Reclassificação do carcinoma broncopulmonar: Diferenciação do tipo histológico em biópsias por imuno-histoquímica

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"https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087321591530194X?idApp=UINPBA00004E" "url" => "/08732159/0000001500000006/v1_201509151513/S087321591530194X/v1_201509151513/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "Artigo de Revisão/Review Article" "titulo" => "Reclassificação do carcinoma broncopulmonar: Diferenciação do tipo histológico em biópsias por imuno-histoquímica" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1101" "paginaFinal" => "1119" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Lina Carvalho" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Lina" "apellidos" => "Carvalho" "email" => array:1 [ 0 => "lcarvalho@huc.min-saude.pt" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cr0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Professora de Anatomia Patológica, Chefe de Serviço dos Hospitais da Universidade de Coimbra" "etiqueta" => "1" "identificador" => "af0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "*" "correspondencia" => "Lina Carvalho Anatomia Patológica Hospitais da Universidade de Coimbra 3000 Coimbra; Portugal." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Reclassifying bronchial-pulmonary carcinoma: Differentiating histological type in biopsies by immunohistochemistry" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-04-28" "fechaAceptado" => "2009-05-19" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570341" "palabras" => array:2 [ 0 => "Carcinoma broncopulmonar" 1 => "imunoistoquímica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570342" "palabras" => array:2 [ 0 => "Bronchial-pulmonary carcinoma" 1 => "immunohistochemistry" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "Os conhecimentos actuais da patologia molecular do cancro do pulmão requerem outra caracterização histológica, para além de carcinoma de células pequenas e carcinoma não pequenas células para suporte da terapia personalizada e entendimento do valor real dos fármacos actualmente disponíveis.Como o diagnóstico e seguimento clínico da maioria dos casos de cancro do pulmão se baseia em produtos de biópsia e citologia, a classificação imunoistoquímica do carcinoma broncopulmonar (IBPCC) é necessária para suporte morfológico da classificação da WHO 1999/2004, clarificando as características celulares das neoplasias e o entendimento da carcinogénese.O painel imunoistoquímico reforça os tipos histológicos principais do carcinoma bronco – pulmonar: carcinoma epidermóide (queratinas de alto peso molecular – HWMC), carcinoma adenoscamoso (CK/ /TTF1, MWMC), carcinoma neuroendócrino (Chrg, Syn, CD56, TTF1, Ki67) e adenocarcinoma (CK7, Ck20, TTF1); as variantes do carcinoma de células grandes e do carcinoma sarcomatóide são englobados num único grupo de carcinomas pleomórficos (CK7, TTF1, HWMC, VMT, desmina, actina), onde cabe o polimorfismo e o pleomorfismo celular.A quimioterapia do carcinoma broncopulmonar continuará baseada no platino e na gemcitabina no futuro próximo e a IBPCC será uma ferramenta simples e eficiente para o registo das características e tipos histológicos do carcinoma do pulmão presentes nas biópsias e amostras citológicas para suporte da evidência clínica e dos ensaios farmacêuticos.Rev Port Pneumol 2009; XV (6): 1101-1119" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "The current state of molecular knowledge on lung cancer demands a histological classification which goes beyond small-cell and non-small-cell carcinoma to provide support for tailored therapy in aiding in understanding of the drugs currently available.As diagnosis and follow-up in the vast majority of lung cancer cases is based on biopsies and cytology samples, Immunohistochemical Bronchial Pulmonary Carcinoma Classification (IBPCC) is necessary to reveal the raft of characteristics available. This provides morphological support for the WHO’s 1999/2004 classification, in addition to an understanding of carcinogenesis.The immunohistochemical panel clarifies the main morphology and cytology characteristics to maintain the leading histological types as squamous cell carcinoma (high weight molecular cytokeratins/HWMC), adenosquamous carcinoma (CK7, TTF1, HWMA), neuroendocrine carcinoma (Chrg, Syn, CD56, TTF1, Ki67), adenocarcinoma (CK7, CK20, TTF1) and bring the polymorphic and pleomorphic carcinomas under a single banner of pleomorphic carcinoma (Ck7, TTF1, HWMC, VMT, Desmin, Actin) which shelters large cell carcinomas and sarcomatoid carcinomas.Lung cancer chemotherapy will still be based on platinum and gemcitabine for the near future and the IBPCC is a simple and efficient tool for streamlining the registration of lung cancer histological characteristics in biopsies and other reduced samples to support clinical evidence and trials.Rev Port Pneumol 2009; XV (6): 1101-1119" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:80 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancro: Cronologia histórica e génese de ideias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.A. Bernarda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "1996" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histological lung cancer types" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Kreyberg" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Pathologica e Microbiologica Scandinavica" "fecha" => "1962" "volumen" => "157" "paginaInicial" => "1" "paginaFinal" => "93" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Kreyberg" 1 => "A.A. Liebow" 2 => "E.A. Uehlinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Histological typing of lung tumours" "fecha" => "1969" "editorial" => "World Health Organization" "editorialLocalizacion" => "Geneva" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "The World Health Organization histological typing of lung tumours" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "1982" "volumen" => "77" "paginaInicial" => "123" "paginaFinal" => "136" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7064914" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673603138032" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumours of the lung, pleura, thymus and heart. Pathology and Genetics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Travis" 1 => "E. Brambilla" 2 => "H.K. Muller-Hermelink" 3 => "C. Harris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "World Health Organization Classification of Tumours" "fecha" => "2004" "editorial" => "IARCPress" "editorialLocalizacion" => "Lyon" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of cigarette smoking on prognosis in small adenocarcinomas of the lung: the association between histologic subtype and smoking status" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Y. Sakao" 1 => "H. Miyamoto" 2 => "S. Oh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/JTO.0b013e31818396e0" "Revista" => array:6 [ "tituloSerie" => "J Thorac Oncol" "fecha" => "2008" "volumen" => "3" "paginaInicial" => "958" "paginaFinal" => "962" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18758296" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.Q. Zhu" 1 => "S.G. da Cunha" 2 => "K. Ding" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2007.14.8924" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2008" "volumen" => "26" "paginaInicial" => "4268" "paginaFinal" => "4275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18626007" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "F.R. Hirsch" 1 => "R.S. Herbst" 2 => "C. Olsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2007.14.0111" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2008" "volumen" => "26" "paginaInicial" => "3351" "paginaFinal" => "3357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18612151" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Projecto de estadiamento do cancro do pulmão pela IASLC: Estudo comparativo entre a 6.ª edição TNM em vigor e a 7.ª edição proposta" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Carvalho" 1 => "E. Cardoso" 2 => "H. Nunes" 3 => "V. Baptista" 4 => "A. Gomes" 5 => "P. Couceiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2009" "volumen" => "15" "numero" => "1" "paginaInicial" => "67" "paginaFinal" => "76" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19145388" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "M. Varella-Garcia" 1 => "T. Mitsudomi" 2 => "Y. Yatabe" 3 => "T. Kosaka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/JTO.0b013e31819667a3" "Revista" => array:7 [ "tituloSerie" => "J Thorac Oncol" "fecha" => "2009" "volumen" => "4" "numero" => "3" "paginaInicial" => "318" "paginaFinal" => "325" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19247083" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Class III beta-tubulin expression and benefit from adjuvant cisplatin/vinorelbine chemotherapy in operable non-small cell lung cancer: analysis of NCIC JBR 10" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Seve" 1 => "R. Lai" 2 => "K. Ding" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1078-0432.CCR-06-1503" "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "994" "paginaFinal" => "999" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289895" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Class III beta-tubulin is a marker of paclitaxel resistance in carcinomas of unknown primary site" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Seve" 1 => "T. Reiman" 2 => "R. Lai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00280-006-0343-1" "Revista" => array:6 [ "tituloSerie" => "Cancer Chemother Pharmacol" "fecha" => "2007" "volumen" => "60" "paginaInicial" => "27" "paginaFinal" => "34" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17021819" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tissue handling and specimen preparation in surgical pathology: issues concerning the recovery of nucleic acids from formalin-fixed, paraffin-embedded tissue" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.M. Hewitt" 1 => "F.A. Lewis" 2 => "Y. Cao" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1043/1543-2165-132.12.1929" "Revista" => array:6 [ "tituloSerie" => "Arch Pathol Lab Med" "fecha" => "2008" "volumen" => "132" "paginaInicial" => "1929" "paginaFinal" => "1935" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19061293" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E. Giovannetti" 1 => "V. Mey" 2 => "S. Nannizzi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1124/mol.104.009373" "Revista" => array:6 [ "tituloSerie" => "Mol Pharmacol" "fecha" => "2005" "volumen" => "68" "paginaInicial" => "110" "paginaFinal" => "118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15795320" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mode of spread in the early phase of lymphatic metastasis in non-small-cell lung cancer: significance of nodal micrometastasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.R. Izbicki" 1 => "B. Passlick" 2 => "S.B. Hosch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0022-5223(96)70044-2" "Revista" => array:6 [ "tituloSerie" => "J Thorac Cardiovasc Surg" "fecha" => "1996" "volumen" => "112" "paginaInicial" => "623" "paginaFinal" => "630" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8800148" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Ceppi" 1 => "M. Volante" 2 => "S. Saviozzi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.22208" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "2006" "volumen" => "107" "paginaInicial" => "1589" "paginaFinal" => "1596" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16955506" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wild type of exons 19 and 21 and polysomy of chromosome 7 were defined for EGFR gene in squamous cell carcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Carvalho" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/JTO.0b013e31817c60ae" "Revista" => array:7 [ "tituloSerie" => "Journal of Thoracic Oncology" "fecha" => "2008" "volumen" => "3" "numero" => "4" "paginaInicial" => "S1:S35" "paginaFinal" => "S36" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18594313" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Squamous cell carcinoma of the lung: polysomy of chromosome 7 and wild type of exon 19 and 21 were defined for EGFR gene" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "V. Sousa" 1 => "M. Silva" 2 => "A. Alarcão" 3 => "P. Couceiro" 4 => "A. Gomes" 5 => "L. Carvalho" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00428-008-0613-x" "Revista" => array:6 [ "tituloSerie" => "Virchows Archiv" "fecha" => "2008" "volumen" => "452" "numero" => "S1" "paginaInicial" => "S1" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18458984" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) gene regulation in the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V. Boggaram" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Sci (Lond)" "fecha" => "2009" "volumen" => "116" "paginaInicial" => "27" "paginaFinal" => "35" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pemetrexed in second line treatment of non-small cell lung cancer. The Portuguese experience" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Araujo" 1 => "F. Barata" 2 => "B. Parente" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2008" "volumen" => "XIV" "numero" => "Supl 2" "paginaInicial" => "S9" "paginaFinal" => "S20" "itemHostRev" => array:3 [ "pii" => "S0016508513018076" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bb0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathologist and molecular biologist, ever the twain shall meet?