Artigo de Revisão/Revision Article
Fibrose quística: Revisão
Cystic fibrosis: Review
Read
5844
Timeswas read the article
2319
Total PDF
3525
Total HTML
Share statistics
array:24 [ "pii" => "S0873215915302208" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30220-8" "estado" => "S350" "fechaPublicacion" => "2008-01-01" "aid" => "12" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "copyrightAnyo" => "2008" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2008;14:89-112" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2590 "formatos" => array:3 [ "EPUB" => 253 "HTML" => 1616 "PDF" => 721 ] ] "itemSiguiente" => array:19 [ "pii" => "S087321591530221X" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30221-X" "estado" => "S350" "fechaPublicacion" => "2008-01-01" "aid" => "1" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2008;14:113-26" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2394 "formatos" => array:3 [ "EPUB" => 215 "HTML" => 1399 "PDF" => 780 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão/Revision Article</span>" "titulo" => "Stress oxidativo na lesão pulmonar neonatal" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "113" "paginaFinal" => "126" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Oxidative stress in the neonatal lung disease" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gustavo Rocha" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Gustavo" "apellidos" => "Rocha" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S087321591530221X?idApp=UINPBA00004E" "url" => "/08732159/0000001400000001/v1_201509151510/S087321591530221X/v1_201509151510/pt/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0873215915302191" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30219-1" "estado" => "S350" "fechaPublicacion" => "2008-01-01" "aid" => "11" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2008;14:55-88" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2563 "formatos" => array:3 [ "EPUB" => 238 "HTML" => 1477 "PDF" => 848 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão/Review Article</span>" "titulo" => "Ecoendoscopia brônquica: Aspectos práticos e aplicabilidade clínica" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "55" "paginaFinal" => "88" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Endobronchial ultrasound: Practical aspects and clinical applications" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "António Bugalho, Michael K. Doris, Juerg Hamacher, Ralf Eberhardt, Felix J. Herth" "autores" => array:5 [ 0 => array:2 [ "nombre" => "António" "apellidos" => "Bugalho" ] 1 => array:2 [ "nombre" => "Michael K." "apellidos" => "Doris" ] 2 => array:2 [ "nombre" => "Juerg" "apellidos" => "Hamacher" ] 3 => array:2 [ "nombre" => "Ralf" "apellidos" => "Eberhardt" ] 4 => array:2 [ "nombre" => "Felix J." "apellidos" => "Herth" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302191?idApp=UINPBA00004E" "url" => "/08732159/0000001400000001/v1_201509151510/S0873215915302191/v1_201509151510/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão/Revision Article</span>" "titulo" => "Fibrose quística: Revisão" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "89" "paginaFinal" => "112" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "C. Damas, A. Amorim, I. Gomes" "autores" => array:3 [ 0 => array:3 [ "nombre" => "C." "apellidos" => "Damas" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cr0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Amorim" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 2 => array:3 [ "nombre" => "I." "apellidos" => "Gomes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "af0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Interna complementar de pneumologia, Serviço de Pneumologia do Hospital de São João, Porto" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Assistente hospitalar de pneumologia, Serviço de Pneumologia do Hospital de São João, Porto" "etiqueta" => "2" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Assistente hospitalar graduada de pneumologia, Serviço de Pneumologia do Hospital de São João, Porto" "etiqueta" => "3" "identificador" => "af0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "*" "correspondencia" => "<span class="elsevierStyleBold">Contacto:</span> Carla Damas, Travessa Fernando Namora 48 5.º esq, 4425 Pedrouços – Maia" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cystic fibrosis: Review" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-01-15" "fechaAceptado" => "2007-09-19" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570327" "palabras" => array:2 [ 0 => "Fibrose quística" 1 => "revisão" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570326" "palabras" => array:2 [ 0 => "Cystic fibrosis" 1 => "review" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A fibrose quística (FQ) é a doença autossómica recessiva mais frequente na raça caucasiana. Caracteriza-se por mutações na CFTR, uma proteína transmembranar responsável pelo transporte de cloretos. Esta proteína tem uma ampla distribuição epitelial, o que dá um carácter sistémico a esta doença e consequentemente múltiplas manifestações clínicas de gravidade variável. A melhoria dos cuidados de saúde, associada ao desenvolvimento do arsenal terapêutico, permitiu um aumento da sobrevida destes doentes, de tal forma que a FQ já não pode ser abordada como doença da idade pediátrica. Também a evolução técnica na transplantação abriu novas perspectivas quanto ao tratamento desta afecção.