Artigo de Revisão/Review Article
A intervenção da célula epitelial na asma
The role of the epithelial cell in asthma
1 Professora Associada com Agregação de Fisiopatologia – Faculdade de Medicina da Universidade de Coimbra Directora do Instituto de Patologia Geral
2 Assistente Hospitalar Graduada em Imunoalergologia nos Hospitais da Universidade de Coimbra. Doutoramento em Medicina Interna – Pneumologia pela Faculdade de Medicina da Universidade de Coimbra
Read
5525
Timeswas read the article
2224
Total PDF
3301
Total HTML
Share statistics
array:24 [ "pii" => "S087321591530146X" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30146-X" "estado" => "S350" "fechaPublicacion" => "2009-05-01" "aid" => "8" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "copyrightAnyo" => "2009" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2009;15:461-72" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2369 "formatos" => array:3 [ "EPUB" => 237 "HTML" => 1436 "PDF" => 696 ] ] "itemSiguiente" => array:19 [ "pii" => "S0873215915301471" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30147-1" "estado" => "S350" "fechaPublicacion" => "2009-05-01" "aid" => "9" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2009;15:473-82" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2583 "formatos" => array:3 [ "EPUB" => 247 "HTML" => 1401 "PDF" => 935 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão/Review Article</span>" "titulo" => "Défice de alfa-1 antitripsina. A experiência do Hospital de Pulido Valente com a terapêutica de reposição" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "473" "paginaFinal" => "482" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Alpha-1 antitrypsin deficiency. The experience of Pulido Valente Hospital with augmentation therapy" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carla Alves Costa, Cristina Santos" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Carla Alves" "apellidos" => "Costa" ] 1 => array:2 [ "nombre" => "Cristina" "apellidos" => "Santos" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301471?idApp=UINPBA00004E" "url" => "/08732159/0000001500000003/v1_201509151500/S0873215915301471/v1_201509151500/pt/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0873215915301458" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30145-8" "estado" => "S350" "fechaPublicacion" => "2009-05-01" "aid" => "7" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2009;15:443-60" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2229 "formatos" => array:3 [ "EPUB" => 231 "HTML" => 1247 "PDF" => 751 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão/Review Article</span>" "titulo" => "Avaliação da inflamação das vias aéreas. Vias áreas superiores e compartimento broncopulmonar" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "443" "paginaFinal" => "460" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Airways inflammation evaluation. Upper and lower airways" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luísa Geraldes, Ana Todo-Bom, Carlos Loureiro" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Luísa" "apellidos" => "Geraldes" ] 1 => array:2 [ "nombre" => "Ana" "apellidos" => "Todo-Bom" ] 2 => array:2 [ "nombre" => "Carlos" "apellidos" => "Loureiro" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301458?idApp=UINPBA00004E" "url" => "/08732159/0000001500000003/v1_201509151500/S0873215915301458/v1_201509151500/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão/Review Article</span>" "titulo" => "A intervenção da célula epitelial na asma" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "461" "paginaFinal" => "472" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Anabela Mota Pinto, Ana Todo-Bom" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Anabela Mota" "apellidos" => "Pinto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Ana" "apellidos" => "Todo-Bom" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Professora Associada com Agregação de Fisiopatologia – Faculdade de Medicina da Universidade de Coimbra Directora do Instituto de Patologia Geral" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar Graduada em Imunoalergologia nos Hospitais da Universidade de Coimbra. Doutoramento em Medicina Interna – Pneumologia pela Faculdade de Medicina da Universidade de Coimbra" "etiqueta" => "2" "identificador" => "af0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The role of the epithelial cell in asthma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-11-13" "fechaAceptado" => "2008-12-30" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570271" "palabras" => array:3 [ 0 => "Asma" 1 => "epitélio" 2 => "inflamação" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570270" "palabras" => array:3 [ 0 => "Asthma" 1 => "epithelium" 2 => "inflammation" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Faz-se uma revisão da intervenção da célula epitelial brônquica na fisiopatologia da asma. O epitélio que reveste as vias respiratórias actua como uma barreira física, separando o meio externo do meio interno pul-monar, controla a permeabilidade intercelular e transcelular, e, deste modo, a acessibilidade dos agressores inalantes às células apresentadoras de antigénio en-volvidas na resposta imunoinflamatória. As células epiteliais unidas por <span class="elsevierStyleItalic">tight junctions</span> contribuem para a integridade das vias aéreas e expressam <span class="elsevierStyleItalic">poliovirus re</span>-<span class="elsevierStyleItalic">ceptor–related protein</span> (PRR), <span class="elsevierStyleItalic">toll like receptors</span> (TLR) e <span class="elsevierStyleItalic">protease-activated receptors</span> (PAR), que reconhecem agentes bacterianos e alergénios. A sua disfunção transforma-as em fonte de mediadores intervenientes na inflamação.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">A interacção bidireccional entre, por um lado, o epitélio e os elementos constitutivos do brônquio e por outro, as partículas inaladas, tem subjacente a forma-ção de uma unidade, com identidade própria desig-nada EMTU – <span class="elsevierStyleItalic">epithelial mesenchymal trophic unit.</span> Esta extensa intervenção coloca a célula epitelial no centro de acção da cronicidade e remodelação do pro-cesso asmático.</p><p id="sp1010" class="elsevierStyleSimplePara elsevierViewall">As doenças infecciosas e o <span class="elsevierStyleItalic">stress</span> ambiental são capazes de induzir alterações a nível da célula epitelial suscep-tíveis de modificar a sua resposta a estimulações futu-ras, nomeadamente a ampliar a resposta a outras agressões infecciosas por acção sinérgica das vias de sinalização.</p><p id="sp2010" class="elsevierStyleSimplePara elsevierViewall">O epitélio brônquico tem assim funções de barreira que lhe permite exercer uma permeabilidade selectiva, a nível intracelular e transcelular, é ainda metabolica-mente activo pelas capacidade de produzir mediadores quimiotácticos e citocinas envolvidos no recrutamento e na activação celular, com repercussão na broncomo-tricidade e na remodelação da parede brônquica.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (3): 461-472</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">It is done a review of the intervention of the epithelial bronchial cell in the pathophysiology of asthma. The respiratory epithelium acts as a physical barrier that separates the external environment from the pulmonary internal environment. It controls the intercellular and trans-cellular permeability and this way the accessibility of the inhaled pathogens to the antigen presenting cells involved in the immuno-inflammatory response. Epithelial cells connected by tight junctions contribute to the barrier function of the airways. They express a poliovirus receiver – related protein (PRR), toll like receptors (TLRs) and protease-activated receptors (PARs), which recognize bacterial agents and allergens. Its dysfunction turns them into important sources of inflammatory mediators.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">The bidirectional interaction between the epithelium and other bronchial wall elements with inhaled particles originates a structure with its own identity, the designated EMTU – Epithelial Mesenchymal Trophic Unit.</p><p id="sp1025" class="elsevierStyleSimplePara elsevierViewall">These observations support a central role for the epithelial cell in chronic inflammation and in the remodelling of the asthmatic process.</p><p id="sp2025" class="elsevierStyleSimplePara elsevierViewall">Infectious diseases and environmental stress can acti-vate different cell receptors and signalling pathways that induce changes in the cell surface modifying their response to future stimulations, namely to other infectious aggressions.</p><p id="sp3025" class="elsevierStyleSimplePara elsevierViewall">The bronchial epithelium has barrier functions with selective permeability; it has metabolic activity producing cytokines and chemokines stimulating the cell’s recruitment and activation, increasing the bronchial reactivity and the remodelling of the airways.