Cadernos de Anatomia Patológica/Pathology Notebooks
Os genes ERCC1 e RRM1 no carcinoma broncopulmonar
ERCC1 and RRM1 genes in lung cancer
Read
5619
Timeswas read the article
2332
Total PDF
3287
Total HTML
Share statistics
array:24 [ "pii" => "S0873215915301641" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30164-1" "estado" => "S350" "fechaPublicacion" => "2009-07-01" "aid" => "8" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "copyrightAnyo" => "2009" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2009;15:683-96" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2340 "formatos" => array:3 [ "EPUB" => 257 "HTML" => 1403 "PDF" => 680 ] ] "itemSiguiente" => array:19 [ "pii" => "S0873215915301756" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30175-6" "estado" => "S350" "fechaPublicacion" => "2009-07-01" "aid" => "19" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "pub" "cita" => "Rev Port Pneumol. 2009;15:751-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2184 "formatos" => array:3 [ "EPUB" => 226 "HTML" => 1213 "PDF" => 745 ] ] "pt" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Normas de Publicação/Instructions for Authors</span>" "titulo" => "Normas de publicação na Revista Portuguesa de Pneumologia" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "751" "paginaFinal" => "754" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Portuguese Journal of Pulmonology Instructions for authors" ] ] "contienePdf" => array:1 [ "pt" => true ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301756?idApp=UINPBA00004E" "url" => "/08732159/0000001500000004/v1_201509151451/S0873215915301756/v1_201509151451/pt/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S087321591530163X" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30163-X" "estado" => "S350" "fechaPublicacion" => "2009-07-01" "aid" => "7" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2009;15:669-82" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2620 "formatos" => array:3 [ "EPUB" => 247 "HTML" => 1532 "PDF" => 841 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão/Review Article</span>" "titulo" => "Modelos experimentais em oncologia: O contributo da cultura de células para o conhecimento da biologia do cancro" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "669" "paginaFinal" => "682" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Experimental models in oncology: Contribution of cell culture on understanding the biology of cancer" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mariana Cruz, Margarida Enes, Marta Pereira, Marília Dourado, Ana Bela Sarmento Ribeiro" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Mariana" "apellidos" => "Cruz" ] 1 => array:2 [ "nombre" => "Margarida" "apellidos" => "Enes" ] 2 => array:2 [ "nombre" => "Marta" "apellidos" => "Pereira" ] 3 => array:2 [ "nombre" => "Marília" "apellidos" => "Dourado" ] 4 => array:2 [ "nombre" => "Ana Bela Sarmento" "apellidos" => "Ribeiro" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087321591530163X?idApp=UINPBA00004E" "url" => "/08732159/0000001500000004/v1_201509151451/S087321591530163X/v1_201509151451/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Cadernos de Anatomia Patológica/Pathology Notebooks</span>" "titulo" => "Os genes ERCC1 e RRM1 no carcinoma broncopulmonar" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "683" "paginaFinal" => "696" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Lina Carvalho, António Silva, Cláudia Andrade, Cláudia Barroso, Cláudia Farinha, José Carlos Fernandes, Raquel Landeiro" "autores" => array:7 [ 0 => array:3 [ "nombre" => "Lina" "apellidos" => "Carvalho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "António" "apellidos" => "Silva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 2 => array:3 [ "nombre" => "Cláudia" "apellidos" => "Andrade" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 3 => array:3 [ "nombre" => "Cláudia" "apellidos" => "Barroso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 4 => array:3 [ "nombre" => "Cláudia" "apellidos" => "Farinha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 5 => array:3 [ "nombre" => "José Carlos" "apellidos" => "Fernandes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 6 => array:3 [ "nombre" => "Raquel" "apellidos" => "Landeiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Professora de Anatomia Patológica/Oncologia Faculdade de Medicina, Universidade de Coimbra" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Disciplina de Oncologia, Anatomia Patológica/Oncologia Faculdade de Medicina, Universidade de Coimbra" "etiqueta" => "2" "identificador" => "af0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "ERCC1 and RRM1 genes in lung cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-02-05" "fechaAceptado" => "2009-02-26" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570219" "palabras" => array:3 [ 0 => "Carcinoma do pulmão de células não pequenas" 1 => "RRM1" 2 => "ERCC1" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570218" "palabras" => array:3 [ 0 => "Non-small cell lung cancer" 1 => "RRM1" 2 => "ERCC1" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">No cancro do pulmão, ainda não se obteve sobrevivência expressiva dos doentes que se apresentam em estádios não cirúrgicos. Os doentes com carcinoma de não pequenas células são tratados com platina e outros fármacos, para os quais se podem caracterizar actualmente marcadores preditivos de resposta terapêutica.