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Assim, cada vez mais esta patologia implica um envolvimento multidisciplinar no qual a pneumologia tem uma parte preponderante.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (1): 89-112</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Cystic Fibrosis (CF) is the recessive autossomic disease more frequent in the caucasian race. The main characteristic is a mutation in CFTR, a trans-membranar protein, responsible for chlorates transportation. This protein has a diffuse epithelial distribution, which gives a multissistemic involvement to this disease, with clinical manifestations with variable degrees of severity. The development of better health care associated with new therapeutic options became responsible for an increase of survival, so CF is no longer a paediatric disease. Lung transplantation also has an important role, bringing new treatment perspectives.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">So, this pathology has an increased multi-disciplinary involvement in which the pulmonologist have a preponderant role.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (1): 89-112</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:68 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Schidlow D, Fiel S. Cystic Fibrosis in Clinical Respiratory Medicine; chapter 40, pp 499-513." ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic fibrosis of the pancreas and its relation to celiac disease. A clinical and pathological study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.H. Andersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Dis Child" "fecha" => "1938" "volumen" => "56" "paginaInicial" => "344" "paginaFinal" => "399" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pancreatic function and disease in early life" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Faber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Arch Path" "fecha" => "1944" "volumen" => "37" "paginaInicial" => "328" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.D. Bethesda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:2 [ "titulo" => "Cystic Fibrosis Foundation" "fecha" => "2000" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antecedentes históricos y epidemiologia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.M.G. Moreno" 1 => "A.S. Posadas" 2 => "A.C. Espinosa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "paginaInicial" => "9" "paginaFinal" => "20" "serieVolumen" => "VIII" "serieTitulo" => "Monografias NeumoMadrid. Fibrosis Quística. Ergon" "serieFecha" => "2005" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The diagnosis of Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Stein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199702133360707" "Revista" => array:6 [ "tituloSerie" => "New Eng J Med" "fecha" => "1997" "volumen" => "336" "paginaInicial" => "487" "paginaFinal" => "497" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9017943" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Cystic Fibrosis Foundation" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "conferencia" => "Patient Registry 2004 – Annual date report" "serieFecha" => "2005" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:1 [ "host" => array:2 [ 0 => array:1 [ "Libro" => array:2 [ "titulo" => "Cystic Fibrosis Foundation" "fecha" => "2006" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "www.cff.org" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic Fibrosis Adult Care Consensus Conference Report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "J.R. Yankaskas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2004" "volumen" => "125" "paginaInicial" => "15" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14718415" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Macromolecular interactions and ion transport in Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "W.B. Guggino" 1 => "S.P. Banks-Schlegl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Resp Critical Care Med" "fecha" => "2004" "volumen" => "170" "paginaInicial" => "815" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "The Cystic fibrosis genetic analysis consortium, CF-GAG" ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "http://www.genet.Sickkids.on.ca/cftr" "fecha" => "2006" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The CFTR gene: structure, mutations and specific therapeutic approaches" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.N. Rafinia" 1 => "L. Linde" 2 => "B. Keron" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "CF in the 21<span class="elsevierStyleSup">st</span> Century" "paginaInicial" => "2" "paginaFinal" => "10" "serieFecha" => "2005" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genética" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.C. Senent" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "paginaInicial" => "29" "paginaFinal" => "43" "serieVolumen" => "VIII" "serieTitulo" => "Monografias NeumoMadrid" "serieFecha" => "2005" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms of disease Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Rowe" 1 => "S. Miller" 2 => "E. Sarscher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra043184" "Revista" => array:7 [ "tituloSerie" => "New Eng J Med" "fecha" => "2005" "volumen" => "352" "numero" => "19" "paginaInicial" => "1992" "paginaFinal" => "1999" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15888700" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nucleotide