Artigo de Revisão/Review Article
Modelos experimentais em oncologia: O contributo da cultura de células para o conhecimento da biologia do cancro
Experimental models in oncology: Contribution of cell culture on understanding the biology of cancer
1 Aluna do 6.º ano de Medicina da Faculdade de Medicina da Universidade de Coimbra 2007-2008
2 Professora da Faculdade de Medicina da Universidade de Coimbra
3 Disciplina de Fisiopatologia, mestrado integrado em Medicina Dentária.
4 Instituto de Bioquímica e disciplina de Biologia Molecular Aplicada. Mestrado integrado em Medicina
Read
6036
Timeswas read the article
2596
Total PDF
3440
Total HTML
Share statistics
array:24 [ "pii" => "S087321591530163X" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30163-X" "estado" => "S350" "fechaPublicacion" => "2009-07-01" "aid" => "7" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "copyrightAnyo" => "2009" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2009;15:669-82" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2620 "formatos" => array:3 [ "EPUB" => 247 "HTML" => 1532 "PDF" => 841 ] ] "itemSiguiente" => array:19 [ "pii" => "S0873215915301641" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30164-1" "estado" => "S350" "fechaPublicacion" => "2009-07-01" "aid" => "8" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2009;15:683-96" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2340 "formatos" => array:3 [ "EPUB" => 257 "HTML" => 1403 "PDF" => 680 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Cadernos de Anatomia Patológica/Pathology Notebooks</span>" "titulo" => "Os genes ERCC1 e RRM1 no carcinoma broncopulmonar" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "683" "paginaFinal" => "696" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "ERCC1 and RRM1 genes in lung cancer" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lina Carvalho, António Silva, Cláudia Andrade, Cláudia Barroso, Cláudia Farinha, José Carlos Fernandes, Raquel Landeiro" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Lina" "apellidos" => "Carvalho" ] 1 => array:2 [ "nombre" => "António" "apellidos" => "Silva" ] 2 => array:2 [ "nombre" => "Cláudia" "apellidos" => "Andrade" ] 3 => array:2 [ "nombre" => "Cláudia" "apellidos" => "Barroso" ] 4 => array:2 [ "nombre" => "Cláudia" "apellidos" => "Farinha" ] 5 => array:2 [ "nombre" => "José Carlos" "apellidos" => "Fernandes" ] 6 => array:2 [ "nombre" => "Raquel" "apellidos" => "Landeiro" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301641?idApp=UINPBA00004E" "url" => "/08732159/0000001500000004/v1_201509151451/S0873215915301641/v1_201509151451/pt/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0873215915301628" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30162-8" "estado" => "S350" "fechaPublicacion" => "2009-07-01" "aid" => "6" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2009;15:655-67" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4076 "formatos" => array:3 [ "EPUB" => 251 "HTML" => 1419 "PDF" => 2406 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão/Review Article</span>" "titulo" => "Ventilação não invasiva" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "655" "paginaFinal" => "667" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Non-invasive ventilation" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Susana Ferreira, Carla Nogueira, Sara Conde, Natália Taveira" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Susana" "apellidos" => "Ferreira" ] 1 => array:2 [ "nombre" => "Carla" "apellidos" => "Nogueira" ] 2 => array:2 [ "nombre" => "Sara" "apellidos" => "Conde" ] 3 => array:2 [ "nombre" => "Natália" "apellidos" => "Taveira" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301628?idApp=UINPBA00004E" "url" => "/08732159/0000001500000004/v1_201509151451/S0873215915301628/v1_201509151451/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão/Review Article</span>" "titulo" => "Modelos experimentais em oncologia: O contributo da cultura de células para o conhecimento da biologia do cancro" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "669" "paginaFinal" => "682" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Mariana Cruz, Margarida Enes, Marta Pereira, Marília Dourado, Ana Bela Sarmento Ribeiro" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Mariana" "apellidos" => "Cruz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Margarida" "apellidos" => "Enes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 2 => array:3 [ "nombre" => "Marta" "apellidos" => "Pereira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 3 => array:3 [ "nombre" => "Marília" "apellidos" => "Dourado" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "af0015" ] ] ] 4 => array:3 [ "nombre" => "Ana Bela Sarmento" "apellidos" => "Ribeiro" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "af0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Aluna do 6.