Infecção na modulaçâo da asma1

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Pinto" "apellidos" => "Mendes" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The role of infection in asthma<a class="elsevierStyleCrossRef" href="#fn0005">1</a>" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-05-23" "fechaAceptado" => "2008-07-08" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570126" "palabras" => array:3 [ 0 => "Asma e infecção" 1 => "asma e vírus" 2 => "endotoxinas" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570127" "palabras" => array:3 [ 0 => "Asthma and infection" 1 => "asthma and virus" 2 => "endotoxins" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "Faz-se uma revisão da influência das infecções no aparecimento e na clínica da asma brônquica. Dá-se o relevo que merece à intervenção virusal, sobretudo ao rinovírus, pela sua influência nas exacerbações, e ao vírus sincicial respiratório, sobre o qual recai a suspeita de poder ser causa determinante no aparecimento da síndroma asmática. Tentam-se esclarecer os mecanismos da resposta imune à agressão virusal em função das debilidades da resposta do asmático e do atópico, sobretudo no período perinatal, salientando-se, ainda, um efeito de potenciação da agressão virusal sobre a resposta atópica. Aborda-se a hipótese higiénica e a sua falta de consistência científica, pelo menos no papel que pretende atribuir a um não demonstrado antagonismo das respostas linfocitárias Th1 e Th2, apontando-se a importância actual da investigação, não das bactérias mas dos produtos bacterianos, como as endotoxinas, na modulação da asma e da atopia, dando-se relevo aos estudos que, a partir deste modelo, demonstram uma influência do ambiente na secreção génica e, consequentemente, no fenótipo. Invocam-se, nas entrelinhas, vários mecanismos que podem explicar a asma neutrofílica que, para muitos, é um paradoxo perante o consagrado domínio do eosinófilo na inflamação asmática.Rev Port Pneumol 2008; XIV (5): 647-675" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "This paper reviews the impact of infections on the onset and clinical course of bronchial asthma. A just emphasis is given to the role viral infections, particularly rhinovirus infections, play in exacerbations, and that played by respiratory syncytial virus, suspected of triggering the asthmatic syndrome. The mechanisms of the immune response to virus attacks are explained, highlighting the asthmatic and allergic patient’s weakened response, particularly in the perinatal period. Further stressed is a potentiating effect of viral aggression on the allergic response. The hygiene hypothesis and its lack of scientific consistency is detailed, at least as far as the role it seeks to confer on an unproven antagonism of the Th1 and Th2 lymphocyte responses. The current importance of research not into bacteria, but into bacterial products, including endotoxins, on the modulation of asthma and allergy is noted. Studies which, along these lines, show an environmental impact on genetic secretion in the phenotype are underlined. Also discussed in passing are several mechanisms which go towards explaining neutrophilic asthma – for many a contradiction, given eosinophilia’s stranglehold on asthmatic inflammation.Rev Port Pneumol 2008; XIV (5): 647-675" ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "Trabalho apresentado no XXIII Congresso de Pneumologia da SPP – Guarda, Novembro 2007 / Paper presented at the XXIII Congresso de Pneumologia da SPP / PSP Pulmonology Congress, Guarda, November 2007" "identificador" => "fn0005" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "Bibliografia / Bibliography" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:114 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Viral infections and asthma inception" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2004.08.031" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2004" "volumen" => "114" "paginaInicial" => "1023" "paginaFinal" => "1026" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term prospective study of children after respiratory syncytial vírus infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1984" "volumen" => "105" "paginaInicial" => "358" "paginaFinal" => "364" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of respiratory syncytial virus, parainfluenza 3, adenovirus and rhinovirus sequences in respiratory tract of infants by polymerase chain reaction and hybridization" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Diagn Virol" "fecha" => "1997" "volumen" => "8" "paginaInicial" => "31" "paginaFinal" => "40" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory syncytial virus: the virus, the disease and the immune response" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Paediatr Respir Rev" "fecha" => "2004" "volumen" => "5" "numero" => "Suppl. A" "paginaInicial" => "223" "paginaFinal" => "238" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is asthma an infectious disease?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2003" "volumen" => "3" "paginaInicial" => "S385" "paginaFinal" => "S390" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory infections and asthma: current treatment strategies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ …1] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1359-6446(04)03239-8" "Revista" => array:6 [ "tituloSerie" => "Drug Discovery Today" "fecha" => "2004" "volumen" => "9" "paginaInicial" => "831" "paginaFinal" => "837" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." 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Artigo de Revisão/Review Article