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Procedeu-se a uma revisão da literatura, tendo como alvo o papel dos genes <span class="elsevierStyleItalic">ERCC1</span> e <span class="elsevierStyleItalic">RRM1</span> na resposta à quimioterapia baseada na platina e na gemcitabina. Actualmente, a expressão destes genes é encarada como preditiva de resposta à quimioterapia em doentes com adenocarcinomas e carcinomas epidermóides, orientando a terapêutica personalizada.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Dados publicados demonstram a utilidade da quimioterapia individualizada, de acordo com os níveis individuais de ERCC1. Estes também são influenciados por variabilidade genética. Assim, a presença de certos polimorfismos, como são os códãos 118 C/T e C8092A, parecem estar relacionados com a carcinogénese, resistência aos citostáticos, tempo de sobrevida e até com o prognóstico.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Estudos clínicos e laboratoriais demonstraram também que a elevada expressão do gene <span class="elsevierStyleItalic">RRM1</span> no NSCLC tem impacto no fenótipo do tumor e na resposta variável à quimioterapia. Doentes submetidos a ressecção cirúrgica, cujos tumores apresentavam expressão aumentado do gene <span class="elsevierStyleItalic">RRM1,</span> têm maior sobrevivência do que os doentes com baixa expressão. No entanto, os doentes com NSCLC avançado sujeitos a quimioterapia com gemcitabina e cisplatina apresentam um pior prognóstico se o tumor apresentar expressão aumentada do gene <span class="elsevierStyleItalic">RRM1</span>.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (4): 683-696</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">In lung cancer, expressive survival has not yet been achieved in non surgical stages. Non-small cell lung cancer (NSCLC) patients are treated with platinum and other drugs. To choose these agents we can actual ly define predictive biomarkers to preview therapeutic response.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">A literature revision was done in order to define the role of <span class="elsevierStyleItalic">ERCC1</span> e <span class="elsevierStyleItalic">RRM1</span> genes in the response to chemotherapy based in platinum and gemcitabine respectively. The expression of these genes is faced as a predictive marker to the chemotherapy response in patients with adenocarcinomas and squamous cell carcinomas, providing a personalized therapy.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Published data supports this behaviour and is useful to individualize therapy accordingly to individual levels of ERCC1 which are modified by genetic mutations. Polymorphisms in codons 118 C/T and C8092A, seem to influence the carcinogenesis, cytostatic resistance, survival and even the prognosis.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Clinical and laboratorial trials showed that high expression of RRM1 gene in NSCLC has impact in the tumoral phenotype. Patients having done surgical ressection and presenting high expression of RRM1 have better survival than those with lower expression. However, patients with advanced NSCLC and treated with chemotherapy with gemcitabine and cisplatin appear to have a poor outcome if the tumor express elevated levels of <span class="elsevierStyleItalic">RRM1</span> gene.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (4): 683-696</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:58 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global and regional estimates of cancer mortality and incidence by site. II. Results for the global burden of disease 2000" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K. Shibuya" 1 => "C.D. Mathers" 2 => "C. Boschi-Pinto" 3 => "A.D. Lopez" 4 => "C.J. Murray" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BMC Cancer" "fecha" => "2002" "volumen" => "2" "paginaInicial" => "37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12502432" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0090429514005615" "estado" => "S300" "issn" => "00904295" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multidisciplinary management of lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Spira" 1 => "D.S. Ettinger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra035536" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "379" "paginaFinal" => "392" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14736930" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RRM1-induced metastasis suppression through PTEN-regulated pathways" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Gautam" 1 => "Z.R. Li" 2 => "G. Bepler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.onc.1206232" "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "2003" "volumen" => "22" "paginaInicial" => "2135" "paginaFinal" => "2142" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12687015" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combined evaluation of Rad51 and ERCC1 expressions for sensitivy to platinum agents in non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "T. Takenaka" 1 => "I. Yoshino" 2 => "H. Kouso" 3 => "T. Ohba" 4 => "T. Yohena" 5 => "A. Osoegawa" 6 => "F. Shoji" 7 => "Y. Maehara" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.22738" "Revista" => array:7 [ "tituloSerie" => "Int J Cancer" "fecha" => "2007" "volumen" => "121" "paginaInicial" => "895" "paginaFinal" => "900" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17417781" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0090429509026223" "estado" => "S300" "issn" => "00904295" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]: a randomised controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:12 [ 0 => "J.Y. Douillard" 1 => "R. Rossel" 2 => "M. De Lena" 3 => "F. Carpagnamo" 4 => "R. Ramlau" 5 => "J.L. Gonzales-Larriba" 6 => "T. Grodzki" 7 => "J.R. Pereira" 8 => "A. Le Groumellec" 9 => "V. Lorusso" 10 => "C. Clary" 11 => "A.J. Torres" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2006" "volumen" => "9" "paginaInicial" => "719" "paginaFinal" => "727" "itemHostRev" => array:3 [ "pii" => "S0302283807008640" "estado" => "S300" "issn" => "03022838" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "For the National Cancer Institute of Canada Clinical Trials Group and National Cancer Institute of the United States Intergroup JBR. 10 trial investigators. Vinorelbine plus cisplatin vs. observation in ressected non-small-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:12 [ 0 => "T. Winton" 1 => "R. Linvingston" 2 => "D. Johnson" 3 => "J. Rigas" 4 => "M. Johnston" 5 => "C. Butts" 6 => "Y. Cormier" 7 => "G. Goss" 8 => "R. Inculet" 9 => "E. Vallieres" 10 => "W. Fry" 11 => "D. Bethune" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa043623" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "2005" "volumen" => "352" "paginaInicial" => "2589" "paginaFinal" => "2597" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15972865" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0302283813002285" "estado" => "S300" "issn" => "03022838" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized clinical trial of adjuvant chemotherapy with paclitaxel and carboplatin following resection in stage IB non-small-cell ling cancer: report of Cancer and Leukemia Group B protocol 9633" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "G.M. Strauss" 1 => "J. Herndon" 2 => "M.A. Maddaus" 3 => "D.W. Johnstone" 4 => "E.A. Johnson" 5 => "D.M. Watson" 6 => "D.J. Sugarbaker" 7 => "R.L. Schilsky" 8 => "M.R. Green" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2004" "volumen" => "22" "numero" => "Suppl 14" "paginaInicial" => "A7019" "itemHostRev" => array:3 [ "pii" => "S0302283807008639" "estado" => "S300" "issn" => "03022838" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Should chemotherapy combinations for advanced non-small-cell lung cancer be platinum-based? A metanalysis of phase III randomized trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.L. Pujol" 1 => "F. Barlesi" 2 => "J.P. Daures" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lung Cancer" "fecha" => "2006" "volumen" => "3" "paginaInicial" => "335" "paginaFinal" => "345" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Three-arm randomized study of two cisplatin-based regimens amd paclitaxel plus gemcitabine in advenced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:12 [ 0 => "E.F. Smit" 1 => "J.P. van Meerbeck" 2 => "P. Lianes" 3 => "C. Debruyne" 4 => "C. Legrand" 5 => "F. Schramel" 6 => "H. Smit" 7 => "R. Gaafar" 8 => "B. Biesma" 9 => "C. Manegold" 10 => "N. Neymark" 11 => "G. Giaconne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2003.03.195" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2003" "volumen" => "21" "paginaInicial" => "3909" "paginaFinal" => "3917" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14581415" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polimorfismos e metilação de genes na selecção da terapêutica do cancro do pulmão" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.P. Hespanhol" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Revista GECP" "fecha" => "2006" "paginaInicial" => "17" "paginaFinal" => "21" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC1 as a risk stratifier in platinum-based chemotherapy for non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K. Olaussen" 1 => "G. Mountzios" 2 => "J. Soria" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Opin Pulm Med" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "287" "paginaFinal" => "289" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA structural elements required for ERCC1-XPF endonuclease activity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.L. De Laat" 1 => "E. Appeldoorn" 2 => "N.G. Jaspers" 3 => "J.H. Hoeijmakers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1998" "volumen" => "273" "paginaInicial" => "7835" "paginaFinal" => "7842" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9525876" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nucleotide excision repair gene (ERCC1) deficiency causes G(2) arrest in hepatocytes and a reduction in liver binucleation:the role of p. 53 and p. 21" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Nunez" 1 => "M.D. Chipchase" 2 => "A.R. Clarke" 3 => "D.W. Melton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "FASEB J" "fecha" => "2000" "volumen" => "14" "paginaInicial" => "1073" "paginaFinal" => "1082" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10834928" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanism of opencomplex and dual incision formation by human nucleotide excision repair factors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E. Evans" 1 => "J.G. Moggs" 2 => "J.R. Hwang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/emboj/16.21.6559" "Revista" => array:6 [ "tituloSerie" => "EMBO J" "fecha" => "1997" "volumen" => "16" "paginaInicial" => "6559" "paginaFinal" => "6573" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9351836" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reaction mechanism of human DNA repair excision nuclease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Mu" 1 => "D.S. Hsu" 2 => "A. Sancar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Biol Chem" "fecha" => "1996" "volumen" => "271" "paginaInicial" => "8285" "paginaFinal" => "8294" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8626523" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nucleotide excision repair. I. From E.coli to yeast" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.H. Hoeijmakers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Trends Genet" "fecha" => "1993" "volumen" => "9" "numero" => "5" "paginaInicial" => "173" "paginaFinal" => "177" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8337754" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Action of DNA repair endonuclease ERCC1/XPF in living cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.B. Houstmuller" 1 => "S. Rademarkers" 2 => "A.L. Nigg" 3 => "D. Hoogstraten" 4 => "J.H. Hoeijmakers" 5 => "W. Vermeulen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Science" "fecha" => "1999" "volumen" => "284" "numero" => "5416" "paginaInicial" => "958" "paginaFinal" => "961" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10320375" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nuclear excision repair-based personalized therapy for non-small cell lung cancer: From hypothesis to reality" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Simon" 1 => "R. Ismail-Khan" 2 => "G. Bepler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.biocel.2015.01.003" "Revista" => array:7 [ "tituloSerie" => "The International Journal of Biochemistry & Cell Biology" "fecha" => "2007" "volumen" => "39" "paginaInicial" => "1318" "paginaFinal" => "1328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25595463" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0210480612002008" "estado" => "S300" "issn" => "02104806" ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nucleotide excision repair" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.H. Hoeilmakers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "II. From yeast to mammals. Trends Genet" "fecha" => "1993" "volumen" => "9" "numero" => "6" "paginaInicial" => "211" "paginaFinal" => "217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8337762" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC1 expression as a predictor of survival in resected patients with non-small-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.R. Simon" 1 => "S. Sharma" 2 => "A. Cantor" 3 => "P. Smith" 4 => "G. Bepler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.127.3.978" "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "numero" => "3" "paginaInicial" => "978" "paginaFinal" => "983" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15764785" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bb0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.A. Olaussen" 1 => "A. Dunant" 2 => "P. Fouret" 3 => "E. Brambilla" 4 => "F. Andre" 5 => "V. Haddad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa060570" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "355" "numero" => "10" "paginaInicial" => "983" "paginaFinal" => "991" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16957145" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bb0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loss of heterozygosity of nucleotide excision repair factors in sporadic ovarian, colon and lung carcinomas: implication for their roles of carcinogenesis in human solid tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Y. Takebayashi" 1 => "K. Nakayama" 2 => "A. Kansaki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Lett" "fecha" => "2001" "volumen" => "174" "paginaInicial" => "115" "paginaFinal" => "125" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11689286" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bb0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Cheng" 1 => "M.R. Spitz" 2 => "W.K. Hong" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Carcinogenesis" "fecha" => "2000" "volumen" => "21" "paginaInicial" => "1527" "paginaFinal" => "1530" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10910954" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bb0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC1 polymorphism is associated with differencial ERCC1 gene expression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.J. Park" 1 => "J. Stoehelmacher" 2 => "W. Zhang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Proc Am Assoc Cancer" "fecha" => "2002" "volumen" => "1591" "itemHostRev" => array:3 [ "pii" => "S0090429513001441" "estado" => "S300" "issn" => "00904295" ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bb0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of