Correspondência/Correspondence to: Isabel Portugal, Centro de Patogénese Molecular, URIA, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
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=> true "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original/Original Article</span>" "titulo" => "Análise genotípica de isolados de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> de um hospital em Lisboa, Portugal" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "761" "paginaFinal" => "769" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "João Perdigão, Catarina Milho, Lurdes Carrilho, Laura Brum, Isabel Portugal" "autores" => array:5 [ 0 => array:3 [ "nombre" => "João" "apellidos" => "Perdigão" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Catarina" "apellidos" => "Milho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 2 => array:3 [ "nombre" => "Lurdes" "apellidos" => "Carrilho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "af0015" ] ] ] 3 => array:3 [ "nombre" => "Laura" "apellidos" => "Brum" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "af0020" ] ] ] 4 => array:4 [ "nombre" => "Isabel" "apellidos" => "Portugal" "email" => array:1 [ 0 => "isabel.portugal@ff.ul.pt" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "af0025" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cr0005" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Licenciado em biologia microbiana e genética, mestre em biologia molecular e genética, Aluno de doutoramento em microbiologia/<span class="elsevierStyleItalic">BsC, Microbiology and Genetics. MsC Molecular Biology and Genetics. PhD Microbiology (partway)</span>" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Licenciada em microbiologia/<span class="elsevierStyleItalic">BsC, Microbiology Molecular</span> Centro de Patogénese Molecular, URIA, Faculdade de Farmácia da Universidade de Lisboa, Portugal/<span class="elsevierStyleItalic">Molecular Pathogenesis Centre, URIA, School of Pharmacy, Universidade de Lisboa, Portugal</span>" "etiqueta" => "2" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Secção de Micobactérias do Serviço de Patologia Clínica do Hospital de Pulido Valente, Lisboa, Portugal/<span class="elsevierStyleItalic">Mycobacteria Section, Clinical Pathology Unit, Hospital de Pulido Valente, Lisboa, Portugal</span>" "etiqueta" => "3" "identificador" => "af0015" ] 3 => array:3 [ "entidad" => "Professora auxiliar convidada da Faculdade de Ciências Médicas da Universidade Nova de Lisboa. Assessora de Bacteriologia do Instituto Nacional de Saúde Dr. Ricardo Jorge. Departamento de Doenças Infecciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal/<span class="elsevierStyleItalic">Assistant Guest Professor, School of Medical Sciences, Universidade Nova de Lisboa. Bacteriology assistant, Instituto Nacional de Saúde Dr. Ricardo Jorge. Department of Infectious Diseases, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal</span>" "etiqueta" => "4" "identificador" => "af0020" ] 4 => array:3 [ "entidad" => "Professora auxiliar da Faculdade de Farmácia da Universidade de Lisboa. Investigadora visitante do Instituto Nacional de Saúde Dr. Ricardo Jorge, Centro de Patogénese Molecular, Faculdade de Farmácia da Universidade de Lisboa, Portugal. Departamento de Doenças Infecciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal/<span class="elsevierStyleItalic">Guest Professor, School of Pharmacy, Universidade de Lisboa. Visiting Researcher, Instituto Nacional de Saúde Dr. Ricardo Jorge, Molecular Pathogenesis Centre, School of Pharmacy, Universidade de Lisboa, Portugal. Department of Infectious Diseases, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal</span>" "etiqueta" => "5" "identificador" => "af0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "*" "correspondencia" => "<span class="elsevierStyleBold">Correspondência/<span class="elsevierStyleItalic">Correspondence to:</span></span> Isabel Portugal, Centro de Patogénese Molecular, URIA, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Genotypic analysis of Mycobacterium