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An economic analysis of erlotinib, docetaxel, pemetrexed and best supportive care as second or third line treatment of non-small cell lung cancer Rev Port Pneumol 2008; 14(6):803-827" ] ] "contienePdf" => array:1 [ "pt" => true ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301562?idApp=UINPBA00004E" "url" => "/08732159/0000001500000003/v1_201509151500/S0873215915301562/v1_201509151500/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão/Review Article</span>" "titulo" => "Avaliação da inflamação das vias aéreas. Vias áreas superiores e compartimento broncopulmonar" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "443" "paginaFinal" => "460" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Luísa Geraldes, Ana Todo-Bom, Carlos Loureiro" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Luísa" "apellidos" => "Geraldes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Ana" "apellidos" => "Todo-Bom" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 2 => array:3 [ "nombre" => "Carlos" "apellidos" => "Loureiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Interna do 5.º ano da especialidade de Imunoalergologia dos HUC, Serviço de Imunoalergologia Departamento de Ciências Pneumológicas e Alergológicas dos Hospitais da Universidade de Coimbra 3000-075 Coimbra" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar Graduado em Imunoalergologia dos HUC, Serviço de Imunoalergologia Departamento de Ciências Pneumológicas e Alergológicas dos Hospitais da Universidade de Coimbra 3000-075 Coimbra" "etiqueta" => "2" "identificador" => "af0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Airways inflammation evaluation. Upper and lower airways" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-12-12" "fechaAceptado" => "2009-01-12" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570267" "palabras" => array:4 [ 0 => "Asma" 1 => "exames auxiliares de diagnós-tico" 2 => "inflamação" 3 => "rinite" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570266" "palabras" => array:4 [ 0 => "Asthma" 1 => "evaluation methods" 2 => "inflammation" 3 => "rhinitis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Faz-se uma revisão sobre métodos de avaliação da inflamação nas vias aéreas que contribuam para o diag-nóstico, terapêutica e prognóstico de patologias como a rinossinusite e a asma. Serão também considerados métodos susceptíveis de fornecer informação relevante sobre inflamação na DPOC.</p><p id="sp0105" class="elsevierStyleSimplePara elsevierViewall">A inflamação crónica das vias aéreas condiciona fenó-menos obstrutivos objectivados na função respiratória basal, na hiperreactividade brônquica e nasal e em quadros clínicos de dificuldade respiratória. A tomo-grafia computorizada informa sobre as dimensões do lúmen, a espessura das paredes brônquicas e os índices de densidade pulmonar, alterações que decorrem da inflamação e remodelação das vias aéreas.</p><p id="sp0205" class="elsevierStyleSimplePara elsevierViewall">Um processo inflamatório localizado nas vias respira-tórias é susceptível de ser detectado por modificações em marcadores sistémicos de inflamação.</p><p id="sp0305" class="elsevierStyleSimplePara elsevierViewall">Os métodos directos recorrem a análise imunoisto-química de tecidos e de fluidos em condições basais ou após estimulação. Os eosinófilos aumentam em biópsias, lavados nasais e broncoalveolares na asma e na rinite e modificam-se com a terapêutica. Ocorrem alterações nas proteínas e expressão de RNAm de me-diadores envolvidos na activação celular.</p><p id="sp0405" class="elsevierStyleSimplePara elsevierViewall">A expectoração induzida identifica inflamação eosi-nofílica que se relaciona inversamente com a função ventilatória.</p><p id="sp0505" class="elsevierStyleSimplePara elsevierViewall">Em cada ciclo respiratório o ar é enriquecido em compostos voláteis produzidos no decurso da respira-ção celular. A FENO é o biomarcador mais estudado e os seus níveis estão elevados na asma.</p><p id="sp6505" class="elsevierStyleSimplePara elsevierViewall">No condensado do ar expirado identificam-se espé-cies reactivas de oxigénio, derivados de membrana, citocinas e quimiocinas pró-inflamatórias. Se a avaliação não invasiva da inflamação for fidedig-na e reprodutível, será imprescindível na monitoriza-ção das doenças das vias aéreas.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (3): 443-460</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">It is done a review of evaluation methods of the inflammation in upper airways and bronchi used for diagnosis, therapeutic approach and prognosis of pa-thologies like rhinosinusitis and asthma. It is also analysed methods that supply relevant information of inflammation in COPD.