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (3): 461-472</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:51 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma. From bronchoconstriction to airways inflammation and remodeling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Bousquet Jean" 1 => "P.K. Jeffery" 2 => "W.W. Busse" 3 => "M. Johnson" 4 => "A.M. Vignola" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.161.5.9903102" "Revista" => array:7 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2000" "volumen" => "161" "numero" => "5" "paginaInicial" => "1720" "paginaFinal" => "1745" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10806180" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fisiopatologia da asma grave" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Todo-Bom" 1 => "A. Mota Pinto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Port Imunoalergol" "fecha" => "2006" "volumen" => "14" "numero" => "Supl 2" "paginaInicial" => "43" "paginaFinal" => "48" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Hammad Hamida" 1 => "B.N. Lambrecht" 2 => "H. Hammad" 3 => "B.N. Lambrecht" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2006.03.041" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2006" "volumen" => "118" "paginaInicial" => "331" "paginaFinal" => "336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16890754" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of FoxP3+ Regulatory T Cells and Th17 cells by retinoids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H. Kim Chang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Dev Immunol" "fecha" => "2008" "volumen" => "416910" "paginaInicial" => "1" "paginaFinal" => "12" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulatory T cells in allergy and asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Larché Mark" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.06-2434" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2007" "volumen" => "132" "paginaInicial" => "1007" "paginaFinal" => "1014" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17873195" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CD4<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>CD25<span class="elsevierStyleHsp" style=""></span>+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Kearley Jennifer" 1 => "D.S. Robinson" 2 => "C.M. Lloyd" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2008.05.048" "Revista" => array:7 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2008" "volumen" => "122" "numero" => "3" "paginaInicial" => "617" "paginaFinal" => "624" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18672278" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epithelial damage and angio-genesis in the airways of children with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Barbato Angelo" 1 => "G. Turato" 2 => "S. Baraldo" 3 => "E. Bazzan" 4 => "F. Calabrese" 5 => "C. Panizzolo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200602-189OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2006" "volumen" => "174" "paginaInicial" => "975" "paginaFinal" => "981" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16917118" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased permeability of asthmatic epithelial cells to pollutants: does this mean that they are intrinsically abnormal?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Knight Darryl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "2002" "volumen" => "32" "paginaInicial" => "1263" "paginaFinal" => "1265" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12220460" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How epithelial cells detect danger: aiding the immune response" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.B. Vroling" 1 => "W.J. Fokkens" 2 => "C.M. van Drunen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Allergy" "fecha" => "2008" "volumen" => "63" "numero" => "9" "paginaInicial" => "1110" "paginaFinal" => "1123" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25273639" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Colognato Renato" 1 => "J.R. Slupsky" 2 => "M. Jendrach" 3 => "L. Burysek" 4 => "T. Syrovets" 5 => "T. Simmet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1182/blood-2002-08-2497" "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2003" "volumen" => "102" "paginaInicial" => "2645" "paginaFinal" => "2652" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12805069" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Hammad Hamida" 1 => "B.N. Lambrecht" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nature Rev" "fecha" => "2008" "volumen" => "8" "paginaInicial" => "193" "paginaFinal" => "204" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pench 13 allergen induces secretion of mediators and degradation of occludin protein of human lung epithelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "H.Y. Tai" 1 => "M.F. Tam" 2 => "H. Chou" 3 => "H.J. Peng" 4 => "S.N. Su" 5 => "D.W. Perng" 6 => "H.D. Shen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1398-9995.2005.00958.x" "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2006" "volumen" => "61" "paginaInicial" => "382" "paginaFinal" => "388" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16436150" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Purification