Nanorradiolipossomas modulados molecularmente para estudar a drenagem linfática pulmonar profunda

array:24 ["pii" => "S0873215915301318" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30131-8" "estado" => "S350" "fechaPublicacion" => "2009-03-01" "aid" => "9" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "copyrightAnyo" => "2009" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2009;15:261-93" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2886 "formatos" => array:3 [ "EPUB" => 214 "HTML" => 1955 "PDF" => 717 ] ] "itemSiguiente" => array:19 [ "pii" => "S087321591530132X" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30132-X" "estado" => "S350" "fechaPublicacion" => "2009-03-01" "aid" => "10" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2009;15:295-304" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2187 "formatos" => array:3 [ "EPUB" => 213 "HTML" => 1322 "PDF" => 652 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "Artigo de Revisão/Review Article" "titulo" => "Teste tuberculínico. Como optimizar?" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "295" "paginaFinal" => "304" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Tuberculin skin test. How to optimise?" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Raquel Duarte" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Raquel" "apellidos" => "Duarte" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087321591530132X?idApp=UINPBA00004E" "url" => "/08732159/0000001500000002/v1_201509151524/S087321591530132X/v1_201509151524/pt/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0873215915301306" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30130-6" "estado" => "S350" "fechaPublicacion" => "2009-03-01" "aid" => "8" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2009;15:241-59" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2425 "formatos" => array:3 [ "EPUB" => 206 "HTML" => 1624 "PDF" => 595 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "Artigo Original/Original Article" "titulo" => "Derrames pleurais parapneumónicos em pediatria: Experiência num hospital central universitário" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "241" "paginaFinal" => "259" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pediatric parapneumonic pleural effusions: Experience in a university central hospital" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Paulo Soares, João Barreira, Susana Pissarra, Teresa Nunes, Inês Azevedo, Luísa Vaz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Paulo" "apellidos" => "Soares" ] 1 => array:2 [ "nombre" => "João" "apellidos" => "Barreira" ] 2 => array:2 [ "nombre" => "Susana" "apellidos" => "Pissarra" ] 3 => array:2 [ "nombre" => "Teresa" "apellidos" => "Nunes" ] 4 => array:2 [ "nombre" => "Inês" "apellidos" => "Azevedo" ] 5 => array:2 [ "nombre" => "Luísa" "apellidos" => "Vaz" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301306?idApp=UINPBA00004E" "url" => "/08732159/0000001500000002/v1_201509151524/S0873215915301306/v1_201509151524/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "Artigo Original/Original Article" "titulo" => "Nanorradiolipossomas modulados molecularmente para estudar a drenagem linfática pulmonar profunda" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "261" "paginaFinal" => "293" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Maria Filomena Rabaça Roque Botelho, Maria Alcide Tavares Marques, Célia Maria Freitas Gomes, Augusto Marques Ferreira da Silva, Vasco António Andrade Figueiredo Bairos, Manuel Amaro de Matos Santos Rosa, Antero Pena Abrunhosa, João José Pedroso de Lima" "autores" => array:8 [ 0 => array:4 [ "nombre" => "Maria Filomena Rabaça Roque" "apellidos" => "Botelho" "email" => array:1 [ 0 => "filomena@ibili.uc.pt" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cr0005" ] ] ] 1 => array:3 [ "nombre" => "Maria Alcide Tavares" "apellidos" => "Marques" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "2" "identificador" => "af0010" ] ] ] 2 => array:3 [ "nombre" => "Célia Maria Freitas" "apellidos" => "Gomes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "1" "identificador" => "af0005" ] ] ] 3 => array:3 [ "nombre" => "Augusto Marques Ferreira" "apellidos" => "da Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "3" "identificador" => "af0015" ] ] ] 4 => array:3 [ "nombre" => "Vasco António Andrade Figueiredo" "apellidos" => "Bairos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "4" "identificador" => "af0020" ] ] ] 5 => array:3 [ "nombre" => "Manuel Amaro de Matos Santos" "apellidos" => "Rosa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "5" "identificador" => "af0025" ] ] ] 6 => array:3 [ "nombre" => "Antero Pena" "apellidos" => "Abrunhosa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "1" "identificador" => "af0005" ] ] ] 7 => array:3 [ "nombre" => "João José Pedroso" "apellidos" => "de Lima" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "1" "identificador" => "af0005" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Instituto de Biofísica e Biomatemática, Faculdade de Medicina, Universidade de Coimbra, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Departmento de Ciências Pneumológicas e Alergológicas, Hospitais da Universidade de Coimbra, Praceta Mota Pinto, 3000-075 Coimbra, Portugal" "etiqueta" => "2" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Departmento de Electrónica e Telecomunicações, Universidade de Aveiro, 3810-193 Aveiro, Portugal" "etiqueta" => "3" "identificador" => "af0015" ] 3 => array:3 [ "entidad" => "Instituto de Histologia e Embriologia, Faculdade de Medicina, Universidade de Coimbra, Rua Larga, 3004-504 Coimbra, Portugal" "etiqueta" => "4" "identificador" => "af0020" ] 4 => array:3 [ "entidad" => "Instituto de Imunologia, Faculdade de Medicina, Universidade de Coimbra, Rua Larga, 3004-504 Coimbra, Portugal" "etiqueta" => "5" "identificador" => "af0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "*" "correspondencia" => "Correspondência/Correspondence to: Maria Filomena Botelho, Instituto de Biofísica e Biomatemática, IBILI-Faculdade de Medicina, Azinhaga de Santa Comba, Celas 3000-548 Coimbra Portugal Tel: +351 239 480240 FAX: +351 239 480258" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Nanoradioliposomes molecularly modulated to study the lung deep lymphatic drainage" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-01-23" "fechaAceptado" => "2009-01-26" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570446" "palabras" => array:4 [ 0 => "Nanorradiolipossomas" 1 => "modulação molecular" 2 => "drenagem linfática pulmonar" 3 => "imagem nuclear funcional" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570445" "palabras" => array:4 [ 0 => "Nanoradioliposomes" 1 => "molecular modulation" 2 => "lung lymphatic drainage" 3 => "functional nuclear imaging" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "A drenagem linfática pulmonar profunda (DLPP) desempenha um papel importante na remoção de materiais estranhos, constituindo os macrófagos alveolares a primeira linha de defesa fagocitária, dada a grande afinidade para microrganismos patogénicos. Os Bacillus subtilis são saprófitas do tracto respiratório humano com ampla utilização em investigação e em biotecnologia.As cadeias linfáticas pulmonares profundas (CLPP) constituem um dos primeiros locais de disseminação de tumores pulmonares.Neste trabalho pretendeu-se desenvolver e validar um método não invasivo para avaliar as CLPP através de nanorradiolipossomas aerosolisados e modulados pela parede do esporo do Bacillus subtilis. O objectivo final foi produzir uma formulação de nanorradiolipossomas capaz de imitar a dinâmica da remoção de esporos pelas CLPP e simultaneamente ter propriedades ideais como traçador para imagiologia molecular.Testámos sete diferentes formulações lipossómicas, tendo a formulação F demonstrado possuir propriedades fisicoquímicas e radiofarmacêuticas que a tornam o traçador ideal para imagiologia molecular in vivo das CLPP.Os nanorradiolipossomas da formulação F após marcação com 99mTc-HMPAO foram administrados sob a forma de aerossóis a 20 Sus scrofa. Visualizaram-se comunicações hilares e interpulmonares nos primeiros 5 minutos após a inalação, as cadeias infradiafragmáticas entre os 10 e os 20 minutos, os gânglios da cadeia aórtica aos 20 minutos e os da região hilar renal aos 30 minutos.Em conclusão, o método proposto visualiza os gânglios linfáticos e a rede linfática pulmonar profunda. A modulação dos nanorradiolipossomas permite que eles atinjam órgãos ou tecidos específicos, conferindo-lhes importantes potencialidades no âmbito do diagnóstico e/ou da terapêutica.Rev Port Pneumol 2009; XV (2): 261-293" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Lung deep lymphatic drainage (LDLD) plays an important role in the removal of foreign materials from lungs being alveolar macrophages the first line of phagocytic defence with high affinity for pathogenic microorganisms. Bacillus subtilis is a well-known genome-decoded saprophyte of the human respiratory tract used in research and in the biotechnology industry.Lung deep lymphatic chains (LDLC) constitute one of the first sites of lung tumours’ dissemination. In this work we intended to develop and validate a non-invasive method for assessing LDLC by nanoradioliposomes aerosolised modulated on the Bacillus subtilis spore wall. The final goal was to produce a nanoradioliposome formulation that can mimics the dynamics of preferential removal of spores by LDLD and present the ideal properties as a tracer for molecular imaging studies.Seven different liposomal formulations were tested, and the formulation-F demonstrated physicochemical and radiopharmaceutical properties that make it an ideal candidate as an in vivo probe for molecular imaging studies of the LDLC.Nanoradioliposomes of the formulation-F after labelling with 99mTc-HMPAO were administered as aerosols to 20 Sus scrofa. Hilar and interpulmonary communications were visualized in first 5 minutes post-inhalation, infradiaphragmatic chains between 10 and 20 minutes, the ganglia of the aortic chain at 20 minutes and those of the renal hilar region at 30 minutes.Conclusion: the proposed method enables visualization of deep lymphatic lung network and lymph nodes. Besides, this technique involving the modulation of nanoradioliposomes targeting specific organs or tissues may be an important tool for diagnostic or even for therapeutic purposes.Rev Port Pneumol 2009; XV (2): 261-293" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:54 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The chemical composition of the cytoplasmic membrane of Bacillus subtilis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.G. Bishop" 1 => "L. Rutberg" 2 => "B. Samuelsson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur J Biohem" "fecha" => "1967" "volumen" => "2" "paginaInicial" => "448" "paginaFinal" => "453" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "JAF Op der Kamp, I Redai, LLM van Deenen, Phosholipid composition of Bacillus subtilis" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Bacteriol" "fecha" => "1969" "volumen" => "99" "paginaInicial" => "298" "paginaFinal" => "303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4979443" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of the Bacillus subtilis spore morphogenetic coat Protein" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "D.C. McPherson" 1 => "H. Kim" 2 => "M. Hahn" 3 => "R. Wang" 4 => "P. Grabowski" 5 => "P. Eichenberger" 6 => "A. Driks1" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/JB.187.24.8278-8290.2005" "Revista" => array:6 [ "tituloSerie" => "CotO J Bacteriol" "fecha" => "2005" "volumen" => "187" "paginaInicial" => "8278" "paginaFinal" => "8290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16321932" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lymphatics and lymphoid tissue" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V. Leak" 1 => "V.J. Ferrans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "The Lung: Scientific Foundations" "paginaInicial" => "779" "paginaFinal" => "786" "serieFecha" => "1997" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fluid Balance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.E. Taylor" 1 => "J.W. Barnard" 2 => "S.A. Barman" 3 => "W.K. Adkins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "The Lung: Scientific Foundations" "paginaInicial" => "1147" "paginaFinal" => "1161" "serieFecha" => "1997" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pulmonary lymphatic system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Nagaishi" 1 => "Y. Okada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "paginaInicial" => "901" "paginaFinal" => "908" "serieVolumen" => "2" "serieTitulo" => "AP Fishman’s Pulmonary Disease and Disorders" "serieFecha" => "1980" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary edema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.P. Fishman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "paginaInicial" => "919" "paginaFinal" => "952" "serieVolumen" => "2" "serieTitulo" => "AP Fishman’s Pulmonary Disease and Disorders" "serieFecha" => "1980" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alveolar clearance and the role of the pulmonary lymphatics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.M. Lauweryns" 1 => "J.H. Baert" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1977.115.4.625" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1977" "volumen" => "115" "paginaInicial" => "625" "paginaFinal" => "683" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/322558" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lymphangiographic visualization of pleural and pulmonary lymphatics in a patient without chylothorax" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Grant" 1 => "B. Levin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/113.1.49" "Revista" => array:6 [ "tituloSerie" => "Radiology" "fecha" => "1974" "volumen" => "113" "paginaInicial" => "49" "paginaFinal" => "50" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4420724" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Targeting colloidal particulates to thoracic lymph nodes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Liua" 1 => "Ho-Lun Wong" 2 => "B. Bowenc Moselhyc" 3 => "X.Y. Wuc" 4 => "M.R. Johnston" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.lungcan.2005.11.006" "Revista" => array:6 [ "tituloSerie" => "Lung Cancer" "fecha" => "2006" "volumen" => "51" "paginaInicial" => "377" "paginaFinal" => "386" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16413084" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Unique bio chemical events in bacterial sporulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.S. Hanson" 1 => "J.A. Peterson" 2 => "A.A. Yousten" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.mi.24.100170.000413" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Microbiol" "fecha" => "1970" "volumen" => "24" "paginaInicial" => "53" "paginaFinal" => "90" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4927140" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Structure and morphogenesis of the bacterial spore coat" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.I. Aronson" 1 => "P. Fitz-James" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Bacteriol Rev" "fecha" => "1976" "volumen" => "40" "paginaInicial" => "360" "paginaFinal" => "402" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/786255" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transport and distribution of charged macromolecules in lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.C. Parker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Adv Microcirc" "fecha" => "1987" "volumen" => "13" "paginaInicial" => "150" "paginaFinal" => "159" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enzyme replacement via liposomes. Variations in lipid composition determine liposomal integrity in biological fluids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.C. Finkelstein" 1 => "G. Weissmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1979" "volumen" => "587" "paginaInicial" => "202" "paginaFinal" => "216" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/486550" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The phospholipid component of small unilamellar liposomes controls the rate of clearance of entrapped solutes from the circulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Gregoriadis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "FEBS Letters" "fecha" => "1980" "volumen" => "119" "paginaInicial" => "43" "paginaFinal" => "46" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7428926" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Properties of multilamellar liposomes containing 99mTcO4-: Effect of distearoylphosphatidylcholine to sphingomyelin ratio" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.R. Zalustry" 1 => "M.A. Noska" 2 => "P.W. Gallagher" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Nucl Med" "fecha" => "1986" "volumen" => "13" "paginaInicial" => "269" "paginaFinal" => "276" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Generation of large unilamellar vesicles from long-chain saturated phosphatidylcholines by extrusion techniques" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Nayar" 1 => "M.J. Hope" 2 => "P.R. Cullis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1989" "volumen" => "986" "paginaInicial" => "200" "paginaFinal" => "206" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Targeting to lymph nodes by subcutaneous administration of liposomes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Oussoren" 1 => "G. Storm" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Inter J Pharma" "fecha" => "1998" "volumen" => "162" "paginaInicial" => "39" "paginaFinal" => "44" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel method of greatly enhanced delivery of liposomes to lymph nodes1" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.T. Phillips" 1 => "R. Klipper" 2 => "B. Goins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JPET" "fecha" => "2000" "volumen" => "295" "paginaInicial" => "309" "paginaFinal" => "313" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recent advances in liposomebased nanoparticles for antigen delivery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W. Yan" 1 => "L. Huang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Polymer Reviews" "fecha" => "2007" "volumen" => "47" "paginaInicial" => "329" "paginaFinal" => "344" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bb0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New aspects of liposomes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.A. Tyrrell" 1 => "T.D. Heath" 2 => "C.M. Colley" 3 => "B.E. Ryman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1976" "volumen" => "457" "paginaInicial" => "259" "paginaFinal" => "302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/793635" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bb0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Kirby" 1 => "J. Clarke" 2 => "G. Gregoriadis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochem J" "fecha" => "1980" "volumen" => "186" "paginaInicial" => "591" "paginaFinal" => "598" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7378067" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bb0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preparation of lipid vesicles containing high levels of entrapped radioactive cations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.R. Mauk" 1 => "R.C. Gamble" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anal Biochem" "fecha" => "1979" "volumen" => "94" "paginaInicial" => "302" "paginaFinal" => "307" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/380400" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bb0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radionuclide-labelled liposomes – A new lymph node imaging agent" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Osborne" 1 => "V.J. Richardson" 2 => "K. Jeysingh" 3 => "B.E. Ryman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Nucl Med" "fecha" => "1979" "volumen" => "6" "paginaInicial" => "75" "paginaFinal" => "83" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bb0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A simple method for produc ing technetium-99m-labeled liposome which is stable in vivo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.T. Phillips" 1 => "A.S. Rudolph" 2 => "B. Goins" 3 => "J.H. Timmons" 4 => "R. Klipper" 5 => "R. Blumhardt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nucl Med Biol" "fecha" => "1992" "volumen" => "19" "paginaInicial" => "539" "paginaFinal" => "547" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bb0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidoreductive state: the major determinant for cellular retention of technetium-99m-HMPAO" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.R. Jacquier-Sarlier" 1 => "B.S. Polla" 2 => "D.O. Slosman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "1996" "volumen" => "37" "paginaInicial" => "1413" "paginaFinal" => "1416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8708786" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bb0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blood-pool imaging using technetium-99m-labeled liposomes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Goins" 1 => "W.T. Phillips" 2 => "R. Klipper" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "1996" "volumen" => "37" "paginaInicial" => "1374" "paginaFinal" => "1379" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8708778" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bb0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dual radiolabeled liposomes: biodistribution studies and localization of focal sites of infection in rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V.D. Awashi" 1 => "B. Goins" 2 => "R. Klipper" 3 => "W.T. Phillips" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nucl Med Biol" "fecha" => "1998" "volumen" => "25" "paginaInicial" => "155" "paginaFinal" => "160" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9468030" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bb0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small-volume extrusion apparatus for preparation of large unilamellar vesicles" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.C. MacDonald" 1 => "R.I. MacDonald" 2 => "B.P.M. Menco" 3 => "K. Takeshita" 4 => "N.K. Subbarao" 5 => "L.-R. Hu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "BiochimBiophys Acta" "fecha" => "1991" "volumen" => "1061" "paginaInicial" => "297" "paginaFinal" => "303" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bb0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preparation of liposomes of defined size and distribution by extrusion through polycarbonate membranes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Olson" 1 => "C.A. Hunt" 2 => "F.C. Szoka" 3 => "W.J. Vail" 4 => "D. Papahadjopoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1979" "volumen" => "557" "paginaInicial" => "9" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/95096" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bb0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.J. Hope" 1 => "M.B. Bally" 2 => "G. Webb" 3 => "P.R. Cullis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1985" "volumen" => "812" "paginaInicial" => "55" "paginaFinal" => "65" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23008845" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bb0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Studies on phosphatidylcholine vesicles. Formation and physical characteristics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Huang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochemistry" "fecha" => "1969" "volumen" => "8" "paginaInicial" => "344" "paginaFinal" => "351" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5777332" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bb0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vivo distribution of vesicles loads with radiopharmaceuticals: a study of different routes of administration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I.R. McDougall" 1 => "J.K. Dunnick" 2 => "M.L. Goris" 3 => "J.P. Kriss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "1975" "volumen" => "16" "paginaInicial" => "488" "paginaFinal" => "491" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1159504" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bb0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacokinetics and biodistribution of [111In]-avidin and [99mTc]-biotin-liposomes injected in the pleural space for the targeting of mediastinal nodes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.A. Medina" 1 => "R. Klipper" 2 => "W.T. Phillips" 3 => "B. Goins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nucl Med Biol" "fecha" => "2004" "volumen" => "31" "paginaInicial" => "41" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14741569" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bb0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of 99mTclabeled liposomes encapsulating blue dye for identification of the sentinel lymph node" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.T. Phillips" 1 => "R. Klipper" 2 => "B. Goins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "2001" "volumen" => "42" "paginaInicial" => "446" "paginaFinal" => "451" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11337521" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bb0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Attachment of 99mTc to lipid vesicles containing the lipophilic chelate dipalmitoylphosphatidyl ethanolamine-DTTA" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Ahkong" 1 => "C. Tilcock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nucl Med Biol" "fecha" => "1992" "volumen" => "19" "paginaInicial" => "831" "paginaFinal" => "840" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bb0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distribution and pharmacology of intravenous 99mtclabeled multilamellar liposomes in rats and mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "L.P. Kasi" 1 => "G. Lopez-Berestein" 2 => "K. Mehta" 3 => "M. Rosenblum" 4 => "H.J. Glenn" 5 => "T.P. Haynie" 6 => "G. Mavligit" 7 => "E.M. Hersh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Nucl Med Biol" "fecha" => "1984" "volumen" => "11" "paginaInicial" => "35" "paginaFinal" => "37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6735607" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bb0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of technetium-99m-liposomes in tumor imaging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Goins" 1 => "R. Klipper" 2 => "A.S. Rudolph" 3 => "W.T. Phillips" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "1994" "volumen" => "35" "paginaInicial" => "1491" "paginaFinal" => "1498" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8071699" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bb0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regional lung deposition and clearance of 99mTc-labeled beclomethasone-DLPC liposomes in mild and severe asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.M. Saari" 1 => "M.T. Vidgren" 2 => "M.O. Koskinen" 3 => "V.M.H. Turjanmaa" 4 => "J.C. Waldrep" 5 => "M.N. Nieminem" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1998" "volumen" => "113" "paginaInicial" => "1573" "paginaFinal" => "1579" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9631796" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bb0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of the size distribution of unilamellar vesicles by gel filtration, quasi-elastic light scattering and electron microscopy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Shurtenberger" 1 => "H. Hauser" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1984" "volumen" => "778" "paginaInicial" => "470" "paginaFinal" => "480" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bb0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Size analysis of biological membrane vesicles by gel filtration, dynamic light scattering and electron microscopy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Perevucnik" 1 => "P. Schurtenberger" 2 => "H. Hauser" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1985" "volumen" => "821" "paginaInicial" => "169" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4063358" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bb0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vesicles of variable sizes produced by a rapid extrusion procedure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.D. Mayer" 1 => "M.J. Hope" 2 => "P.R. Cullis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1986" "volumen" => "858" "paginaInicial" => "161" "paginaFinal" => "168" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3707960" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bb0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Investigations of a new, highly negative liposome with improved biodistribution for imaging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.J. Hnatowich" 1 => "B. Clancy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "1980" "volumen" => "21" "paginaInicial" => "662" "paginaFinal" => "669" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7391841" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bb0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The stability of liposomes to nebulization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.M.G. Taylor" 1 => "G. Taylor" 2 => "I.W. Kellaway" 3 => "J. Stevens" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Pharm" "fecha" => "1990" "volumen" => "58" "paginaInicial" => "57" "paginaFinal" => "61" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bb0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nebulization of liposome. I. Effects of lipid composition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.W. Niven" 1 => "H. Schreier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Pharm Res" "fecha" => "1990" "volumen" => "7" "paginaInicial" => "11271133" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bb0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The stability of liposomes to ultrasonic nebulization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.K.M. Leung" 1 => "P.A. Bridges" 2 => "K.M.G. Taylor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Pharm" "fecha" => "1996" "volumen" => "145" "paginaInicial" => "95" "paginaFinal" => "102" ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bb0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiation absorbed dose from tc-99m diethylenetriaminepentaacetic acid (DTPA)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "S. Thomas" 1 => "H. Atkins" 2 => "J. McAfee" 3 => "M.D. Blaufox" 4 => "M. Fernandez" 5 => "P.T. Kirchner" 6 => "R.C. Reba" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "1984" "volumen" => "25" "paginaInicial" => "503" "paginaFinal" => "505" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6400025" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bb0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:1 [ "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "International Commission of Radiation Protection Publication 30" "fecha" => "1988" "editorial" => "Pergamon Press" "editorialLocalizacion" => "New York" ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bb0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Technical and biological considerations on the use of radiolabeled liposomes for diagnostic imaging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.J. Caride" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nucl Med Biol" "fecha" => "1990" "volumen" => "17" "paginaInicial" => "35" "paginaFinal" => "39" ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bb0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biodistribution and ima ging studies of technetium-99m-labeled liposomes in rats with focal infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Goins" 1 => "R. Klipper" 2 => "A.S. Rudolph" 3 => "R.O. Cliff" 4 => "R. Blumhardt" 5 => "W.T. Phillips" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Nucl Med" "fecha" => "1993" "volumen" => "34" "paginaInicial" => "2160" "paginaFinal" => "2168" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8254404" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bb0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interactions of sugars with membranes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "J.H. Crowe" 1 => "L.M. Crowe" 2 => "J.F. Carpenter" 3 => "A.S. Rudolph" 4 => "C.A. Wistrom" 5 => "B.J. Spargo" 6 => "T.J. Anchordoguy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1988" "volumen" => "947" "paginaInicial" => "367" "paginaFinal" => "384" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3285894" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bb0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modification of lipid phase behavior with membrane bound cryoprotectants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.P. Goodrich" 1 => "T.M. Handel" 2 => "J.D. Baldeschwieler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochim Biophys Acta" "fecha" => "1988" "volumen" => "938" "paginaInicial" => "143" "paginaFinal" => "154" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3342228" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bb0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nebulization of monodisperse latex sphere suspensions in air-jet and ultrasonic nebulizers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O.N.M. Mc Callion" 1 => "K.M.G. Taylor" 2 => "M. Thomas" 3 => "A.J. Taylor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Pharm" "fecha" => "1996" "volumen" => "133" "paginaInicial" => "203" "paginaFinal" => "214" ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bb0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.F. Phalen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "Basic morphology and physiology of the respiratory tract, in: Inhalation Studies: Foundations and techniques" "paginaInicial" => "51" "serieFecha" => "1984" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001500000002/v1_201509151524/S0873215915301318/v1_201509151524/pt/main.assets" "Apartado" => array:4 [ "identificador" => "9575" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Artigos originais" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001500000002/v1_201509151524/S0873215915301318/v1_201509151524/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301318?idApp=UINPBA00004E"]