º ano de Medicina da Faculdade de Medicina da Universidade de Coimbra 2007-2008" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Professora da Faculdade de Medicina da Universidade de Coimbra" "etiqueta" => "2" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Disciplina de Fisiopatologia, mestrado integrado em Medicina Dentária." "etiqueta" => "3" "identificador" => "af0015" ] 3 => array:3 [ "entidad" => "Instituto de Bioquímica e disciplina de Biologia Molecular Aplicada. Mestrado integrado em Medicina" "etiqueta" => "4" "identificador" => "af0020" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Experimental models in oncology: Contribution of cell culture on understanding the biology of cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-08-08" "fechaAceptado" => "2009-02-05" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570217" "palabras" => array:4 [ 0 => "Cultura de células" 1 => "oncologia" 2 => "células dendríticas" 3 => "terapêutica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570216" "palabras" => array:4 [ 0 => "Cell culture" 1 => "oncology" 2 => "dendritic cells" 3 => "therapy" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A cultura de tecidos surgiu no século xx (Harrison, 1907) para estudar o comportamento das células animais em ambiente homeostático e em situações de <span class="elsevierStyleItalic">stress</span>.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">A capacidade de estudar as células a nível molecular relaciona-se com a forma como as células podem crescer e ser manipuladas em laboratório. A cultura de células <span class="elsevierStyleItalic">in vitro</span> permitiu estudar crescimento, diferenciação e morte celular e efectuar manipulações genéticas necessárias ao perfeito conhecimento da estrutura e funções dos genes.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">A cultura de células estaminais humanas veio colmatar algumas limitações inerentes aos restantes modelos de cultura. Ao que parece, as células estaminais cancerígenas mantêm-se quiescentes nos locais metastáticos até serem activadas por sinais apropriados do microambiente.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Vários estudos revelaram que diferentes tipos de cancros podem surgir da transformação maligna de células estaminais. A eliminação destas células progenitoras tumorais é essencial para o desenvolvimento de novas abordagens terapêuticas mais eficazes em cancros agressivos. Por outro lado, a utilização de células dendríticas modificadas em cultura poderá contribuir para a produção de uma potencial vacina terapêutica eficaz para obter a regressão tumoral.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (4): 669-682</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">In the beginning of the 20<span class="elsevierStyleSup">th</span> century, tissue culture was started with the aim of studying the behaviour of animal cells in normal and stress conditions.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">The cell study at molecular level depends on their capacity of growing and how they can be manipulated in laboratory. <span class="elsevierStyleItalic">In vitro</span> cell culture allows us the possibility of studying biological key processes, such as growth, differentiation and cell death, and also to do genetic manipulations essential to the knowledge of structure and genes function.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Human stem cells culture provides strategies to circumvent other models’ deficiencies.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">It seems that cancer stem cells remain quiescent until activation by appropriated micro-environmental stimulation.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">Several studies reveal that different cancer types could be due to stem cell malignant transformations. Removal of these cells is essential to the development of more effective cancer therapies for advanced disease. On the other hand, dendritic cells modified in culture may be used as a therapeutic vaccine in order to induce tumour withraw.