of a novel aminopeptidase from the pollen of parietária-judaica that alters epithelial integrity and degrades neuropeptides" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Cortes" 1 => "A.L. Carvalho" 2 => "A. Todo-Bom" 3 => "C. Faro" 4 => "E. Pires" 5 => "P. Veríssimo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2006.05.029" "Revista" => array:7 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2006" "volumen" => "118" "numero" => "4" "paginaInicial" => "878" "paginaFinal" => "884" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17030241" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogen recognition with Toll-like receptors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Kawai Taro" 1 => "S. Akira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.coi.2005.02.007" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Immunol" "fecha" => "2005" "volumen" => "17" "paginaInicial" => "338" "paginaFinal" => "344" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15950447" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "No Bit PARt for PAR-1" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Laurent Geoffrey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1165/rcmb.F304" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Cell Mol Biol" "fecha" => "2005" "volumen" => "33" "paginaInicial" => "213" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16107573" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Suzuki Tomoko" 1 => "T.J. Moraes" 2 => "E. Vachon" 3 => "H.H. Ginzberg" 4 => "T.T. Huang" 5 => "M.A. Matthay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1165/rcmb.2005-0109OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Cell Mol Biol" "fecha" => "2005" "volumen" => "33" "paginaInicial" => "231" "paginaFinal" => "247" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15891109" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Ebeling Cory" 1 => "T. Lam" 2 => "J.R. Gordon" 3 => "M.D. Hollenberg" 4 => "H. Vliagoftis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "2007" "volumen" => "179" "paginaInicial" => "2910" "paginaFinal" => "2917" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17709505" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidant and antioxidant balance in the airways and airway diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Rahman Irfan" 1 => "S.K. Biswas" 2 => "A. Kode" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejphar.2005.12.087" "Revista" => array:6 [ "tituloSerie" => "Eur J Pharmacol" "fecha" => "2006" "volumen" => "533" "paginaInicial" => "222" "paginaFinal" => "239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16500642" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Comhair Susy" 1 => "P.R. Bhathena" 2 => "C. Farver" 3 => "F.B. Thunnissen" 4 => "S.C. Erzurum" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1096/fj.00-0085com" "Revista" => array:6 [ "tituloSerie" => "FASEB J" "fecha" => "2001" "volumen" => "15" "paginaInicial" => "70" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11149894" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TH2 polarization by Der p 1– pulsed monocyte-derived dendritic cells is due to the allergic status of the donors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:5 [ 0 => "Hammad Hamida" 1 => "A.S. Charbonnier" 2 => "C. Duez" 3 => "G.A. Jacquet Astewart" 4 => "A.-B. Tonnel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Blood" "fecha" => "2001" "volumen" => "98" "paginaInicial" => "1135" "paginaFinal" => "1141" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11493462" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bb0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The epithelium takes centre stage in asthma and atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Holgate Stephen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.it.2007.04.007" "Revista" => array:6 [ "tituloSerie" => "Trends Immunol" "fecha" => "2007" "volumen" => "28" "paginaInicial" => "248" "paginaFinal" => "251" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17466594" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bb0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel functions of two chemokines in allergic disease thymus and activation-regulated chemokine (TARC)/CCL17 and macrophage-derived chemokine (MDC)/CCL22" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Arima Masafumi" 1 => "T. Fukuda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy Clin Immunol Int – J World Allergy Org" "fecha" => "2006" "volumen" => "18" "numero" => "2" "paginaInicial" => "58" "paginaFinal" => "64" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bb0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Ying