Statistics

Artigo Original/Original Article

Nanorradiolipossomas modulados molecularmente para estudar a drenagem linfática pulmonar profunda

Nanoradioliposomes molecularly modulated to study the lung deep lymphatic drainage

Maria Filomena Rabaça Roque Botelho1,

Corresponding author

filomena@ibili.uc.pt

Correspondência/Correspondence to: Maria Filomena Botelho, Instituto de Biofísica e Biomatemática, IBILI-Faculdade de Medicina, Azinhaga de Santa Comba, Celas 3000-548 Coimbra Portugal Tel: +351 239 480240 FAX: +351 239 480258

, Maria Alcide Tavares Marques2, Célia Maria Freitas Gomes1, Augusto Marques Ferreira da Silva3, Vasco António Andrade Figueiredo Bairos4, Manuel Amaro de Matos Santos Rosa5, Antero Pena Abrunhosa1, João José Pedroso de Lima1

1 Instituto de Biofísica e Biomatemática, Faculdade de Medicina, Universidade de Coimbra, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal

2 Departmento de Ciências Pneumológicas e Alergológicas, Hospitais da Universidade de Coimbra, Praceta Mota Pinto, 3000-075 Coimbra, Portugal

3 Departmento de Electrónica e Telecomunicações, Universidade de Aveiro, 3810-193 Aveiro, Portugal

4 Instituto de Histologia e Embriologia, Faculdade de Medicina, Universidade de Coimbra, Rua Larga, 3004-504 Coimbra, Portugal

