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Artigo de Revisão/Review Article
Avaliação da inflamação das vias aéreas. Vias áreas superiores e compartimento broncopulmonar
Airways inflammation evaluation. Upper and lower airways
Luísa Geraldes1, Ana Todo-Bom2, Carlos Loureiro2
1 Interna do 5.º ano da especialidade de Imunoalergologia dos HUC, Serviço de Imunoalergologia Departamento de Ciências Pneumológicas e Alergológicas dos Hospitais da Universidade de Coimbra 3000-075 Coimbra
2 Assistente Hospitalar Graduado em Imunoalergologia dos HUC, Serviço de Imunoalergologia Departamento de Ciências Pneumológicas e Alergológicas dos Hospitais da Universidade de Coimbra 3000-075 Coimbra
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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Faz-se uma revis&#227;o sobre m&#233;todos de avalia&#231;&#227;o da inflama&#231;&#227;o nas vias a&#233;reas que contribuam para o diag-n&#243;stico&#44; terap&#234;utica e progn&#243;stico de patologias como a rinossinusite e a asma&#46; Ser&#227;o tamb&#233;m considerados m&#233;todos suscept&#237;veis de fornecer informa&#231;&#227;o relevante sobre inflama&#231;&#227;o na DPOC&#46;</p><p id="sp0105" class="elsevierStyleSimplePara elsevierViewall">A inflama&#231;&#227;o cr&#243;nica das vias a&#233;reas condiciona fen&#243;-menos obstrutivos objectivados na fun&#231;&#227;o respirat&#243;ria basal&#44; na hiperreactividade br&#244;nquica e nasal e em quadros cl&#237;nicos de dificuldade respirat&#243;ria&#46; A tomo-grafia computorizada informa sobre as dimens&#245;es do l&#250;men&#44; a espessura das paredes br&#244;nquicas e os &#237;ndices de densidade pulmonar&#44; altera&#231;&#245;es que decorrem da inflama&#231;&#227;o e remodela&#231;&#227;o das vias a&#233;reas&#46;</p><p id="sp0205" class="elsevierStyleSimplePara elsevierViewall">Um processo inflamat&#243;rio localizado nas vias respira-t&#243;rias &#233; suscept&#237;vel de ser detectado por modifica&#231;&#245;es em marcadores sist&#233;micos de inflama&#231;&#227;o&#46;</p><p id="sp0305" class="elsevierStyleSimplePara elsevierViewall">Os m&#233;todos directos recorrem a an&#225;lise imunoisto-qu&#237;mica de tecidos e de fluidos em condi&#231;&#245;es basais ou ap&#243;s estimula&#231;&#227;o&#46; Os eosin&#243;filos aumentam em bi&#243;psias&#44; lavados nasais e broncoalveolares na asma e na rinite e modificam-se com a terap&#234;utica&#46; Ocorrem altera&#231;&#245;es nas prote&#237;nas e express&#227;o de RNAm de me-diadores envolvidos na activa&#231;&#227;o celular&#46;</p><p id="sp0405" class="elsevierStyleSimplePara elsevierViewall">A expectora&#231;&#227;o induzida identifica inflama&#231;&#227;o eosi-nof&#237;lica que se relaciona inversamente com a fun&#231;&#227;o ventilat&#243;ria&#46;</p><p id="sp0505" class="elsevierStyleSimplePara elsevierViewall">Em cada ciclo respirat&#243;rio o ar &#233; enriquecido em compostos vol&#225;teis produzidos no decurso da respira-&#231;&#227;o celular&#46; A FENO &#233; o biomarcador mais estudado e os seus n&#237;veis est&#227;o elevados na asma&#46;</p><p id="sp6505" class="elsevierStyleSimplePara elsevierViewall">No condensado do ar expirado identificam-se esp&#233;-cies reactivas de oxig&#233;nio&#44; derivados de membrana&#44; citocinas e quimiocinas pr&#243;-inflamat&#243;rias&#46; Se a avalia&#231;&#227;o n&#227;o invasiva da inflama&#231;&#227;o for fidedig-na e reprodut&#237;vel&#44; ser&#225; imprescind&#237;vel na monitoriza-&#231;&#227;o das doen&#231;as das vias a&#233;reas&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;3&#41;&#58; 443-460</span></p></span>"
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        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">It is done a review of evaluation methods of the inflammation in upper airways and bronchi used for diagnosis&#44; therapeutic approach and prognosis of pa-thologies like rhinosinusitis and asthma&#46; It is also analysed methods that supply relevant information of inflammation in COPD&#46;</p><p id="sp0115" class="elsevierStyleSimplePara elsevierViewall">The chronic inflammation of the airways is associated to respiratory distress&#44; obstruction in basal lung function tests and to bronchial and nasal hyperreactivity&#46; Computerized tomography informs about lu-men dimensions&#44; bronchial walls thickness and pulmonary density&#46; These changes are associated to inflammation and to remodelling of the airways&#46; Localized inflammation in respiratory tract can be detected by modifications of systemic inflammatory markers&#46;</p><p id="sp0215" class="elsevierStyleSimplePara elsevierViewall">The direct evaluation of inflammatory airways changes are based on immune&#44; histological and chemical analysis of lung tissue obtained by biopsies and by fluids recoil in basal conditions or after stimulation&#46; The eosinophils are increased in biopsies and in nasal and bronchoalveolar lavage in asthma and rhinitis and can change with therapy&#46; Proteins and mRNA expression of cellular activation mediators are also observed&#46;</p><p id="sp0315" class="elsevierStyleSimplePara elsevierViewall">The induced sputum identifies eosinophilic inflammation that is inversely associated with lung function parameters&#46;</p><p id="sp0415" class="elsevierStyleSimplePara elsevierViewall">In each respiratory cycle the air is enriched in organic volatile compounds produced by cellular breathing&#46; FENO is the bio marker more deeply studied in asthma and its increase is well documented in this disorder&#46;</p><p id="sp0515" class="elsevierStyleSimplePara elsevierViewall">In the exhaled air condensed&#44; reactive oxygen species&#44; membrane mediators&#44; cytokines&#44; and chemokines are identified&#46; If the non invasive evaluation of inflammation became reliable and reproducible it will be indispensable in monitoring the airways diseases&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;3&#41;&#58; 443-460</span></p></span>"
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ISSN: 08732159
Original language: Portuguese
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Pulmonology

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