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K.M. Kerr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.lungcan.2008.10.010" "Revista" => array:6 [ "tituloSerie" => "Lung Cancer" "fecha" => "2009" "volumen" => "63" "paginaInicial" => "161" "paginaFinal" => "163" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19027983" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bb0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroid transcription factor-1 distinguishes metastatic pulmonary from well-differentiated neuroendocrine tumors of other sites" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.M. Oliveira" 1 => "H.D. Tazelaar" 2 => "J.L. Myers" 3 => "L.A. Erickson" 4 => "R.V. Lloyd" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2001" "volumen" => "25" "paginaInicial" => "815" "paginaFinal" => "819" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11395561" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bb0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TGT3, thyroid transcription factor I, and Sp1 elements regulate transcriptional activity of the 1.3-kilobase pair promoter of T1alpha, a lung alveolar type I cell gene" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.I. Ramirez" 1 => "A.K. Rishi" 2 => "Y.X. Cao" 3 => "M.C. Williams" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Biol Chem" "fecha" => "1997" "volumen" => "272" "paginaInicial" => "26 285" "paginaFinal" => "26 294" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bb0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/ NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "E.S. Ngan" 1 => "B.H. Lang" 2 => "T. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/jnci/djn471" "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2009" "volumen" => "101" "paginaInicial" => "162" "paginaFinal" => "175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19176457" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bb0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between morphology and EGFR mutations in lung adenocarcinomas Significance of the micropapillary pattern and the hobnail cell type" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Ninomiya" 1 => "M. Hiramatsu" 2 => "K. Inamura" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.lungcan.2008.04.017" "Revista" => array:6 [ "tituloSerie" => "Lung Cancer" "fecha" => "2009" "volumen" => "63" "paginaInicial" => "235" "paginaFinal" => "240" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18571764" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bb0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroglobulin repression of thyroid transcription factor 1 (TTF-1) gene expression is mediated by decreased DNA binding of nuclear factor I proteins which control constitutive TTF-1 expression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Nakazato" 1 => "H.K. Chung" 2 => "L. Ulianich" 3 => "A. Grassadonia" 4 => "K. Suzuki" 5 => "L.D. Kohn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mol Cell Biol" "fecha" => "2000" "volumen" => "20" "paginaInicial" => "8499" "paginaFinal" => "8512" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11046146" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bb0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N. Motoi" 1 => "J. Szoke" 2 => "G.J. Riely" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/PAS.0b013e31815cb162" "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2008" "volumen" => "32" "paginaInicial" => "810" "paginaFinal" => "827" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18391747" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bb0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary adenocarcinomas: classification and reporting" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. Kerr" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Histopathology" "fecha" => "2009" "volumen" => "54" "numero" => "12" "paginaInicial" => "27" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bb0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchiolar columnar cell dysplasia-genetic analysis of a novel preneoplastic lesion of peripheral lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "R. Ullman" 1 => "M. Bongiovanni" 2 => "I. Halbwedl" 3 => "S. Petzmann" 4 => "M. Gogg-Kammerer" 5 => "A. Sapino" 6 => "M. Papotti" 7 => "G. Bussolati" 8 => "H. Popper" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00428-003-0797-z" "Revista" => array:7 [ "tituloSerie" => "Virchows Archiv" "fecha" => "2003" "volumen" => "442" "numero" => "5" "paginaInicial" => "429" "paginaFinal" => "436" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12684770" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bb0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Brambilla E" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Lantuéjul" 1 => "D. Salameire" 2 => "C. Salon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2559.2008.03182.x" "Revista" => array:6 [ "tituloSerie" => "Pulmonary preneoplasia. sequential molecular carcinogenetic events. Histopathology" "fecha" => "2009" "volumen" => "54" "paginaInicial" => "43" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19187179" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bb0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Small adenocarcinoma of the lung. Histologic characteristics and prognosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Noguchi" 1 => "A. Morikawa" 2 => "M. Kawasaki" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1995" "volumen" => "75" "paginaInicial" => "2844" "paginaFinal" => "2852" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7773933" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bb0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "True papillary carcinoma of the lung: a distinct clinicopathologic entity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.A. Silver" 1 => "F.B. Askin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "1997" "volumen" => "21" "paginaInicial" => "43" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8990140" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bb0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroid transcription factor 1 is an independent prognostic factor for patients with stage I lung adenocarcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "V.K. Anagnostou" 1 => "K.N. Syrigos" 2 => "G. Bepler" 3 => "R.J. Homer" 4 => "D.L. Rimm" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2008.17.0043" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2009" "volumen" => "27" "paginaInicial" => "271" "paginaFinal" => "278" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19064983" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bb0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reproducibility of the diagnosis of small adenocarcinoma of the lung and usefulness of an educational program for the diagnostic criteria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Noguchi" 1 => "Y. Minami" 2 => "T. Iijima" 3 => "Y. Matsuno" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1440-1827.2005.01782.x" "Revista" => array:6 [ "tituloSerie" => "Pathol Int" "fecha" => "2005" "volumen" => "55" "paginaInicial" => "8" "paginaFinal" => "13" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15660697" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bb0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictive biomarkers for EGFR therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Sakurada" 1 => "M.S. Tsao" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "I Drugs" "fecha" => "2009" "volumen" => "12" "paginaInicial" => "34" "paginaFinal" => "38" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19127503" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bb0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemically detected micrometastases in peribronchial and mediastinal lymph nodes from patients with T1, N0, M0 pulmonary adenocarcinomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.S. Goldstein" 1 => "A. Mani" 2 => "G. Chmielewski" 3 => "R. Welsh" 4 => "S. Pursel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2000" "volumen" => "24" "paginaInicial" => "274" "paginaFinal" => "279" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10680895" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bb0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Pohlenz" 1 => "A. Dumitrescu" 2 => "D. Zundel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI14192" "Revista" => array:6 [ "tituloSerie" => "J Clin Invest" "fecha" => "2002" "volumen" => "109" "paginaInicial" => "469" "paginaFinal" => "473" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11854318" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bb0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mesothelioma treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Parente" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2008" "volumen" => "XIV" "numero" => "Sup.2" "paginaInicial" => "S35" "paginaFinal" => "S44" ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bb0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA methylation markers and early recurrence in stage I lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.V. Brock" 1 => "C.M. Hooker" 2 => "E. Ota-Machida" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0706550" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2008" "volumen" => "358" "paginaInicial" => "1118" "paginaFinal" => "1128" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18337602" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bb0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemistry of pulmonary and pleural neoplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.B. Beasly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1043/1543-2165(2008)132[1062:IOPAPN]2.0.CO;2" "Revista" => array:6 [ "tituloSerie" => "Arch Pathol Lab Med" "fecha" => "2008" "volumen" => "132" "paginaInicial" => "1062" "paginaFinal" => "1072" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18605762" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bb0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Problems in mesothelioma diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Addis" 1 => "H. Roche" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2559.2008.03178.x" "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "2009" "volumen" => "54" "paginaInicial" => "55" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19054156" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bb0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Terasaki" 1 => "T. Niki" 2 => "Y. Matsuno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2003" "volumen" => "27" "paginaInicial" => "937" "paginaFinal" => "951" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12826886" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bb0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biomarkers of response to epidermal growth factor receptor inhibitors in Non-small-cell lung cancer working group: standardization for use in the clinical trial setting" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.A. Eberhard" 1 => "G. Giaccone" 2 => "B.E. Johnson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2007.12.9858" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2008" "volumen" => "26" "paginaInicial" => "983" "paginaFinal" => "994" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18281673" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bb0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidermal growth factor receptor mutation status and adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "H. Suehisa" 1 => "S. Toyooka" 2 => "K. Hotta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2007.11.8646" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "3952" "paginaFinal" => "3957" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17761979" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bb0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Z. Zheng" 1 => "T. Chen" 2 => "X. Li" 3 => "E. Haura" 4 => "A. Sharma" 5 => "G. Bepler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa065411" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "paginaInicial" => "800" "paginaFinal" => "808" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17314339" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bb0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic and predictive importance of p53 and RAS for adjuvant chemotherapy in non small-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.S. Tsao" 1 => "S. Viel-Ronen" 2 => "K. Ding" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2007.12.6953" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "5240" "paginaFinal" => "5247" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18024870" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bb0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K.A. Olaussen" 1 => "A. Dunant" 2 => "P. Fouret" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa060570" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "355" "paginaInicial" => "983" "paginaFinal" => "991" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16957145" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bb0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Bepler" 1 => "I. Kusmartseva" 2 => "S. Sharma" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2006.06.1101" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2006" "volumen" => "24" "paginaInicial" => "4731" "paginaFinal" => "4737" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16966686" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bb0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemical expression of estrogen and progesterone receptors in primary pulmonary neuroendocrine tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Sica" 1 => "P.L. Wagner" 2 => "N. Altorki" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1043/1543-2165-132.12.1889" "Revista" => array:6 [ "tituloSerie" => "Arch