5 Instituto de Imunologia, Faculdade de Medicina, Universidade de Coimbra, Rua Larga, 3004-504 Coimbra, Portugal

Read

6376

Times
was read the article

2607

Total PDF

3769

Total HTML

Share statistics

 array:24 [
  "pii" => "S0873215915301318"
  "issn" => "08732159"
  "doi" => "10.1016/S0873-2159(15)30131-8"
  "estado" => "S350"
  "fechaPublicacion" => "2009-03-01"
  "aid" => "9"
  "copyright" => "Sociedade Portuguesa de Pneumologia&#47;SPP"
  "copyrightAnyo" => "2009"
  "documento" => "simple-article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2009;15:261-93"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2886
    "formatos" => array:3 [
      "EPUB" => 214
      "HTML" => 1955
      "PDF" => 717
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S087321591530132X"
    "issn" => "08732159"
    "doi" => "10.1016/S0873-2159(15)30132-X"
    "estado" => "S350"
    "fechaPublicacion" => "2009-03-01"
    "aid" => "10"
    "copyright" => "Sociedade Portuguesa de Pneumologia&#47;SPP"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "rev"
    "cita" => "Rev Port Pneumol. 2009;15:295-304"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2187
      "formatos" => array:3 [
        "EPUB" => 213
        "HTML" => 1322
        "PDF" => 652
      ]
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revis&#227;o&#47;Review Article</span>"
      "titulo" => "Teste tubercul&#237;nico&#46; Como optimizar&#63;"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "295"
          "paginaFinal" => "304"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Tuberculin skin test&#46; How to optimise&#63;"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Raquel Duarte"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "Raquel"
              "apellidos" => "Duarte"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087321591530132X?idApp=UINPBA00004E"
    "url" => "/08732159/0000001500000002/v1_201509151524/S087321591530132X/v1_201509151524/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0873215915301306"
    "issn" => "08732159"
    "doi" => "10.1016/S0873-2159(15)30130-6"
    "estado" => "S350"
    "fechaPublicacion" => "2009-03-01"
    "aid" => "8"
    "copyright" => "Sociedade Portuguesa de Pneumologia&#47;SPP"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2009;15:241-59"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2425
      "formatos" => array:3 [
        "EPUB" => 206
        "HTML" => 1624
        "PDF" => 595
      ]
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original&#47;Original Article</span>"
      "titulo" => "Derrames pleurais parapneum&#243;nicos em pediatria&#58; Experi&#234;ncia num hospital central universit&#225;rio"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "241"
          "paginaFinal" => "259"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Pediatric parapneumonic pleural effusions&#58; Experience in a university central hospital"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Paulo Soares, Jo&#227;o Barreira, Susana Pissarra, Teresa Nunes, In&#234;s Azevedo, Lu&#237;sa Vaz"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Paulo"
              "apellidos" => "Soares"
            ]
            1 => array:2 [
              "nombre" => "Jo&#227;o"
              "apellidos" => "Barreira"
            ]
            2 => array:2 [
              "nombre" => "Susana"
              "apellidos" => "Pissarra"
            ]
            3 => array:2 [
              "nombre" => "Teresa"
              "apellidos" => "Nunes"
            ]
            4 => array:2 [
              "nombre" => "In&#234;s"
              "apellidos" => "Azevedo"
            ]
            5 => array:2 [
              "nombre" => "Lu&#237;sa"
              "apellidos" => "Vaz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301306?idApp=UINPBA00004E"
    "url" => "/08732159/0000001500000002/v1_201509151524/S0873215915301306/v1_201509151524/pt/main.assets"
  ]
  "pt" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original&#47;Original Article</span>"
    "titulo" => "Nanorradiolipossomas modulados molecularmente para estudar a drenagem linf&#225;tica pulmonar profunda"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "261"
        "paginaFinal" => "293"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Maria Filomena Raba&#231;a Roque Botelho, Maria Alcide Tavares Marques, C&#233;lia Maria Freitas Gomes, Augusto Marques Ferreira da Silva, Vasco Ant&#243;nio Andrade Figueiredo Bairos, Manuel Amaro de Matos Santos Rosa, Antero Pena Abrunhosa, Jo&#227;o Jos&#233; Pedroso de Lima"
        "autores" => array:8 [
          0 => array:4 [
            "nombre" => "Maria Filomena Raba&#231;a Roque"
            "apellidos" => "Botelho"
            "email" => array:1 [
              0 => "filomena&#64;ibili&#46;uc&#46;pt"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "af0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cr0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Maria Alcide Tavares"
            "apellidos" => "Marques"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">2</span>"
                "identificador" => "af0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#233;lia Maria Freitas"
            "apellidos" => "Gomes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "af0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Augusto Marques Ferreira"
            "apellidos" => "da Silva"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">3</span>"
                "identificador" => "af0015"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Vasco Ant&#243;nio Andrade Figueiredo"
            "apellidos" => "Bairos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">4</span>"
                "identificador" => "af0020"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Manuel Amaro de Matos Santos"
            "apellidos" => "Rosa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">5</span>"
                "identificador" => "af0025"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Antero Pena"
            "apellidos" => "Abrunhosa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "af0005"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Jo&#227;o Jos&#233; Pedroso"
            "apellidos" => "de Lima"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "af0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:5 [
          0 => array:3 [
            "entidad" => "Instituto de Biof&#237;sica e Biomatem&#225;tica&#44; Faculdade de Medicina&#44; Universidade de Coimbra&#44; Azinhaga de Santa Comba&#44; Celas&#44; 3000-548 Coimbra&#44; Portugal"
            "etiqueta" => "1"
            "identificador" => "af0005"
          ]
          1 => array:3 [
            "entidad" => "Departmento de Ci&#234;ncias Pneumol&#243;gicas e Alergol&#243;gicas&#44; Hospitais da Universidade de Coimbra&#44; Praceta Mota Pinto&#44; 3000-075 Coimbra&#44; Portugal"
            "etiqueta" => "2"
            "identificador" => "af0010"
          ]
          2 => array:3 [
            "entidad" => "Departmento de Electr&#243;nica e Telecomunica&#231;&#245;es&#44; Universidade de Aveiro&#44; 3810-193 Aveiro&#44; Portugal"
            "etiqueta" => "3"
            "identificador" => "af0015"
          ]
          3 => array:3 [
            "entidad" => "Instituto de Histologia e Embriologia&#44; Faculdade de Medicina&#44; Universidade de Coimbra&#44; Rua Larga&#44; 3004-504 Coimbra&#44; Portugal"
            "etiqueta" => "4"
            "identificador" => "af0020"
          ]
          4 => array:3 [
            "entidad" => "Instituto de Imunologia&#44; Faculdade de Medicina&#44; Universidade de Coimbra&#44; Rua Larga&#44; 3004-504 Coimbra&#44; Portugal"
            "etiqueta" => "5"
            "identificador" => "af0025"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cr0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "<span class="elsevierStyleBold">Correspond&#234;ncia&#47;<span class="elsevierStyleItalic">Correspondence to&#58;</span></span> Maria Filomena Botelho&#44; Instituto de Biof&#237;sica e Biomatem&#225;tica&#44; IBILI-Faculdade de Medicina&#44; Azinhaga de Santa Comba&#44; Celas 3000-548 Coimbra Portugal Tel&#58; &#43;<span class="elsevierStyleHsp" style=""></span>351 239 480240 FAX&#58; &#43;<span class="elsevierStyleHsp" style=""></span>351 239 480258"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Nanoradioliposomes molecularly modulated to study the lung deep lymphatic drainage"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2009-01-23"
    "fechaAceptado" => "2009-01-26"
    "PalabrasClave" => array:2 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec570446"
          "palabras" => array:4 [
            0 => "Nanorradiolipossomas"
            1 => "modula&#231;&#227;o molecular"
            2 => "drenagem linf&#225;tica pulmonar"
            3 => "imagem nuclear funcional"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key-words"
          "identificador" => "xpalclavsec570445"
          "palabras" => array:4 [
            0 => "Nanoradioliposomes"
            1 => "molecular modulation"
            2 => "lung lymphatic drainage"
            3 => "functional nuclear imaging"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A drenagem linf&#225;tica pulmonar profunda &#40;DLPP&#41; desempenha um papel importante na remo&#231;&#227;o de materiais estranhos&#44; constituindo os macr&#243;fagos alveolares a primeira linha de defesa fagocit&#225;ria&#44; dada a grande afinidade para microrganismos patog&#233;nicos&#46; Os <span class="elsevierStyleItalic">Bacillus subtilis</span> s&#227;o sapr&#243;fitas do tracto respirat&#243;rio humano com ampla utiliza&#231;&#227;o em investiga&#231;&#227;o e em biotecnologia&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">As cadeias linf&#225;ticas pulmonares profundas &#40;CLPP&#41; constituem um dos primeiros locais de dissemina&#231;&#227;o de tumores pulmonares&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Neste trabalho pretendeu-se desenvolver e validar um m&#233;todo n&#227;o invasivo para avaliar as CLPP atrav&#233;s de nanorradiolipossomas aerosolisados e modulados pela parede do esporo do <span class="elsevierStyleItalic">Bacillus subtilis</span>&#46; O objectivo final foi produzir uma formula&#231;&#227;o de nanorradiolipossomas capaz de imitar a din&#226;mica da remo&#231;&#227;o de esporos pelas CLPP e simultaneamente ter propriedades ideais como tra&#231;ador para imagiologia molecular&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Test&#225;mos sete diferentes formula&#231;&#245;es liposs&#243;micas&#44; tendo a formula&#231;&#227;o F demonstrado possuir propriedades fisicoqu&#237;micas e radiofarmac&#234;uticas que a tornam o tra&#231;ador ideal para imagiologia molecular <span class="elsevierStyleItalic">in vivo</span> das CLPP&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Os nanorradiolipossomas da formula&#231;&#227;o F ap&#243;s marca&#231;&#227;o com <span class="elsevierStyleSup">99m</span>Tc-HMPAO foram administrados sob a forma de aeross&#243;is a 20 <span class="elsevierStyleItalic">Sus scrofa</span>&#46; Visualizaram-se comunica&#231;&#245;es hilares e interpulmonares nos primeiros 5 minutos ap&#243;s a inala&#231;&#227;o&#44; as cadeias infradiafragm&#225;ticas entre os 10 e os 20 minutos&#44; os g&#226;nglios da cadeia a&#243;rtica aos 20 minutos e os da regi&#227;o hilar renal aos 30 minutos&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Em conclus&#227;o&#44; o m&#233;todo proposto visualiza os g&#226;nglios linf&#225;ticos e a rede linf&#225;tica pulmonar profunda&#46; A modula&#231;&#227;o dos nanorradiolipossomas permite que eles atinjam &#243;rg&#227;os ou tecidos espec&#237;ficos&#44; conferindo-lhes importantes potencialidades no &#226;mbito do diagn&#243;stico e&#47;ou da terap&#234;utica&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;2&#41;&#58; 261-293</span></p></span>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Lung deep lymphatic drainage &#40;LDLD&#41; plays an important role in the removal of foreign materials from lungs being alveolar macrophages the first line of phagocytic defence with high affinity for pathogenic microorganisms&#46; <span class="elsevierStyleItalic">Bacillus subtilis</span> is a well-known genome-decoded saprophyte of the human respiratory tract used in research and in the biotechnology industry&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Lung deep lymphatic chains &#40;LDLC&#41; constitute one of the first sites of lung tumours&#8217; dissemination&#46; In this work we intended to develop and validate a non-invasive method for assessing LDLC by nanoradioliposomes aerosolised modulated on the <span class="elsevierStyleItalic">Bacillus subtilis</span> spore wall&#46; The final goal was to produce a nanoradioliposome formulation that can mimics the dynamics of preferential removal of spores by LDLD and present the ideal properties as a tracer for molecular imaging studies&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">Seven different liposomal formulations were tested&#44; and the formulation-F demonstrated physicochemical and radiopharmaceutical properties that make it an ideal candidate as an <span class="elsevierStyleItalic">in vivo</span> probe for molecular imaging studies of the LDLC&#46;</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">Nanoradioliposomes of the formulation-F after labelling with 99mTc-HMPAO were administered as aerosols to 20 <span class="elsevierStyleItalic">Sus scrofa</span>&#46; Hilar and interpulmonary communications were visualized in first 5 minutes post-inhalation&#44; infradiaphragmatic chains between 10 and 20 minutes&#44; the ganglia of the aortic chain at 20 minutes and those of the renal hilar region at 30 minutes&#46;</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall">Conclusion&#58; the proposed method enables visualization of deep lymphatic lung network and lymph nodes&#46; Besides&#44; this technique involving the modulation of nanoradioliposomes targeting specific organs or tissues may be an important tool for diagnostic or even for therapeutic purposes&#46;</p><p id="sp0065" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;2&#41;&#58; 261-293</span></p></span>"
      ]
    ]
    "lecturaRecomendada" => array:1 [
      0 => array:3 [
        "vista" => "all"
        "titulo" => "<span class="elsevierStyleSectionTitle" id="st0030">Bibliography</span>"
        "seccion" => array:1 [
          0 => array:2 [
            "vista" => "all"