Infecção na modulaçâo da asma1

The role of infection in asthma1

J. Pinto Mendes

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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Faz-se uma revis&#227;o da influ&#234;ncia das infec&#231;&#245;es no aparecimento e na cl&#237;nica da asma br&#244;nquica&#46; D&#225;-se o relevo que merece &#224; interven&#231;&#227;o virusal&#44; sobretudo ao rinov&#237;rus&#44; pela sua influ&#234;ncia nas exacerba&#231;&#245;es&#44; e ao v&#237;rus sincicial respirat&#243;rio&#44; sobre o qual recai a suspeita de poder ser causa determinante no aparecimento da s&#237;ndroma asm&#225;tica&#46; Tentam-se esclarecer os mecanismos da resposta imune &#224; agress&#227;o virusal em fun&#231;&#227;o das debilidades da resposta do asm&#225;tico e do at&#243;pico&#44; sobretudo no per&#237;odo perinatal&#44; salientando-se&#44; ainda&#44; um efeito de potencia&#231;&#227;o da agress&#227;o virusal sobre a resposta at&#243;pica&#46; Aborda-se a hip&#243;tese higi&#233;nica e a sua falta de consist&#234;ncia cient&#237;fica&#44; pelo menos no papel que pretende atribuir a um n&#227;o demonstrado antagonismo das respostas linfocit&#225;rias Th<span class="elsevierStyleInf">1</span> e Th<span class="elsevierStyleInf">2&#44;</span> apontando-se a import&#226;ncia actual da investiga&#231;&#227;o&#44; n&#227;o das bact&#233;rias mas dos produtos bacterianos&#44; como as endotoxinas&#44; na modula&#231;&#227;o da asma e da atopia&#44; dando-se relevo aos estudos que&#44; a partir deste modelo&#44; demonstram uma influ&#234;ncia do ambiente na secre&#231;&#227;o g&#233;nica e&#44; consequentemente&#44; no fen&#243;tipo&#46; Invocam-se&#44; nas entrelinhas&#44; v&#225;rios mecanismos que podem explicar a asma neutrof&#237;lica que&#44; para muitos&#44; &#233; um paradoxo perante o consagrado dom&#237;nio do eosin&#243;filo na inflama&#231;&#227;o asm&#225;tica&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;5&#41;&#58; 647-675</span></p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">This paper reviews the impact of infections on the onset and clinical course of bronchial asthma&#46; A just emphasis is given to the role viral infections&#44; particularly rhinovirus infections&#44; play in exacerbations&#44; and that played by respiratory syncytial virus&#44; suspected of triggering the asthmatic syndrome&#46; The mechanisms of the immune response to virus attacks are explained&#44; highlighting the asthmatic and allergic patient&#8217;s weakened response&#44; particularly in the perinatal period&#46; Further stressed is a potentiating effect of viral aggression on the allergic response&#46; The hygiene hypothesis and its lack of scientific consistency is detailed&#44; at least as far as the role it seeks to confer on an unproven antagonism of the Th<span class="elsevierStyleInf">1</span> and Th<span class="elsevierStyleInf">2</span> lymphocyte responses&#46; The current importance of research not into bacteria&#44; but into bacterial products&#44; including endotoxins&#44; on the modulation of asthma and allergy is noted&#46; Studies which&#44; along these lines&#44; show an environmental impact on genetic secretion in the phenotype are underlined&#46; Also discussed in passing are several mechanisms which go towards explaining neutrophilic asthma &#8211; for many a contradiction&#44; given eosinophilia&#8217;s stranglehold on asthmatic inflammation&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;5&#41;&#58; 647-675</span></p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="np0005">Trabalho apresentado no XXIII Congresso de Pneumologia da SPP &#8211; Guarda&#44; Novembro 2007 &#47; Paper presented at the XXIII Congresso de Pneumologia da SPP &#47; PSP Pulmonology Congress&#44; Guarda&#44; November 2007</p>"
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                          "volumen" => "100"
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                        "titulo" => "Viral infections and asthma inception"
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                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "2004"
                          "volumen" => "114"
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                        "titulo" => "Community study of role of viral infections in exacerbations of asthma in 9-11 years old children"
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                        "doi" => "10.1164/rccm.200312-1647OC"
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                          "tituloSerie" => "Am J Respir Crit Care Med"
                          "fecha" => "2004"
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Article information