Pathol Lab Med" "fecha" => "2008" "volumen" => "132" "paginaInicial" => "1889" "paginaFinal" => "1895" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19061285" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bb0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuroendocrine carcinomas of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Moran" 1 => "S. Suster" 2 => "D. Coppola" 3 => "M. Wick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1309/AJCP9H1OTMUCSKQW" "Revista" => array:6 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "2009" "volumen" => "131" "paginaInicial" => "206" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19141381" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bb0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetics of a combined lung small cell carcinoma and large cell neuroendocrine carcinoma with adenocarcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Fellegara" 1 => "T. D’Adda" 2 => "F.P. Pilato" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00428-008-0620-y" "Revista" => array:6 [ "tituloSerie" => "Virchows Arch" "fecha" => "2008" "volumen" => "453" "paginaInicial" => "107" "paginaFinal" => "115" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18551311" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bb0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combined small cell lung carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Wagner" 1 => "N. Kitabayashi" 2 => "Y.-T. Chen" 3 => "A. Saqi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1309/AJCPYNPFL56POZQY" "Revista" => array:6 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "2009" "volumen" => "131" "paginaInicial" => "376" "paginaFinal" => "382" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19228643" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bb0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumorlets, multicentric carcinoids, lymph-nodal metástases and long term behaviour in bronchial carcinoids" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "P. Ferolla" 1 => "N. Daddi" 2 => "M. Urbani" 3 => "A. Semeraro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/JTO.0b013e318197f2e7" "Revista" => array:7 [ "tituloSerie" => "Journal of Thoracic Oncology" "fecha" => "2009" "volumen" => "4" "numero" => "3" "paginaInicial" => "383" "paginaFinal" => "387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19247084" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bb0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Results of systematic nodal dissection in typical nad atypical carcinoid tumors of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Wurtz" 1 => "L. Benhamed" 2 => "M. Conti" 3 => "B. Bouchindhomme" 4 => "H. Porte" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/JTO.0b013e3181951aa6" "Revista" => array:7 [ "tituloSerie" => "Journal of Thoracic Oncology" "fecha" => "2009" "volumen" => "4" "numero" => "3" "paginaInicial" => "388" "paginaFinal" => "394" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19247085" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bb0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thyroid transcription factor 1: a marker for lung adenoarinoma in body cavity fluids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Gomez-Fernandez" 1 => "M. Jorda" 2 => "P.I. Delgado" 3 => "P. Ganjei-Azar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.10743" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "2002" "volumen" => "96" "paginaInicial" => "289" "paginaFinal" => "293" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12378596" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bb0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The synergistic activity of thyroid transcription factor 1 and Pax 8 relies on the promoter/enhancer interplay" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Miccadei" 1 => "L.R. De" 2 => "E. Zammarchi" 3 => "P.G. Natali" 4 => "D. Civitareale" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/mend.16.4.0808" "Revista" => array:6 [ "tituloSerie" => "Mol Endocrinol" "fecha" => "2002" "volumen" => "16" "paginaInicial" => "837" "paginaFinal" => "846" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11923479" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bb0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How could pharmacogenomics help improve patient survival?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Rosell" 1 => "E. Felip" 2 => "L. Paz-Ares" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0169-5002(07)70426-9" "Revista" => array:7 [ "tituloSerie" => "Lung Cancer" "fecha" => "2007" "volumen" => "57" "numero" => "Suppl 2" "paginaInicial" => "S35" "paginaFinal" => "S41" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17686445" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bb0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The challenge of classifying poorly differentiated tumours of the lung" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "W. Wallace" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2559.2008.03181.x" "Revista" => array:6 [ "tituloSerie" => "Histopathology" "fecha" => "2009" "volumen" => "54" "paginaInicial" => "28" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19187178" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bb0295" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vitro chemosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.R. Hanauske" 1 => "U. Eismann" 2 => "O. Oberschmidt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10637-007-9060-9" "Revista" => array:6 [ "tituloSerie" => "Invest New Drugs" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "417" "paginaFinal" => "423" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17534577" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bb0300" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "3p22.1 and 10q22.3 deletions detected by fluorescence in situ hybridization (FISH): a potential new tool for early detection of non-small cell lung Cancer (NSCLC)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Yendamuri" 1 => "A.A. Vaporciyan" 2 => "T. Zaidi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/JTO.0b013e3181834f3a" "Revista" => array:6 [ "tituloSerie" => "J Thorac Oncol" "fecha" => "2008" "volumen" => "3" "paginaInicial" => "979" "paginaFinal" => "984" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18758299" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bb0305" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung câncer treatment. Biology based decision, from gene to histology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "V.P. Hespanhol" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2008" "volumen" => "XIV" "numero" => "Supl 2" "paginaInicial" => "S27" "paginaFinal" => "S34" ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bb0310" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pemetrexed in second line of