array:24 [
  "pii" => "S0873215915302853"
  "issn" => "08732159"
  "doi" => "10.1016/S0873-2159(15)30285-3"
  "estado" => "S350"
  "fechaPublicacion" => "2008-11-01"
  "aid" => "3"
  "copyright" => "Sociedade Portuguesa de Pneumologia/SPP"
  "copyrightAnyo" => "2008"
  "documento" => "simple-article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2008;14:747-68"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2847
    "formatos" => array:3 [
      "EPUB" => 237
      "HTML" => 1783
      "PDF" => 827
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0873215915302865"
    "issn" => "08732159"
    "doi" => "10.1016/S0873-2159(15)30286-5"
    "estado" => "S350"
    "fechaPublicacion" => "2008-11-01"
    "aid" => "4"
    "copyright" => "Sociedade Portuguesa de Pneumologia/SPP"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2008;14:769-85"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2791
      "formatos" => array:3 [
        "EPUB" => 230
        "HTML" => 1800
        "PDF" => 761
      ]
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original&#47;Original Article</span>"
      "titulo" => "Correla&#231;&#227;o entre hipoxemia moderada e fun&#231;&#227;o muscular esquel&#233;tica perif&#233;rica na doen&#231;a pulmonar obstrutiva cr&#243;nica &#8211; Estudo-piloto"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "769"
          "paginaFinal" => "785"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Correlation between mild hypoxaemia and limb skeletal muscle function in chronic obstructive pulmonary disease &#8211; Pilot study"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#233;rgio Leite Rodrigues, C&#233;sar Augusto Melo e Silva, C&#233;sar Ferreira Amorim, Terezinha Lima, Fernanda Almeida Ribeiro, Carlos Alberto de Assis Viegas"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "S&#233;rgio"
              "apellidos" => "Leite Rodrigues"
            ]
            1 => array:2 [
              "nombre" => "C&#233;sar"
              "apellidos" => "Augusto Melo e Silva"
            ]
            2 => array:2 [
              "nombre" => "C&#233;sar"
              "apellidos" => "Ferreira Amorim"
            ]
            3 => array:2 [
              "nombre" => "Terezinha"
              "apellidos" => "Lima"
            ]
            4 => array:2 [
              "nombre" => "Fernanda"
              "apellidos" => "Almeida Ribeiro"
            ]
            5 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Alberto de Assis Viegas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302865?idApp=UINPBA00004E"
    "url" => "/08732159/0000001400000006/v1_201509151433/S0873215915302865/v1_201509151433/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0873215915302841"
    "issn" => "08732159"
    "doi" => "10.1016/S0873-2159(15)30284-1"
    "estado" => "S350"
    "fechaPublicacion" => "2008-11-01"
    "aid" => "2"
    "copyright" => "Sociedade Portuguesa de Pneumologia&#47;SPP"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2008;14:727-46"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2176
      "formatos" => array:3 [
        "EPUB" => 228
        "HTML" => 1268
        "PDF" => 680
      ]
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original&#47;Original Article</span>"
      "titulo" => "Estudo de polimorfismos gen&#233;ticos do HLA &#40;classes I e II&#41; e do TNF-&#945; em doentes com sarcoidose"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "727"
          "paginaFinal" => "746"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "HLA class I and II and TNF-&#945; gene polymorphisms in sarcoidosis patients"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ant&#243;nio Morais, Helena Alves, Bruno Lima, Lu&#237;s Delgado, Ricardo Gon&#231;alves, Sandra Tafulo"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Ant&#243;nio"
              "apellidos" => "Morais"
            ]
            1 => array:2 [
              "nombre" => "Helena"
              "apellidos" => "Alves"
            ]
            2 => array:2 [
              "nombre" => "Bruno"
              "apellidos" => "Lima"
            ]
            3 => array:2 [
              "nombre" => "Lu&#237;s"
              "apellidos" => "Delgado"
            ]
            4 => array:2 [
              "nombre" => "Ricardo"
              "apellidos" => "Gon&#231;alves"
            ]
            5 => array:2 [
              "nombre" => "Sandra"
              "apellidos" => "Tafulo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302841?idApp=UINPBA00004E"
    "url" => "/08732159/0000001400000006/v1_201509151433/S0873215915302841/v1_201509151433/pt/main.assets"
  ]
  "pt" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original&#47;Original Article</span>"
    "titulo" => "Preval&#234;ncia da asma e da rinite em adolescentes de 13 anos do Porto&#44; Portugal"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "747"
        "paginaFinal" => "768"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Helena Falc&#227;o, Elisabete Ramos, Agostinho Marques, Henrique Barros"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Helena"
            "apellidos" => "Falc&#227;o"
            "email" => array:1 [
              0 => "hfalcao&#64;med&#46;up&#46;pt"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "af0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cr0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Elisabete"
            "apellidos" => "Ramos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">2</span>"
                "identificador" => "af0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Agostinho"
            "apellidos" => "Marques"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">3</span>"
