Artigo Original/Original Article
Polimorfismos dos alelos m1 e m2 do gene CYP1A1: Susceptibilidade genética para o cancro do pulmão
CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer
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D. Medical Genetics – Instituto de Genética" "etiqueta" => "6" "identificador" => "af0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "*" "correspondencia" => "Paula Mota, Instituto de Genética. Faculdade de Medicina, Rua Larga 3000, Coimbra" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-04-28" "fechaAceptado" => "2009-06-08" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570106" "palabras" => array:5 [ 0 => "Cancro do pulmão" 1 => "tabaco" 2 => "citocromo p450" 3 => "CYP1A1" 4 => "desequilíbrio de ligação" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570107" "palabras" => array:5 [ 0 => "Lung cancer" 1 => "smoking" 2 => "cytochrome P450" 3 => "CYP1A1" 4 => "linkage disequilibrium" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">O cancro do pulmão é considerado uma doença relacionada com o meio ambiente, consequência da exposição a agentes mutagénicos, nomeadamente os presentes no fumo do tabaco. O gene CYP1A1 codifica a enzima aril hidrocarboneto hidroxilase (AHH), da fase I, do sistema multienzimático do citocromo P450, que desempenha uma função preponderante na bioactivação dos procarcinogénios do tabaco. Dois polimorfismos do CYP1A1, m1 (transição T6235C) e m2 (transição A4889G), estão associados a uma maior actividade enzimática, tendo sido referidos como factores genéticos de susceptibilidade para o cancro do pulmão.</p><p id="sp2005" class="elsevierStyleSimplePara elsevierViewall">Este trabalho teve como objectivo verificar esta possível associação em 175 doentes com cancro do pulmão e 217 controlos da Região Centro de Portugal, por RFLP (polimorfismo de comprimento de fragmentos de restrição).</p><p id="sp1005" class="elsevierStyleSimplePara elsevierViewall">Foi encontrada a seguinte distribuição para as frequências alélicas: 0.12 e 1.14, para os alelos mutados C e G, respectivamente, na população controlo. Os resultados não revelaram significado estatístico quando comparados com a distribuição encontrada na população de doentes. Relativamente à distribuição genotípica, a situação foi semelhante, não se registando significado estatístico, mesmo quando foram considerados genótipos de alto risco. Tal como noutras populações de diferente origem étnica, parece existir desequilíbrio de ligação para ambos os polimorfimos na população-controlo. Concluímos que nesta amostra de população portuguesa os polimorfismos m1 e m2 de CYP1A1 são particularmente raros, parecendo não existir relevância clínica nem associação à susceptibilidade ao cancro do pulmão.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2010; XVI (1): 89-98</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Lung cancer is considered an environment-related disease that develops as a consequence of exposure to mutagenic agents, namely those present in tobacco. The CYP1A1 gene codifies the phase I enzyme aryl hydrocarbon hydroxilase (AHH) belonging to the cytochrome P450 system that plays a major role in the bio-activation of tobacco procarcinogenes. Two CYP1A1 polymorphisms, m1 (T6235C transition) and m2 (A4889G transition), are associated with greater enzymatic activity and have been described as genetic susceptibility factors for lung cancer.