Caso Clínico/Case Report
Tumor carcinóide do timo – Caso clínico
Thymic carcinoid – case report
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"https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915300155?idApp=UINPBA00004E" "url" => "/08732159/0000001600000001/v1_201509151437/S0873215915300155/v1_201509151437/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Caso Clínico/Case Report</span>" "titulo" => "Tumor carcinóide do timo – Caso clínico" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "177" "paginaFinal" => "185" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Lina Carvalho, Luís Eugénio Fernandes, Filipe Ferreira, Filipa Januário, Diogo Robles, Inês Sanches, Edgar Vaz, Manuel Antunes" "autores" => array:8 [ 0 => array:4 [ "nombre" => "Lina" "apellidos" => "Carvalho" "email" => array:1 [ 0 => "lcarvalho@huc.min-saude.pt" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Luís 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"referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "af0015" ] ] ] 7 => array:3 [ "nombre" => "Manuel" "apellidos" => "Antunes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Anatomia Patológica" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Cirurgia Cardiotorácica" "etiqueta" => "2" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Alunos da disciplina de Oncologia – 6.º ano – Medicina – Faculdade de Medicina da Universidade de Coimbra/<span class="elsevierStyleItalic">6<span class="elsevierStyleSup">th</span> year Oncology medical students</span>" "etiqueta" => "3" "identificador" => "af0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Thymic carcinoid – case report" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-04-28" "fechaAceptado" => "2009-07-08" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570095" "palabras" => array:3 [ 0 => "Timo" 1 => "carcinóide" 2 => "prognóstico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570094" "palabras" => array:3 [ 0 => "Thymus" 1 => "carcinoid" 2 => "prognosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Os tumores neuroendócrinos primários representam cerca de 4% do total dos tumores do mediastino anterior, incluindo o timo, afectando mais homens que mulheres numa razão de 3:1 e apresentando uma maior incidência entre os 40 e os 60 anos. Antigamente classificados como timomas, desde 1972 são considerados um grupo distinto de neoplasias tímicas, podendo ser biologicamente activos, estando sobretudo associados à síndroma NEM-1 (19<span class="elsevierStyleHsp" style=""></span>a 25% dos doentes, sendo nestes casos mais agressivos).</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">São descritos como tendo grande progressão local, recorrência e metástases em elevada percentagem de casos, o que determina um mau prognóstico. O estadiamento é o parâmetro mais importante para determinar a sobrevida. Tumores detectados em fase precoce e capsulados associam-se a um excelente prognóstico, enquanto em estádios avançados, localmente invasivos, têm prognóstico relativamente pobre.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">A remoção cirúrgica completa, para todos os tumores tímicos, é a base da terapêutica e o factor crítico para a sobrevivência a longo prazo, independentemente do tipo histológico. São uma causa de morte importante, nomeadamente os tumores associados a NEM-1 e síndroma de Cushing, e há autores que defendem a realização de timectomia profiláctica nestes doentes.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2010; XVI (1): 177-185</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Primary neuroendocrine tumours (carcinoid tumours) account for about 4% of anterior mediastinal tumours concerning thymus localization. They appear to have a male predilection (3:1 ratio) and occur mostly between 40 and 60 years of age. Classified primarily as thymomas, they have been considered a different group of thymic neoplasia since 1972. They can be biologically active, mostly associated with MEN-1 (19-25% of patients and more aggressive in these cases).</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">As a locally invasive disease, with recurrence and metastasis in a high percentage of cases, it correlates with a poor prognosis. Staging is the most important determinant of survival. Encapsulated tumours diagnosed in early stages have an excellent prognosis, while locally invasive tumours in more advanced stages have a relatively poor prognosis as happens with thymomas.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Complete surgical removal is the critical factor for long-term survival rates and the basis for treatment of all thymic tumours, independent of histologic type. As an important cause of death, especially in carcinoid tumours associated with MEN-1 and Cushing’s syndrome, some authors advocate the need for profilactic thymectomy in these patients.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2010; XVI (1): 177-185</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:34 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mediastinal endocrine neoplasm of probable thymic origin, related to carcinoid tumour. clinicalopathologic study of 8 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Rosai" 1 => "E. Higa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1972" "volumen" => "29" "paginaInicial" => "1061" "paginaFinal" => "1075" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4111691" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Travis" 1 => "E. Brambilla" 2 => "H. Muller-Hermelink" 3 => "C. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Tumors of the lung, pleura, thymus and heart" "fecha" => "2004" "editorial" => "WHO, IARC Press" "editorialLocalizacion" => "Lyon" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Rosai" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:5 [ "edicion" => "2" "titulo" => "Histological Typing of Tumours of the Thymus" "fecha" => "1999" "editorial" => "Springer-Verlag" "editorialLocalizacion" => "New York, NY" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thymic tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Detterbeck" 1 => "A.M. Parsons" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2003.10.001" "Revista" => array:7 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2004" "volumen" => "77" "paginaInicial" => "1860" "paginaFinal" => "1869" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15111216" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0002939408008970" "estado" => "S300" "issn" => "00029394" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The position of pulmonary carcinoids within the spectrum of neuroendocrine tumours of the lung and other tissues" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Ullmann" 1 => "S. Petzmann" 2 => "H. 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Article information
ISSN: 08732159Original language: Portuguese
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| 2017 October | 26 | 19 | 45 |
| 2017 September | 24 | 18 | 42 |
| 2017 August | 17 | 12 | 29 |
| 2017 July | 14 | 10 | 24 |
| 2017 June | 27 | 25 | 52 |
| 2017 May | 34 | 16 | 50 |
| 2017 April | 15 | 37 | 52 |
| 2017 March | 17 | 24 | 41 |
| 2017 February | 15 | 16 | 31 |
| 2017 January | 12 | 6 | 18 |
| 2016 December | 12 | 7 | 19 |
| 2016 November | 7 | 14 | 21 |
| 2016 October | 9 | 9 | 18 |
| 2016 September | 3 | 5 | 8 |
| 2016 August | 4 | 4 | 8 |
| 2016 July | 4 | 8 | 12 |
| 2016 June | 0 | 14 | 14 |
| 2016 May | 0 | 3 | 3 |
| 2016 April | 5 | 1 | 6 |
| 2016 March | 5 | 6 | 11 |
| 2016 February | 5 | 11 | 16 |
| 2016 January | 6 | 4 | 10 |
| 2015 December | 11 | 3 | 14 |
| 2015 November | 4 | 1 | 5 |
| 2015 October | 2 | 3 | 5 |
Show all
