Artigo Original/Original Article
Proteína C reactiva e gravidade da bronquiolite aguda
C Reactive protein and disease severity in bronchiolitis
1 Interna Complementar de Pediatria, Serviço de Pediatria HSJ / Paediatrics resident, Paediatrics Department, HSJ
2 Interno Complementar de Pediatria, Serviço de Pediatria HSJ / Paediatrics resident, Paediatrics Department, HSJ
3 Assistente hospitalar de Pediatria, Serviço de Pediatria HSJ / Paediatrics consultant, Paediatrics Department, HSJ
4 Assistente hospitalar de Pediatria, Unidade de Pneumologia Pediátrica do Serviço de Pediatria HSJ / Paediatrics consultant, Paediatric Pulmonology Unit, Paediatrics Department, HSJ
5 Chefe de Serviço de Pediatria, Unidade de Pneumologia Pediátrica do Serviço de Pediatria HSJ / Head, Paediatrics, Paediatric Pulmonology Unit, Paediatrics Department HSJ
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"apellidos" => "Guedes-Vaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "af0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Interna Complementar de Pediatria, Serviço de Pediatria HSJ / Paediatrics resident, Paediatrics Department, HSJ" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Interno Complementar de Pediatria, Serviço de Pediatria HSJ / Paediatrics resident, Paediatrics Department, HSJ" "etiqueta" => "2" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Assistente hospitalar de Pediatria, Serviço de Pediatria HSJ / Paediatrics consultant, Paediatrics Department, HSJ" "etiqueta" => "3" "identificador" => "af0015" ] 3 => array:3 [ "entidad" => "Assistente hospitalar de Pediatria, Unidade de Pneumologia Pediátrica do Serviço de Pediatria HSJ / Paediatrics consultant, Paediatric Pulmonology Unit, Paediatrics Department, HSJ" "etiqueta" => "4" "identificador" => "af0020" ] 4 => array:3 [ "entidad" => "Chefe de Serviço de Pediatria, Unidade de Pneumologia Pediátrica do Serviço de Pediatria HSJ / Head, Paediatrics, Paediatric Pulmonology Unit, Paediatrics Department HSJ" "etiqueta" => "5" "identificador" => "af0025" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "C Reactive protein and disease severity in bronchiolitis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-05-21" "fechaAceptado" => "2008-09-19" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570519" "palabras" => array:3 [ 0 => "Bronquiolite" 1 => "diagnóstico" 2 => "proteína C reactiva" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570518" "palabras" => array:3 [ 0 => "Bronchiolitis" 1 => "diagnosis" 2 => "C reactive protein" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">O diagnóstico de bronquiolite aguda é essencialmente clínico. A utilidade de exames laboratoriais, em particular do doseamento da proteína C reactiva (PCR), não está bem estabelecida.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">O objectivo deste trabalho foi avaliar a relação entre o valor da PCR e os marcadores indirectos de gravidade em doentes com diagnóstico de bronquiolite.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Foram incluídos no estudo todos os doentes admitidos no Serviço de Pediatria do HSJ durante o ano de 2006 e que tiveram como diagnóstico principal bronquiolite, tendo sido feita uma revisão retrospectiva do processo clínico desses doentes.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Foram incluídos 176 doentes com idades compreendidas entre zero e 36 meses (mediana de 4 meses); 63,1% eram do sexo masculino. O doseamento da PCR tinha sido efectuado em 94,3% dos doentes, com valores compreendidos entre zero e 256<span class="elsevierStyleHsp" style=""></span>mg/L e com mediana de 11<span class="elsevierStyleHsp" style=""></span>mg/L.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">O valor da PCR, na população estudada, apresentou uma relação estatisticamente significativa com a admissão em unidade de cuidados intensivos (UCI) (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,008), a duração do internamento hospitalar (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,025) e a necessidade de oxigenoterapia (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,022).</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Desta forma, este trabalho coloca a hipótese de o valor de PCR poder ser um marcador de gravidade e ter significado prognóstico em doentes com bronquiolite. Mais estudos são necessários para validar estes resultados e esclarecer se existe uma relação real entre as variáveis estudadas ou se esta é produzida pelo efeito confundidor de outras infecções.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (1): 55-65</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">A diagnosis of bronchiolitis is made clinically and the use of supportive laboratory examinations, including the quantification of C reactive protein (CRP), is not well established.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to evaluate the correlation between CRP value and indirect markers of disease severity in patients with bronchiolitis.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">This study included the patients diagnosed with bronchiolitis admitted to the Pediatrics Department of S. João Hospital in 2006. A retrospective review was made through analysing clinical files.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">176 patients aged 0 to 36 months (median of 4 months) were included. 63.1% were males. CRP level was measured in 94.3% of the patients, with values ranging from zero to 256<span class="elsevierStyleHsp" style=""></span>mg/L and a median of 11<span class="elsevierStyleHsp" style=""></span>mg/L.