tuberculosis isolates from a Lisbon hospital in Portugal" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-03-30" "fechaAceptado" => "2009-04-17" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570181" "palabras" => array:4 [ 0 => "Família Lisboa" 1 => "tuberculose" 2 => "multirresistência" 3 => "MIRU" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570180" "palabras" => array:4 [ 0 => "Lisboa family" 1 => "tuberculosis" 2 => "multidrug resistance" 3 => "MIRU" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Portugal apresenta uma das taxas de incidência de tuberculose mais altas da União Europeia, tendo a Região de Saúde de Lisboa uma taxa de incidência muito acima da média nacional. O presente estudo analisa a transmissão, susceptibilidade aos antibacilares e características de uma população de estudo de um hospital central de Lisboa. Cento e trinta e dois isolados clínicos de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> foram pre-viamente testados quanto à susceptibilidade aos antibacilares de primeira linha. A taxa de multirresistência encontrada foi de 3,0%, enquanto 13,6% dos isolados eram resistentes a um ou mais antibacilares de primeira linha. A serologia para o VIH estava disponível para 98 doentes, 26 (26,5%) eram positivos. Os isolados foram genotipados por MIRU-VNTR e 53 (40,2%) dos 132 isolados encontravam-se distribuídos por 17 <span class="elsevierStyleItalic">clusters</span> MIRU-VNTR diferentes de dois ou mais isolados. De todos os isolados analisados, 25,8% perten-ciam à família Lisboa. Concluímos que a transmissão de estirpes de <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>, resistentes e susceptíveis, está a ocorrer, com especial preocupação para as estirpes Lisboa.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (5): 761-769</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Portugal has one of the highest tuberculosis notification rates of the European Union with Lisbon Health Region having an incidence rate well above the national average. The present study analyses the transmission, drug susceptibility and characteristics of a study population from a Central Lisbon’s Hospital. One hundred and thirty-two <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> clinical isolates were previously tested for drug susceptibility to first-line drugs. The multidrug (MDR) resistance rate was found to be 3.0%, while 13.6% of the isolates were resistant to one or more first-line drugs. HIV serology was available for 98 patients, 26 (26.5%) were positive. Genotyping was performed by MIRU-VNTR and 53 (40,2%) out of the 132 isolates were found to be distributed through 17 MIRU-VNTR clusters of two or more isolates. Lisboa strains accounted for 25.8% of all strains. We conclude that transmission of resistant and susceptible <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> strains is occurring, with special concern for Lisboa strains.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009; XV (5): 761-769</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surveillance of tuberculosis cases in Europe" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.B. Euro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Report on tuberculosis cases notified in 2006" "fecha" => "2008" "editorial" => "Institut de veille sanitaire" "editorialLocalizacion" => "Saint-Maurice, France" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Programa Nacional de Luta contra a Tuberculose" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "DGS" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Tuberculose: Ponto da Situação em Portugal em 2006, dados preliminares em Março 2007" "fecha" => "2007" "editorial" => "Direcção-Geral de Saúde" "editorialLocalizacion" => "Lisbon, Portugal" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multidrug-resistant tuberculosis in Lisbon, Portugal: A Molecular Epidemiological Perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "J. Perdigão" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/mdr.2008.0798" "Revista" => array:7 [ "tituloSerie" => "Microb Drug Resist" "fecha" => "2008" "volumen" => "14" "numero" => "2" "paginaInicial" => "133" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18573039" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." 