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (4): 669-682</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Bruce Alberts" 1 => "D. Bray" 2 => "J. Lewis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:5 [ "edicion" => "3" "titulo" => "Biologia molecular da célula" "fecha" => "1997" "editorial" => "Editora Artes Médicas" "editorialLocalizacion" => "Porto Alegre" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The culture of cell culture" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Susan Lindee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "2007" "volumen" => "316" "numero" => "5831" "paginaInicial" => "1568" "paginaFinal" => "1569" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Culture of animal cells – A manual of basic technique" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Ian Freshney" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "Second edition" "fecha" => "1987" "editorial" => "Alan R Liss, Inc" "editorialLocalizacion" => "New York" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer stem cells: redefining the paradigm of cancer treatment strategies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Michael Dean" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1124/mi.6.3.5" "Revista" => array:6 [ "tituloSerie" => "Molecular Interventions" "fecha" => "2006" "volumen" => "6" "paginaInicial" => "140" "paginaFinal" => "148" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16809475" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:1 [ "host" => array:2 [ 0 => array:1 [ "Libro" => array:3 [ "titulo" => "Stem cells and the future of regenerative medicine – Free executive summary" "fecha" => "2002" "editorial" => "National Academy of Sciences" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "http://www.nap.edu/catalog/10195.html" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Concise Review. Recent advances on the significance of stem cells in tissue regeneration and cancer therapies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Murielle Mimeault" 1 => "K. Batra Surinder" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1634/stemcells.2006-0066" "Revista" => array:7 [ "tituloSerie" => "Stem cells" "fecha" => "2006" "volumen" => "24" "numero" => "11" "paginaInicial" => "2319" "paginaFinal" => "2345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16794264" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stem cells, cancer and cancer stem cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Tannishtha Reya" 1 => "S.J. Morrison" 2 => "M.F. Clarke" 3 => "I.L. Weissman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/35102167" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "2001" "volumen" => "414" "paginaInicial" => "105" "paginaFinal" => "111" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11689955" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The function of stem cells and their future roles in health care" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.H. Cedar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.12968/bjon.2006.15.2.20372" "Revista" => array:7 [ "tituloSerie" => "Br J Nurs" "fecha" => "2006" "volumen" => "15" "numero" => "2" "paginaInicial" => "104" "paginaFinal" => "107" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16493287" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Margarida Vieira, Gomes A, Castelo-Branco G, Santos R. Células estaminais em obstetrícia e ginecologia, Parte I: conceitos gerais e aplicações. <a href="http://www.crioestaminal.pt/web/eng/pdfs">www.crioestaminal.pt/web/eng/pdfs</a>." ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Considerations for targeting malignant stem cells in leukemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Monica L Guzman" 1 => "C.T. Jordan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Control" "fecha" => "2004" "volumen" => "11" "paginaInicial" => "97" "paginaFinal" => "104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15024346" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of non small cell lung cancer stage IV – ACCP Evidence Based Pratice Guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.A. Socinski" 1 => "R. Crowell" 2 => "T.E. Hensing" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2007" "volumen" => "132" "paginaInicial" => "89" "paginaFinal" => "277" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Erlotinib e matástases cerebrais" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F. Barata" 1 => "T. Costa" 2 => "A. Figueiredo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2008" "volumen" => "XIV" "numero" => "supl 3" "paginaInicial" => "S35" "paginaFinal" => "S42" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Philip C. Hoffman" 1 => "A.M. Mauer" 2 => "E.E. Vokes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(00)82038-3" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2000" "volumen" => "355" "paginaInicial" => "479" "paginaFinal" => "485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10841143" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inibidores da tirosina-cinase no CPNPC avançado: A propósito de um caso clínico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Ana Ferreira Alves" 1 => "M. Liebermann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0873-2159(15)30318-4" "Revista" => array:7 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2008" "volumen" => "14" "numero" => "supl 3" "paginaInicial" => "S23" "paginaFinal" => "S28" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25967683" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "NCCN Clinical Practice Guidelines in Oncology" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Non-Small Cell Lung Cancer" "fecha" => "2008" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal growth receptor biology (IMC-C225)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "E.S. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cur Op Onc" "fecha" => "2001" "volumen" => "13" "numero" => "6" "paginaInicial" => "506" "paginaFinal" => "513" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Erlotinib no controlo tumoral prolongado do carcinona do pulmão de não pequenas células avançado (CPNPC)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Teresa Guimarães" 1 => "A. Castro" 2 => "N. Cortesão" 3 => "J. Ferreira" 4 => "F. João" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0873-2159(15)30329-9" "Revista" => array:7 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2008" "volumen" => "14" "numero" => "supl 3" "paginaInicial" => "S9" "paginaFinal" => "S15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25967896" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduced erlotinib sensitivity of epidermal growth factor receptor-mutant non-small cell lung cancer following cisplatin exposure: A cell culture model of second-line erlotinib treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "T.M. Chin" 1 => "M.P. Quinlan" 2 => "A. Singh" 3 => "L.V. Sequist" 4 => "T.J. Lynch" 5 => "D.A. Haber" 6 => "S.V. Sharma" 7 => "J. Settleman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1078-0432.CCR-08-0093" "Revista" => array:7 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2008" "volumen" => "14" "numero" => "21" "paginaInicial" => "6867" "paginaFinal" => "6876" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18980981" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Erlotinib na segunda linha de tratamento do cancro do pulmão de não pequenas células – Caso clínico" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Araújo" 1 => "M. Soares" 2 => "I. Azevedo" 3 => "A. Araújo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0873-2159(15)30317-2" "Revista" => array:7 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2008" "volumen" => "14" "numero" => "supl 3" "paginaInicial" => "S17" "paginaFinal" => "S22" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25967682" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiogenesis and Lung Cancer: Prognostic and therapeutic implications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Roy S Herbst" 1 => "A. Onn" 2 => "A. Sandler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2005.18.853" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "3243" "paginaFinal" => "3256" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15886312" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bb0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Designing a Vaccine for cancer: a look into dendritic cell cancer vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Jonathan M Ng" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "McMaster Educater" "fecha" => "2004" "volumen" => "3" "paginaInicial" => "13" "paginaFinal" => "18" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bb0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dendritic cell-based vaccines for the treatment of cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.J. Mulé" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Michigan Oncology Journal, Summer" "fecha" => "1998" "itemHostRev" => array:3 [ "pii" => "S0210480610004420" "estado" => "S300" "issn" => "02104806" ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bb0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immuno-gene therapy of cancer with tumor-mRNA transfected dendritic cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Kyte" 1 => "G. Gaudernack" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Cancer Immunology Immunother" "fecha" => "2006" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bb0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunotherapy of cancer with dendritic cell-based vaccines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Gilboa" 1 => "S.K. Nair" 2 => "H.K. Lyerly" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Immunology Immunother" "fecha" => "1998" "volumen" => "46" "numero" => "2" "paginaInicial" => "82" "paginaFinal" => "87" "itemHostRev" => array:3 [ "pii" => "S0022534708006186" "estado" => "S300" "issn" => "00225347" ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bb0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "H. Bohnenkamp" ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Libro" => array:2 [ "titulo" => "Process development for the generation of matured monocyte-derived dendritic cells suitable for clinical