                "identificador" => "af0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Henrique"
            "apellidos" => "Barros"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">4</span>"
                "identificador" => "af0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Investigadora&#44; Servi&#231;o de Higiene e Epidemiologia&#44; Faculdade de Medicina da Universidade do Porto &#47; Researcher&#44; Hygiene and Epidemiology Unit&#44; School of Medicine&#44; University of Porto&#46;"
            "etiqueta" => "1"
            "identificador" => "af0005"
          ]
          1 => array:3 [
            "entidad" => "Professora&#44; Servi&#231;o de Higiene e Epidemiologia&#44; Faculdade de Medicina da Universidade do Porto &#47; Professor&#44; Hygiene and Epidemiology Unit&#44; School of Medicine&#44; University of Porto&#46;"
            "etiqueta" => "2"
            "identificador" => "af0010"
          ]
          2 => array:3 [
            "entidad" => "Professor Catedr&#225;tico&#44; Servi&#231;o de Pneumologia&#44; Faculdade de Medicina da Universidade do Porto &#47; Cathedratic Professor&#44; Pulmonology Unit&#44; School of Medicine&#44; University of Porto&#46;"
            "etiqueta" => "3"
            "identificador" => "af0015"
          ]
          3 => array:3 [
            "entidad" => "Professor Catedr&#225;tico e Director do Servi&#231;o de Higiene e Epidemiologia&#44; Faculdade de Medicina da Universidade do Porto &#47; Cathedratic Professor and Head&#44; Hygiene and Epidemiology Unit&#44; School of Medicine&#44; University of Porto&#46;"
            "etiqueta" => "4"
            "identificador" => "af0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cr0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "<span class="elsevierStyleBold">Correspond&#234;ncia</span> &#47; <span class="elsevierStyleItalic"><span class="elsevierStyleBold">Correspondence to&#58;</span></span> Helena Falc&#227;o&#44; Servi&#231;o de Higiene e Epidemiologia da Faculdade de Medicina&#44; Alameda Prof&#46; Hern&#226;ni Monteiro&#44; 4200-319 Porto&#44; Portugal&#44; Phone&#58; &#43;<span class="elsevierStyleHsp" style=""></span>351-225507597 &#47; Fax&#58; &#43;<span class="elsevierStyleHsp" style=""></span>351-225095618"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Prevalence of asthma and rhinitis in 13 year old adolescents in Porto&#44; Portugal"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2008-07-08"
    "fechaAceptado" => "2008-09-19"
    "PalabrasClave" => array:2 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec570057"
          "palabras" => array:6 [
            0 => "Adolescentes"
            1 => "asma"
            2 => "rinite"
            3 => "estudos transversais"
            4 => "preval&#234;ncia"
            5 => "tend&#234;ncia"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key-words"
          "identificador" => "xpalclavsec570056"
          "palabras" => array:6 [
            0 => "Adolescents"
            1 => "asthma"
            2 => "rhinitis"
            3 => "cross-sectional studies"
            4 => "prevalence"
            5 => "trends"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introdu&#231;&#227;o&#58;</span> As preval&#234;ncias da asma e rinite t&#234;m aumentado nas &#250;ltimas d&#233;cadas&#44; mas nos &#250;ltimos anos tem sido referida a sua estabiliza&#231;&#227;o ou mesmo diminui&#231;&#227;o&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivo&#58;</span> O objectivo foi o de descrever a preval&#234;ncia de rinite&#44; asma ou sintomas do tipo da asma em adolescentes urbanos de 13 anos&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">M&#233;todos&#58;</span> Os participantes eleg&#237;veis foram todos os alunos das escolas p&#250;blicas e privadas do Porto&#44; nascidos em 1990&#59; 2161 &#40;77&#44;5&#37;&#41; concordaram em participar&#46; Atrav&#233;s de question&#225;rios autoaplicados&#44; a informa&#231;&#227;o recolhida contemplou aspectos sociais&#44; demogr&#225;ficos&#44; comportamentais&#44; hist&#243;ria cl&#237;nica de asma e doen&#231;as al&#233;rgicas do adolescente e fam&#237;lia&#46; Foi usada a vers&#227;o portuguesa do <span class="elsevierStyleItalic">International Study of Asthma and Allergies in Childhood&#8217;s</span> &#40;ISAAC&#41; e foram efectuadas espirometrias&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados&#58;</span> Nesta amostra de adolescentes urbanos de 13 anos&#44; a preval&#234;ncia da asma durante a vida foi de 12&#44;9&#37;&#44; 84&#44;4&#37; com diagn&#243;stico m&#233;dico&#46; A pieira durante a vida foi 18&#44;3&#37; e no &#250;ltimo ano de 9&#44;3&#37;&#46; A rinite foi relatada por 10&#44;1&#37;&#44; mas a preval&#234;ncia durante a vida de adolescentes com espirros&#44; rinorreia serosa ou obstru&#231;&#227;o nasal&#44; foi de 32&#44;0&#37;&#44; e no &#250;ltimo ano de 27&#44;4&#37;&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclus&#227;o&#58;</span> Verificou-se uma estabiliza&#231;&#227;o ou mesmo diminui&#231;&#227;o da preval&#234;ncia dos sintomas e diagn&#243;stico de asma e rinite nos adolescentes do Porto&#44; quando comparada com os resultados do ISAAC em 2002&#44; tal como noutras investiga&#231;&#245;es na Europa&#46; A asma e a rinite est&#227;o frequentemente presentes no mesmo doente e a tosse nocturna &#233; um importante sintoma que surge associado aos sintomas nasais&#46; A fun&#231;&#227;o pulmonar permitiu discriminar os adolescentes com queixas respirat&#243;rias&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;6&#41;&#58; 