Sun" 1 => "B. O’Connor" 2 => "J. Ratoff" 3 => "Q. Meng" 4 => "K. Mallett" 5 => "D. Cousins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "2005" "volumen" => "174" "paginaInicial" => "8183" "paginaFinal" => "8190" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15944327" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bb0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Substance P in long-lasting asthma: Immunoinflammatory pathways" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Todo-Bom Ana" 1 => "A. Mota Pinto" 2 => "S. Vale Pereira" 3 => "V. Alves" 4 => "M. Dourado" 5 => "M. Santos Rosa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy Clin Immunol Int – J World Allergy Org" "fecha" => "2006" "volumen" => "18" "numero" => "6" "paginaInicial" => "242" "paginaFinal" => "248" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bb0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory cells as source of tachykinin-induced mucus secretion in chronic bronchitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Springer Jochen" 1 => "D.A. Groneberg" 2 => "R. Pregla" 3 => "A. Fischer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.regpep.2004.07.017" "Revista" => array:7 [ "tituloSerie" => "Regul Pept" "fecha" => "2005" "volumen" => "124" "numero" => "1–3" "paginaInicial" => "195" "paginaFinal" => "201" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15544859" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bb0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epithelial-mesenchymal interactions in the pathogenesis of asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Holgate Stephen" 1 => "D.E. Davies" 2 => "P.M. Lackie" 3 => "S.J. Wilson" 4 => "S.M. Puddicombe" 5 => "J.L. Lordan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2000" "volumen" => "105" "paginaInicial" => "193" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10669837" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bb0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of epithelial injury and repair in the origins of asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Hackett Tillie-Louise" 1 => "D.A. Knight" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ACI.0b013e328013d61b" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Allergy Clin Immunol" "fecha" => "2007" "volumen" => "7" "paginaInicial" => "63" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17218813" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bb0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Processes involved in the repair of in-jured airway epithelia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Y. Tesfaigzi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Immunol Ther Exp (Warsz)" "fecha" => "2003" "volumen" => "51" "paginaInicial" => "283" "paginaFinal" => "288" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bb0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Allakhverdi Zoulfia" 1 => "M.R. Comeau" 2 => "H.K. Jessup" 3 => "B.R. Yoon" 4 => "A. Brewer" 5 => "S. Chartier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1084/jem.20062211" "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "2007" "volumen" => "204" "paginaInicial" => "253" "paginaFinal" => "258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17242164" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bb0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Liu Yong-Jun" 1 => "V. Soumelis" 2 => "N. Watanabe" 3 => "T. Ito" 4 => "Y.H. Wang" 5 => "R.W. Malefyt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.immunol.25.022106.141718" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Immunol" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "193" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17129180" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bb0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TSLP: finally in the limelight" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Leonard Warren" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Nature Immunol" "fecha" => "2002" "volumen" => "3" "paginaInicial" => "605" "paginaFinal" => "607" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bb0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epithelial stress and structural remodelling in childhood asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I.A. Fedorov" 1 => "S.J. Wilson" 2 => "D.E. Davies" 3 => "S.T. Holgate" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2004.030262" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2005" "volumen" => "60" "paginaInicial" => "389" "paginaFinal" => "394" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15860714" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bb0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chymase-positive