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Caso Clínico/Case Report
Imunocitoma IgA. A propósito de um caso clínico
Immunocytoma IgA. Case report
Bebiana Conde1,
Corresponding author
bebianaconde@gmail.com

Centro Hospitalar de Trás-os-Montes e Alto Douro Av. da Noruega 5000 Vila Real
, Ana Fernandes2, Manuel Cunha3, Abel Afonso2
1 Interna do Internato Complementar de Pneumologia
2 Chefe de Serviço de Pneumologia
3 Assistente Graduado de Hematologia Clínica
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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">O imunocitoma &#233; um linfoma n&#227;o Hodgkin &#40;LNH&#41; de c&#233;lulas B&#44; com evolu&#231;&#227;o habitualmente indolente&#46; Representa aproximadamente 1-3&#37; dos LNH e atinge habitualmente adultos com mais de 50 anos&#44; podendo manifestar-se por adenomegalias&#44; hepatomegalia&#44; esplenomegalia e linfocitose em 15 a 30&#37; dos casos&#46; Raramente tem envolvimento pulmonar&#46; Com frequ&#234;ncia ocorrendo picos monoclonais de imunoglobulinas&#44; s&#233;ricos&#44; frequentemente IgM e raramente IgA&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Como exemplo desta patologia apresentamos o caso cl&#237;nico de um doente do sexo masculino&#44; 52 anos&#44; com cl&#237;nica de infec&#231;&#245;es respirat&#243;rias bacterianas de repeti&#231;&#227;o&#44; com necessidade de internamentos sucessivos&#44; cuja investiga&#231;&#227;o identificou um imunocitoma IgA&#44; est&#225;dio IV&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Assumindo-se o diagn&#243;stico de um linfoma indolente&#44; decidiu-se iniciar terap&#234;utica profil&#225;ctica com imunoglobulinas humanas poliespec&#237;ficas&#44; tendo havido diminui&#231;&#227;o das infec&#231;&#245;es respirat&#243;rias&#46; Posteriormente&#44; a evid&#234;ncia de progress&#227;o do linfoma condicionou o in&#237;cio de poliquimioterapia&#44; com o esquema ciclofosfamida&#44; vincristina&#44; prednisolona &#40;CVP&#41; e rituximab&#174;&#44; tendo-se alcan&#231;ado uma resposta parcial&#44; que se manteve durante dois anos&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;1&#41;&#58; 121-127</span></p></span>"
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      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Immunocytoma is a non-Hodgkin&#8217;s indolent evolution B cell lymphoma&#46; It accounts for approximately 1-3&#37; of non-Hodgkin&#39;s limphomas and usually onsets in adults aged over 50 years old&#46; It manifests as lymphadenopathy&#44; splenomegaly&#44; hepatomegaly and lymphcytosis in 15-30&#37; of cases and is rarely seen with pulmonary involvement&#46; Monocloncal peaks of serum immunoglobulin often occur&#46; These are IgM and rarely IgA&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">We present as an example a male patient aged 52 years old&#44; with recurrent respiratory infections&#46; Clinical work-up identified an immunocytoma IgA stage IV&#46; Diagnosing an indolent lymphoma&#44; we prophylactic polyspecific human immunoglobulin to treat the respiratory infection&#46; Evidence of lymphoma progression leads us to prescribe combined cyclo-phosphamide &#40;C&#41;&#44; vincristine &#40;V&#41;&#44; prednisone &#40;P&#41; e rituximab &#40;R&#41; &#40;CVP-R&#41;&#44; which has obtained a partial response over two years&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;1&#41;&#58; 121-127</span></p></span>"
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Article information
ISSN: 08732159
Original language: Portuguese
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Pulmonology

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