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Micobactérias atípicas em doentes sem síndroma de imunodeficiência adquirida
Nontuberculous mycobacteria in non-AIDS patients
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Marinho, G. Fernandes, T. Carvalho, D. Pinheiro, I. Gomes" "autores" => array:5 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Marinho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "G." "apellidos" => "Fernandes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 2 => array:3 [ "nombre" => "T." "apellidos" => "Carvalho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 3 => array:3 [ "nombre" => "D." "apellidos" => "Pinheiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 4 => array:3 [ "nombre" => "I." "apellidos" => "Gomes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Serviço de Pneumologia do HSJ (Director: Prof. Dr. J. Agostinho Marques), Porto, Portugal / <span class="elsevierStyleItalic">Pulmonology Unit, Hospital São João, Oporto, Portugal</span>" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Serviço de Microbiologia do HSJ (Directora: Prof.ª Dr.ª MJ Vaz), Porto, Portugal / <span class="elsevierStyleItalic">Microbiology Unit, Hospital São João, Oporto, Portugal</span>" "etiqueta" => "2" "identificador" => "af0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Nontuberculous mycobacteria in non-AIDS patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-08-11" "fechaAceptado" => "2008-01-07" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570481" "palabras" => array:3 [ 0 => "Micobactérias atípicas" 1 => "isolamento" 2 => "doença pulmonar" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570480" "palabras" => array:3 [ 0 => "Nontuberculous mycobacteria" 1 => "isolation" 2 => "pulmonary disease" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">As micobactérias não tuberculosas (MNT) têm um papel patogénico de importância crescente em doentes com serologia positiva para o vírus da imunodeficiência humana (VIH), em doentes com doença pulmonar cró-nica, em outras doenças crónicas, e ainda nos idosos.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivo:</span> Avaliar a importância do isolamento de MNT em amostras respiratórias em doentes adultos sem infecção VIH.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Material e métodos:</span> Estudo retrospectivo dos doentes do Hospital de São João sem infecção VIH conhe-cida, com pelo menos uma amostra respiratória positiva para MNT, entre 1997 e 2004.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados:</span> Foram encontrados 102 doentes com idade mediana de 63 anos; 67% do sexo masculino. Sessenta e três doentes (62%) apresentavam patologia respiratória prévia, maioritariamente sequelas de tu-berculose pulmonar (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19). O agente mais isolado (47%) foi o <span class="elsevierStyleItalic">Mycobacterium avium complex</span> (MAC).</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Foram identificados 16 casos de doença (15,7%), 14 dos quais cumpriam os critérios definidos pela <span class="elsevierStyleItalic">American Thoracic Society.</span> Dez homens e 6 mulheres, idade mediana de 65 anos. Doze doentes tinham doença pulmonar prévia.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Todos tinham clínica de infecção respiratória. As altera-ções mais observadas no Rx de tórax foram o infiltrado pulmonar, a opacidade linear e a cavitação. O MAC foi o causador de doença em 75% (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>12) dos casos.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusão:</span> O isolamento de micobactérias atípicas em amostras respiratórias, nomeadamente em doentes com patologia pulmonar prévia, não significou doença na grande maioria dos casos, mesmo em doentes com doença pulmonar prévia. O agente mais frequentemente isolado foi o MAC, tendo a sua importância relativa sido ainda maior nos casos de doença pulmonar por MNT.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (3): 323-337</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Nontuberculous mycobacteria (NTM) play an increasingly significant pathogenic role in HIV-positive patients, in patients with chronic lung disease, in other chronic conditions and in the elderly.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aims:</span> Evaluate the importance of NTM isolation in respiratory samples in patients without HIV-infection.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Methods:</span> Retrospective evaluation of our hospital patients with no known AIDS, with at least one NTM positive respiratory sample, from 1997-2004.</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results:</span> We found 102 patients, with a median age of 63 years; 67% male. Sixty-three (62%) had underlying lung disease, mainly tuberculosis sequelae (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19). The majority (47%) of the isolations were <span class="elsevierStyleItalic">Mycobacterium avium complex</span> (MAC).</p><p id="sp0065" class="elsevierStyleSimplePara elsevierViewall">A diagnosis of <span class="elsevierStyleItalic">Mycobacterium</span> pulmonary disease was made in 16 patients (15.7%), 14 of which met the American Thoracic Society diagnostic criteria. Ten male and 6 female; median age 65 years. Twelve had underlying lung disease. All of them had respiratory infection complaints. Chest X-rays showed mainly pulmonary infiltrates, linear opacities and cavitation. MAC was the cause of mycobacterium respiratory disease in 12 patients (75%).</p><p id="sp0070" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusion:</span> NTM isolation did not equal pulmonary NTM disease in the majority of cases, even in patients with underlying lung disease. MAC was the most commonly isolated agent and its relative importance was higher in the presence of NTM disease.</p><p id="sp0075" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (3): 323-337</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0040">Bibliografia / Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:32 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of opportunist mycobacterial infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Subcommittee of Joint Tuberculosis Committee of British Thoracic Society" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2000" "volumen" => "55" "paginaInicial" => "210" "paginaFinal" => "218" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10679540" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nontuberculous mycobacteria in non-HIV patients: epidemiology, treatment and response" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.T. Henry" 1 => "L. Inamdar" 2 => "D. O`Riordain" 3 => "M. 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Holland" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cytokine Growth Factor Rev" "fecha" => "2000" "volumen" => "11" "paginaInicial" => "321" "paginaFinal" => "333" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10959079" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "American Thoracic Society" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Diagnosis and treatment of disease caused by nontu-berculous mycobacteria" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.156.2.atsstatement" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1997" "volumen" => "156" "paginaInicial" => "S1" "paginaFinal" => "S25" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9279284" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary disease caused by rapid growing mycobacteria" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Daley Charles" 1 => "Griffith E. David" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chest Med" "fecha" => "2002" "volumen" => "23" "paginaInicial" => "623" "paginaFinal" => "632" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12370998" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nontuberculous Mycobacteria-Multicenter Prevalence Study in Cystic Fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "Kenneth N. Olivier" 1 => "David J. Weber" 2 => "Richard J. Wallace" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Respir Crit Care" "fecha" => "2003" "volumen" => "167" "paginaInicial" => "828" "paginaFinal" => "834" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nontu-berculous mycobacterial infection in young children with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.R. Esther Jr." 1 => "M.M. Henry" 2 => "P.L. Molina" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ppul.20222" "Revista" => array:6 [ "tituloSerie" => "Pediatr Pulmonol" "fecha" => "2005" "volumen" => "40" "paginaInicial" => "39" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15858802" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Age-related prevalence and distribution on nontuberculous mycobacterial species among patients with cystic fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Pierre-Audigier" 1 => "A. Ferroni" 2 => "I. Sermet-Gaudelas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/JCM.43.7.3467-3470.2005" "Revista" => array:6 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2005" "volumen" => "43" "paginaInicial" => "3467" "paginaFinal" => "3470" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16000480" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchiectasis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.F. Barker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMra012519" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2002" "volumen" => "346" "paginaInicial" => "1383" "paginaFinal" => "1393" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11986413" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nontuberculous mycobacteria in patients with bronchiectasis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Wickremasinghe" 1 => "L.J. Ozerovitch" 2 => "G. Davies" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Thorax" "fecha" => "2005" "volumen" => "60" "paginaInicial" => "1048" "paginaFinal" => "1051" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." 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Article information
ISSN: 08732159Original language: Portuguese
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