mast cells play a role in the vascular component of airway remodeling in asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Zanini Andrea" 1 => "A. Chetta" 2 => "M. Saetta" 3 => "S. Baraldo" 4 => "R. D’Ippolito" 5 => "A. Castagnaro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2007.04.021" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2007" "volumen" => "120" "paginaInicial" => "329" "paginaFinal" => "333" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17559912" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bb0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an <span class="elsevierStyleItalic">in vitro</span> co-culture model of airway remodeling in asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Zhang Shaoli" 1 => "H. Smartt" 2 => "S.T. Holgate" 3 => "W.R. Roche" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lab Invest" "fecha" => "1999" "volumen" => "79" "paginaInicial" => "395" "paginaFinal" => "405" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10211992" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bb0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute allergen-induced airway remodeling in atopic asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Phipps Simon" 1 => "F. Benyahia" 2 => "T.T. Ou" 3 => "J. Barkans" 4 => "D.S. Robinson" 5 => "A.B. Kay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1165/rcmb.2004-0193OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Cell Mol Biol" "fecha" => "2004" "volumen" => "31" "paginaInicial" => "626" "paginaFinal" => "632" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15333330" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bb0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Willis Brigham" 1 => "Z. Borok" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajplung.00163.2007" "Revista" => array:6 [ "tituloSerie" => "Am J Physiol Lung Cell Mol Physiol" "fecha" => "2007" "volumen" => "293" "paginaInicial" => "L525" "paginaFinal" => "L534" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17631612" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bb0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tissue fibrocytes in patients with mild asthma: a possible link to thickness of reticular basement membrane?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Nihlberg Kristian" 1 => "K. Larsen" 2 => "A. Hultgardh-Nilsson" 3 => "A. Malmstrom" 4 => "L. Bjermer" 5 => "G. Westergren-Thorsson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1465-9921-7-50" "Revista" => array:5 [ "tituloSerie" => "Respir Res" "fecha" => "2006" "volumen" => "7" "paginaInicial" => "50" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16571120" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bb0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5-flanking region" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Chen Yin" 1 => "Y.H. Zhao" 2 => "Y.P. Di" 3 => "R. Wu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1165/ajrcmb.25.5.4298" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Cell Mol Biol" "fecha" => "2001" "volumen" => "25" "paginaInicial" => "542" "paginaFinal" => "553" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11713095" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bb0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A morphometric study of mucins and small airway plugging in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Burgel Pierre-Régis" 1 => "D. Montani" 2 => "C. Danel" 3 => "D.J. Dusser" 4 => "J.A. Nadel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2006.062190" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2007" "volumen" => "62" "paginaInicial" => "153" "paginaFinal" => "161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16928707" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bb2205" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metallo-proteinases mediate mucin 5<span class="elsevierStyleHsp" style=""></span>AC expression by epidermal growth factor receptor activation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Deshmukh Hitesh" 1 => "L.M. Case" 2 => "S.C. Wesselkamper" 3 => "M.T. Borchers" 4 => "L.D. Martin" 5 => "H.G. Shertzer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200408-1003OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2005" "volumen" => "171" "paginaInicial" => "305" "paginaFinal" => "314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15531749" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bb0200" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Lordan James" 1 => "F. Bucchieri" 2 => "A. Richter" 3 => "A. Konstantinidis" 4 => "J.W. Holloway" 5 => "M. Thornber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Immunol" "fecha" => "2002" "volumen" => "169" "paginaInicial" => "407" "paginaFinal" => "414" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12077271" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bb0205" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Zhou Beiyun" 1 => "D.K. Ann" 2 => "X. Li" 3 => "K.J. Kim" 4 => "H. Lin" 5 => "P. Minoo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajpcell.00070.2006" "Revista" => array:6 [ "tituloSerie" => "Am J Physiol Cell Physiol" "fecha" => "2007" "volumen" => "292" "paginaInicial" => "C1280" "paginaFinal" => "C1290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17108010" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bb0210" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Shear stress regulates aquaporin-5 and airway epithelial barrier function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Sidhaye Venkataramana" 1 => "K.S. Schweitzer" 2 => "M.J. Caterina" 3 => "L. Shimoda" 4 => "L.S. King" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.0712287105" "Revista" => array:7 [ "tituloSerie" => "PNAS" "fecha" => "2008" "volumen" => "105" "numero" => "9" "paginaInicial" => "3345" "paginaFinal" => "3350" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18305162" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bb0215" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The family of five: TIR domain-containing adaptors in Toll-like receptor signalling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. O’Neill Luke" 1 => "A.G. Bowie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nri2079" "Revista" => array:7 [ "tituloSerie" => "Nat Rev Immunol" "fecha" => "2007" "volumen" => "7" "numero" => "5" "paginaInicial" => "353" "paginaFinal" => "364" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17457343" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bb0220" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The “wisdom” of lung surfactant: balancing host defense and surface tension-reducing functions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Wright Jo Rae" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajplung.00261.2006" "Revista" => array:7 [ "tituloSerie" => "Am J Physiol Lung Cell Mol Physiol" "fecha" => "2006" "volumen" => "291" "numero" => "5" "paginaInicial" => "L847" "paginaFinal" => "L850" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16861381" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bb0225" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Innate immunity: toll-like receptors and some more. a brief history, basic organization and relevance for the human newborn" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Fleer André" 1 => "T.G. Krediet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000102054" "Revista" => array:7 [ "tituloSerie" => "Neonatology" "fecha" => "2007" "volumen" => "92" "numero" => "3" "paginaInicial" => "145" "paginaFinal" => "157" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17476116" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bb0230" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of neuraminidase in lethal synergism between influenza virus and <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. McCullers Jonathan" 1 => "K.C. Bartmess" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/368163" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "2003" "volumen" => "187" "paginaInicial" => "1000" "paginaFinal" => "1009" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12660947" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bb0235" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Structural changes in the airways in asthma observations and consequences" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Bai Tony" 1 => "D.A. Knight" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Sci (Lond)" "fecha" => "2005" "volumen" => "108" "paginaInicial" => "463" "paginaFinal" => "477" ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bb0240" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Synergistic proinflammatory responses induced by poly-microbial colonization of epithelial surfaces" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Ratner Adam" 1 => "E.S. Lysenko" 2 => "M.N. Paul" 3 => "J.N. Weiser" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Proc Natl Acad Sci (USA)" "fecha" => "2005" "volumen" => "102" "paginaInicial" => "3429" "paginaFinal" => "3434" ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bb0245" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory infections. Do we ever recover?