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A experiência do Hospital de Pulido Valente com a terapêutica de reposição" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "473" "paginaFinal" => "482" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Carla Alves Costa, Cristina Santos" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Carla Alves" "apellidos" => "Costa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Cristina" "apellidos" => "Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Interna do Internato Complementar de Pneumologia, Hospital de Dia de Insuficientes Respiratórios; Unidade de Reabilitação Respiratória, Responsável: Fátima Rodrigues Departamento de Pneumologia do Hospital de Pulido Valente, CHLN, EPE" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar Graduada de Pneumologia, Hospital de Dia de Insuficientes Respiratórios; Unidade de Reabilitação Respiratória, Responsável: Fátima Rodrigues Departamento de Pneumologia do Hospital de Pulido Valente, CHLN, EPE" "etiqueta" => "2" "identificador" => "af0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Alpha-1 antitrypsin deficiency. The experience of Pulido Valente Hospital with augmentation therapy" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-09-24" "fechaAceptado" => "2008-12-31" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570276" "palabras" => array:3 [ 0 => "lfa-1 antitripsina" 1 => "terapêutica de reposição" 2 => "enfisema" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570277" "palabras" => array:3 [ 0 => "Alpha-1 antitrypsin" 1 => "augmentation therapy" 2 => "emphysema" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A alfa-1 antitripsina (AAT) é sintetizada pelo fíga-do, com uma semivida plasmática de 4-5 dias. Apresenta acção inibidora das proteases, com particular afinidade para a elastase dos neutrófilos. A sua deficiência está associada a uma menor protecção pulmonar da acção das enzimas dos neutrófilos activados.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">A deficiência de AAT é uma doença genética resultante da herança de dois alelos deficientes. Dos alelos deficientes, o mais frequente é o Pi*Z, sendo a forma homozigótica Pi*ZZ responsável por níveis séricos mais baixos, habitualmente inferiores a 50<span class="elsevierStyleHsp" style=""></span>mg/dl. O limiar de protecção é 80<span class="elsevierStyleHsp" style=""></span>mg/dl. O ta-bagismo aumenta francamente o risco de enfisema nestes doentes.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">O objectivo da terapêutica de reposição é a manuten-ção de níveis séricos de AAT acima do limiar protector, retardando a progressão da doença.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Os autores apresentam a experiência do Hospital de Dia de Insuficientes Respiratórios do Hospital de Pulido Valente, de cinco doentes com enfisema por deficiência de AAT, fazendo reposição endovenosa se-manal com prolastina®.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Foi efectuada uma avaliação clínica, funcional respiratória e radiológica dos doentes entre 2003 e 2007. Verificou-se estabilidade clínica e radiológica e menor declínio anual de FEV<span class="elsevierStyleInf">1</span> após início do tratamento.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">A reposição com prolastina® é um tratamento de custos elevados, havendo falta de estudos aleatorizados e controlados que demonstrem a sua eficácia clínica. A evidência do benefício é baseada em estudos observacionais. A nossa <span class="elsevierStyleBold">experiência é positiva, com benefícios clínicos, funcionais e radiológicos</span>. Apesar de estar descrita na literatura uma redução da mortalida-de, ainda não foi possível fazer essa inferência na nossa pequena amostra.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (3): 473-481</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Alpha-1 antitrypsin (AAT) is synthesised in the liver and has half-life of 4-5 days. AAT has antiprotease activity, with particular affinity for neutrophil elastase. Its deficiency leads to a lack of effective lung protection against activated neutrophil enzymes.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Deficiency of AAT is a genetic disorder that occurs as a result of the inheritance of two protease inhibitor deficient alleles. Of the deficient alleles, Pi*Z is the most common, and the homozygous form Pi*ZZ results in the lowest serum levels, usually below 50<span class="elsevierStyleHsp" style=""></span>mg/ dl. The “protective threshold” is 80<span class="elsevierStyleHsp" style=""></span>mg/dl. Smoking increases the risk of emphysema.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">The current goal of augmentation therapy is to raise the plasma levels, above protective threshold and slow disease progression.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">The authors present the experience of the Day Care Hospital of the Pulido Valente Hospital with five male patients presenting emphysema due to AAT deficiency, receiving weekly intravenous treatment with Prolastin®. We performed a clinical, respiratory functional and radiological evaluation between 2003 and 2007.