</p><p id="sp0115" class="elsevierStyleSimplePara elsevierViewall">The chronic inflammation of the airways is associated to respiratory distress, obstruction in basal lung function tests and to bronchial and nasal hyperreactivity. Computerized tomography informs about lu-men dimensions, bronchial walls thickness and pulmonary density. These changes are associated to inflammation and to remodelling of the airways. Localized inflammation in respiratory tract can be detected by modifications of systemic inflammatory markers.</p><p id="sp0215" class="elsevierStyleSimplePara elsevierViewall">The direct evaluation of inflammatory airways changes are based on immune, histological and chemical analysis of lung tissue obtained by biopsies and by fluids recoil in basal conditions or after stimulation. The eosinophils are increased in biopsies and in nasal and bronchoalveolar lavage in asthma and rhinitis and can change with therapy. Proteins and mRNA expression of cellular activation mediators are also observed.</p><p id="sp0315" class="elsevierStyleSimplePara elsevierViewall">The induced sputum identifies eosinophilic inflammation that is inversely associated with lung function parameters.</p><p id="sp0415" class="elsevierStyleSimplePara elsevierViewall">In each respiratory cycle the air is enriched in organic volatile compounds produced by cellular breathing. FENO is the bio marker more deeply studied in asthma and its increase is well documented in this disorder.</p><p id="sp0515" class="elsevierStyleSimplePara elsevierViewall">In the exhaled air condensed, reactive oxygen species, membrane mediators, cytokines, and chemokines are identified. If the non invasive evaluation of inflammation became reliable and reproducible it will be indispensable in monitoring the airways diseases.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (3): 443-460</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:67 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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Original language: Portuguese
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 3 | 0 | 3 |
2024 October | 39 | 37 | 76 |
2024 September | 30 | 27 | 57 |
2024 August | 46 | 39 | 85 |
2024 July | 34 | 41 | 75 |
2024 June | 33 | 31 | 64 |
2024 May | 30 | 39 | 69 |
2024 April | 36 | 26 | 62 |
2024 March | 30 | 33 | 63 |
2024 February | 29 | 35 | 64 |
2024 January | 26 | 18 | 44 |
2023 December | 32 | 26 | 58 |
2023 November | 19 | 25 | 44 |
2023 October | 18 | 31 | 49 |
2023 September | 25 | 35 | 60 |
2023 August | 26 | 22 | 48 |
2023 July | 21 | 34 | 55 |
2023 June | 16 | 12 | 28 |
2023 May | 33 | 22 | 55 |
2023 April | 18 | 15 | 33 |
2023 March | 16 | 29 | 45 |
2023 February | 19 | 17 | 36 |
2023 January | 26 | 16 | 42 |
2022 December | 19 | 23 | 42 |
2022 November | 34 | 30 | 64 |
2022 October | 28 | 33 | 61 |
2022 September | 26 | 38 | 64 |
2022 August | 27 | 44 | 71 |
2022 July | 22 | 39 | 61 |
2022 June | 21 | 33 | 54 |
2022 May | 29 | 31 | 60 |
2022 April | 31 | 34 | 65 |
2022 March | 17 | 25 | 42 |
2022 February | 32 | 27 | 59 |
2022 January | 27 | 30 | 57 |
2021 December | 27 | 38 | 65 |
2021 November | 26 | 28 | 54 |
2021 October | 31 | 34 | 65 |
2021 September | 32 | 27 | 59 |
2021 August | 18 | 13 | 31 |
2021 July | 17 | 22 | 39 |
2021 June | 28 | 27 | 55 |
2021 May | 36 | 25 | 61 |
2021 April | 42 | 47 | 89 |
2021 March | 38 | 17 | 55 |
2021 February | 47 | 17 | 64 |
2021 January | 26 | 14 | 40 |
2020 December | 37 | 13 | 50 |
2020 November | 40 | 11 | 51 |
2020 October | 25 | 26 | 51 |
2020 September | 73 | 19 | 92 |
2020 August | 45 | 33 | 78 |
2020 July | 75 | 22 | 97 |
2020 June | 64 | 19 | 83 |
2020 May | 59 | 25 | 84 |
2020 April | 55 | 6 | 61 |
2020 March | 44 | 11 | 55 |
2020 February | 53 | 21 | 74 |
2020 January | 46 | 19 | 65 |
2019 December | 46 | 24 | 70 |
2019 November | 47 | 16 | 63 |
2019 October | 38 | 15 | 53 |
2019 September | 44 | 22 | 66 |
2019 August | 56 | 24 | 80 |
2019 July | 23 | 26 | 49 |
2019 June | 38 | 22 | 60 |
2019 May | 40 | 24 | 64 |
2019 April | 36 | 39 | 75 |
2019 March | 61 | 21 | 82 |
2019 February | 39 | 15 | 54 |
2019 January | 52 | 26 | 78 |
2018 December | 40 | 14 | 54 |
2018 November | 18 | 1 | 19 |
2018 October | 4 | 8 | 12 |
2018 September | 10 | 7 | 17 |
2018 August | 41 | 34 | 75 |
2018 July | 31 | 35 | 66 |
2018 June | 43 | 41 | 84 |
2018 May | 38 | 33 | 71 |
2018 April | 39 | 46 | 85 |
2018 March | 21 | 28 | 49 |
2018 February | 16 | 12 | 28 |
2018 January | 22 | 12 | 34 |
2017 December | 18 | 7 | 25 |
2017 November | 46 | 11 | 57 |
2017 October | 23 | 13 | 36 |
2017 September | 27 | 11 | 38 |
2017 August | 16 | 14 | 30 |
2017 July | 10 | 13 | 23 |
2017 June | 18 | 9 | 27 |
2017 May | 32 | 13 | 45 |
2017 April | 11 | 5 | 16 |
2017 March | 17 | 5 | 22 |
2017 February | 13 | 5 | 18 |
2017 January | 15 | 5 | 20 |
2016 December | 14 | 4 | 18 |
2016 November | 8 | 5 | 13 |
2016 October | 11 | 9 | 20 |
2016 September | 2 | 4 | 6 |
2016 August | 2 | 4 | 6 |
2016 July | 2 | 3 | 5 |
2016 April | 4 | 12 | 16 |
2016 March | 1 | 2 | 3 |
2016 February | 4 | 6 | 10 |
2016 January | 8 | 4 | 12 |
2015 December | 9 | 3 | 12 |
2015 November | 5 | 1 | 6 |
2015 October | 3 | 4 | 7 |