two human ovarian carcinoma cell lines (A2780/CP70 and MCAS) that are equally resistant to platinum, but differ at codon 118 of the ERCC1 gene" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.J. Yu" 1 => "K.B. Lee" 2 => "C. Mu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Oncol" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "555" "paginaFinal" => "560" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10675489" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bb0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC1 gene polymorphism as a predictor for clinical outcome in advenced colorectal cancer patients treated with platinum-based chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.J. Park" 1 => "W. Zhang" 2 => "J. Stoehlmaker" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin Adv Hematol Oncol" "fecha" => "2003" "volumen" => "1" "paginaInicial" => "162" "paginaFinal" => "166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16224397" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0022534709011975" "estado" => "S300" "issn" => "00225347" ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bb0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of an ERCC1 polymorphism with adul-onset glioma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Chen" 1 => "J. Wiencke" 2 => "K. Aldape" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Epidemiol Biomark Prev" "fecha" => "2000" "volumen" => "9" "paginaInicial" => "843" "paginaFinal" => "847" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bb0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA repair gene ERCC1 and ERCC2/XPD polymorphisms and risk of squamous cell carcinoma of the head and neck" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.M. Sturgis" 1 => "K.R. Dahlstrom" 2 => "M.R. Spitz" 3 => "Q. Wei" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Otolarungol Head Neck Surg" "fecha" => "2002" "volumen" => "128" "paginaInicial" => "1084" "paginaFinal" => "1088" "itemHostRev" => array:3 [ "pii" => "S0210480614000643" "estado" => "S300" "issn" => "02104806" ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bb0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymorphisms of DNA repair genes and risk of non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "S. Zienolddiny" 1 => "D. Campa" 2 => "H. Lind" 3 => "D. Ryberg" 4 => "V. Skaug" 5 => "L. Stangeland" 6 => "D. Phillips" 7 => "F. Canzian" 8 => "A. Haugen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/carcin/bgi232" "Revista" => array:7 [ "tituloSerie" => "Carcinogenesis" "fecha" => "2006" "volumen" => "27" "numero" => "3" "paginaInicial" => "560" "paginaFinal" => "567" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16195237" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bb0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A nucleotide polymorphism in ERCC1 in human ovarian cancer cells lines and tumor tissues" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.J. Yu" 1 => "C. Mu" 2 => "K.B. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mutat Res" "fecha" => "1997" "volumen" => "382" "paginaInicial" => "13" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9360634" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bb0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "<a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6240">http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6240</a>" ] ] ] 31 => array:3 [ "identificador" => "bb0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.D. Davidson" 1 => "L. Ma" 2 => "M. Flagella" 3 => "S. Geeganage" 4 => "L.M. Gelbert" 5 => "C.A. Slapak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/0008-5472.CAN-03-3363" "Revista" => array:6 [ "tituloSerie" => "Cancer Research" "fecha" => "2004" "volumen" => "64" "paginaInicial" => "3761" "paginaFinal" => "3766" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15172981" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bb0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gemcitabine: Current status of phase I and II trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S.B. Kaye" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1994.12.8.1527" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1994" "volumen" => "12" "paginaInicial" => "1527" "paginaFinal" => "1531" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8040662" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bb0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Z. Zheng" 1 => "T. Chen" 2 => "X. Li" 3 => "E. Haura" 4 => "A. Sharma" 5 => "G. Bepler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa065411" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "paginaInicial" => "800" "paginaFinal" => "808" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17314339" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bb0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ribonucleotide reductase M1 gene promoter activity polymorphisms, population frequencies and clinical relevance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:13 [ 0 => "G. Bepler" 1 => "Z. Zheng" 2 => "A. Gautam" 3 => "S. Sharma" 4 => "A. Cantor" 5 => "A. Sharma" 6 => "W.D. Cress" 7 => "Y.C.K. Kim" 8 => "R. Rosell" 9 => "C. McBride" 10 => "L. Robinson" 11 => "E. Sommerers" 12 => "E. Haura" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.lungcan.2004.07.043" "Revista" => array:6 [ "tituloSerie" => "Lung Cancer" "fecha" => "2005" "volumen" => "47" "paginaInicial" => "183" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15639717" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bb0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RRM1 and PTEN as prognostic parameters for overall and disease-free survival patients with non-small-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Bepler" 1 => "S. Sharma" 2 => "A. Cantor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2004.12.002" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2004" "volumen" => "22" "paginaInicial" => "1878" "paginaFinal" => "1885" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15143080" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bb0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.K. Fukunaga" 1 => "S. Marsh" 2 => "D.J. Murry" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.tpj.6500259" "Revista" => array:6 [ "tituloSerie" => "Pharmacogenomics J" "fecha" => "2004" "volumen" => "4" "paginaInicial" => "307" "paginaFinal" => "314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15224082" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bb0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gemcitabine: Metabolism, mechanisms of action, and self potentiation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "W. Plunkett" 1 => "P. Huang" 2 => "Y.Z. Xu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "Semin Oncol" "fecha" => "1995" "volumen" => "22" "numero" => "suppl 11" "paginaInicial" => "3" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8604451" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0302283812005271" "estado" => "S300" "issn" => "03022838" ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bb0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vivo induction of resistance to gemcitabine resultas in increased expression of ribonucleotide reductase subunit M1 as the major determinant" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "A.M. Bergman" 1 => "P.P. Eijk" 2 => "V.W.T.R. van Haperen" 3 => "K. Smid" 4 => "G. Veerman" 5 => "I. Hubeek" 6 => "P. van den Ijssel" 7 => "B. Ylstra" 8 => "G.J. Peters" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/0008-5472.CAN-04-4557" "Revista" => array:5 [ "tituloSerie" => "Cancer Res" "fecha" => "2005" "volumen" => "65" "numero" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15994957" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bb0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemotherapy in nonsmall cell lung cancer: a meta-analysis using updated data on individual patients from 52 rendomized clinical trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Nonsmall Cell Lung Cancer Collaborative Group" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "1995" "volumen" => "311" "paginaInicial" => "899" "paginaFinal" => "909" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7580546" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bb0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized study of adjuvant chemotherapy for completely resected stage I, II or IIIA nonsmall-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G.V. Scagliotti" 1 => "R. Fossati" 2 => "V. Torri" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2003" "volumen" => "95" "paginaInicial" => "1453" "paginaFinal" => "1461" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14519751" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bb0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cisplatin-based adjuvant chemotherapy in patients with completely resected nonsmall-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "The International Adjuvant Lung Cancer Trial Collaborative Group" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa031644" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "351" "paginaFinal" => "360" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14736927" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bb0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Should adjuvant chemotherapy become standart treatment in all patients with resected nonsmall-cell lung cancer?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Le Chevalier" 1 => "R. Arriagada" 2 => "J.P. Pignon" 3 => "G.V. Scagliotti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2005" "volumen" => "6" "paginaInicial" => "182" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15759364" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bb0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Arriagada" 1 => "B. Bergman" 2 => "A. Dunant" 3 => "T. Le Chevalier" 4 => "J.P. Pignon" 5 => "J. Vansteenkiste" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "N Eng J Med" "fecha" => "2004" "volumen" => "350" "numero" => "4" "paginaInicial" => "351" "paginaFinal" => "360" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bb0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Results of the randomized adjuvant lung cancer trials (IALT): Cisplatin-based chemotherapy (CT) <span class="elsevierStyleItalic">vs.