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Goulding" 1 => "R. Snelgrove" 2 => "J. Saldana" 3 => "A. Didierlaurent" 4 => "M. Cavanagh" 5 => "E. Gwyer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1513/pats.200706-066TH" "Revista" => array:6 [ "tituloSerie" => "Proc Am Thorac Soc" "fecha" => "2007" "volumen" => "4" "paginaInicial" => "618" "paginaFinal" => "625" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18073393" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bb0250" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The evolutionary continuum from lung development to homeostasis and repair" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.S. Torday" 1 => "V.K. Rehan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajplung.00379.2006" "Revista" => array:6 [ "tituloSerie" => "Am J Physiol Lung Cell Mol Physiol" "fecha" => "2007" "volumen" => "292" "paginaInicial" => "L608" "paginaFinal" => "L611" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17085519" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001500000003/v1_201509151500/S087321591530146X/v1_201509151500/pt/main.assets" "Apartado" => array:4 [ "identificador" => "43356" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Artigos de revisão" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001500000003/v1_201509151500/S087321591530146X/v1_201509151500/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087321591530146X?idApp=UINPBA00004E" ]
Article information
ISSN: 08732159Original language: Portuguese
The statistics are updated each day
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 2 | 7 |
| 2024 October | 58 | 22 | 80 |
| 2024 September | 53 | 26 | 79 |
| 2024 August | 60 | 36 | 96 |
| 2024 July | 33 | 35 | 68 |
| 2024 June | 34 | 29 | 63 |
| 2024 May | 28 | 34 | 62 |
| 2024 April | 28 | 30 | 58 |
| 2024 March | 44 | 37 | 81 |
| 2024 February | 35 | 23 | 58 |
| 2024 January | 25 | 30 | 55 |
| 2023 December | 30 | 20 | 50 |
| 2023 November | 28 | 22 | 50 |
| 2023 October | 29 | 28 | 57 |
| 2023 September | 24 | 29 | 53 |
| 2023 August | 19 | 10 | 29 |
| 2023 July | 20 | 29 | 49 |
| 2023 June | 15 | 16 | 31 |
| 2023 May | 26 | 20 | 46 |
| 2023 April | 49 | 12 | 61 |
| 2023 March | 21 | 35 | 56 |
| 2023 February | 41 | 18 | 59 |
| 2023 January | 35 | 20 | 55 |
| 2022 December | 38 | 30 | 68 |
| 2022 November | 48 | 30 | 78 |
| 2022 October | 19 | 22 | 41 |
| 2022 September | 24 | 30 | 54 |
| 2022 August | 34 | 37 | 71 |
| 2022 July | 24 | 39 | 63 |
| 2022 June | 23 | 30 | 53 |
| 2022 May | 31 | 39 | 70 |
| 2022 April | 23 | 33 | 56 |
| 2022 March | 28 | 25 | 53 |
| 2022 February | 19 | 29 | 48 |
| 2022 January | 23 | 36 | 59 |
| 2021 December | 18 | 33 | 51 |
| 2021 November | 27 | 36 | 63 |
| 2021 October | 18 | 35 | 53 |
| 2021 September | 24 | 32 | 56 |
| 2021 August | 14 | 24 | 38 |
| 2021 July | 24 | 28 | 52 |
| 2021 June | 26 | 29 | 55 |
| 2021 May | 19 | 20 | 39 |
| 2021 April | 57 | 41 | 98 |
| 2021 March | 38 | 14 | 52 |
| 2021 February | 42 | 20 | 62 |
| 2021 January | 34 | 18 | 52 |
| 2020 December | 25 | 12 | 37 |
| 2020 November | 44 | 26 | 70 |
| 2020 October | 23 | 23 | 46 |
| 2020 September | 54 | 20 | 74 |
| 2020 August | 48 | 34 | 82 |
| 2020 July | 55 | 20 | 75 |
| 2020 June | 60 | 19 | 79 |
| 2020 May | 48 | 33 | 81 |
| 2020 April | 39 | 40 | 79 |
| 2020 March | 37 | 22 | 59 |
| 2020 February | 45 | 24 | 69 |
| 2020 January | 38 | 13 | 51 |
| 2019 December | 41 | 33 | 74 |
| 2019 November | 42 | 16 | 58 |
| 2019 October | 34 | 17 | 51 |
| 2019 September | 44 | 20 | 64 |
| 2019 August | 67 | 23 | 90 |
| 2019 July | 59 | 20 | 79 |
| 2019 June | 49 | 16 | 65 |
| 2019 May | 66 | 30 | 96 |
| 2019 April | 52 | 28 | 80 |
| 2019 March | 58 | 17 | 75 |
| 2019 February | 50 | 16 | 66 |
| 2019 January | 57 | 31 | 88 |
| 2018 December | 31 | 14 | 45 |
| 2018 November | 9 | 1 | 10 |
| 2018 October | 9 | 12 | 21 |
| 2018 September | 15 | 6 | 21 |
| 2018 August | 47 | 20 | 67 |
| 2018 July | 31 | 28 | 59 |
| 2018 June | 53 | 12 | 65 |
| 2018 May | 41 | 17 | 58 |
| 2018 April | 36 | 23 | 59 |
| 2018 March | 39 | 26 | 65 |
| 2018 February | 20 | 7 | 27 |
| 2018 January | 44 | 14 | 58 |
| 2017 December | 27 | 7 | 34 |
| 2017 November | 51 | 14 | 65 |
| 2017 October | 32 | 15 | 47 |
| 2017 September | 44 | 12 | 56 |
| 2017 August | 23 | 17 | 40 |
| 2017 July | 17 | 8 | 25 |
| 2017 June | 19 | 10 | 29 |
| 2017 May | 35 | 12 | 47 |
| 2017 April | 12 | 5 | 17 |
| 2017 March | 17 | 41 | 58 |
| 2017 February | 14 | 5 | 19 |
| 2017 January | 11 | 3 | 14 |
| 2016 December | 11 | 6 | 17 |
| 2016 November | 12 | 6 | 18 |
| 2016 October | 11 | 6 | 17 |
| 2016 September | 3 | 11 | 14 |
| 2016 August | 3 | 4 | 7 |
| 2016 July | 2 | 4 | 6 |
| 2016 May | 6 | 0 | 6 |
| 2016 April | 1 | 1 | 2 |
| 2016 March | 1 | 8 | 9 |
| 2016 February | 4 | 5 | 9 |
| 2016 January | 5 | 6 | 11 |
| 2015 December | 7 | 6 | 13 |
| 2015 November | 6 | 3 | 9 |
| 2015 October | 2 | 3 | 5 |
Show all
