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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Portugal apresenta uma das taxas de incid&#234;ncia de tuberculose mais altas da Uni&#227;o Europeia&#44; tendo a Regi&#227;o de Sa&#250;de de Lisboa uma taxa de incid&#234;ncia muito acima da m&#233;dia nacional&#46; O presente estudo analisa a transmiss&#227;o&#44; susceptibilidade aos antibacilares e caracter&#237;sticas de uma popula&#231;&#227;o de estudo de um hospital central de Lisboa&#46; Cento e trinta e dois isolados cl&#237;nicos de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> foram pre-viamente testados quanto &#224; susceptibilidade aos antibacilares de primeira linha&#46; A taxa de multirresist&#234;ncia encontrada foi de 3&#44;0&#37;&#44; enquanto 13&#44;6&#37; dos isolados eram resistentes a um ou mais antibacilares de primeira linha&#46; A serologia para o VIH estava dispon&#237;vel para 98 doentes&#44; 26 &#40;26&#44;5&#37;&#41; eram positivos&#46; Os isolados foram genotipados por MIRU-VNTR e 53 &#40;40&#44;2&#37;&#41; dos 132 isolados encontravam-se distribu&#237;dos por 17 <span class="elsevierStyleItalic">clusters</span> MIRU-VNTR diferentes de dois ou mais isolados&#46; De todos os isolados analisados&#44; 25&#44;8&#37; perten-ciam &#224; fam&#237;lia Lisboa&#46; Conclu&#237;mos que a transmiss&#227;o de estirpes de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#44; resistentes e suscept&#237;veis&#44; est&#225; a ocorrer&#44; com especial preocupa&#231;&#227;o para as estirpes Lisboa&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;5&#41;&#58; 761-769</span></p></span>"
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Artigo Original/Original Article
Análise genotípica de isolados de Mycobacterium tuberculosis de um hospital em Lisboa, Portugal
Genotypic analysis of Mycobacterium tuberculosis isolates from a Lisbon hospital in Portugal
João Perdigão1, Catarina Milho2, Lurdes Carrilho3, Laura Brum4, Isabel Portugal5,
Corresponding author
isabel.portugal@ff.ul.pt

Correspondência/Correspondence to: Isabel Portugal, Centro de Patogénese Molecular, URIA, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
1 Licenciado em biologia microbiana e genética, mestre em biologia molecular e genética, Aluno de doutoramento em microbiologia/BsC, Microbiology and Genetics. MsC Molecular Biology and Genetics. PhD Microbiology (partway)
2 Licenciada em microbiologia/BsC, Microbiology Molecular Centro de Patogénese Molecular, URIA, Faculdade de Farmácia da Universidade de Lisboa, Portugal/Molecular Pathogenesis Centre, URIA, School of Pharmacy, Universidade de Lisboa, Portugal
3 Secção de Micobactérias do Serviço de Patologia Clínica do Hospital de Pulido Valente, Lisboa, Portugal/Mycobacteria Section, Clinical Pathology Unit, Hospital de Pulido Valente, Lisboa, Portugal
4 Professora auxiliar convidada da Faculdade de Ciências Médicas da Universidade Nova de Lisboa. Assessora de Bacteriologia do Instituto Nacional de Saúde Dr. Ricardo Jorge. Departamento de Doenças Infecciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal/Assistant Guest Professor, School of Medical Sciences, Universidade Nova de Lisboa. Bacteriology assistant, Instituto Nacional de Saúde Dr. Ricardo Jorge. Department of Infectious Diseases, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal
5 Professora auxiliar da Faculdade de Farmácia da Universidade de Lisboa. Investigadora visitante do Instituto Nacional de Saúde Dr. Ricardo Jorge, Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Portugal. Departamento de Doenças Infecciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal/Guest Professor, School of Pharmacy, Universidade de Lisboa. Visiting Researcher, Instituto Nacional de Saúde Dr. Ricardo Jorge, Molecular Pathogenesis Centre, School of Pharmacy, Universidade de Lisboa, Portugal. Department of Infectious Diseases, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal
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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Portugal apresenta uma das taxas de incid&#234;ncia de tuberculose mais altas da Uni&#227;o Europeia&#44; tendo a Regi&#227;o de Sa&#250;de de Lisboa uma taxa de incid&#234;ncia muito acima da m&#233;dia nacional&#46; O presente estudo analisa a transmiss&#227;o&#44; susceptibilidade aos antibacilares e caracter&#237;sticas de uma popula&#231;&#227;o de estudo de um hospital central de Lisboa&#46; Cento e trinta e dois isolados cl&#237;nicos de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> foram pre-viamente testados quanto &#224; susceptibilidade aos antibacilares de primeira linha&#46; A taxa de multirresist&#234;ncia encontrada foi de 3&#44;0&#37;&#44; enquanto 13&#44;6&#37; dos isolados eram resistentes a um ou mais antibacilares de primeira linha&#46; A serologia para o VIH estava dispon&#237;vel para 98 doentes&#44; 26 &#40;26&#44;5&#37;&#41; eram positivos&#46; Os isolados foram genotipados por MIRU-VNTR e 53 &#40;40&#44;2&#37;&#41; dos 132 isolados encontravam-se distribu&#237;dos por 17 <span class="elsevierStyleItalic">clusters</span> MIRU-VNTR diferentes de dois ou mais isolados&#46; De todos os isolados analisados&#44; 25&#44;8&#37; perten-ciam &#224; fam&#237;lia Lisboa&#46; Conclu&#237;mos que a transmiss&#227;o de estirpes de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#44; resistentes e suscept&#237;veis&#44; est&#225; a ocorrer&#44; com especial preocupa&#231;&#227;o para as estirpes Lisboa&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;5&#41;&#58; 761-769</span></p></span>"
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Article information
ISSN: 08732159
Original language: Portuguese
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