non-small cell lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Barata" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2008" "volumen" => "XIV" "numero" => "Supl 2" "paginaInicial" => "S21" "paginaFinal" => "S26" ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bb0315" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary adenocarcinoma: review of 106 cases and proposed new classification" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Edwards" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Pathol" "fecha" => "1987" "volumen" => "40" "paginaInicial" => "125" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3818979" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bb0320" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence-based pathology and the pathologic evaluation of thymomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Rosai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1043/1543-2165-132.12.1859.c" "Revista" => array:5 [ "tituloSerie" => "Arch Pathol Lab Med" "fecha" => "2008" "volumen" => "132" "paginaInicial" => "1859" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19061279" "web" => "Medline" ] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bb0325" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Zhong" 1 => "J. Roybal" 2 => "R. Chaerkady" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/0008-5472.CAN-08-1529" "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "2008" "volumen" => "68" "paginaInicial" => "7237" "paginaFinal" => "7245" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18757440" "web" => "Medline" ] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bb0330" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is class III beta-tubulin a predictive factor in patients receiving tubulin-binding agents?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Seve" 1 => "C. Dumontet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(08)70029-9" "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2008" "volumen" => "9" "paginaInicial" => "168" "paginaFinal" => "175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18237851" "web" => "Medline" ] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bb0335" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T. Donnem" 1 => "S. Al-Saad" 2 => "K. Al-Shibli" 3 => "S. Andersen" 4 => "L.T. Busund" 5 => "R.M. Bremnes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/JTO.0b013e3181834f52" "Revista" => array:6 [ "tituloSerie" => "J Thorac Oncol" "fecha" => "2008" "volumen" => "3" "paginaInicial" => "963" "paginaFinal" => "970" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18758297" "web" => "Medline" ] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bb0340" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammation, epithelial to mesenchimal transition and epidermal growth factor receptor tyrosine kinase inhibitor resistence" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "K. Crysam" 1 => "J. Lee" 2 => "M. Dohadwala" 3 => "B. Gardner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/JTO.0b013e3181630ece" "Revista" => array:7 [ "tituloSerie" => "J Thorac Oncol" "fecha" => "2008" "volumen" => "3" "numero" => "2" "paginaInicial" => "107" "paginaFinal" => "110" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18303428" "web" => "Medline" ] ] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bb0345" "etiqueta" => "69." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular signatures of lung cancer-toward personalized therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.S. Herbst" 1 => "S.M. 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Reclassificação do carcinoma broncopulmonar: Diferenciação do tipo histológico em biópsias por imuno-histoquímica

Reclassifying bronchial-pulmonary carcinoma: Differentiating histological type in biopsies by immunohistochemistry

Lina Carvalho1,

Corresponding author

lcarvalho@huc.min-saude.pt

Lina Carvalho Anatomia Patológica Hospitais da Universidade de Coimbra 3000 Coimbra; Portugal.

1 Professora de Anatomia Patológica, Chefe de Serviço dos Hospitais da Universidade de Coimbra

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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Os conhecimentos actuais da patologia molecular do cancro do pulm&#227;o requerem outra caracteriza&#231;&#227;o histol&#243;gica&#44; para al&#233;m de carcinoma de c&#233;lulas pequenas e carcinoma n&#227;o pequenas c&#233;lulas para suporte da terapia personalizada e entendimento do valor real dos f&#225;rmacos actualmente dispon&#237;veis&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Como o diagn&#243;stico e seguimento cl&#237;nico da maioria dos casos de cancro do pulm&#227;o se baseia em produtos de bi&#243;psia e citologia&#44; a classifica&#231;&#227;o imunoistoqu&#237;mica do carcinoma broncopulmonar &#40;IBPCC&#41; &#233; necess&#225;ria para suporte morfol&#243;gico da classifica&#231;&#227;o da WHO 1999&#47;2004&#44; clarificando as caracter&#237;sticas celulares das neoplasias e o entendimento da carcinog&#233;nese&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">O painel imunoistoqu&#237;mico refor&#231;a os tipos histol&#243;gicos principais do carcinoma bronco &#8211; pulmonar&#58; carcinoma epiderm&#243;ide &#40;queratinas de alto peso molecular &#8211; HWMC&#41;&#44; carcinoma adenoscamoso &#40;CK&#47; &#47;TTF1&#44; MWMC&#41;&#44; carcinoma neuroend&#243;crino &#40;Chrg&#44; Syn&#44; CD56&#44; TTF1&#44; Ki67&#41; e adenocarcinoma &#40;CK7&#44; Ck20&#44; TTF1&#41;&#59; as variantes do carcinoma de c&#233;lulas grandes e do carcinoma sarcomat&#243;ide s&#227;o englobados num &#250;nico grupo de carcinomas pleom&#243;rficos &#40;CK7&#44; TTF1&#44; HWMC&#44; VMT&#44; desmina&#44; actina&#41;&#44; onde cabe o polimorfismo e o pleomorfismo celular&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">A quimioterapia do carcinoma broncopulmonar continuar&#225; baseada no platino e na gemcitabina no futuro pr&#243;ximo e a IBPCC ser&#225; uma ferramenta simples e eficiente para o registo das caracter&#237;sticas e tipos histol&#243;gicos do carcinoma do pulm&#227;o presentes nas bi&#243;psias e amostras citol&#243;gicas para suporte da evid&#234;ncia cl&#237;nica e dos ensaios farmac&#234;uticos&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;6&#41;&#58; 1101-1119</span></p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">The current state of molecular knowledge on lung cancer demands a histological classification which goes beyond small-cell and non-small-cell carcinoma to provide support for tailored therapy in aiding in understanding of the drugs currently available&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">As diagnosis and follow-up in the vast majority of lung cancer cases is based on biopsies and cytology samples&#44; Immunohistochemical Bronchial Pulmonary Carcinoma Classification &#40;IBPCC&#41; is necessary to reveal the raft