            "bibliografiaReferencia" => array:54 [
              0 => array:3 [
                "identificador" => "bb0005"
                "etiqueta" => "1&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The chemical composition of the cytoplasmic membrane of <span class="elsevierStyleItalic">Bacillus subtilis</span>"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "D&#46;G&#46; Bishop"
                              1 => "L&#46; Rutberg"
                              2 => "B&#46; Samuelsson"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Eur J Biohem"
                          "fecha" => "1967"
                          "volumen" => "2"
                          "paginaInicial" => "448"
                          "paginaFinal" => "453"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              1 => array:3 [
                "identificador" => "bb0010"
                "etiqueta" => "2&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "titulo" => "JAF Op der Kamp&#44; I Redai&#44; LLM van Deenen&#44; Phosholipid composition of <span class="elsevierStyleItalic">Bacillus subtilis</span>"
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Bacteriol"
                          "fecha" => "1969"
                          "volumen" => "99"
                          "paginaInicial" => "298"
                          "paginaFinal" => "303"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4979443"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              2 => array:3 [
                "identificador" => "bb0015"
                "etiqueta" => "3&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Characterization of the <span class="elsevierStyleItalic">Bacillus subtilis</span> spore morphogenetic coat Protein"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:7 [
                              0 => "D&#46;C&#46; McPherson"
                              1 => "H&#46; Kim"
                              2 => "M&#46; Hahn"
                              3 => "R&#46; Wang"
                              4 => "P&#46; Grabowski"
                              5 => "P&#46; Eichenberger"
                              6 => "A&#46; Driks1"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1128/JB.187.24.8278-8290.2005"
                        "Revista" => array:6 [
                          "tituloSerie" => "CotO J Bacteriol"
                          "fecha" => "2005"
                          "volumen" => "187"
                          "paginaInicial" => "8278"
                          "paginaFinal" => "8290"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16321932"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              3 => array:3 [
                "identificador" => "bb0020"
                "etiqueta" => "4&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Lymphatics and lymphoid tissue"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "V&#46; Leak"
                              1 => "V&#46;J&#46; Ferrans"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:4 [
                          "titulo" => "The Lung&#58; Scientific Foundations"
                          "paginaInicial" => "779"
                          "paginaFinal" => "786"
                          "serieFecha" => "1997"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              4 => array:3 [
                "identificador" => "bb0025"
                "etiqueta" => "5&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Fluid Balance"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "A&#46;E&#46; Taylor"
                              1 => "J&#46;W&#46; Barnard"
                              2 => "S&#46;A&#46; Barman"
                              3 => "W&#46;K&#46; Adkins"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:4 [
                          "titulo" => "The Lung&#58; Scientific Foundations"
                          "paginaInicial" => "1147"
                          "paginaFinal" => "1161"
                          "serieFecha" => "1997"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              5 => array:3 [
                "identificador" => "bb0030"
                "etiqueta" => "6&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The pulmonary lymphatic system"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "C&#46; Nagaishi"
                              1 => "Y&#46; Okada"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:5 [
                          "paginaInicial" => "901"
                          "paginaFinal" => "908"
                          "serieVolumen" => "2"
                          "serieTitulo" => "AP Fishman&#8217;s Pulmonary Disease and Disorders"
                          "serieFecha" => "1980"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              6 => array:3 [
                "identificador" => "bb0035"
                "etiqueta" => "7&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pulmonary edema"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "A&#46;P&#46; Fishman"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:5 [
                          "paginaInicial" => "919"
                          "paginaFinal" => "952"
                          "serieVolumen" => "2"
                          "serieTitulo" => "AP Fishman&#8217;s Pulmonary Disease and Disorders"
                          "serieFecha" => "1980"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              7 => array:3 [
                "identificador" => "bb0040"
                "etiqueta" => "8&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Alveolar clearance and the role of the pulmonary lymphatics"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "J&#46;M&#46; Lauweryns"
                              1 => "J&#46;H&#46; Baert"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/arrd.1977.115.4.625"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am Rev Respir Dis"
                          "fecha" => "1977"
                          "volumen" => "115"
                          "paginaInicial" => "625"
                          "paginaFinal" => "683"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/322558"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              8 => array:3 [
                "identificador" => "bb0045"
                "etiqueta" => "9&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Lymphangiographic visualization of pleural and pulmonary lymphatics in a patient without chylothorax"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "T&#46; Grant"
                              1 => "B&#46; Levin"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1148/113.1.49"
                        "Revista" => array:6 [
                          "tituloSerie" => "Radiology"
                          "fecha" => "1974"
                          "volumen" => "113"
                          "paginaInicial" => "49"
                          "paginaFinal" => "50"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4420724"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              9 => array:3 [
                "identificador" => "bb0050"
                "etiqueta" => "10&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Targeting colloidal particulates to thoracic lymph nodes"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "J&#46; Liua"
                              1 => "Ho-Lun Wong"
                              2 => "B&#46; Bowenc Moselhyc"
                              3 => "X&#46;Y&#46; Wuc"
                              4 => "M&#46;R&#46; Johnston"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/j.lungcan.2005.11.006"
                        "Revista" => array:6 [
                          "tituloSerie" => "Lung Cancer"
                          "fecha" => "2006"
                          "volumen" => "51"
                          "paginaInicial" => "377"
                          "paginaFinal" => "386"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16413084"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              10 => array:3 [
                "identificador" => "bb0055"
                "etiqueta" => "11&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Unique bio chemical events in bacterial sporulation"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "R&#46;S&#46; Hanson"
                              1 => "J&#46;A&#46; Peterson"
                              2 => "A&#46;A&#46; Yousten"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1146/annurev.mi.24.100170.000413"
                        "Revista" => array:6 [
                          "tituloSerie" => "Annu Rev Microbiol"
                          "fecha" => "1970"
                          "volumen" => "24"
                          "paginaInicial" => "53"
                          "paginaFinal" => "90"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4927140"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              11 => array:3 [
                "identificador" => "bb0060"
                "etiqueta" => "12&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Structure and morphogenesis of the bacterial spore coat"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "A&#46;I&#46; Aronson"
                              1 => "P&#46; Fitz-James"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Bacteriol Rev"
                          "fecha" => "1976"
                          "volumen" => "40"
                          "paginaInicial" => "360"
                          "paginaFinal" => "402"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/786255"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              12 => array:3 [
                "identificador" => "bb0065"
                "etiqueta" => "13&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Transport and distribution of charged macromolecules in lung"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "J&#46;C&#46; Parker"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Adv Microcirc"
                          "fecha" => "1987"
                          "volumen" => "13"
                          "paginaInicial" => "150"
                          "paginaFinal" => "159"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              13 => array:3 [
                "identificador" => "bb0070"
                "etiqueta" => "14&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Enzyme replacement via liposomes&#46; Variations in lipid composition determine liposomal integrity in biological fluids"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "M&#46;C&#46; Finkelstein"
                              1 => "G&#46; Weissmann"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Biochim Biophys Acta"
                          "fecha" => "1979"
                          "volumen" => "587"
                          "paginaInicial" => "202"
                          "paginaFinal" => "216"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/486550"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              14 => array:3 [
                "identificador" => "bb0075"
                "etiqueta" => "15&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The phospholipid component of small unilamellar liposomes controls the rate of clearance of entrapped solutes from the circulation"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "J&#46; Gregoriadis"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "FEBS Letters"
                          "fecha" => "1980"
                          "volumen" => "119"
                          "paginaInicial" => "43"
                          "paginaFinal" => "46"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7428926"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              15 => array:3 [
                "identificador" => "bb0080"
                "etiqueta" => "16&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Properties of multilamellar liposomes containing 99mTcO4-&#58; Effect of distearoylphosphatidylcholine to sphingomyelin ratio"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "M&#46;R&#46; Zalustry"
                              1 => "M&#46;A&#46; Noska"
                              2 => "P&#46;W&#46; Gallagher"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "J Nucl Med"
                          "fecha" => "1986"
                          "volumen" => "13"
                          "paginaInicial" => "269"
                          "paginaFinal" => "276"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              16 => array:3 [
                "identificador" => "bb0085"
                "etiqueta" => "17&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Generation of large unilamellar vesicles from long-chain saturated phosphatidylcholines by extrusion techniques"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "R&#46; Nayar"
                              1 => "M&#46;J&#46; Hope"
                              2 => "P&#46;R&#46; Cullis"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Biochim Biophys Acta"
                          "fecha" => "1989"
                          "volumen" => "986"
                          "paginaInicial" => "200"
                          "paginaFinal" => "206"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              17 => array:3 [
                "identificador" => "bb0090"
                "etiqueta" => "18&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Targeting to lymph nodes by subcutaneous administration of liposomes"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "C&#46; Oussoren"
                              1 => "G&#46; Storm"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Inter J Pharma"
                          "fecha" => "1998"
                          "volumen" => "162"
                          "paginaInicial" => "39"
                          "paginaFinal" => "44"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              18 => array:3 [
                "identificador" => "bb0095"
                "etiqueta" => "19&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Novel method of greatly enhanced delivery of liposomes to lymph nodes1"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "W&#46;T&#46; Phillips"
                              1 => "R&#46; Klipper"
                              2 => "B&#46; Goins"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "JPET"
                          "fecha" => "2000"
                          "volumen" => "295"
                          "paginaInicial" => "309"