triphosphates are required to open CFRT-generated chloride channels" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.P. Anderson" 1 => "H.A. Berger" 2 => "D.P. Rich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Science" "fecha" => "1991" "volumen" => "253" "paginaInicial" => "205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1712985" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Ratjen" 1 => "G. Doning" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(03)12567-6" "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "2003" "volumen" => "361" "paginaInicial" => "681" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12606185" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genothype-phenotype correlation for pulmonary function in Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "J. Gracia" 1 => "F. Mata" 2 => "A. Alvarez" 3 => "T. Casals" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2004.031153" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2005" "volumen" => "60" "paginaInicial" => "558" "paginaFinal" => "563" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15994263" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genotype-fenotype correlations in CF" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Dorfman" 1 => "J. Ziclanski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "paginaInicial" => "61" "paginaFinal" => "68" "serieTitulo" => "CF in the 21<span class="elsevierStyleSup">st</span> Century" "serieFecha" => "2005" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Pathophysiology and management of pulmonary infections in cystic fibrosis" ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200304-505SO" "Revista" => array:6 [ "tituloSerie" => "Am J Resp Crit Care Med" "fecha" => "2003" "volumen" => "168" "paginaInicial" => "918" "paginaFinal" => "951" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14555458" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic fibrosis foundation consensus report on pulmonary complications of cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.V. Schidlow" 1 => "L.M. Taussing" 2 => "M.R. Knowles" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "1993" "volumen" => "15" "paginaInicial" => "187" "paginaFinal" => "198" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8327283" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bb0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of pulmonary disease in patients with Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.W. Ramsey" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Eng J Med" "fecha" => "1996" "volumen" => "335" "paginaInicial" => "179" "paginaFinal" => "188" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bb0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patogenia in Monografias NeumoMadrid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G.G. Hernandez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "fecha" => "2005" "volumen" => "VIII" "paginaInicial" => "45" "paginaFinal" => "55" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bb0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long term study of one hundred five patients with cystic fibrosis studies made over stoll year period" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Shwachman" 1 => "L.L. Kulczyky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Dis Child" "fecha" => "1958" "volumen" => "96" "paginaInicial" => "6" "paginaFinal" => "15" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bb0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Afectación respiratória en el niño Monografias NeumoMadrid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.A.N. Rodrigues" 1 => "A.S. González" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Fibrosis Quística. Ergon" "fecha" => "2005" "volumen" => "VIII" "numero" => "VI" "paginaInicial" => "79" "paginaFinal" => "90" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bb0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Iron deficiency in Cystic Fibrosis relationship to lung disease severity and chronic Pseudomonas aeruginosa infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Reid" 1 => "N.J. Withers" 2 => "L. Francis" 3 => "W. Wilson" 4 => "T.C. Kotsimbos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2002" "volumen" => "121" "paginaInicial" => "48" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11796431" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bb0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Burkholderia and emerging pathogens in Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.J. Lipuma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Semin Resp Crit Care Med" "fecha" => "2003" "volumen" => "24" "paginaInicial" => "681" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bb0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic fibrosis foundation consensus report on pulmonary complications of cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.V. Schidlow" 1 => "L.M. Taussing" 2 => "M.R. Knowles" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "1993" "volumen" => "15" "paginaInicial" => "187" "paginaFinal" => "198" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8327283" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bb0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fibrosis quística: consenso sobre el tratamiento