</span> noCT in 1867 patients with resected non-small cell lung cancer (NSCLC)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T. Le Chevalier" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Proc ASCO" "fecha" => "2003" "paginaInicial" => "21" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bb0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.V. Lord" 1 => "J. Branbender" 2 => "D. Gandara" 3 => "V. Alberola" 4 => "C. Camps" 5 => "M. Domine" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin. Cancer Res" "fecha" => "2002" "volumen" => "8" "numero" => "7" "paginaInicial" => "2286" "paginaFinal" => "2291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12114432" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bb0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non-smal cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.R. Simon" 1 => "A. Sharma" 2 => "X. Li" 3 => "T. Hazelton" 4 => "F. Walsh" 5 => "C. Williams" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2007" "paginaInicial" => "25" ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bb0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Bepler" 1 => "I. Kusmartseva" 2 => "S. Sharma" 3 => "A. Gautam" 4 => "A. Cantor" 5 => "A. Sharma" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2006.06.1101" "Revista" => array:7 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2006" "volumen" => "24" "numero" => "29" "paginaInicial" => "4731" "paginaFinal" => "4737" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16966686" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bb0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase II study of sequential gemcitabine (G) and carboplatin (C) followed by docetaxel (D) as first-line chemotherapy for patients with advanced non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Chiappori" 1 => "G. Simon" 2 => "C. Rocha Lima" 3 => "C. Williams" 4 => "E. Haura" 5 => "J. Vaughn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lung Cancer" "fecha" => "2005" "volumen" => "41" "numero" => "2" "paginaInicial" => "S225" ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bb0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Customizing cisplatin based chemotherapy on quantitative excision repair cross-complementing 1 mRNA expression: a phase III randomized trial in non-small cell lung cancer. The 31st Congress of the European Society of Medical Oncology, 30 September – 3 October 2006; Istanbul, Turkey" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "R. Rosell" 1 => "D. Gandara" 2 => "M. Cobo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Ann Oncol" "fecha" => "2006" "volumen" => "17" "numero" => "suppl 9" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bb0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC 1 and RRM1 gene expressions but EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Ceppi" 1 => "M. Vollante" 2 => "S. Novello" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/annonc/mdl300" "Revista" => array:6 [ "tituloSerie" => "Ann Oncol" "fecha" => "2006" "volumen" => "17" "paginaInicial" => "1818" "paginaFinal" => "1825" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16980606" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bb0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ribonucleotide reductase M1 (RRM1) 2464G<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>A polymorphism shows an association with gemcitabine chemosensitivity in cancer cell lines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "W.S. Kwon" 1 => "S.Y. Rha" 2 => "Y.H. Choi" 3 => "J.O. Lee" 4 => "K.H. Park" 5 => "J.J. Jung" 6 => "T.S. Kim" 7 => "H.-C. Jeung" 8 => "H.C. Chung" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.fpc.0000204999.29924.da" "Revista" => array:8 [ "tituloSerie" => "Pharmacogenetics and Genomics" "fecha" => "2006" "volumen" => "16" "numero" => "6" "paginaInicial" => "429" "paginaFinal" => "438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16708051" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0190962212022992" "estado" => "S300" "issn" => "01909622" ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bb0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "W. Zhou" 1 => "S. Gurubhagavatula" 2 => "G. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1078-0432.CCR-04-0247" "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2004" "volumen" => "10" "paginaInicial" => "4939" "paginaFinal" => "4943" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15297394" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bb0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Single nucleotide polymorphisms and outcome in docetaxel – cisplatin – treated advanced non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D. Isla" 1 => "C. Sarries" 2 => "R. Rosell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/annonc/mdh319" "Revista" => array:6 [ "tituloSerie" => "Ann Oncol" "fecha" => "2004" "volumen" => "15" "paginaInicial" => "1194" "paginaFinal" => "1203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15277258" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bb0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Automated quantitative analysis (AQUA) of in situ protein expression, antibody concentration, and prognosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. McCabe" 1 => "M. Dolled-Filhart" 2 => "R.L. Camp" 3 => "D.L. Rimm" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jnci/dji427" "Revista" => array:7 