747-768</span></p></span>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Background&#58;</span> The prevalence of asthma and rhinitis has been increasing over the past few decades&#44; but the last few years have seen these rates stabilise or even decrease&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aim&#58;</span> The aim of our study was to describe the prevalence of rhinitis&#44; asthma or asthma-like symptoms in 13 year-old urban adolescents&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Methods&#58;</span> Eligible participants were all students at state and private schools in Porto born in 1990&#46; 2161 &#40;77&#46;5&#37;&#41; agreed to participate&#46; Information was obtained using self-administered questionnaires inquiring into social&#44; demographic&#44; behavioural and clinical history including asthma and allergic diseases in the adolescent and the family&#46; We used the Portuguese version of the International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41; questionnaire and we also performed spirometry tests&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results&#58;</span> In this sample of 13 year old urban adolescents the prevalence of asthma ever was 12&#46;9&#37;&#44; 84&#46;4&#37; with physician diagnosis&#46; Lifetime wheezing was reported by 18&#46;3&#37; and current wheezing by 9&#46;3&#37; of the adolescents&#46; Rhinitis was referred to by 10&#46;1&#37;&#44; but the prevalence of adolescents with sneezing ever&#44; or a runny&#47;blocked nose&#44; was 32&#46;0&#37; and the prevalence in the last 12 months was 27&#46;4&#37;&#46;</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusion&#58;</span> We concluded that there was stabilisation or even decrease in the prevalence of asthma and rhinitis symptoms and diagnosis in adolescents reported in Porto&#44; compared with the 2002 ISAAC study&#44; as observed in other surveys in Europe&#46; Asthma and rhinitis is frequently present in the same patient and nocturnal cough is an important symptom concomitant with nasal symptoms&#46; Measures of lung function permitted the discrimination of adolescents with respiratory complaints&#46;</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;6&#41;&#58; 747-768</span></p></span>"
      ]
    ]
    "lecturaRecomendada" => array:1 [
      0 => array:3 [
        "vista" => "all"
        "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia &#47; Bibliography</span>"
        "seccion" => array:1 [
          0 => array:2 [
            "vista" => "all"
            "bibliografiaReferencia" => array:54 [
              0 => array:3 [
                "identificador" => "bb0005"
                "etiqueta" => "1&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Trends in prevalence of atopic diseases and allergic sensitization in children in Eastern Germany"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "J&#46; Heinrich"
                              1 => "B&#46; Hoelscher"
                              2 => "C&#46; Frye"
                              3 => "I&#46; Meyer"
                              4 => "M&#46; Wjst"
                              5 => "H&#46;E&#46; Wichmann"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2002"
                          "volumen" => "19"
                          "paginaInicial" => "1040"
                          "paginaFinal" => "1046"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12108854"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              1 => array:3 [
                "identificador" => "bb0010"
                "etiqueta" => "2&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Are asthma and allergies in children and adolescents increasing&#63; Results from ISAAC phase I and phase III surveys in M&#252;nster&#44; Germany"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:7 [
                              0 => "W&#46; Maziak"
                              1 => "T&#46; Behrens"
                              2 => "T&#46; Brasky"
                              3 => "H&#46; Duhme"
                              4 => "P&#46; Rzehak"
                              5 => "S&#46; Weiland"
                              6 => "U&#46; Keil"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2003"
                          "volumen" => "58"
                          "paginaInicial" => "572"
                          "paginaFinal" => "579"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12823113"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              2 => array:3 [
                "identificador" => "bb0015"
                "etiqueta" => "3&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Trends in prevalence of asthma and allergy in Finnish young men&#58; nationwide study"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "J&#46; Latvala"
                              1 => "L&#46; von Hertzen"
                              2 => "H&#46; Lindholm"
                              3 => "T&#46; Haahtela"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1136/bmj.38448.603924.AE"
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "2005"
                          "volumen" => "330"
                          "paginaInicial" => "1186"
                          "paginaFinal" => "1187"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15849204"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              3 => array:3 [
                "identificador" => "bb0020"
                "etiqueta" => "4&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Current controversies&#58; sinus disease and the lower airways"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "S&#46;G&#46; Campanella"
