<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>15/h). None had a history of lung disease. Age, weight, BMI and neck circumference were significantly higher in the OSA group. There was no significant difference in the lung volumes between the two groups. However, in the moderate/severe OSA patients,AHI correlated with expiratory reserve volume (ERV), airway resistance (Raw) and BMI; mO2 correlated with functional residual capacity (FRC) and BMI (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). In regression analysis, BMI, FRC and ERV were found to be associated with AHI and/or mO2, but only ERV was found to be independently related to AHI.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">We found that repeated ahead ERV, FRC and BMI were associated with the occurrence of obstructive events. This association has been described with similar results and could be due to a combination of the effects of obesity and diffuse airway obstruction.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Obesity is known to be a major risk factor for OSA linked with increased neck circumference and amounts of peripharyngeal fat, which could narrow and compress the upper airway<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>; obesity may also play a role by reducing lung volumes. Obesity affects ERV by decreasing FRC, and ERV may also be reduced with an increase in residual volume (RV) that occurs, not exclusively, but particularly in the obese, due to premature closure of the small peripheral airways.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> We found that the absolute effect of the correlation of ERV with obstructive events was similar to the effect of BMI, but ERV remained influential independently of all confounders such as BMI. The reduction in end-expiratory lung volumes, which are accentuated in sleep, may lead to a reduction in tracheal traction on the pharynx and so increasing its collapsibility. Conversely, increases in lung volumes have been shown to increase tracheal traction with stabilization of the upper airway during inspiration,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and in OSA patients, they have been shown to decrease positive airway pressure requirements and OSA severity, suggesting improvements in pharyngeal collapsibility.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Although this relationship seems unequivocal, as shown in our study, more research is needed in order to define more precisely which end-expiratory volume – ERV, FRC or even RV – plays the major role and how it influences the occurrence of obstructive events during sleep.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">BMI: body mass index; FEV1: forced expiratory volume in the 1st second; FVC: forced vital capacity; TLC: total lung capacity; RV: residual volume; FRC: forced residual capacity; ERV: expiratory reserve volume; Raw: airway resistance.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col">Patients’ parameters \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="4" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">AHI</th><th class="td" title="table-head " colspan="4" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">mO2</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Spearmann's correlation</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Regression analysis</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Spearmann's correlation</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Regression analysis</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">R</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Univariate \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Multivariate \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">R</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Univariate \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Multivariate \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.129 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.018 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">BMI (kg/m<span class="elsevierStyleSup">2</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.571 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.042 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.499 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.012 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Neck circumference (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.346 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Abdominal cir. (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.255 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.209 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Epworth's score \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.163 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.177 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">FEV1 (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.287 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.169 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">FVC (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.407 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.029 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">TLC (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.426 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.203 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">RV (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.102 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.279 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">FRC (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.388 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.531 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.019 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.033 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">ERV (l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.577 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.0015 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.262 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Raw \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.516 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.014 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.026 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">(ns) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab884728.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 20 | 11 | 31 |
2024 October | 101 | 40 | 141 |
2024 September | 106 | 30 | 136 |
2024 August | 133 | 43 | 176 |
2024 July | 139 | 46 | 185 |
2024 June | 104 | 29 | 133 |
2024 May | 93 | 25 | 118 |
2024 April | 90 | 33 | 123 |
2024 March | 75 | 32 | 107 |
2024 February | 53 | 24 | 77 |
2024 January | 79 | 22 | 101 |
2023 December | 79 | 30 | 109 |
2023 November | 87 | 32 | 119 |
2023 October | 76 | 25 | 101 |
2023 September | 67 | 28 | 95 |
2023 August | 51 | 22 | 73 |
2023 July | 73 | 30 | 103 |
2023 June | 47 | 16 | 63 |
2023 May | 66 | 32 | 98 |
2023 April | 63 | 15 | 78 |
2023 March | 95 | 31 | 126 |
2023 February | 70 | 25 | 95 |
2023 January | 69 | 22 | 91 |
2022 December | 61 | 21 | 82 |
2022 November | 74 | 32 | 106 |
2022 October | 65 | 37 | 102 |
2022 September | 40 | 20 | 60 |
2022 August | 45 | 34 | 79 |
2022 July | 40 | 43 | 83 |
2022 June | 38 | 30 | 68 |
2022 May | 56 | 47 | 103 |
2022 April | 53 | 32 | 85 |
2022 March | 60 | 63 | 123 |
2022 February | 46 | 45 | 91 |
2022 January | 49 | 40 | 89 |
2021 December | 34 | 40 | 74 |
2021 November | 44 | 33 | 77 |
2021 October | 38 | 29 | 67 |
2021 September | 54 | 36 | 90 |
2021 August | 65 | 25 | 90 |
2021 July | 38 | 28 | 66 |
2021 June | 42 | 29 | 71 |
2021 May | 73 | 34 | 107 |
2021 April | 123 | 81 | 204 |
2021 March | 122 | 16 | 138 |
2021 February | 130 | 24 | 154 |
2021 January | 80 | 10 | 90 |
2020 December | 80 | 14 | 94 |
2020 November | 74 | 22 | 96 |
2020 October | 66 | 26 | 92 |
2020 September | 99 | 15 | 114 |
2020 August | 88 | 34 | 122 |
2020 July | 113 | 24 | 137 |
2020 June | 93 | 20 | 113 |
2020 May | 94 | 29 | 123 |
2020 April | 87 | 7 | 94 |
2020 March | 80 | 18 | 98 |
2020 February | 82 | 18 | 100 |
2020 January | 95 | 16 | 111 |
2019 December | 83 | 24 | 107 |
2019 November | 96 | 24 | 120 |
2019 October | 103 | 23 | 126 |
2019 September | 103 | 26 | 129 |
2019 August | 141 | 23 | 164 |
2019 July | 141 | 36 | 177 |
2019 June | 152 | 14 | 166 |
2019 May | 175 | 25 | 200 |
2019 April | 149 | 32 | 181 |
2019 March | 178 | 17 | 195 |
2019 February | 171 | 11 | 182 |
2019 January | 150 | 29 | 179 |
2018 December | 97 | 7 | 104 |
2018 November | 28 | 5 | 33 |
2018 October | 44 | 7 | 51 |
2018 September | 30 | 4 | 34 |
2018 August | 60 | 24 | 84 |
2018 July | 44 | 20 | 64 |
2018 June | 46 | 15 | 61 |
2018 May | 68 | 18 | 86 |
2018 April | 73 | 23 | 96 |
2018 March | 77 | 18 | 95 |
2018 February | 44 | 12 | 56 |
2018 January | 66 | 16 | 82 |
2017 December | 76 | 19 | 95 |
2017 November | 77 | 14 | 91 |
2017 October | 36 | 25 | 61 |
2017 September | 45 | 8 | 53 |
2017 August | 33 | 12 | 45 |
2017 July | 33 | 17 | 50 |
2017 June | 57 | 15 | 72 |
2017 May | 45 | 25 | 70 |
2017 April | 27 | 2 | 29 |
2017 March | 19 | 9 | 28 |
2017 February | 23 | 8 | 31 |
2017 January | 31 | 5 | 36 |
2016 December | 20 | 8 | 28 |
2016 November | 25 | 6 | 31 |
2016 October | 10 | 10 | 20 |
2016 September | 22 | 5 | 27 |
2016 August | 11 | 7 | 18 |
2016 July | 3 | 10 | 13 |
2016 June | 0 | 20 | 20 |
2016 May | 0 | 5 | 5 |
2016 April | 33 | 1 | 34 |
2016 March | 33 | 9 | 42 |
2016 February | 40 | 14 | 54 |
2016 January | 30 | 10 | 40 |
2015 December | 51 | 16 | 67 |
2015 November | 37 | 11 | 48 |
2015 October | 37 | 9 | 46 |
2015 September | 41 | 10 | 51 |
2015 August | 36 | 10 | 46 |
2015 July | 20 | 8 | 28 |
2015 June | 28 | 9 | 37 |
2015 May | 37 | 9 | 46 |
2015 April | 29 | 16 | 45 |
2015 March | 17 | 2 | 19 |
2015 February | 40 | 5 | 45 |
2015 January | 32 | 10 | 42 |
2014 December | 39 | 14 | 53 |
2014 November | 34 | 13 | 47 |
2014 October | 29 | 11 | 40 |
2014 September | 21 | 17 | 38 |
2014 August | 37 | 23 | 60 |
2014 July | 39 | 21 | 60 |
2014 June | 58 | 39 | 97 |
2014 May | 80 | 51 | 131 |