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2005" "volumen" => "97" "numero" => "24" "paginaInicial" => "1808" "paginaFinal" => "1815" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16368942" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bb0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ERCC1 measurements in clinical oncology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E. Reed" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMe068162" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "355" "paginaInicial" => "1054" "paginaFinal" => "1055" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16957152" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bb0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA repair: a double-edged sword" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Q. Wei" 1 => "M.L. Frazier" 2 => "B. Levin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2000" "volumen" => "92" "paginaInicial" => "440" "paginaFinal" => "441" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10716953" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bb0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA repair and survival in lung cancer – the two faces of Janus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.F. Gazdar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMp068308" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "paginaInicial" => "771" "paginaFinal" => "773" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17314336" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001500000004/v1_201509151451/S0873215915301641/v1_201509151451/pt/main.assets" "Apartado" => array:4 [ "identificador" => "43376" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Cadernos de Anatomia Patológica" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001500000004/v1_201509151451/S0873215915301641/v1_201509151451/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915301641?idApp=UINPBA00004E" ]
Article information
ISSN: 08732159Original language: Portuguese
The statistics are updated each day
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 1 | 3 |
| 2024 October | 43 | 28 | 71 |
| 2024 September | 26 | 24 | 50 |
| 2024 August | 44 | 37 | 81 |
| 2024 July | 34 | 40 | 74 |
| 2024 June | 24 | 19 | 43 |
| 2024 May | 34 | 43 | 77 |
| 2024 April | 33 | 36 | 69 |
| 2024 March | 27 | 29 | 56 |
| 2024 February | 46 | 32 | 78 |
| 2024 January | 30 | 23 | 53 |
| 2023 December | 27 | 35 | 62 |
| 2023 November | 26 | 29 | 55 |
| 2023 October | 13 | 35 | 48 |
| 2023 September | 23 | 40 | 63 |
| 2023 August | 26 | 18 | 44 |
| 2023 July | 21 | 30 | 51 |
| 2023 June | 27 | 12 | 39 |
| 2023 May | 26 | 23 | 49 |
| 2023 April | 27 | 15 | 42 |
| 2023 March | 18 | 28 | 46 |
| 2023 February | 16 | 26 | 42 |
| 2023 January | 28 | 25 | 53 |
| 2022 December | 17 | 24 | 41 |
| 2022 November | 54 | 42 | 96 |
| 2022 October | 31 | 30 | 61 |
| 2022 September | 20 | 43 | 63 |
| 2022 August | 39 | 45 | 84 |
| 2022 July | 29 | 42 | 71 |
| 2022 June | 21 | 42 | 63 |
| 2022 May | 43 | 37 | 80 |
| 2022 April | 25 | 48 | 73 |
| 2022 March | 27 | 28 | 55 |
| 2022 February | 26 | 37 | 63 |
| 2022 January | 32 | 35 | 67 |
| 2021 December | 29 | 48 | 77 |
| 2021 November | 32 | 26 | 58 |
| 2021 October | 29 | 37 | 66 |
| 2021 September | 32 | 37 | 69 |
| 2021 August | 20 | 23 | 43 |
| 2021 July | 35 | 23 | 58 |
| 2021 June | 23 | 41 | 64 |
| 2021 May | 19 | 40 | 59 |
| 2021 April | 59 | 52 | 111 |
| 2021 March | 41 | 20 | 61 |
| 2021 February | 49 | 20 | 69 |
| 2021 January | 39 | 16 | 55 |
| 2020 December | 26 | 8 | 34 |
| 2020 November | 53 | 15 | 68 |
| 2020 October | 32 | 20 | 52 |
| 2020 September | 57 | 21 | 78 |
| 2020 August | 57 | 36 | 93 |
| 2020 July | 45 | 22 | 67 |
| 2020 June | 42 | 16 | 58 |
| 2020 May | 64 | 19 | 83 |
| 2020 April | 46 | 12 | 58 |
| 2020 March | 45 | 11 | 56 |
| 2020 February | 48 | 22 | 70 |
| 2020 January | 45 | 17 | 62 |
| 2019 December | 52 | 25 | 77 |
| 2019 November | 43 | 11 | 54 |
| 2019 October | 36 | 18 | 54 |
| 2019 September | 49 | 20 | 69 |
| 2019 August | 60 | 24 | 84 |
| 2019 July | 40 | 12 | 52 |
| 2019 June | 34 | 25 | 59 |
| 2019 May | 59 | 40 | 99 |
| 2019 April | 53 | 25 | 78 |
| 2019 March | 36 | 17 | 53 |
| 2019 February | 69 | 21 | 90 |
| 2019 January | 50 | 23 | 73 |
| 2018 December | 16 | 12 | 28 |
| 2018 November | 8 | 0 | 8 |
| 2018 October | 6 | 6 | 12 |
| 2018 September | 15 | 8 | 23 |
| 2018 August | 40 | 19 | 59 |
| 2018 July | 36 | 24 | 60 |
| 2018 June | 40 | 15 | 55 |
| 2018 May | 43 | 14 | 57 |
| 2018 April | 43 | 29 | 72 |
| 2018 March | 44 | 33 | 77 |
| 2018 February | 19 | 9 | 28 |
| 2018 January | 30 | 9 | 39 |
| 2017 December | 55 | 19 | 74 |
| 2017 November | 41 | 10 | 51 |
| 2017 October | 33 | 15 | 48 |
| 2017 September | 18 | 12 | 30 |
| 2017 August | 24 | 12 | 36 |
| 2017 July | 19 | 7 | 26 |
| 2017 June | 24 | 15 | 39 |
| 2017 May | 46 | 9 | 55 |
| 2017 April | 11 | 8 | 19 |
| 2017 March | 19 | 28 | 47 |
| 2017 February | 16 | 6 | 22 |
| 2017 January | 12 | 7 | 19 |
| 2016 December | 17 | 10 | 27 |
| 2016 November | 10 | 2 | 12 |
| 2016 October | 12 | 8 | 20 |
| 2016 September | 3 | 1 | 4 |
| 2016 August | 4 | 2 | 6 |
| 2016 July | 4 | 1 | 5 |
| 2016 May | 0 | 6 | 6 |
| 2016 April | 11 | 2 | 13 |
| 2016 March | 4 | 2 | 6 |
| 2016 February | 2 | 13 | 15 |
| 2016 January | 14 | 6 | 20 |
| 2015 December | 7 | 2 | 9 |
| 2015 November | 6 | 1 | 7 |
| 2015 October | 2 | 6 | 8 |
Show all