ISSN: 08732159
Original language: Portuguese

DOI:10.1016/S0873-2159(15)30275-0

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Year/Month	Html	Pdf	Total

2024 November	5	4	9
2024 October	25	30	55
2024 September	26	22	48
2024 August	39	34	73
2024 July	38	34	72
2024 June	25	20	45
2024 May	32	26	58
2024 April	34	26	60
2024 March	30	31	61
2024 February	23	16	39
2024 January	21	27	48
2023 December	19	19	38
2023 November	26	26	52
2023 October	24	38	62
2023 September	26	22	48
2023 August	32	29	61
2023 July	26	29	55
2023 June	20	22	42
2023 May	25	26	51
2023 April	29	20	49
2023 March	22	38	60
2023 February	45	36	81
2023 January	44	22	66
2022 December	39	37	76
2022 November	55	42	97
2022 October	46	22	68
2022 September	27	73	100
2022 August	34	53	87
2022 July	26	32	58
2022 June	19	32	51
2022 May	35	36	71
2022 April	26	38	64
2022 March	24	21	45
2022 February	30	25	55
2022 January	28	33	61
2021 December	25	26	51
2021 November	20	26	46
2021 October	42	39	81
2021 September	20	21	41
2021 August	23	21	44
2021 July	34	22	56
2021 June	21	21	42
2021 May	27	35	62
2021 April	70	48	118
2021 March	51	20	71
2021 February	43	17	60
2021 January	23	9	32
2020 December	24	11	35
2020 November	50	14	64
2020 October	27	20	47
2020 September	53	28	81
2020 August	60	21	81
2020 July	67	22	89
2020 June	55	30	85
2020 May	64	20	84
2020 April	77	25	102
2020 March	73	20	93
2020 February	60	19	79
2020 January	50	20	70
2019 December	60	24	84
2019 November	69	29	98
2019 October	73	26	99
2019 September	56	33	89
2019 August	76	30	106
2019 July	53	22	75
2019 June	42	26	68
2019 May	60	40	100
2019 April	45	15	60
2019 March	62	23	85
2019 February	42	9	51
2019 January	56	18	74
2018 December	25	4	29
2018 November	1	6	7
2018 October	9	4	13
2018 September	13	10	23
2018 August	50	30	80
2018 July	33	31	64
2018 June	45	19	64
2018 May	49	18	67
2018 April	37	37	74
2018 March	35	29	64
2018 February	26	8	34
2018 January	26	20	46
2017 December	27	12	39
2017 November	32	17	49
2017 October	24	22	46
2017 September	32	7	39
2017 August	34	12	46
2017 July	20	8	28
2017 June	29	17	46
2017 May	40	16	56
2017 April	16	5	21
2017 March	13	4	17
2017 February	12	2	14
2017 January	12	6	18
2016 December	13	7	20
2016 November	9	3	12
2016 October	9	7	16
2016 September	5	16	21
2016 August	10	2	12
2016 July	4	3	7
2016 June	0	2	2
2016 May	1	8	9
2016 April	1	22	23
2016 March	2	6	8
2016 February	8	6	14
2016 January	5	4	9
2015 December	8	6	14
2015 November	1	2	3
2015 October	2	2	4

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