Artigo de Revisão/Review Article
Modelos experimentais em oncologia: O contributo da cultura de células para o conhecimento da biologia do cancro
Experimental models in oncology: Contribution of cell culture on understanding the biology of cancer
1 Aluna do 6.º ano de Medicina da Faculdade de Medicina da Universidade de Coimbra 2007-2008
2 Professora da Faculdade de Medicina da Universidade de Coimbra
3 Disciplina de Fisiopatologia, mestrado integrado em Medicina Dentária.
4 Instituto de Bioquímica e disciplina de Biologia Molecular Aplicada. Mestrado integrado em Medicina
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array:1 [ 0 => array:3 [ "autoresLista" => "Mariana Cruz, Margarida Enes, Marta Pereira, Marília Dourado, Ana Bela Sarmento Ribeiro" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Mariana" "apellidos" => "Cruz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Margarida" "apellidos" => "Enes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 2 => array:3 [ "nombre" => "Marta" "apellidos" => "Pereira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 3 => array:3 [ "nombre" => "Marília" "apellidos" => "Dourado" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" 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"etiqueta" => "3" "identificador" => "af0015" ] 3 => array:3 [ "entidad" => "Instituto de Bioquímica e disciplina de Biologia Molecular Aplicada. Mestrado integrado em Medicina" "etiqueta" => "4" "identificador" => "af0020" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Experimental models in oncology: Contribution of cell culture on understanding the biology of cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-08-08" "fechaAceptado" => "2009-02-05" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570217" "palabras" => array:4 [ 0 => "Cultura de células" 1 => "oncologia" 2 => "células dendríticas" 3 => "terapêutica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570216" "palabras" => array:4 [ 0 => "Cell culture" 1 => "oncology" 2 => "dendritic cells" 3 => "therapy" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A cultura de tecidos surgiu no século xx (Harrison, 1907) para estudar o comportamento das células animais em ambiente homeostático e em situações de <span class="elsevierStyleItalic">stress</span>.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">A capacidade de estudar as células a nível molecular relaciona-se com a forma como as células podem crescer e ser manipuladas em laboratório. A cultura de células <span class="elsevierStyleItalic">in vitro</span> permitiu estudar crescimento, diferenciação e morte celular e efectuar manipulações genéticas necessárias ao perfeito conhecimento da estrutura e funções dos genes.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">A cultura de células estaminais humanas veio colmatar algumas limitações inerentes aos restantes modelos de cultura. Ao que parece, as células estaminais cancerígenas mantêm-se quiescentes nos locais metastáticos até serem activadas por sinais apropriados do microambiente.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Vários estudos revelaram que diferentes tipos de cancros podem surgir da transformação maligna de células estaminais. A eliminação destas células progenitoras tumorais é essencial para o desenvolvimento de novas abordagens terapêuticas mais eficazes em cancros agressivos. Por outro lado, a utilização de células dendríticas modificadas em cultura poderá contribuir para a produção de uma potencial vacina terapêutica eficaz para obter a regressão tumoral.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (4): 669-682</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">In the beginning of the 20<span class="elsevierStyleSup">th</span> century, tissue culture was started with the aim of studying the behaviour of animal cells in normal and stress conditions.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">The cell study at molecular level depends on their capacity of growing and how they can be manipulated in laboratory. <span class="elsevierStyleItalic">In vitro</span> cell culture allows us the possibility of studying biological key processes, such as growth, differentiation and cell death, and also to do genetic manipulations essential to the knowledge of structure and genes function.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Human stem cells culture provides strategies to circumvent other models’ deficiencies.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">It seems that cancer stem cells remain quiescent until activation by appropriated micro-environmental stimulation.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">Several studies reveal that different cancer types could be due to stem cell malignant transformations. Removal of these cells is essential to the development of more effective cancer therapies for advanced disease. On the other hand, dendritic cells modified in culture may be used as a therapeutic vaccine in order to induce tumour withraw.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (4): 669-682</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Bruce Alberts" 1 => "D. Bray" 2 => "J. 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Article information
ISSN: 08732159Original language: Portuguese
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