</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall">CRP value in this population had a statistically significant relation with admission to Intensive Care Unit (ICU) (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.008), length of hospital stay (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.025) and need for supplementary oxygen during hospital stay (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.022).</p><p id="sp0065" class="elsevierStyleSimplePara elsevierViewall">This work raises the hypothesis that the CRP value on admission might be a marker of disease severity and have prognostic significance in patients with bronchiolitis. Further investigation is necessary to validate these results and exclude the potential confounding effect of associated infections.</p><p id="sp0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (1): 55-65</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia / Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis – clinical practice guideline" ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1542/peds.2006-2223" "Revista" => array:7 [ "tituloSerie" => "Pediatrics" "fecha" => "2006" "volumen" => "118" "numero" => "4" "paginaInicial" => "1774" "paginaFinal" => "1793" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17015575" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Behrman, Kliegmam, Jenson" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Goodman D. Bronchiolitis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Nelson Textbook of Pediatrics. Saunders" "paginaInicial" => "1415" "paginaFinal" => "1417" "serieFecha" => "2004" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infecciones virales de vias respiratorias inferiores en lactantes hospitalizados: etiologia, caracteristicas clinicas y factores de riesgo" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ 0 => "G. Garcia" 1 => "M.O. Gabin" 2 => "C.C. Reya" 3 => "M.I. Avarez" 4 => "J.A. Ruiz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "2001" "volumen" => "55" "paginaInicial" => "101" "paginaFinal" => "107" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11472660" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Procalcitonin, Interleukine-6, C-reactive protein and leukocyte counts in infants with bronchiolitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Resch" 1 => "C. Gusenleiner" 2 => "W. Muller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.inf.0000066196.23839.b0" "Revista" => array:7 [ "tituloSerie" => "Pediatr Infect Dis J" "fecha" => "2003" "volumen" => "22" "numero" => "5" "paginaInicial" => "475" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12792393" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001500000001/v1_201509151539/S0873215915301094/v1_201509151539/pt/main.assets" "Apartado" => array:4 [ "identificador" => "9575" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Artigos originais" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001500000001/v1_201509151539/S0873215915301094/v1_201509151539/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301094?idApp=UINPBA00004E" ]
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ISSN: 08732159Original language: Portuguese
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| 2022 September | 36 | 38 | 74 |
| 2022 August | 44 | 39 | 83 |
| 2022 July | 45 | 44 | 89 |
| 2022 June | 67 | 54 | 121 |
| 2022 May | 76 | 57 | 133 |
| 2022 April | 34 | 24 | 58 |
| 2022 March | 39 | 26 | 65 |
| 2022 February | 35 | 35 | 70 |
| 2022 January | 62 | 39 | 101 |
| 2021 December | 32 | 36 | 68 |
| 2021 November | 47 | 37 | 84 |
| 2021 October | 55 | 35 | 90 |
| 2021 September | 37 | 37 | 74 |
| 2021 August | 50 | 26 | 76 |
| 2021 July | 38 | 15 | 53 |
| 2021 June | 33 | 25 | 58 |
| 2021 May | 37 | 29 | 66 |
| 2021 April | 89 | 90 | 179 |
| 2021 March | 102 | 32 | 134 |
| 2021 February | 101 | 13 | 114 |
| 2021 January | 90 | 18 | 108 |
| 2020 December | 48 | 9 | 57 |
| 2020 November | 59 | 16 | 75 |
| 2020 October | 52 | 23 | 75 |
| 2020 September | 82 | 22 | 104 |
| 2020 August | 91 | 24 | 115 |
| 2020 July | 130 | 18 | 148 |
| 2020 June | 137 | 16 | 153 |
| 2020 May | 128 | 29 | 157 |
| 2020 April | 106 | 16 | 122 |
| 2020 March | 99 | 11 | 110 |
| 2020 February | 149 | 18 | 167 |
| 2020 January | 72 | 16 | 88 |
| 2019 December | 85 | 18 | 103 |
| 2019 November | 88 | 16 | 104 |
| 2019 October | 66 | 21 | 87 |
| 2019 September | 73 | 19 | 92 |
| 2019 August | 99 | 17 | 116 |
| 2019 July | 100 | 20 | 120 |
| 2019 June | 99 | 12 | 111 |
| 2019 May | 126 | 33 | 159 |
| 2019 April | 100 | 20 | 120 |
| 2019 March | 67 | 18 | 85 |
| 2019 February | 63 | 15 | 78 |
| 2019 January | 75 | 27 | 102 |
| 2018 December | 47 | 20 | 67 |
| 2018 November | 19 | 4 | 23 |
| 2018 October | 14 | 11 | 25 |
| 2018 September | 21 | 8 | 29 |
| 2018 August | 55 | 17 | 72 |
| 2018 July | 60 | 22 | 82 |
| 2018 June | 68 | 23 | 91 |
| 2018 May | 103 | 20 | 123 |
| 2018 April | 105 | 22 | 127 |
| 2018 March | 107 | 43 | 150 |
| 2018 February | 75 | 9 | 84 |
| 2018 January | 76 | 14 | 90 |
| 2017 December | 101 | 19 | 120 |
| 2017 November | 52 | 16 | 68 |
| 2017 October | 26 | 16 | 42 |
| 2017 September | 36 | 13 | 49 |
| 2017 August | 26 | 19 | 45 |
| 2017 July | 27 | 14 | 41 |
| 2017 June | 43 | 17 | 60 |
| 2017 May | 29 | 7 | 36 |
| 2017 April | 20 | 3 | 23 |
| 2017 March | 20 | 3 | 23 |
| 2017 February | 14 | 7 | 21 |
| 2017 January | 22 | 2 | 24 |
| 2016 December | 17 | 12 | 29 |
| 2016 November | 14 | 6 | 20 |
| 2016 October | 18 | 5 | 23 |
| 2016 September | 7 | 4 | 11 |
| 2016 August | 3 | 1 | 4 |
| 2016 July | 4 | 7 | 11 |
| 2016 May | 1 | 0 | 1 |
| 2016 April | 1 | 1 | 2 |
| 2016 March | 1 | 11 | 12 |
| 2016 February | 3 | 5 | 8 |
| 2016 January | 6 | 5 | 11 |
| 2015 December | 8 | 2 | 10 |
| 2015 November | 4 | 3 | 7 |
| 2015 October | 3 | 2 | 5 |
Show all