del pneumotórax y de la hemoptisis massiva y sobre las indicaciones del transplante pulmonar" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Prados" 1 => "L. Máiz" 2 => "C. Antelo" 3 => "F. Baranda" 4 => "J. Blázquez" 5 => "J.M. Borro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2000" "volumen" => "36" "paginaInicial" => "411" "paginaFinal" => "416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11000930" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bb0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Monografías NeumoMadrid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.T.M. Martinez" 1 => "P.A. Herrero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cap Complicaciones respiratórias no infecciosas más frequentes" "fecha" => "2005" "volumen" => "VIII" "paginaInicial" => "99" "paginaFinal" => "111" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bb0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic bronchopulmonary aspergillosis in cystic fibrosis. A European epidemiological study. Epidemiologic Registry of Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Mastella" 1 => "M. Rainisio" 2 => "H.K. Harms" 3 => "M.E. Hodson" 4 => "C. Koch" 5 => "J. Navarro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Resp J" "fecha" => "2000" "volumen" => "16" "paginaInicial" => "464" "paginaFinal" => "471" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bb0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Afectación respiratória en el adulto Monografias NeumoMadrid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.C.P. Sanchez" 1 => "L.G. Camera" 2 => "I.F. Navarro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Fibrosis Quística. Ergon" "fecha" => "2005" "volumen" => "VIII" "numero" => "VII" "paginaInicial" => "91" "paginaFinal" => "98" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bb0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Lacaille" 1 => "J. Schmitz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Semin Pediatr Gastroenterolog Nutr" "fecha" => "1993" "volumen" => "4" "paginaInicial" => "1" "paginaFinal" => "15" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bb0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Monografías NeumoMadrid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.D.G. Novo" 1 => "C.G. Castillo" 2 => "J. Manzanares" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Fibrosis Quística Moreno RMG, Posadas AS. Cap Manifestaciones digestivas" "fecha" => "2005" "volumen" => "VIII" "paginaInicial" => "113" "paginaFinal" => "130" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bb0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection and follow up of exocrine pancreatic insufficiency in cystic fibrosis: a review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Leus" 1 => "S. Van Bervliet" 2 => "E. Robberecht" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Pediatr" "fecha" => "2000" "volumen" => "159" "paginaInicial" => "563" "paginaFinal" => "568" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10968231" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bb0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "GI complications after lung transplantation in patients with Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Gilljam" 1 => "C. Chapman" 2 => "E. Tullis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2003" "volumen" => "123" "paginaInicial" => "37" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12527600" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bb0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Colombo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/jhep.2002.37136" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2002" "volumen" => "36" "paginaInicial" => "1374" "paginaFinal" => "1382" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12447862" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bb0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Monografías NeumoMadrid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.M.G. Moreno" 1 => "A.S. Posadas" 2 => "D.S.J. Diego" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Fibrosis Quística Moreno RMG, Posadas AS. Cap Otras manifestaciones prevalentes" "fecha" => "2005" "volumen" => "VIII" "paginaInicial" => "131" "paginaFinal" => "139" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bb0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elborn Stuart" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Kerem" 1 => "S. Conway" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jcf.2004.12.002" "Revista" => array:6 [ "tituloSerie" => "Heijerman H Standards of care for patients with cystic fibrosis: a European consensus: Journal of Cystic Fibrosis" "fecha" => "2005" "volumen" => "4" "paginaInicial" => "7" "paginaFinal" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15752677" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bb0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic Fibrosis Adult Care. Consensus Conference Report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.R. Yankaskas" 1 => "B.C. Marshall" 2 => "B. Sufian" 3 => "R.H. Simon" 4 => "D. Rodman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2004" "volumen" => "125" "paginaInicial" => "1S" "paginaFinal" => "39S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14734689" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bb0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Male fertility in cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.A. Dodge" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1995" "volumen" => "346" "paginaInicial" => "587" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7650999" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bb0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutations in Cystic Fibrosis gene in patients with congenital absence of vas deferens" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Chillon" 1 => "T. Casals" 2 => "B. Mercier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199506013322204" "Revista" => array:5 [ "tituloSerie" => "New Eng J Med" "fecha" => "1995" "volumen" => "332" "paginaInicial" => "1475" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7739684" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bb0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fertility in men with Cystic Fibrosis. An update on current surgical pratices ans outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.J. McCallum" 1 => "J.M. Milunsky" 2 => "D.L. Cunningham" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2000" "volumen" => "118" "paginaInicial" => "1059" "paginaFinal" => "1062" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11035677" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bb0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pregnancy in Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Gilljam" 1 => "M. Antonion" 2 => "J. Shin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Fetal and maternal outcome. Chest" "fecha" => "2000" "volumen" => "118" "paginaInicial" => "85" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10893364" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bb0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low bone mineral density density in adults with Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.S. Haworth" 1 => "P.L. Selby" 2 => "A.K. Webb" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Thorax" "fecha" => "1999" "volumen" => "54" "paginaInicial" => "961" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10525552" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bb0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduced bone density in Cystic Fibrosis. Delta F508 mutations is an independent risk factor" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.J. King" 1 => "D.J. Topliss" 2 => "Kotsimbos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Eur Resp J" "fecha" => "2005" "volumen" => "25" "paginaInicial" => "54" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bb0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Boeck K, Wilschanski M, Taylor C, Cuppens H, Dodge J, Sinaasappel M. Cystic fibrosis: terminology and diagnostic algorithms. Thorax 61:627-35." ] ] ] 46 => array:3 [ "identificador" => "bb0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "World Health Organisation" ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Libro" => array:2 [ "titulo" => "Classification of cystic fibrosis and related disorders" "fecha" => "2001" ] ] 1 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Cystic Fibros" "fecha" => "2002" "volumen" => "1" "paginaInicial" => "5" "paginaFinal" => "8" ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bb0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.E. Gibson" 1 => "R.E. Cooke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1959" "volumen" => "23" "paginaInicial" => "545" "paginaFinal" => "549" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13633369" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bb0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Guidelines for the performance of the sweat test for the investigation of cystic fibrosis in the UK" ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "http//:WWW.acb.org.uk" "fecha" => "2002" ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bb0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Monografías NeumoMadrid vol VIII/2005 Fibrosis Quística Moreno R M G, Posadas A S. Cap Diagnóstico. Landeira C A, Aguero M I G, Carrasco M C M pág 141-54." ] ] ] 50 => array:3 [ "identificador" => "bb0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The diagnosis of Cystic Fibrosis: a consensus statement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Rosenstein" 1 => "G. Cutting" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Journal of Pediatrics" "fecha" => "1998" "volumen" => "132" "paginaInicial" => "589" "paginaFinal" => "595" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9580754" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bb0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multicenter study of the effect of solution temperature on nasal potential difference measurements" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.P. Boyle" 1 => "M. Dirner-West" 2 => "L. Miljam" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2003" "volumen" => "124" "paginaInicial" => "482" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12907532" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bb0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nasal airway ion transport is linked to the Cystic Fibrosis phenotype in adult patient" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "I. Fajac" 1 => "D. Hubert" 2 => "D. Guillermot" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2003.020933" "Revista" => array:5 [ "tituloSerie" => "Thorax" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "971" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15516474" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bb0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Paediatric origins of adult lung disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Robinson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "237" "paginaFinal" => "241" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11182019" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bb0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prophylactic antibiotics for Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Smith" 1 => "S. Walters" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/14651858.CD009601.pub2" "Revista" => array:4 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2003" "volumen" => "3" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23543580" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bb0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systematic review of anti-staphylococcal antibiotherapy in Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K. McCaffery" 1 => "R.E. Oliver" 2 => "M. Franklin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1999" "volumen" => "54" "paginaInicial" => "380" "paginaFinal" => "383" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10212099" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bb0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamiento antimicrobiano frente a la colonización pulmonar por Pseudomonas aeruginosa en el paciente com fibrose quistica" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "R. Cantón" 1 => "N. Cobos" 2 => "J. Gracia" 3 => "F. Baquero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Archivos de Bronconeumologia" "fecha" => "2005" "volumen" => "41" "numero" => "Sup 1" "paginaInicial" => "1" "paginaFinal" => "25" ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bb0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and efficacy of tobramycin solution for inhalation in patients with cystic fibrosis. The results of 2 phases placebo controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.W. Ramsey" 1 => "J. Burns" 2 => "A.L. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "1997" "volumen" => "14" "paginaInicial" => "137" "paginaFinal" => "138" ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bb0295" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intermittent administration of inhaled tobramycin in patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "B.W. Ramsey" 1 => "M.S. Pepe" 2 => "J.M. Quan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N England J Med" "fecha" => "1999" "volumen" => "340" "paginaInicial" => "23" "paginaFinal" => "30" ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bb0300" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term survival and nutrional data in patients with cystic fibrosis treated in a Danish centre" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Nir" 1 => "S. Lanng" 2 => "H.K. Johansen" 3 => "C. Koch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1996" "volumen" => "51" "paginaInicial" => "1023" "paginaFinal" => "1027" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8977604" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bb0305" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Determinants of adherence in adults with Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.J. Kettler" 1 => "S.M. Sawyer" 2 => "H.R. Winefield" 3 => "H.W. Greville" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2002" "volumen" => "57" "paginaInicial" => "459" "paginaFinal" => "464" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11978927" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bb0310" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aerosolized antibiotics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Pico" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Chest" "fecha" => "1998" "volumen" => "15" ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bb0315" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Controlled trial of long term inhaled hypertonic saline in patients with Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "M.R. Elkeis" 1 => "M. Robinson" 2 => "B.R. Rose" 3 => "C. Harbour" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Eng J Med" "fecha" => "2006" "volumen" => "356" "paginaInicial" => "229" "paginaFinal" => "240" ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bb0320" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International approaches to the prescription of long-term oxygen" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.J. Wijkastra" 1 => "G.H. Guyatt" 2 => "N. Ambrosino" 3 => "B.R. Celli" 4 => "R. Guell" 5 => "J.F. Muir" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2001" "volumen" => "18" "paginaInicial" => "909" "paginaFinal" => "913" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11829095" "web" => "Medline" ] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bb0325" "etiqueta" => "65." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Non-invasive ventilation in Chronic Obstructive Pulmonary disease, Bronquiectasis and Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Wedziche" 1 => "J.F. Muir" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "777" "paginaFinal" => "784" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12358358" "web" => "Medline" ] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bb0330" "etiqueta" => "66." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recombinant Deoxiribonuclease for Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.P. Jones" 1 => "C.E. Wallis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/14651858.CD003881.pub3" "Revista" => array:4 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2000" "volumen" => "2" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22336797" "web" => "Medline" ] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bb0335" "etiqueta" => "67." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Azithromycin in patients with cystic Fibrosis chronically infected with <span class="elsevierStyleItalic">Pseudomonas aeruginosa</span>. A randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Sainan" 1 => "B. Marshall" 2 => "N. Mayer-Hemblet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.290.13.1749" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2003" "volumen" => "290" "paginaInicial" => "1749" "paginaFinal" => "1756" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14519709" "web" => "Medline" ] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bb0340" "etiqueta" => "68." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung transplantation in Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.R. Yankaskas" 1 => "G.B. Mallory" 2 => "Consensus Committee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1998" "volumen" => "113" "paginaInicial" => "217" "paginaFinal" => "226" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9440593" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001400000001/v1_201509151510/S0873215915302208/v1_201509151510/pt/main.assets" "Apartado" => array:4 [ "identificador" => "43356" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Artigos de revisão" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001400000001/v1_201509151510/S0873215915302208/v1_201509151510/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302208?idApp=UINPBA00004E" ]
Article information
ISSN: 08732159Original language: Portuguese
The statistics are updated each day
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 3 | 12 |
| 2024 October | 40 | 56 | 96 |
| 2024 September | 49 | 38 | 87 |
| 2024 August | 49 | 53 | 102 |
| 2024 July | 53 | 39 | 92 |
| 2024 June | 30 | 27 | 57 |
| 2024 May | 40 | 35 | 75 |
| 2024 April | 41 | 28 | 69 |
| 2024 March | 32 | 39 | 71 |
| 2024 February | 26 | 29 | 55 |
| 2024 January | 17 | 29 | 46 |
| 2023 December | 22 | 34 | 56 |
| 2023 November | 22 | 22 | 44 |
| 2023 October | 19 | 31 | 50 |
| 2023 September | 21 | 31 | 52 |
| 2023 August | 25 | 15 | 40 |
| 2023 July | 20 | 37 | 57 |
| 2023 June | 27 | 14 | 41 |
| 2023 May | 22 | 22 | 44 |
| 2023 April | 17 | 21 | 38 |
| 2023 March | 17 | 18 | 35 |
| 2023 February | 25 | 35 | 60 |
| 2023 January | 20 | 27 | 47 |
| 2022 December | 21 | 23 | 44 |
| 2022 November | 35 | 37 | 72 |
| 2022 October | 29 | 24 | 53 |
| 2022 September | 20 | 38 | 58 |
| 2022 August | 38 | 42 | 80 |
| 2022 July | 26 | 32 | 58 |
| 2022 June | 21 | 27 | 48 |
| 2022 May | 42 | 42 | 84 |
| 2022 April | 13 | 32 | 45 |
| 2022 March | 24 | 43 | 67 |
| 2022 February | 41 | 28 | 69 |
| 2022 January | 30 | 32 | 62 |
| 2021 December | 24 | 34 | 58 |
| 2021 November | 22 | 29 | 51 |
| 2021 October | 37 | 28 | 65 |
| 2021 September | 50 | 28 | 78 |
| 2021 August | 38 | 20 | 58 |
| 2021 July | 33 | 33 | 66 |
| 2021 June | 27 | 25 | 52 |
| 2021 May | 41 | 31 | 72 |
| 2021 April | 63 | 53 | 116 |
| 2021 March | 49 | 18 | 67 |
| 2021 February | 40 | 18 | 58 |
| 2021 January | 25 | 18 | 43 |
| 2020 December | 28 | 11 | 39 |
| 2020 November | 43 | 23 | 66 |
| 2020 October | 25 | 17 | 42 |
| 2020 September | 62 | 18 | 80 |
| 2020 August | 55 | 24 | 79 |
| 2020 July | 61 | 15 | 76 |
| 2020 June | 50 | 18 | 68 |
| 2020 May | 57 | 21 | 78 |
| 2020 April | 46 | 9 | 55 |
| 2020 March | 36 | 15 | 51 |
| 2020 February | 41 | 31 | 72 |
| 2020 January | 40 | 15 | 55 |
| 2019 December | 36 | 27 | 63 |
| 2019 November | 47 | 22 | 69 |
| 2019 October | 30 | 10 | 40 |
| 2019 September | 49 | 21 | 70 |
| 2019 August | 69 | 20 | 89 |
| 2019 July | 66 | 19 | 85 |
| 2019 June | 66 | 9 | 75 |
| 2019 May | 55 | 36 | 91 |
| 2019 April | 50 | 19 | 69 |
| 2019 March | 58 | 13 | 71 |
| 2019 February | 55 | 10 | 65 |
| 2019 January | 79 | 11 | 90 |
| 2018 December | 42 | 9 | 51 |
| 2018 November | 17 | 7 | 24 |
| 2018 October | 23 | 0 | 23 |
| 2018 September | 20 | 11 | 31 |
| 2018 August | 38 | 22 | 60 |
| 2018 July | 36 | 34 | 70 |
| 2018 June | 43 | 23 | 66 |
| 2018 May | 65 | 23 | 88 |
| 2018 April | 67 | 38 | 105 |
| 2018 March | 38 | 33 | 71 |
| 2018 February | 32 | 12 | 44 |
| 2018 January | 31 | 10 | 41 |
| 2017 December | 63 | 20 | 83 |
| 2017 November | 39 | 25 | 64 |
| 2017 October | 43 | 24 | 67 |
| 2017 September | 42 | 16 | 58 |
| 2017 August | 26 | 19 | 45 |
| 2017 July | 20 | 5 | 25 |
| 2017 June | 28 | 15 | 43 |
| 2017 May | 41 | 15 | 56 |
| 2017 April | 12 | 4 | 16 |
| 2017 March | 12 | 16 | 28 |
| 2017 February | 14 | 4 | 18 |
| 2017 January | 12 | 6 | 18 |
| 2016 December | 17 | 8 | 25 |
| 2016 November | 10 | 5 | 15 |
| 2016 October | 15 | 11 | 26 |
| 2016 September | 8 | 8 | 16 |
| 2016 August | 5 | 3 | 8 |
| 2016 July | 1 | 1 | 2 |
| 2016 May | 6 | 0 | 6 |
| 2016 April | 2 | 6 | 8 |
| 2016 March | 1 | 11 | 12 |
| 2016 February | 7 | 9 | 16 |
| 2016 January | 5 | 7 | 12 |
| 2015 December | 5 | 3 | 8 |
| 2015 November | 1 | 2 | 3 |
| 2015 October | 2 | 2 | 4 |
Show all