</p><p id="sp1015" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to verify if this association holds true in blood samples of 175 lung cancer pa tients and 217 non-cancer patients from Portugal’s midlands region. The samples were studied by restriction fragment length polymorphism (RFLP) assay. The allelic frequencies of the mutant alleles were 0.12 for allele C and 1.14 for allele G in the control population. The results were not statistically different from those alleles in the patient population. There was also no statistically significant difference in genotype distribution in lung cancer patients and controls even when combining high risk genotypes. In our control sample, as in other populations of different ethnic origin, both polymorphisms also seem to be in linkage disequilibrium. We conclude that in this sample of the Portuguese population, CYP1A1 m1 and m2 polymorphisms are too rare to be of clinical relevance, and do not seem to be associated with susceptibility to lung cancer.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2010; XVI (1): 89-98</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:39 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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Article information
ISSN: 08732159Original language: Portuguese
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| 2022 January | 32 | 33 | 65 |
| 2021 December | 20 | 45 | 65 |
| 2021 November | 27 | 40 | 67 |
| 2021 October | 32 | 63 | 95 |
| 2021 September | 22 | 39 | 61 |
| 2021 August | 28 | 58 | 86 |
| 2021 July | 18 | 16 | 34 |
| 2021 June | 31 | 20 | 51 |
| 2021 May | 46 | 35 | 81 |
| 2021 April | 58 | 73 | 131 |
| 2021 March | 47 | 16 | 63 |
| 2021 February | 45 | 22 | 67 |
| 2021 January | 36 | 17 | 53 |
| 2020 December | 37 | 8 | 45 |
| 2020 November | 41 | 21 | 62 |
| 2020 October | 40 | 21 | 61 |
| 2020 September | 52 | 27 | 79 |
| 2020 August | 68 | 22 | 90 |
| 2020 July | 126 | 12 | 138 |
| 2020 June | 68 | 22 | 90 |
| 2020 May | 83 | 20 | 103 |
| 2020 April | 74 | 13 | 87 |
| 2020 March | 53 | 19 | 72 |
| 2020 February | 49 | 26 | 75 |
| 2020 January | 54 | 21 | 75 |
| 2019 December | 56 | 28 | 84 |
| 2019 November | 80 | 22 | 102 |
| 2019 October | 48 | 22 | 70 |
| 2019 September | 61 | 16 | 77 |
| 2019 August | 59 | 21 | 80 |
| 2019 July | 50 | 23 | 73 |
| 2019 June | 38 | 17 | 55 |
| 2019 May | 71 | 37 | 108 |
| 2019 April | 66 | 27 | 93 |
| 2019 March | 67 | 15 | 82 |
| 2019 February | 45 | 8 | 53 |
| 2019 January | 65 | 16 | 81 |
| 2018 December | 28 | 6 | 34 |
| 2018 November | 9 | 0 | 9 |
| 2018 October | 5 | 7 | 12 |
| 2018 September | 7 | 6 | 13 |
| 2018 August | 42 | 16 | 58 |
| 2018 July | 35 | 20 | 55 |
| 2018 June | 39 | 18 | 57 |
| 2018 May | 58 | 19 | 77 |
| 2018 April | 66 | 32 | 98 |
| 2018 March | 56 | 30 | 86 |
| 2018 February | 30 | 9 | 39 |
| 2018 January | 65 | 13 | 78 |
| 2017 December | 78 | 16 | 94 |
| 2017 November | 37 | 23 | 60 |
| 2017 October | 19 | 9 | 28 |
| 2017 September | 24 | 14 | 38 |
| 2017 August | 17 | 8 | 25 |
| 2017 July | 19 | 11 | 30 |
| 2017 June | 29 | 21 | 50 |
| 2017 May | 35 | 13 | 48 |
| 2017 April | 16 | 6 | 22 |
| 2017 March | 17 | 4 | 21 |
| 2017 February | 11 | 2 | 13 |
| 2017 January | 10 | 2 | 12 |
| 2016 December | 16 | 4 | 20 |
| 2016 November | 6 | 4 | 10 |
| 2016 October | 10 | 6 | 16 |
| 2016 September | 2 | 11 | 13 |
| 2016 August | 3 | 3 | 6 |
| 2016 July | 4 | 2 | 6 |
| 2016 June | 0 | 1 | 1 |
| 2016 May | 5 | 13 | 18 |
| 2016 April | 1 | 1 | 2 |
| 2016 March | 7 | 6 | 13 |
| 2016 February | 5 | 10 | 15 |
| 2016 January | 9 | 5 | 14 |
| 2015 December | 9 | 7 | 16 |
| 2015 November | 3 | 1 | 4 |
| 2015 October | 2 | 2 | 4 |
Show all