                          "paginaFinal" => "313"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              19 => array:3 [
                "identificador" => "bb0100"
                "etiqueta" => "20&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Recent advances in liposomebased nanoparticles for antigen delivery"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "W&#46; Yan"
                              1 => "L&#46; Huang"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Polymer Reviews"
                          "fecha" => "2007"
                          "volumen" => "47"
                          "paginaInicial" => "329"
                          "paginaFinal" => "344"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              20 => array:3 [
                "identificador" => "bb0105"
                "etiqueta" => "21&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "New aspects of liposomes"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "D&#46;A&#46; Tyrrell"
                              1 => "T&#46;D&#46; Heath"
                              2 => "C&#46;M&#46; Colley"
                              3 => "B&#46;E&#46; Ryman"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Biochim Biophys Acta"
                          "fecha" => "1976"
                          "volumen" => "457"
                          "paginaInicial" => "259"
                          "paginaFinal" => "302"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/793635"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              21 => array:3 [
                "identificador" => "bb0110"
                "etiqueta" => "22&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "C&#46; Kirby"
                              1 => "J&#46; Clarke"
                              2 => "G&#46; Gregoriadis"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Biochem J"
                          "fecha" => "1980"
                          "volumen" => "186"
                          "paginaInicial" => "591"
                          "paginaFinal" => "598"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7378067"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              22 => array:3 [
                "identificador" => "bb0115"
                "etiqueta" => "23&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Preparation of lipid vesicles containing high levels of entrapped radioactive cations"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "M&#46;R&#46; Mauk"
                              1 => "R&#46;C&#46; Gamble"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Anal Biochem"
                          "fecha" => "1979"
                          "volumen" => "94"
                          "paginaInicial" => "302"
                          "paginaFinal" => "307"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/380400"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              23 => array:3 [
                "identificador" => "bb0120"
                "etiqueta" => "24&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Radionuclide-labelled liposomes &#8211; A new lymph node imaging agent"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "P&#46; Osborne"
                              1 => "V&#46;J&#46; Richardson"
                              2 => "K&#46; Jeysingh"
                              3 => "B&#46;E&#46; Ryman"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Int J Nucl Med"
                          "fecha" => "1979"
                          "volumen" => "6"
                          "paginaInicial" => "75"
                          "paginaFinal" => "83"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              24 => array:3 [
                "identificador" => "bb0125"
                "etiqueta" => "25&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "A simple method for produc ing technetium-99<span class="elsevierStyleHsp" style=""></span>m-labeled liposome which is stable in vivo"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "W&#46;T&#46; Phillips"
                              1 => "A&#46;S&#46; Rudolph"
                              2 => "B&#46; Goins"
                              3 => "J&#46;H&#46; Timmons"
                              4 => "R&#46; Klipper"
                              5 => "R&#46; Blumhardt"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Nucl Med Biol"
                          "fecha" => "1992"
                          "volumen" => "19"
                          "paginaInicial" => "539"
                          "paginaFinal" => "547"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              25 => array:3 [
                "identificador" => "bb0130"
                "etiqueta" => "26&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Oxidoreductive state&#58; the major determinant for cellular retention of technetium-99<span class="elsevierStyleHsp" style=""></span>m-HMPAO"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "M&#46;R&#46; Jacquier-Sarlier"
                              1 => "B&#46;S&#46; Polla"
                              2 => "D&#46;O&#46; Slosman"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Nucl Med"
                          "fecha" => "1996"
                          "volumen" => "37"
                          "paginaInicial" => "1413"
                          "paginaFinal" => "1416"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8708786"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              26 => array:3 [
                "identificador" => "bb0135"
                "etiqueta" => "27&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Blood-pool imaging using technetium-99<span class="elsevierStyleHsp" style=""></span>m-labeled liposomes"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "B&#46; Goins"
                              1 => "W&#46;T&#46; Phillips"
                              2 => "R&#46; Klipper"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Nucl Med"
                          "fecha" => "1996"
                          "volumen" => "37"
                          "paginaInicial" => "1374"
                          "paginaFinal" => "1379"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8708778"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              27 => array:3 [
                "identificador" => "bb0140"
                "etiqueta" => "28&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Dual radiolabeled liposomes&#58; biodistribution studies and localization of focal sites of infection in rats"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "V&#46;D&#46; Awashi"
                              1 => "B&#46; Goins"
                              2 => "R&#46; Klipper"
                              3 => "W&#46;T&#46; Phillips"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Nucl Med Biol"
                          "fecha" => "1998"
                          "volumen" => "25"
                          "paginaInicial" => "155"
                          "paginaFinal" => "160"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9468030"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              28 => array:3 [
                "identificador" => "bb0145"
                "etiqueta" => "29&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Small-volume extrusion apparatus for preparation of large unilamellar vesicles"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "R&#46;C&#46; MacDonald"
                              1 => "R&#46;I&#46; MacDonald"
                              2 => "B&#46;P&#46;M&#46; Menco"
                              3 => "K&#46; Takeshita"
                              4 => "N&#46;K&#46; Subbarao"
                              5 => "L&#46;-R&#46; Hu"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "BiochimBiophys Acta"
                          "fecha" => "1991"
                          "volumen" => "1061"
                          "paginaInicial" => "297"
                          "paginaFinal" => "303"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              29 => array:3 [
                "identificador" => "bb0150"
                "etiqueta" => "30&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Preparation of liposomes of defined size and distribution by extrusion through polycarbonate membranes"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "F&#46; Olson"
                              1 => "C&#46;A&#46; Hunt"
                              2 => "F&#46;C&#46; Szoka"
                              3 => "W&#46;J&#46; Vail"
                              4 => "D&#46; Papahadjopoulos"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Biochim Biophys Acta"
                          "fecha" => "1979"
                          "volumen" => "557"
                          "paginaInicial" => "9"
                          "paginaFinal" => "23"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/95096"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              30 => array:3 [
                "identificador" => "bb0155"
                "etiqueta" => "31&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Production of large unilamellar vesicles by a rapid extrusion procedure&#58; characterization of size distribution&#44; trapped volume and ability to maintain a membrane potential"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "M&#46;J&#46; Hope"
                              1 => "M&#46;B&#46; Bally"
                              2 => "G&#46; Webb"
                              3 => "P&#46;R&#46; Cullis"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Biochim Biophys Acta"
                          "fecha" => "1985"
                          "volumen" => "812"
                          "paginaInicial" => "55"
                          "paginaFinal" => "65"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23008845"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              31 => array:3 [
                "identificador" => "bb0160"
                "etiqueta" => "32&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Studies on phosphatidylcholine vesicles&#46; Formation and physical characteristics"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "C&#46; Huang"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Biochemistry"
                          "fecha" => "1969"
                          "volumen" => "8"
                          "paginaInicial" => "344"
                          "paginaFinal" => "351"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5777332"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              32 => array:3 [
                "identificador" => "bb0165"
                "etiqueta" => "33&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "In vivo distribution of vesicles loads with radiopharmaceuticals&#58; a study of different routes of administration"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "I&#46;R&#46; McDougall"
                              1 => "J&#46;K&#46; Dunnick"
                              2 => "M&#46;L&#46; Goris"
                              3 => "J&#46;P&#46; Kriss"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Nucl Med"
                          "fecha" => "1975"
                          "volumen" => "16"
                          "paginaInicial" => "488"
                          "paginaFinal" => "491"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1159504"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              33 => array:3 [
                "identificador" => "bb0170"
                "etiqueta" => "34&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Pharmacokinetics and biodistribution of &#91;111In&#93;-avidin and &#91;99mTc&#93;-biotin-liposomes injected in the pleural space for the targeting of mediastinal nodes"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "L&#46;A&#46; Medina"
                              1 => "R&#46; Klipper"
                              2 => "W&#46;T&#46; Phillips"
                              3 => "B&#46; Goins"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Nucl Med Biol"
                          "fecha" => "2004"
                          "volumen" => "31"
                          "paginaInicial" => "41"
                          "paginaFinal" => "51"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14741569"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              34 => array:3 [
                "identificador" => "bb0175"
                "etiqueta" => "35&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Use of 99mTclabeled liposomes encapsulating blue dye for identification of the sentinel lymph node"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "W&#46;T&#46; Phillips"
                              1 => "R&#46; Klipper"
                              2 => "B&#46; Goins"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Nucl Med"
                          "fecha" => "2001"
                          "volumen" => "42"
                          "paginaInicial" => "446"
                          "paginaFinal" => "451"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11337521"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              35 => array:3 [
                "identificador" => "bb0180"
                "etiqueta" => "36&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Attachment of 99mTc to lipid vesicles containing the lipophilic chelate dipalmitoylphosphatidyl ethanolamine-DTTA"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "F&#46; Ahkong"
                              1 => "C&#46; Tilcock"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Nucl Med Biol"
                          "fecha" => "1992"
                          "volumen" => "19"
                          "paginaInicial" => "831"
                          "paginaFinal" => "840"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              36 => array:3 [
                "identificador" => "bb0185"
                "etiqueta" => "37&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Distribution and pharmacology of intravenous 99mtclabeled multilamellar liposomes in rats and mice"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "L&#46;P&#46; Kasi"
                              1 => "G&#46; Lopez-Berestein"
                              2 => "K&#46; Mehta"
                              3 => "M&#46; Rosenblum"
                              4 => "H&#46;J&#46; Glenn"
                              5 => "T&#46;P&#46; Haynie"