aplication" "fecha" => "2006" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "www.Fz-juelich.de/ibt/cell/matured-dendritic-cells" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bb0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dendritic cell therapy for GU malignancies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Vieweg" ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "State of the science – Genitourinary" "fecha" => "2002" "paginaInicial" => "14" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "www.webtie.org/SOTS/Meetings/Genitourinary/SUO_12_13_14_2002/lectures.htm" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bb0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An effective cancer vaccine modality: lentiviral modification of dendritic cells expressing multiple cancer-specific antigens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Wang" 1 => "J. He" 2 => "C. Lui" 3 => "L.J. Chang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.vaccine.2006.02.025" "Revista" => array:6 [ "tituloSerie" => "Vaccine" "fecha" => "2006" "volumen" => "24" "paginaInicial" => "3477" "paginaFinal" => "3489" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16530303" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bb0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dendritic cell therapy with improved outcome in glioma multiformr – A case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Khan" 1 => "S. Yaqin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Zhejiang University Sc B" "fecha" => "2006" "volumen" => "7" "paginaInicial" => "114" "paginaFinal" => "117" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bb0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetically modified dendritic cells for cancer immunotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Ribas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Gene Therapy" "fecha" => "2005" "volumen" => "5" "numero" => "6" "paginaInicial" => "619" "paginaFinal" => "628" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bb0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dendritic cells in cancer immunotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Fong" 1 => "E.G. Engleman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Annual Rev Immunol" "fecha" => "2000" "volumen" => "18" "paginaInicial" => "245" "paginaFinal" => "273" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bb0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunotherapy of hormone-refractory prostate cancer with antigen-loaded dendritic cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.J. Small" 1 => "P. Fratesi" 2 => "D.M. Reese" 3 => "G. Strang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Clinical Oncol" "fecha" => "2000" "volumen" => "18" "paginaInicial" => "3894" "paginaFinal" => "3903" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bb0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vaccinations of melanoma patients with peptide or tumor lysatepulsed dendritic cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.O. Nestle" 1 => "S. Alijagic" 2 => "M. Gilliet" 3 => "Y. Sun" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Nat Med" "fecha" => "1998" "volumen" => "4" "numero" => "3" "paginaInicial" => "328" "paginaFinal" => "332" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9500607" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bb0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dendritic cell vaccines for cancer immunotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.M. Timmerman" 1 => "R. Levy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Annual Rev Medicine" "fecha" => "1999" "volumen" => "50" "paginaInicial" => "507" "paginaFinal" => "529" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bb0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen specific T cell responses in DTH skin test" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W.J. Lesterhuis" 1 => "L.J. Vries" 2 => "D.H. Schuurhuis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Annual Oncology" "fecha" => "2006" "volumen" => "17" "paginaInicial" => "974" "paginaFinal" => "980" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bb0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dendritic cell-based immunotherapy for ovarian cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.D. Santin" 1 => "S. Bellone" 2 => "L.J. Underwood" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Minerva Ginecol" "fecha" => "2002" "volumen" => "54" "numero" => "2" "paginaInicial" => "133" "paginaFinal" => "144" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12032451" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bb0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sensitization of malignant glioma to chemotherapy through dendritic cell vaccination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Liu" 