</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall">The results point to a slower progression of the disease, with clinical and radiological stability and a reduced rate of FEV<span class="elsevierStyleInf">1</span> decline.</p><p id="sp0065" class="elsevierStyleSimplePara elsevierViewall">Augmentation therapy is an expensive treatment and its use is lacking supportive evidence of efficacy by randomized controlled clinical trials. Evidence that it confers benefits is based on observational studies. <span class="elsevierStyleBold">Our experience is positive, showing clinical, radiological and functional benefits</span>. The literature available points to a decrease in mortality, but we could not affirm so in our small population.</p><p id="sp0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (3): 473-481</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Alpha-1 antitrypsin deficiency – Clinical aspects and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Thomas" 1 => "W. 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of alpha-1-antitrypsin deficiency" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.M. Rovner" 1 => "J.K. Stoller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "www.uptodate.com" "fecha" => "2008" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "High-resoluion computed tomography scanning in α-1 antitrypsin deficiency: relationship to lung function and health status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L.J. Dowson" 1 => "P.J. Guest" 2 => "S.L. Hill" 3 => "R.L. Holder" 4 => "R.A. Stockley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2001" "volumen" => "17" "paginaInicial" => "1097" "paginaFinal" => "1104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11491150" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "17." 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Original language: Portuguese
Year/Month | Html | Total | |
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2024 November | 5 | 3 | 8 |
2024 October | 58 | 45 | 103 |
2024 September | 63 | 42 | 105 |
2024 August | 81 | 44 | 125 |
2024 July | 68 | 43 | 111 |
2024 June | 47 | 46 | 93 |
2024 May | 39 | 51 | 90 |
2024 April | 44 | 46 | 90 |
2024 March | 52 | 36 | 88 |
2024 February | 38 | 38 | 76 |
2024 January | 34 | 46 | 80 |
2023 December | 25 | 35 | 60 |
2023 November | 33 | 35 | 68 |
2023 October | 30 | 54 | 84 |
2023 September | 30 | 43 | 73 |
2023 August | 30 | 28 | 58 |
2023 July | 32 | 51 | 83 |
2023 June | 26 | 32 | 58 |
2023 May | 28 | 40 | 68 |
2023 April | 23 | 30 | 53 |
2023 March | 41 | 47 | 88 |
2023 February | 23 | 36 | 59 |
2023 January | 33 | 43 | 76 |
2022 December | 25 | 32 | 57 |
2022 November | 42 | 44 | 86 |
2022 October | 45 | 37 | 82 |
2022 September | 29 | 67 | 96 |
2022 August | 42 | 79 | 121 |
2022 July | 36 | 65 | 101 |
2022 June | 22 | 33 | 55 |
2022 May | 34 | 46 | 80 |
2022 April | 23 | 40 | 63 |
2022 March | 33 | 33 | 66 |
2022 February | 37 | 32 | 69 |
2022 January | 23 | 43 | 66 |
2021 December | 23 | 51 | 74 |
2021 November | 25 | 51 | 76 |
2021 October | 37 | 50 | 87 |
2021 September | 32 | 45 | 77 |
2021 August | 19 | 33 | 52 |
2021 July | 22 | 28 | 50 |
2021 June | 25 | 43 | 68 |
2021 May | 22 | 40 | 62 |
2021 April | 64 | 77 | 141 |
2021 March | 66 | 27 | 93 |
2021 February | 49 | 27 | 76 |
2021 January | 50 | 16 | 66 |
2020 December | 29 | 21 | 50 |
2020 November | 44 | 19 | 63 |
2020 October | 33 | 33 | 66 |
2020 September | 67 | 24 | 91 |
2020 August | 68 | 42 | 110 |
2020 July | 90 | 26 | 116 |
2020 June | 68 | 29 | 97 |
2020 May | 58 | 44 | 102 |
2020 April | 60 | 26 | 86 |
2020 March | 45 | 21 | 66 |
2020 February | 46 | 76 | 122 |
2020 January | 49 | 30 | 79 |
2019 December | 51 | 39 | 90 |
2019 November | 48 | 30 | 78 |
2019 October | 51 | 18 | 69 |
2019 September | 56 | 64 | 120 |
2019 August | 71 | 22 | 93 |
2019 July | 37 | 20 | 57 |
2019 June | 50 | 26 | 76 |
2019 May | 47 | 53 | 100 |
2019 April | 43 | 40 | 83 |
2019 March | 38 | 23 | 61 |
2019 February | 35 | 20 | 55 |
2019 January | 43 | 28 | 71 |
2018 December | 22 | 14 | 36 |
2018 November | 2 | 5 | 7 |
2018 October | 6 | 7 | 13 |
2018 September | 13 | 7 | 20 |
2018 August | 50 | 18 | 68 |
2018 July | 32 | 36 | 68 |
2018 June | 52 | 23 | 75 |
2018 May | 42 | 15 | 57 |
2018 April | 54 | 28 | 82 |
2018 March | 37 | 26 | 63 |
2018 February | 23 | 11 | 34 |
2018 January | 36 | 9 | 45 |
2017 December | 19 | 14 | 33 |
2017 November | 43 | 18 | 61 |
2017 October | 34 | 16 | 50 |
2017 September | 33 | 14 | 47 |
2017 August | 30 | 13 | 43 |
2017 July | 18 | 6 | 24 |
2017 June | 24 | 35 | 59 |
2017 May | 37 | 17 | 54 |
2017 April | 17 | 7 | 24 |
2017 March | 24 | 37 | 61 |
2017 February | 10 | 7 | 17 |
2017 January | 20 | 3 | 23 |
2016 December | 16 | 7 | 23 |
2016 November | 9 | 4 | 13 |
2016 October | 10 | 16 | 26 |
2016 September | 1 | 0 | 1 |
2016 August | 3 | 3 | 6 |
2016 July | 3 | 1 | 4 |
2016 June | 4 | 0 | 4 |
2016 May | 0 | 10 | 10 |
2016 April | 1 | 5 | 6 |
2016 March | 1 | 5 | 6 |
2016 February | 9 | 6 | 15 |
2016 January | 4 | 6 | 10 |
2015 December | 6 | 7 | 13 |
2015 November | 5 | 2 | 7 |
2015 October | 3 | 2 | 5 |