                              6 => "G&#46; Mavligit"
                              7 => "E&#46;M&#46; Hersh"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Int J Nucl Med Biol"
                          "fecha" => "1984"
                          "volumen" => "11"
                          "paginaInicial" => "35"
                          "paginaFinal" => "37"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6735607"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              37 => array:3 [
                "identificador" => "bb0190"
                "etiqueta" => "38&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Use of technetium-99<span class="elsevierStyleHsp" style=""></span>m-liposomes in tumor imaging"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "B&#46; Goins"
                              1 => "R&#46; Klipper"
                              2 => "A&#46;S&#46; Rudolph"
                              3 => "W&#46;T&#46; Phillips"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Nucl Med"
                          "fecha" => "1994"
                          "volumen" => "35"
                          "paginaInicial" => "1491"
                          "paginaFinal" => "1498"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8071699"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              38 => array:3 [
                "identificador" => "bb0195"
                "etiqueta" => "39&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Regional lung deposition and clearance of 99mTc-labeled beclomethasone-DLPC liposomes in mild and severe asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "S&#46;M&#46; Saari"
                              1 => "M&#46;T&#46; Vidgren"
                              2 => "M&#46;O&#46; Koskinen"
                              3 => "V&#46;M&#46;H&#46; Turjanmaa"
                              4 => "J&#46;C&#46; Waldrep"
                              5 => "M&#46;N&#46; Nieminem"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "1998"
                          "volumen" => "113"
                          "paginaInicial" => "1573"
                          "paginaFinal" => "1579"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9631796"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              39 => array:3 [
                "identificador" => "bb0200"
                "etiqueta" => "40&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Characterization of the size distribution of unilamellar vesicles by gel filtration&#44; quasi-elastic light scattering and electron microscopy"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "P&#46; Shurtenberger"
                              1 => "H&#46; Hauser"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Biochim Biophys Acta"
                          "fecha" => "1984"
                          "volumen" => "778"
                          "paginaInicial" => "470"
                          "paginaFinal" => "480"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              40 => array:3 [
                "identificador" => "bb0205"
                "etiqueta" => "41&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Size analysis of biological membrane vesicles by gel filtration&#44; dynamic light scattering and electron microscopy"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "G&#46; Perevucnik"
                              1 => "P&#46; Schurtenberger"
                              2 => "H&#46; Hauser"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Biochim Biophys Acta"
                          "fecha" => "1985"
                          "volumen" => "821"
                          "paginaInicial" => "169"
                          "paginaFinal" => "173"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4063358"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              41 => array:3 [
                "identificador" => "bb0210"
                "etiqueta" => "42&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Vesicles of variable sizes produced by a rapid extrusion procedure"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "L&#46;D&#46; Mayer"
                              1 => "M&#46;J&#46; Hope"
                              2 => "P&#46;R&#46; Cullis"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Biochim Biophys Acta"
                          "fecha" => "1986"
                          "volumen" => "858"
                          "paginaInicial" => "161"
                          "paginaFinal" => "168"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3707960"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              42 => array:3 [
                "identificador" => "bb0215"
                "etiqueta" => "43&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Investigations of a new&#44; highly negative liposome with improved biodistribution for imaging"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "D&#46;J&#46; Hnatowich"
                              1 => "B&#46; Clancy"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Nucl Med"
                          "fecha" => "1980"
                          "volumen" => "21"
                          "paginaInicial" => "662"
                          "paginaFinal" => "669"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7391841"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              43 => array:3 [
                "identificador" => "bb0220"
                "etiqueta" => "44&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The stability of liposomes to nebulization"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "K&#46;M&#46;G&#46; Taylor"
                              1 => "G&#46; Taylor"
                              2 => "I&#46;W&#46; Kellaway"
                              3 => "J&#46; Stevens"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Int J Pharm"
                          "fecha" => "1990"
                          "volumen" => "58"
                          "paginaInicial" => "57"
                          "paginaFinal" => "61"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              44 => array:3 [
                "identificador" => "bb0225"
                "etiqueta" => "45&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Nebulization of liposome&#46; I&#46; Effects of lipid composition"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "R&#46;W&#46; Niven"
                              1 => "H&#46; Schreier"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:4 [
                          "tituloSerie" => "Pharm Res"
                          "fecha" => "1990"
                          "volumen" => "7"
                          "paginaInicial" => "11271133"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              45 => array:3 [
                "identificador" => "bb0230"
                "etiqueta" => "46&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The stability of liposomes to ultrasonic nebulization"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "K&#46;K&#46;M&#46; Leung"
                              1 => "P&#46;A&#46; Bridges"
                              2 => "K&#46;M&#46;G&#46; Taylor"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Int J Pharm"
                          "fecha" => "1996"
                          "volumen" => "145"
                          "paginaInicial" => "95"
                          "paginaFinal" => "102"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              46 => array:3 [
                "identificador" => "bb0235"
                "etiqueta" => "47&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Radiation absorbed dose from tc-99<span class="elsevierStyleHsp" style=""></span>m diethylenetriaminepentaacetic acid &#40;DTPA&#41;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:7 [
                              0 => "S&#46; Thomas"
                              1 => "H&#46; Atkins"
                              2 => "J&#46; McAfee"
                              3 => "M&#46;D&#46; Blaufox"
                              4 => "M&#46; Fernandez"
                              5 => "P&#46;T&#46; Kirchner"
                              6 => "R&#46;C&#46; Reba"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Nucl Med"
                          "fecha" => "1984"
                          "volumen" => "25"
                          "paginaInicial" => "503"
                          "paginaFinal" => "505"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6400025"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              47 => array:3 [
                "identificador" => "bb0240"
                "etiqueta" => "48&#46;"
                "referencia" => array:1 [
                  0 => array:1 [
                    "host" => array:1 [
                      0 => array:1 [
                        "Libro" => array:4 [
                          "titulo" => "International Commission of Radiation Protection Publication 30"
                          "fecha" => "1988"
                          "editorial" => "Pergamon Press"
                          "editorialLocalizacion" => "New York"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              48 => array:3 [
                "identificador" => "bb0245"
                "etiqueta" => "49&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Technical and biological considerations on the use of radiolabeled liposomes for diagnostic imaging"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "V&#46;J&#46; Caride"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Nucl Med Biol"
                          "fecha" => "1990"
                          "volumen" => "17"
                          "paginaInicial" => "35"
                          "paginaFinal" => "39"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              49 => array:3 [
                "identificador" => "bb0250"
                "etiqueta" => "50&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Biodistribution and ima ging studies of technetium-99<span class="elsevierStyleHsp" style=""></span>m-labeled liposomes in rats with focal infection"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "B&#46; Goins"
                              1 => "R&#46; Klipper"
                              2 => "A&#46;S&#46; Rudolph"
                              3 => "R&#46;O&#46; Cliff"
                              4 => "R&#46; Blumhardt"
                              5 => "W&#46;T&#46; Phillips"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Nucl Med"
                          "fecha" => "1993"
                          "volumen" => "34"
                          "paginaInicial" => "2160"
                          "paginaFinal" => "2168"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8254404"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              50 => array:3 [
                "identificador" => "bb0255"
                "etiqueta" => "51&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Interactions of sugars with membranes"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:7 [
                              0 => "J&#46;H&#46; Crowe"
                              1 => "L&#46;M&#46; Crowe"
                              2 => "J&#46;F&#46; Carpenter"
                              3 => "A&#46;S&#46; Rudolph"
                              4 => "C&#46;A&#46; Wistrom"
                              5 => "B&#46;J&#46; Spargo"
                              6 => "T&#46;J&#46; Anchordoguy"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Biochim Biophys Acta"
                          "fecha" => "1988"
                          "volumen" => "947"
                          "paginaInicial" => "367"
                          "paginaFinal" => "384"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3285894"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              51 => array:3 [
                "identificador" => "bb0260"
                "etiqueta" => "52&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Modification of lipid phase behavior with membrane bound cryoprotectants"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "R&#46;P&#46; Goodrich"
                              1 => "T&#46;M&#46; Handel"
                              2 => "J&#46;D&#46; Baldeschwieler"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Biochim Biophys Acta"
                          "fecha" => "1988"
                          "volumen" => "938"
                          "paginaInicial" => "143"
                          "paginaFinal" => "154"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3342228"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              52 => array:3 [
                "identificador" => "bb0265"
                "etiqueta" => "53&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Nebulization of monodisperse latex sphere suspensions in air-jet and ultrasonic nebulizers"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "O&#46;N&#46;M&#46; Mc Callion"
                              1 => "K&#46;M&#46;G&#46; Taylor"
                              2 => "M&#46; Thomas"
                              3 => "A&#46;J&#46; Taylor"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Int J Pharm"
                          "fecha" => "1996"
                          "volumen" => "133"
                          "paginaInicial" => "203"
                          "paginaFinal" => "214"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              53 => array:3 [
                "identificador" => "bb0270"
                "etiqueta" => "54&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "R&#46;F&#46; Phalen"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:3 [
                          "titulo" => "Basic morphology and physiology of the respiratory tract&#44; in&#58; Inhalation Studies&#58; Foundations and techniques"
                          "paginaInicial" => "51"
                          "serieFecha" => "1984"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/08732159/0000001500000002/v1_201509151524/S0873215915301318/v1_201509151524/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9575"
    "tipo" => "SECCION"
    "pt" => array:2 [
      "titulo" => "Artigos originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "pt"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001500000002/v1_201509151524/S0873215915301318/v1_201509151524/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301318?idApp=UINPBA00004E"
]

