Artigo Especial/Special Article
Tratamento da tuberculose de infecção latente. As recomendações actuais
Latent tuberculosis infection treatment. Current recommendations
R. Duarte1,2,3,4,
, M. Villar5,6,*, A. Carvalho1,3,*
,**
Corresponding author
raquelfduarte@gmail.com
Correspondência: Dra. Raquel Duarte, CDP Vila Nova de Gaia, Rua Conselheiro Veloso, Vila Nova de Gaia
Correspondência: Dra. Raquel Duarte, CDP Vila Nova de Gaia, Rua Conselheiro Veloso, Vila Nova de Gaia
1 Centro Diagnóstico Pneumológico de Vila Nova de Gaia
2 Centro de Referência de Tuberculose Multi-resistente da Região Norte
3 Centro Hospitalar de Vila Nova de Gaia/Espinho
4 Faculdade de Medicina. Universidade do Porto.
5 Centro Diagnóstico Pneumológico de Venda Nova. Lisboa
6 Centro de Referência Nacional de Tuberculose Multi-resistente
* Comissão de Trabalho de Tuberculose da Sociedade Portuguesa de Pneumologia
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Lisboa" "etiqueta" => "5" "identificador" => "af0025" ] 5 => array:3 [ "entidad" => "Centro de Referência Nacional de Tuberculose Multi-resistente" "etiqueta" => "6" "identificador" => "af0030" ] 6 => array:3 [ "entidad" => "Comissão de Trabalho de Tuberculose da Sociedade Portuguesa de Pneumologia" "etiqueta" => "*" "identificador" => "af0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "**" "correspondencia" => "<span class="elsevierStyleBold">Correspondência:</span> Dra. Raquel Duarte, CDP Vila Nova de Gaia, Rua Conselheiro Veloso, Vila Nova de Gaia" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Latent tuberculosis infection treatment. Current recommendations" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-01-25" "fechaAceptado" => "2010-05-11" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570272" "palabras" => array:4 [ 0 => "Tuberculose" 1 => "tuberculose infecção latente" 2 => "tratamento" 3 => "preventivo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec570273" "palabras" => array:4 [ 0 => "Tuberculosis" 1 => "latent tuberculosis infection" 2 => "treatment" 3 => "preventive" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">O diagnóstico e tratamento da infecção latente por <span class="elsevierStyleItalic"><span class="elsevierStyleBold">Mycobacterium tuberculosis</span></span> reduz significativamente o risco de desenvolvimento de tuberculose activa e a transmissão da doença na comunidade. O rastreio da tuberculose infecção latente deve passar pela exclusão de doença activa (inquérito de sintomas e radiografia pulmonar) e avaliação da resposta imunológica ao <span class="elsevierStyleItalic"><span class="elsevierStyleBold">M</span></span>. <span class="elsevierStyleItalic"><span class="elsevierStyleBold">tuberculosis</span></span> através dos testes actualmente ao dispor, como o teste tuberculínico e os testes IGRA (<span class="elsevierStyleItalic">interferon</span>-<span class="elsevierStyleItalic">gamma release assay</span>). A escolha do esquema de tratamento deve ter em linha de conta a eficácia, a adesão e os efeitos colaterais associados ao mesmo Este documento actualiza as recomendações sobre tratamento da tuberculose infecção latente. São apresentadas indicações sobre quem deve ser rastreado e revistos os esquemas de tratamento.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2010; XVI (5): 809-814</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Diagnosis and treatment of latent infection with Mycobacterium tuberculosis (LTBI), significantly reduces the risk of developing active tuberculosis and the transmission of the disease in the community. LTBI screening must pass by the exclusion of active disease (symptoms enquiry and chest radiography) and assessment of immune response to Mycobacterium tuberculosis testing with the tests currently available – tuberculin skin test and interferon-gamma release assay (IGRA). The choice of treatment must take into account the efficacy and side effects associated with the same. This document provides updated recommendations on latent tuberculosis infection treatment. Topics covered include whom to test for TB and reviewed LTBI treatment regimens.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2010; XVI (5): 809-814</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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Article information
ISSN: 08732159Original language: Portuguese
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