of characteristics available&#46; This provides morphological support for the WHO&#8217;s 1999&#47;2004 classification&#44; in addition to an understanding of carcinogenesis&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">The immunohistochemical panel clarifies the main morphology and cytology characteristics to maintain the leading histological types as squamous cell carcinoma &#40;high weight molecular cytokeratins&#47;HWMC&#41;&#44; adenosquamous carcinoma &#40;CK7&#44; TTF1&#44; HWMA&#41;&#44; neuroendocrine carcinoma &#40;Chrg&#44; Syn&#44; CD56&#44; TTF1&#44; Ki67&#41;&#44; adenocarcinoma &#40;CK7&#44; CK20&#44; TTF1&#41; and bring the polymorphic and pleomorphic carcinomas under a single banner of pleomorphic carcinoma &#40;Ck7&#44; TTF1&#44; HWMC&#44; VMT&#44; Desmin&#44; Actin&#41; which shelters large cell carcinomas and sarcomatoid carcinomas&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Lung cancer chemotherapy will still be based on platinum and gemcitabine for the near future and the IBPCC is a simple and efficient tool for streamlining the registration of lung cancer histological characteristics in biopsies and other reduced samples to support clinical evidence and trials&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2009&#59; XV &#40;6&#41;&#58; 1101-1119</span></p></span>"
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              0 => array:3 [
                "identificador" => "bb0005"
                "etiqueta" => "1&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Cancro&#58; Cronologia hist&#243;rica e g&#233;nese de ideias"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "R&#46;A&#46; Bernarda"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Libro" => array:1 [
                          "fecha" => "1996"
                        ]
                      ]
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                ]
              ]
              1 => array:3 [
                "identificador" => "bb0010"
                "etiqueta" => "2&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Histological lung cancer types"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "L&#46; Kreyberg"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:5 [
                          "tituloSerie" => "Acta Pathologica e Microbiologica Scandinavica"
                          "fecha" => "1962"
                          "volumen" => "157"
                          "paginaInicial" => "1"
                          "paginaFinal" => "93"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              2 => array:3 [
                "identificador" => "bb0015"
                "etiqueta" => "3&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "L&#46; Kreyberg"
                              1 => "A&#46;A&#46; Liebow"
                              2 => "E&#46;A&#46; Uehlinger"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Libro" => array:4 [
                          "titulo" => "Histological typing of lung tumours"
                          "fecha" => "1969"
                          "editorial" => "World Health Organization"
                          "editorialLocalizacion" => "Geneva"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              3 => array:3 [
                "identificador" => "bb0020"
                "etiqueta" => "4&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:1 [
                        "titulo" => "The World Health Organization histological typing of lung tumours"
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Am J Clin Pathol"
                          "fecha" => "1982"
                          "volumen" => "77"
                          "paginaInicial" => "123"
                          "paginaFinal" => "136"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7064914"
                              "web" => "Medline"
                            ]
                          ]
                          "itemHostRev" => array:3 [
                            "pii" => "S0140673603138032"
                            "estado" => "S300"
                            "issn" => "01406736"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              4 => array:3 [
                "identificador" => "bb0025"
                "etiqueta" => "5&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Tumours of the lung&#44; pleura&#44; thymus and heart&#46; Pathology and Genetics"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "W&#46; Travis"
                              1 => "E&#46; Brambilla"
                              2 => "H&#46;K&#46; Muller-Hermelink"
                              3 => "C&#46; Harris"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Libro" => array:4 [
                          "titulo" => "World Health Organization Classification of Tumours"
                          "fecha" => "2004"
                          "editorial" => "IARCPress"
                          "editorialLocalizacion" => "Lyon"
                        ]
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                  ]
                ]
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                  0 => array:2 [
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                      0 => array:2 [
                        "titulo" => "The impact of cigarette smoking on prognosis in small adenocarcinomas of the lung&#58; the association between histologic subtype and smoking status"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => true
                            "autores" => array:3 [
                              0 => "Y&#46; Sakao"
                              1 => "H&#46; Miyamoto"
                              2 => "S&#46; Oh"
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                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1097/JTO.0b013e31818396e0"
                        "Revista" => array:6 [
                          "tituloSerie" => "J Thorac Oncol"
                          "fecha" => "2008"
                          "volumen" => "3"
                          "paginaInicial" => "958"
                          "paginaFinal" => "962"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18758296"
                              "web" => "Medline"
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                        "autores" => array:1 [
                          0 => array:2 [
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                            "autores" => array:3 [
                              0 => "C&#46;Q&#46; Zhu"
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                              2 => "K&#46; Ding"
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                          ]
                        ]
                      ]
                    ]
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                      0 => array:2 [
                        "doi" => "10.1200/JCO.2007.14.8924"
                        "Revista" => array:6 [
                          "tituloSerie" => "J Clin Oncol"
                          "fecha" => "2008"
                          "volumen" => "26"
                          "paginaInicial" => "4268"
                          "paginaFinal" => "4275"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18626007"
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                    "contribucion" => array:1 [
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                            ]
                          ]
                        ]
                      ]
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                    "host" => array:1 [
                      0 => array:2 [
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                          "paginaFinal" => "3357"
                          "link" => array:1 [
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                              5 => "P&#46; Couceiro"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Rev Port Pneumol"
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                          "paginaFinal" => "76"
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                        "titulo" => "EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery"
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                              3 => "T&#46; Kosaka"
                            ]
                          ]
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                          "tituloSerie" => "J Thorac Oncol"
                          "fecha" => "2009"
                          "volumen" => "4"
                          "numero" => "3"
                          "paginaInicial" => "318"
                          "paginaFinal" => "325"
                          "link" => array:1 [
                            0 => array:2 [
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                        "titulo" => "Class III beta-tubulin expression and benefit from adjuvant cisplatin&#47;vinorelbine chemotherapy in operable non-small cell lung cancer&#58; analysis of NCIC JBR 10"
                        "autores" => array:1 [
                          0 => array:2 [
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                            "autores" => array:3 [
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                              1 => "R&#46; Lai"
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                            ]
                          ]
                        ]
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                    "host" => array:1 [
                      0 => array:2 [
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                          "tituloSerie" => "Clin Cancer Res"
                          "fecha" => "2007"
                          "volumen" => "13"
                          "paginaInicial" => "994"
                          "paginaFinal" => "999"
                          "link" => array:1 [
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                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17289895"
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                          ]
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                            ]
                          ]
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                      0 => array:2 [
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                          "tituloSerie" => "Cancer Chemother Pharmacol"
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                          "link" => array:1 [
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                          "tituloSerie" => "Arch Pathol Lab Med"
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                          "paginaFinal" => "1935"
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                          "tituloSerie" => "Mol Pharmacol"
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                          "paginaFinal" => "118"
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                          "tituloSerie" => "J Thorac Cardiovasc Surg"
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                          "paginaFinal" => "630"
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                          ]
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Article information

ISSN: 08732159
Original language: Portuguese

DOI:10.1016/S0873-2159(15)30195-1

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 October	48	30	78
2024 September	29	19	48
2024 August	58	40	98
2024 July	35	30	65
2024 June	26	37	63
2024 May	45	42	87
2024 April	37	27	64
2024 March	38	28	66
2024 February	31	33	64
2024 January	30	28	58
2023 December	20	24	44
2023 November	20	21	41
2023 October	27	25	52
2023 September	22	30	52
2023 August	22	20	42
2023 July	30	30	60
2023 June	28	12	40
2023 May	39	28	67
2023 April	43	16	59
2023 March	31	24	55
2023 February	19	21	40
2023 January	27	19	46
2022 December	17	28	45
2022 November	38	36	74
2022 October	35	27	62
2022 September	21	37	58
2022 August	34	35	69
2022 July	22	33	55
2022 June	27	41	68
2022 May	36	38	74
2022 April	29	31	60
2022 March	22	27	49
2022 February	19	28	47
2022 January	43	35	78
2021 December	29	44	73
2021 November	26	28	54
2021 October	29	48	77
2021 September	27	25	52
2021 August	18	25	43
2021 July	19	25	44
2021 June	18	22	40
2021 May	21	30	51
2021 April	56	25	81
2021 March	29	11	40
2021 February	39	24	63
2021 January	44	10	54
2020 December	30	6	36
2020 November	37	32	69
2020 October	27	11	38
2020 September	61	35	96
2020 August	39	23	62
2020 July	43	24	67
2020 June	51	21	72
2020 May	66	26	92
2020 April	74	19	93
2020 March	58	17	75
2020 February	41	27	68
2020 January	62	34	96
2019 December	51	25	76
2019 November	56	13	69
2019 October	41	24	65
2019 September	38	24	62
2019 August	54	20	74
2019 July	31	7	38
2019 June	34	10	44
2019 May	44	32	76
2019 April	43	22	65
2019 March	50	22	72
2019 February	61	11	72
2019 January	53	18	71
2018 December	28	15	43
2018 November	2	0	2
2018 October	5	7	12
2018 September	13	8	21
2018 August	34	23	57
2018 July	30	31	61
2018 June	42	18	60
2018 May	44	23	67
2018 April	43	28	71
2018 March	35	28	63
2018 February	26	13	39
2018 January	21	8	29
2017 December	32	10	42
2017 November	41	20	61
2017 October	36	14	50
2017 September	34	22	56
2017 August	21	15	36
2017 July	23	7	30
2017 June	25	33	58
2017 May	31	19	50
2017 April	16	18	34
2017 March	17	37	54
2017 February	13	7	20
2017 January	14	8	22
2016 December	13	6	19
2016 November	7	6	13
2016 October	9	17	26
2016 September	2	9	11
2016 August	5	4	9
2016 July	3	4	7
2016 June	2	3	5
2016 May	7	3	10
2016 April	4	6	10
2016 March	1	14	15
2016 February	6	8	14
2016 January	6	7	13
2015 December	7	4	11
2015 November	5	1	6
2015 October	4	1	5

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