Article information

ISSN: 08732159
Original language: Portuguese

DOI:10.1016/S0873-2159(15)30131-8

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	7	3	10
2024 October	41	35	76
2024 September	29	21	50
2024 August	49	37	86
2024 July	34	38	72
2024 June	18	36	54
2024 May	23	66	89
2024 April	28	64	92
2024 March	29	40	69
2024 February	34	25	59
2024 January	17	21	38
2023 December	21	33	54
2023 November	15	38	53
2023 October	13	38	51
2023 September	25	39	64
2023 August	14	23	37
2023 July	28	32	60
2023 June	25	12	37
2023 May	29	23	52
2023 April	30	18	48
2023 March	29	41	70
2023 February	27	16	43
2023 January	28	18	46
2022 December	26	32	58
2022 November	42	40	82
2022 October	29	35	64
2022 September	17	33	50
2022 August	38	59	97
2022 July	29	40	69
2022 June	21	34	55
2022 May	39	35	74
2022 April	14	38	52
2022 March	24	32	56
2022 February	23	33	56
2022 January	27	41	68
2021 December	33	41	74
2021 November	30	47	77
2021 October	23	43	66
2021 September	26	43	69
2021 August	19	33	52
2021 July	23	29	52
2021 June	23	31	54
2021 May	27	57	84
2021 April	43	102	145
2021 March	36	23	59
2021 February	32	23	55
2021 January	31	17	48
2020 December	29	14	43
2020 November	51	21	72
2020 October	24	28	52
2020 September	67	19	86
2020 August	66	30	96
2020 July	78	26	104
2020 June	46	20	66
2020 May	59	21	80
2020 April	48	26	74
2020 March	61	17	78
2020 February	43	59	102
2020 January	48	22	70
2019 December	50	20	70
2019 November	58	19	77
2019 October	48	19	67
2019 September	50	33	83
2019 August	96	20	116
2019 July	89	21	110
2019 June	84	21	105
2019 May	79	25	104
2019 April	75	32	107
2019 March	140	18	158
2019 February	100	36	136
2019 January	123	41	164
2018 December	68	12	80
2018 November	19	5	24
2018 October	19	7	26
2018 September	13	13	26
2018 August	47	18	65
2018 July	46	28	74
2018 June	49	20	69
2018 May	63	19	82
2018 April	57	31	88
2018 March	59	27	86
2018 February	21	6	27
2018 January	30	8	38
2017 December	28	13	41
2017 November	42	8	50
2017 October	23	10	33
2017 September	27	17	44
2017 August	22	9	31
2017 July	26	4	30
2017 June	30	12	42
2017 May	43	5	48
2017 April	19	3	22
2017 March	16	3	19
2017 February	17	3	20
2017 January	14	3	17
2016 December	12	2	14
2016 November	7	2	9
2016 October	11	14	25
2016 September	4	2	6
2016 August	7	3	10
2016 July	7	2	9
2016 June	2	1	3
2016 May	7	5	12
2016 April	3	7	10
2016 March	5	4	9
2016 February	9	4	13
2016 January	2	6	8
2015 December	8	2	10
2015 November	5	1	6
2015 October	2	2	4

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter