Artigo Original/Original Article
Efeitos do salbutamol e do formoterol sobre pressão arterial, frequência cardíaca e saturação de oxigénio em asmáticos, durante uma hora
One hour effects of salbutamol and formoterol on blood pressure, heart rate and oxygen saturation in asthmatics
Geraldo Andrade Capuchinho-Júnior1, Ricardo Marques Dias2,
, Sônia Regina da Silva de Carvalho3
Corresponding author
dias.ricardomarques@gmail.com
Correspondência / Corresponding author: Ricardo Marques Dias, Rua Barão da Torre 388/104 – CEP 22411-000, Ipanema – Rio de Janeiro – RJ - Brasil.
Correspondência / Corresponding author: Ricardo Marques Dias, Rua Barão da Torre 388/104 – CEP 22411-000, Ipanema – Rio de Janeiro – RJ - Brasil.
1 Académico da Escola de Medicina e Cirurgia da Universidade Federal do Estado do Rio de Janeiro (UniRio), bolseiro do Programa de Iniciação Científica da UNIRIO (IC/ UniRio) / Scholarship holder, UNIRIO Scientific Initiation Programme (IC/UniRio).
2 Professor Titular de Pneumologia da UniRio, Doutor em Medicina (Pneumologia). Líder do Grupo de Pesquisa “Pneumologia-UNIRIO” / Titular Professor, Pulmonology, UniRio, MD (Pulmonology). UniRio-Pulmonology research team leader.
3 Professora Adjunta da UniRio, Mestre em Medicina (Pneumologia) / Assistant Professor, UniRio, MSc Medicine (Pulmonology).
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Líder do Grupo de Pesquisa “Pneumologia-UNIRIO” / <span class="elsevierStyleItalic">Titular Professor, Pulmonology, UniRio, MD (Pulmonology). UniRio-Pulmonology research team leader.</span>" "etiqueta" => "2" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Professora Adjunta da UniRio, Mestre em Medicina (Pneumologia) / <span class="elsevierStyleItalic">Assistant Professor, UniRio, MSc Medicine (Pulmonology).</span>" "etiqueta" => "3" "identificador" => "af0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "*" "correspondencia" => "<span class="elsevierStyleBold">Correspondência / <span class="elsevierStyleItalic">Corresponding author:</span></span> Ricardo Marques Dias, Rua Barão da Torre 388/104 – CEP 22411-000, Ipanema – Rio de Janeiro – RJ - Brasil." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "One hour effects of salbutamol and formoterol on blood pressure, heart rate and oxygen saturation in asthmatics" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-08-15" "fechaAceptado" => "2008-01-07" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570484" "palabras" => array:5 [ 0 => "Asma" 1 => "broncodilatadores/efeitos adversos" 2 => "frequência cardíaca" 3 => "pressão arterial sistémica" 4 => "saturação de oxigénio" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570485" "palabras" => array:5 [ 0 => "Asthma" 1 => "bronchodilator agents/adverse effects" 2 => "heart rate" 3 => "blood pressure" 4 => "oxygen saturation" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivo:</span> Analisar os possíveis efeitos do uso de β-2 -agonistas, de curta e longa duração, nas pressões arteriais sistólica (PAS) e diastólica (PAD), na saturação parcial de oxigénio (SpO<span class="elsevierStyleInf">2</span>) e na frequência cardíaca (FC), durante o período de uma hora.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Material e métodos:</span> Vinte e quatro doentes com asma persistente grave, em tratamento no ambulatório de Pneumologia do Hospital Universitário Gaffrée e Guinle, foram seleccionados para um ensaio clínico sequencial e cruzado. Os valores da PAS, PAD, SpO<span class="elsevierStyleInf">2</span> e FC foram registados antes e após o uso de broncodilatadores, salbutamol 400<span class="elsevierStyleHsp" style=""></span>μg e formoterol 12<span class="elsevierStyleHsp" style=""></span>μg, em dias diferentes, com intervalo mínimo de 24 horas.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados:</span> Todos os doentes apresentaram distúrbio ventilatório obstrutivo, identificado pela redução da relação entre o volume expiratório forçado no primeiro segundo (VEMS) e a capacidade vital forçada (CVF). Após o uso de substância broncodilatadora, não houve variação significativa nas PAS e PAD, nem na FC; po-rém, a SpO<span class="elsevierStyleInf">2</span> aumentou com o uso de salbutamol.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusão:</span> Não foram observadas alterações hemo-dinâmicas significativas após o uso de salbutamol e formoterol nas doses preconizadas.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (3): 353-361</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aim:</span> To analyse systolic (SBP) and diastolic blood pressure (DBP), partial oxygen saturation (SpO<span class="elsevierStyleInf">2</span>) and heart rate (HR) disorders for an hour after short and long acting ß<span class="elsevierStyleInf">2</span>-agonists.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Material and methods:</span> Twenty-four severe persistent asthma Pulmonology outpatients at Hospital Universitário Gaffrée e Guinle were selected. SBP, DBP, SpO<span class="elsevierStyleInf">2</span> and HR values were determined before and after 400<span class="elsevierStyleHsp" style=""></span>μg of salbutamol and 12<span class="elsevierStyleHsp" style=""></span>μg of formoterol, on different days, with a minimum interval of 24 hours.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results:</span> All patients showed ventilatory obstruction, as seen by a reduced FEV1/FVC ratio. There was no statistical SBP/DBP/HR difference after bronchodilator agents, but SpO<span class="elsevierStyleInf">2</span> increased with salbutamol.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusion:</span> A standard dose of salbutamol and formoterol does not cause haemodynamic disorder.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (3): 353-361</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0020">Bibliografia / Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:14 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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Güler" 3 => "M. Tuncer" 4 => "C. Sezgi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "numero" => "3" "paginaInicial" => "9" "paginaFinal" => "1136" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute electrophysiologic of inhaled salbutamol in humans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "E.M. Kallergis" 1 => "E.G. Manios" 2 => "E.M. Kanoupakis" 3 => "S.E. Schiza" 4 => "H.E. Mavrakis" 5 => "N.K. Klapsinos" 6 => "P.E. Vardas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "127" "paginaInicial" => "63" "paginaFinal" => "2057" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meta-analyses. Effect of long-acting beta agonist on severe asthma exacerbations and asthma-related deaths" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.R. Salpeter" 1 => "N.S. Buckley" 2 => "T.M. Ormiston" 3 => "E.E. 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Article information
ISSN: 08732159Original language: Portuguese
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