1 => "K.L. Black" 2 => "J.S. Yu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1586/14760584.5.2.233" "Revista" => array:7 [ "tituloSerie" => "Expert Rev Vaccines" "fecha" => "2006" "volumen" => "5" "numero" => "2" "paginaInicial" => "233" "paginaFinal" => "247" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16608423" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bb0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current state and perspectives of dendritic cell vaccination in cancer immunotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Farkas" 1 => "C. Conrad" 2 => "G. Tonel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000092592" "Revista" => array:6 [ "tituloSerie" => "Skin Pharmacol Physiol" "fecha" => "2006" "volumen" => "19" "paginaInicial" => "124" "paginaFinal" => "131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16612139" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001500000004/v1_201509151451/S087321591530163X/v1_201509151451/pt/main.assets" "Apartado" => array:4 [ "identificador" => "43356" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Artigos de revisão" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001500000004/v1_201509151451/S087321591530163X/v1_201509151451/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087321591530163X?idApp=UINPBA00004E" ]
Article information
ISSN: 08732159Original language: Portuguese
The statistics are updated each day
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 2 | 6 |
| 2024 October | 43 | 40 | 83 |
| 2024 September | 31 | 39 | 70 |
| 2024 August | 43 | 55 | 98 |
| 2024 July | 36 | 39 | 75 |
| 2024 June | 25 | 31 | 56 |
| 2024 May | 46 | 51 | 97 |
| 2024 April | 40 | 32 | 72 |
| 2024 March | 34 | 37 | 71 |
| 2024 February | 35 | 33 | 68 |
| 2024 January | 25 | 27 | 52 |
| 2023 December | 27 | 37 | 64 |
| 2023 November | 25 | 43 | 68 |
| 2023 October | 18 | 48 | 66 |
| 2023 September | 25 | 35 | 60 |
| 2023 August | 23 | 34 | 57 |
| 2023 July | 25 | 34 | 59 |
| 2023 June | 24 | 20 | 44 |
| 2023 May | 26 | 25 | 51 |
| 2023 April | 23 | 17 | 40 |
| 2023 March | 18 | 27 | 45 |
| 2023 February | 20 | 20 | 40 |
| 2023 January | 30 | 22 | 52 |
| 2022 December | 24 | 25 | 49 |
| 2022 November | 38 | 37 | 75 |
| 2022 October | 39 | 29 | 68 |
| 2022 September | 19 | 37 | 56 |
| 2022 August | 46 | 34 | 80 |
| 2022 July | 31 | 43 | 74 |
| 2022 June | 18 | 30 | 48 |
| 2022 May | 43 | 31 | 74 |
| 2022 April | 28 | 33 | 61 |
| 2022 March | 23 | 27 | 50 |
| 2022 February | 24 | 32 | 56 |
| 2022 January | 23 | 38 | 61 |
| 2021 December | 38 | 46 | 84 |
| 2021 November | 28 | 30 | 58 |
| 2021 October | 23 | 39 | 62 |
| 2021 September | 25 | 35 | 60 |
| 2021 August | 28 | 38 | 66 |
| 2021 July | 34 | 31 | 65 |
| 2021 June | 24 | 34 | 58 |
| 2021 May | 27 | 36 | 63 |
| 2021 April | 35 | 47 | 82 |
| 2021 March | 48 | 17 | 65 |
| 2021 February | 47 | 16 | 63 |
| 2021 January | 49 | 24 | 73 |
| 2020 December | 24 | 28 | 52 |
| 2020 November | 49 | 12 | 61 |
| 2020 October | 28 | 22 | 50 |
| 2020 September | 50 | 19 | 69 |
| 2020 August | 41 | 28 | 69 |
| 2020 July | 54 | 25 | 79 |
| 2020 June | 51 | 22 | 73 |
| 2020 May | 70 | 25 | 95 |
| 2020 April | 47 | 11 | 58 |
| 2020 March | 62 | 15 | 77 |
| 2020 February | 50 | 37 | 87 |
| 2020 January | 58 | 20 | 78 |
| 2019 December | 53 | 28 | 81 |
| 2019 November | 55 | 19 | 74 |
| 2019 October | 59 | 21 | 80 |
| 2019 September | 48 | 23 | 71 |
| 2019 August | 55 | 24 | 79 |
| 2019 July | 37 | 26 | 63 |
| 2019 June | 40 | 18 | 58 |
| 2019 May | 48 | 31 | 79 |
| 2019 April | 33 | 24 | 57 |
| 2019 March | 49 | 13 | 62 |
| 2019 February | 46 | 21 | 67 |
| 2019 January | 54 | 20 | 74 |
| 2018 December | 25 | 7 | 32 |
| 2018 November | 5 | 0 | 5 |
| 2018 October | 3 | 8 | 11 |
| 2018 September | 6 | 11 | 17 |
| 2018 August | 44 | 18 | 62 |
| 2018 July | 30 | 28 | 58 |
| 2018 June | 48 | 18 | 66 |
| 2018 May | 54 | 15 | 69 |
| 2018 April | 65 | 34 | 99 |
| 2018 March | 45 | 31 | 76 |
| 2018 February | 38 | 18 | 56 |
| 2018 January | 44 | 18 | 62 |
| 2017 December | 72 | 19 | 91 |
| 2017 November | 51 | 18 | 69 |
| 2017 October | 34 | 22 | 56 |
| 2017 September | 45 | 16 | 61 |
| 2017 August | 32 | 15 | 47 |
| 2017 July | 22 | 12 | 34 |
| 2017 June | 27 | 27 | 54 |
| 2017 May | 40 | 12 | 52 |
| 2017 April | 7 | 11 | 18 |
| 2017 March | 19 | 58 | 77 |
| 2017 February | 18 | 6 | 24 |
| 2017 January | 17 | 7 | 24 |
| 2016 December | 17 | 12 | 29 |
| 2016 November | 6 | 15 | 21 |
| 2016 October | 10 | 11 | 21 |
| 2016 September | 6 | 13 | 19 |
| 2016 August | 4 | 6 | 10 |
| 2016 July | 2 | 5 | 7 |
| 2016 June | 0 | 4 | 4 |
| 2016 April | 4 | 1 | 5 |
| 2016 March | 1 | 4 | 5 |
| 2016 February | 3 | 9 | 12 |
| 2016 January | 12 | 6 | 18 |
| 2015 December | 8 | 7 | 15 |
| 2015 November | 5 | 2 | 7 |
| 2015 October | 2 | 3 | 5 |
Show all
