Caso Clínico/Clinical Case
Défice de alfa-1 antitripsina. A propósito de dois casos clínicos
Alpha-1 antitrypsin deficiency. Two cases report
1 Interna do Complementar de Medicina Interna, Serviço de Pneumologia, Centro Hospitalar de Setúbal, EPE, Rua Camilo Castelo Branco, 2910-446 Setúbal – Portugal
2 Assistente Hospitalar Graduada de Pneumologia, Serviço de Pneumologia, Centro Hospitalar de Setúbal, EPE, Rua Camilo Castelo Branco, 2910-446 Setúbal – Portugal
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Two cases report" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-10-01" "fechaAceptado" => "2007-10-26" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570415" "palabras" => array:3 [ 0 => "Défice de alfa-1 antitripsina" 1 => "fenótipo Pi ZZ" 2 => "enfisema" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570416" "palabras" => array:3 [ 0 => "Alpha-1 antitrypsin deficiency" 1 => "phenotype Pi ZZ" 2 => "emphysema" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">O défice de alfa-1 antitripsina é uma doença hereditária autossómica codominante. O fenótipo Pi ZZ está associado com maior frequência à doença pulmonar, sendo responsável pelo aparecimento precoce de enfisema, sobretudo nos fumadores. Os autores apresentam dois casos de diagnóstico tardio e em que estiveram presentes outros factores que terão contribuído para o aparecimento de manifestações clínicas.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIV (2): 295-302</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">The alpha-1 antitrypsin deficiency is an hereditary autosomic codominant disease. The phenotype Pi ZZ is associated more frequently with pulmonary disease and is responsible for the presence of emphysema early in life, particularly in smokers. The author’s present two cases which diagnosis were performed later in life and in which other factors could be also responsible for clinical manifestations.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIV (2): 295-302</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Worldwide racial and ethnic distribution of alpha-1-antitrypsin deficiency: details of an analysis of published genetic epidemiological surveys" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F.J. de Serres" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2002" "volumen" => "122" "paginaInicial" => "29" "paginaFinal" => "1818" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "α<span class="elsevierStyleInf">1</span>-Antitrypsin deficiency in Europe: geographical distribution of Pi types S and Z" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.C. Hutchison" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Respir Med" "fecha" => "1998" "volumen" => "92" "paginaInicial" => "77" "paginaFinal" => "367" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic epidemiology of alpha-1 antitrypsin deficiency: France, Italy, Portugal and Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F.J. de Serres" 1 => "I. Blanco" 2 => "E.F. Bustillo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Genet" "fecha" => "2003" "volumen" => "63" "paginaInicial" => "490" "paginaFinal" => "509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12786756" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Natural history and life expectancy in severe Alpha<span class="elsevierStyleInf">1</span>-antitrypsin deficiency, PiZ" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Larsson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Med Scand" "fecha" => "1978" "volumen" => "204" "paginaInicial" => "345" "paginaFinal" => "351" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/309708" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features and history of the destructive lung disease associated with alpha-1 antitrypsin deficiency of adults with pulmonary symptoms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.L. Brantly" 1 => "L.D. Paul" 2 => "B.H. Miller" 3 => "R.T. Falk" 4 => "M. Wu" 5 => "R.G. Crystal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/138.2.327" "Revista" => array:6 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1988" "volumen" => "138" "paginaInicial" => "327" "paginaFinal" => "336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3264124" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of