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Portugal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "1999" "volumen" => "3" "numero" => "3" "paginaInicial" => "207" "paginaFinal" => "213" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10094321" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Discrimination of multidrug-resistant <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> IS6110 fingerprint subclusters by rpoB gene mutation analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I. Portugal" 1 => "S. Maia" 2 => "J. 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Original language: Portuguese
Year/Month | Html | Total | |
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2024 October | 47 | 45 | 92 |
2024 September | 32 | 35 | 67 |
2024 August | 38 | 47 | 85 |
2024 July | 38 | 31 | 69 |
2024 June | 21 | 36 | 57 |
2024 May | 26 | 35 | 61 |
2024 April | 32 | 29 | 61 |
2024 March | 24 | 25 | 49 |
2024 February | 28 | 35 | 63 |
2024 January | 18 | 21 | 39 |
2023 December | 26 | 24 | 50 |
2023 November | 17 | 30 | 47 |
2023 October | 16 | 28 | 44 |
2023 September | 26 | 33 | 59 |
2023 August | 23 | 16 | 39 |
2023 July | 22 | 26 | 48 |
2023 June | 19 | 13 | 32 |
2023 May | 24 | 22 | 46 |
2023 April | 25 | 18 | 43 |
2023 March | 26 | 30 | 56 |
2023 February | 19 | 24 | 43 |
2023 January | 19 | 17 | 36 |
2022 December | 21 | 26 | 47 |
2022 November | 39 | 35 | 74 |
2022 October | 28 | 36 | 64 |
2022 September | 21 | 35 | 56 |
2022 August | 37 | 43 | 80 |
2022 July | 22 | 42 | 64 |
2022 June | 21 | 35 | 56 |
2022 May | 38 | 35 | 73 |
2022 April | 22 | 34 | 56 |
2022 March | 31 | 25 | 56 |
2022 February | 21 | 34 | 55 |
2022 January | 30 | 38 | 68 |
2021 December | 29 | 43 | 72 |
2021 November | 26 | 27 | 53 |
2021 October | 25 | 45 | 70 |
2021 September | 24 | 41 | 65 |
2021 August | 13 | 12 | 25 |
2021 July | 30 | 25 | 55 |
2021 June | 14 | 20 | 34 |
2021 May | 20 | 28 | 48 |
2021 April | 30 | 53 | 83 |
2021 March | 36 | 31 | 67 |
2021 February | 50 | 10 | 60 |
2021 January | 25 | 18 | 43 |
2020 December | 27 | 10 | 37 |
2020 November | 42 | 15 | 57 |
2020 October | 30 | 26 | 56 |
2020 September | 61 | 23 | 84 |
2020 August | 94 | 22 | 116 |
2020 July | 80 | 23 | 103 |
2020 June | 70 | 18 | 88 |
2020 May | 59 | 21 | 80 |
2020 April | 60 | 10 | 70 |
2020 March | 66 | 10 | 76 |
2020 February | 122 | 46 | 168 |
2020 January | 70 | 17 | 87 |
2019 December | 68 | 25 | 93 |
2019 November | 71 | 14 | 85 |
2019 October | 74 | 20 | 94 |
2019 September | 59 | 29 | 88 |
2019 August | 107 | 14 | 121 |
2019 July | 100 | 14 | 114 |
2019 June | 111 | 7 | 118 |
2019 May | 71 | 37 | 108 |
2019 April | 95 | 21 | 116 |
2019 March | 161 | 15 | 176 |
2019 February | 149 | 14 | 163 |
2019 January | 153 | 18 | 171 |
2018 December | 91 | 11 | 102 |
2018 November | 28 | 1 | 29 |
2018 October | 31 | 7 | 38 |
2018 September | 15 | 9 | 24 |
2018 August | 40 | 19 | 59 |
2018 July | 27 | 30 | 57 |
2018 June | 54 | 18 | 72 |
2018 May | 59 | 28 | 87 |
2018 April | 42 | 23 | 65 |
2018 March | 59 | 32 | 91 |
2018 February | 21 | 11 | 32 |
2018 January | 27 | 22 | 49 |
2017 December | 38 | 14 | 52 |
2017 November | 37 | 12 | 49 |
2017 October | 29 | 11 | 40 |
2017 September | 19 | 12 | 31 |
2017 August | 22 | 15 | 37 |
2017 July | 19 | 12 | 31 |
2017 June | 20 | 13 | 33 |
2017 May | 40 | 13 | 53 |
2017 April | 15 | 3 | 18 |
2017 March | 12 | 3 | 15 |
2017 February | 15 | 1 | 16 |
2017 January | 14 | 5 | 19 |
2016 December | 15 | 3 | 18 |
2016 November | 9 | 2 | 11 |
2016 October | 9 | 7 | 16 |
2016 September | 2 | 1 | 3 |
2016 August | 5 | 2 | 7 |
2016 July | 5 | 4 | 9 |
2016 May | 0 | 6 | 6 |
2016 April | 1 | 3 | 4 |
2016 March | 2 | 11 | 13 |
2016 February | 3 | 11 | 14 |
2016 January | 7 | 5 | 12 |
2015 December | 7 | 4 | 11 |
2015 November | 6 | 2 | 8 |
2015 October | 2 | 3 | 5 |