Caso Clínico/Clinical Case
Infecção por Bordetella pertussis com hipertensão pulmonar grave num recém-nascido com boa evolução clínica – Caso clínico
Pertussis with severe pulmonary hypertension in a newborn with good outcome – case report
Sérgia Soares1, Gustavo Rocha1,
, Susana Pissarra1,*, Ana Carriço2, Inês Azevedo3,*, Joana Sobrinho Simões4, Hercília Guimarães1,*
,**
Corresponding author
gusrocha@oninet.pt
Correspondence: Gustavo Rocha, Serviço de Neonatologia / Departamento de Pediatria, Hospital de São João – Piso 2, Alameda Prof. Hernâni Monteiro, 4202 – 451, Porto, Portugal, Tel: +351 225095816, Fax: +351225512273.
Correspondence: Gustavo Rocha, Serviço de Neonatologia / Departamento de Pediatria, Hospital de São João – Piso 2, Alameda Prof. Hernâni Monteiro, 4202 – 451, Porto, Portugal, Tel: +351 225095816, Fax: +351225512273.
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Os recém-nascidos e lactentes ainda sem imunização completa e filhos de mães com baixos títulos de anticorpos para a <span class="elsevierStyleItalic">Bordetella pertussis</span> são altamente susceptíveis à infecção e têm maior risco de doença grave e morte. A infecção por <span class="elsevierStyleItalic">Bordetella pertussis</span> associada a hipertensão pulmonar no recém-nascido é frequentemente fatal. Os autores descrevem um caso clínico de doença grave num recém-nascido com insuficiência respiratória aguda e hipertensão pulmonar grave, tratado com sucesso com sildenafil e óxido nítrico inalado.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (5): 687-692</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">In spite of the availability and widespread use of vaccines, pertussis is far from controlled. Newborns and infants too young to be fully vaccinated, born from mothers with low antibody titers to <span class="elsevierStyleItalic">Bordetella pertussis</span>, are highly susceptible to infection and at risk of severe disease and death. Pertussis associated with pulmonary hypertension in the newborn is often fatal. The authors report a clinical case of severe pertussis-induced respiratory failure associated to severe pulmonary hypertension in a neonate successfully treated with sildenafil and inhaled nitric oxide.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (5): 687-692</span></p></span>" ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="np0005">Faculty of Medicine of Porto University, Porto, Portugal</p>" "identificador" => "fn0005" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosing pertussis: the role of polymerase chain reaction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "E. Bamberger" 1 => "N. Lahat" 2 => "V. Gershtein" 3 => "R. Gershtein" 4 => "D. Benilevi" 5 => "S. Shapiro" 6 => "I. Kassis" 7 => "L. Rubin" 8 => "I. Srugo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Isr Med Assoc J" "fecha" => "2005" "volumen" => "7" "paginaInicial" => "351" "paginaFinal" => "354" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15984374" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." 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Koidl" 1 => "M. Bozic" 2 => "A. Burmeiter" 3 => "M. Hess" 4 => "E. Marth" 5 => "H. Kessler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/JCM.01303-06" "Revista" => array:6 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2007" "volumen" => "45" "paginaInicial" => "347" "paginaFinal" => "350" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17151212" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A specific real-time PCR assay for the detection of <span class="elsevierStyleItalic">Bordetella pertussis</span>" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Vincart" 1 => "R. De Mendonça" 2 => "S. Rottiers" 3 => "F. Vermeulen" 4 => "M.J. Struelens" 5 => "O. 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Article information
ISSN: 08732159Original language: Portuguese
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