genetic polymorphisms in environmental health" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.N. Kelada" 1 => "D.L. Eaton" 2 => "S.S. Wang" 3 => "N.R. Rothman" 4 => "M.J. Khoury" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Environ Health Perspect" "fecha" => "2003" "volumen" => "111" "paginaInicial" => "1055" "paginaFinal" => "1064" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12826477" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atopy, asthma and emphysema in patients with severe alpha-1-antitrypsin deficiency" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "E. Eden" 1 => "D. Mitchell" 2 => "B. Mehlman" 3 => "H. Khouli" 4 => "M. Mejat" 5 => "M.H. Grieco" 6 => "G.M. Turino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.156.1.9508014" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1997" "volumen" => "156" "paginaInicial" => "68" "paginaFinal" => "74" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9230728" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "RA Stockley. α<span class="elsevierStyleInf">1</span>-antitrypsin deficiency. Clinical manifestations and natural history" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Needhmam" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "441" "paginaFinal" => "445" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15115878" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetics and respiratory disease. 2. Alpha<span class="elsevierStyleInf">1</span>-antitrypsin deficiency, cirrhosis and emphysema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Mahadeva" 1 => "D.A. Lomas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1998" "volumen" => "53" "paginaInicial" => "501" "paginaFinal" => "505" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9713452" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trends in the diagnosis of symptomatic patients with α<span class="elsevierStyleInf">1</span>- Antitrypsin deficiency between 1968 and 2003" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Michael A. Campos" 1 => "Adam Wanner" 2 => "Guoyam Zhang" 3 => "Robert A. Sandhaus" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "paginaInicial" => "86" "paginaFinal" => "1179" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Delay in diagnosis of α<span class="elsevierStyleInf">1</span>- Antitrypsin deficiency. A continuing problem" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "James K. Stoller" 1 => "Robert A. Sandhaus" 2 => "Gerard Turino" 3 => "Ryan Dickson" 4 => "Keith Rodgers" 5 => "Charlie Strange" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.128.1.94" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "paginaInicial" => "94" "paginaFinal" => "1989" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16002921" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival of patients with severe α<span class="elsevierStyleInf">1</span>-antitrypsin deficiency with special reference to non-index cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Seersholm" 1 => "A. Kok-Jensen" 2 => "A. Dirksen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1994" "volumen" => "49" "paginaInicial" => "8" "paginaFinal" => "695" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8153946" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decline in FEV1 rotated to smoking status in individuals with severe alpha1–antitrypsin deficiency (PiZZ)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Piitulainen" 1 => "S. Eriksson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir J" "fecha" => "1999" "volumen" => "13" "paginaInicial" => "51" "paginaFinal" => "247" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Airways obstruction and two year survival in patients with severe alpha1-antitrypsin deficiency" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Seersholm" 1 => "A. Dirksen" 2 => "A. Kok-Jensen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir J" "fecha" => "1994" "volumen" => "7" "paginaInicial" => "7" "paginaFinal" => "1985" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antitrypsin and emphysema. Perspective and prospects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.A. Pierce" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1988" "volumen" => "259" "paginaInicial" => "5" "paginaFinal" => "2890" "itemHostRev" => array:3 [ "pii" => "S0140673601067289" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Talecris Biotherapeutics, Inc.; Alpha1-Proteinase Inhibitor (Human). Prolastin®. Resumo das características do medicamento." ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001400000002/v1_201509151520/S0873215915302385/v1_201509151520/pt/main.assets" "Apartado" => array:4 [ "identificador" => "43360" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Casos Clínicos/Cases Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001400000002/v1_201509151520/S0873215915302385/v1_201509151520/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302385?idApp=UINPBA00004E" ]
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ISSN: 08732159Original language: Portuguese
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| 2024 July | 34 | 43 | 77 |
| 2024 June | 29 | 29 | 58 |
| 2024 May | 31 | 40 | 71 |
| 2024 April | 34 | 28 | 62 |
| 2024 March | 36 | 21 | 57 |
| 2024 February | 31 | 23 | 54 |
| 2024 January | 25 | 24 | 49 |
| 2023 December | 25 | 31 | 56 |
| 2023 November | 32 | 27 | 59 |
| 2023 October | 17 | 25 | 42 |
| 2023 September | 22 | 32 | 54 |
| 2023 August | 17 | 19 | 36 |
| 2023 July | 28 | 39 | 67 |
| 2023 June | 27 | 17 | 44 |
| 2023 May | 25 | 25 | 50 |
| 2023 April | 17 | 24 | 41 |
| 2023 March | 31 | 33 | 64 |
| 2023 February | 25 | 23 | 48 |
| 2023 January | 29 | 28 | 57 |
| 2022 December | 22 | 20 | 42 |
| 2022 November | 44 | 38 | 82 |
| 2022 October | 44 | 24 | 68 |
| 2022 September | 20 | 40 | 60 |
| 2022 August | 37 | 61 | 98 |
| 2022 July | 33 | 35 | 68 |
| 2022 June | 23 | 33 | 56 |
| 2022 May | 35 | 75 | 110 |
| 2022 April | 20 | 29 | 49 |
| 2022 March | 31 | 31 | 62 |
| 2022 February | 44 | 25 | 69 |
| 2022 January | 69 | 43 | 112 |
| 2021 December | 27 | 39 | 66 |
| 2021 November | 44 | 30 | 74 |
| 2021 October | 94 | 25 | 119 |
| 2021 September | 28 | 30 | 58 |
| 2021 August | 24 | 26 | 50 |
| 2021 July | 30 | 22 | 52 |
| 2021 June | 35 | 29 | 64 |
| 2021 May | 38 | 25 | 63 |
| 2021 April | 86 | 60 | 146 |
| 2021 March | 81 | 38 | 119 |
| 2021 February | 78 | 20 | 98 |
| 2021 January | 44 | 23 | 67 |
| 2020 December | 40 | 11 | 51 |
| 2020 November | 53 | 21 | 74 |
| 2020 October | 29 | 13 | 42 |
| 2020 September | 132 | 41 | 173 |
| 2020 August | 110 | 22 | 132 |
| 2020 July | 132 | 28 | 160 |
| 2020 June | 70 | 23 | 93 |
| 2020 May | 86 | 20 | 106 |
| 2020 April | 79 | 14 | 93 |
| 2020 March | 61 | 15 | 76 |
| 2020 February | 45 | 28 | 73 |
| 2020 January | 66 | 31 | 97 |
| 2019 December | 57 | 44 | 101 |
| 2019 November | 74 | 40 | 114 |
| 2019 October | 73 | 34 | 107 |
| 2019 September | 64 | 36 | 100 |
| 2019 August | 82 | 39 | 121 |
| 2019 July | 61 | 21 | 82 |
| 2019 June | 46 | 32 | 78 |
| 2019 May | 59 | 39 | 98 |
| 2019 April | 57 | 35 | 92 |
| 2019 March | 63 | 17 | 80 |
| 2019 February | 54 | 16 | 70 |
| 2019 January | 58 | 23 | 81 |
| 2018 December | 35 | 15 | 50 |
| 2018 November | 8 | 4 | 12 |
| 2018 October | 14 | 0 | 14 |
| 2018 September | 20 | 8 | 28 |
| 2018 August | 37 | 17 | 54 |
| 2018 July | 40 | 24 | 64 |
| 2018 June | 44 | 14 | 58 |
| 2018 May | 52 | 17 | 69 |
| 2018 April | 49 | 24 | 73 |
| 2018 March | 58 | 25 | 83 |
| 2018 February | 21 | 5 | 26 |
| 2018 January | 25 | 12 | 37 |
| 2017 December | 30 | 10 | 40 |
| 2017 November | 31 | 16 | 47 |
| 2017 October | 27 | 18 | 45 |
| 2017 September | 26 | 16 | 42 |
| 2017 August | 25 | 14 | 39 |
| 2017 July | 19 | 6 | 25 |
| 2017 June | 19 | 10 | 29 |
| 2017 May | 39 | 7 | 46 |
| 2017 April | 8 | 5 | 13 |
| 2017 March | 21 | 11 | 32 |
| 2017 February | 13 | 4 | 17 |
| 2017 January | 15 | 5 | 20 |
| 2016 December | 12 | 6 | 18 |
| 2016 November | 8 | 5 | 13 |
| 2016 October | 12 | 5 | 17 |
| 2016 September | 6 | 9 | 15 |
| 2016 August | 3 | 1 | 4 |
| 2016 July | 4 | 3 | 7 |
| 2016 June | 1 | 0 | 1 |
| 2016 May | 0 | 1 | 1 |
| 2016 April | 1 | 4 | 5 |
| 2016 March | 2 | 5 | 7 |
| 2016 February | 5 | 13 | 18 |
| 2016 January | 4 | 9 | 13 |
| 2015 December | 8 | 2 | 10 |
| 2015 November | 4 | 4 | 8 |
| 2015 October | 3 | 1 | 4 |
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