                              1 => "M&#46;I&#46; Asher"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Pediatr Pulmonol"
                          "fecha" => "2001"
                          "volumen" => "31"
                          "numero" => "2"
                          "paginaInicial" => "165"
                          "paginaFinal" => "172"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11180693"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              4 => array:3 [
                "identificador" => "bb0025"
                "etiqueta" => "5&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Allergic rhinitis and asthma comorbidity in a survey of young adults in Italy"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:10 [
                              0 => "M&#46; Bugiani"
                              1 => "A&#46; Carosso"
                              2 => "E&#46; Migliore"
                              3 => "P&#46; Piccioni"
                              4 => "A&#46; Corsico"
                              5 => "M&#46; Olivieri"
                              6 => "M&#46; Ferrari"
                              7 => "Pirina P&#46;"
                              8 => "de Marco R&#46;"
                              9 => "ISAYA &#40;ECRHS Italy&#41; Study Group"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1398-9995.2005.00659.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2005"
                          "volumen" => "60"
                          "paginaInicial" => "165"
                          "paginaFinal" => "170"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15647036"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              5 => array:3 [
                "identificador" => "bb0030"
                "etiqueta" => "6&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "World Health Organization&#46; Allergic rhinitis and its impact on asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "J&#46; Bousquet"
                              1 => "P&#46; van Cauwenberge"
                              2 => "N&#46; Khaltaev"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "In collaboration with the World Health Organization&#46; Executive summary of the workshop report&#46; Allergy"
                          "fecha" => "2002"
                          "volumen" => "57"
                          "paginaInicial" => "841"
                          "paginaFinal" => "855"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12169183"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              6 => array:3 [
                "identificador" => "bb0035"
                "etiqueta" => "7&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Risk factors for early&#44; persistent&#44; and late-onset wheezing in young children"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "F&#46; Rusconi"
                              1 => "C&#46; Galassi"
                              2 => "G&#46; Corbo"
                              3 => "F&#46; Forastiere"
                              4 => "A&#46; Biggeri"
                              5 => "G&#46; Ciccone"
                              6 => "E&#46; Renzoni"
                              7 => "SIDRIA Collaborative Group"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.160.5.9811002"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Respir Crit Care Med"
                          "fecha" => "1999"
                          "volumen" => "160"
                          "paginaInicial" => "1617"
                          "paginaFinal" => "1622"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10556130"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              7 => array:3 [
                "identificador" => "bb0040"
                "etiqueta" => "8&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Overview of comorbid associations of allergic rhinitis"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "S&#46; Spector"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1997"
                          "volumen" => "99"
                          "paginaInicial" => "S773"
                          "paginaFinal" => "S780"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9042070"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              8 => array:3 [
                "identificador" => "bb0045"
                "etiqueta" => "9&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Allergic rhinitis and asthma&#58; how important is the link&#63;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "J&#46; Corren"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1997"
                          "volumen" => "99"
                          "numero" => "2"
                          "paginaInicial" => "S781"
                          "paginaFinal" => "S786"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9042071"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              9 => array:3 [
                "identificador" => "bb0050"
                "etiqueta" => "10&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Asthma and wheezing symptoms in young people in six Western countries"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "A&#46; Hublet"
                              1 => "A&#46; Andersen"
                              2 => "E&#46; Godeau"
                              3 => "C&#46; Vereecken"
                              4 => "R&#46; Valimaa"
                              5 => "J&#46; Tynjala"
                              6 => "W&#46; Boyce"
                              7 => "L&#46; Maes"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Rev Epidemiol Sante Publique"
                          "fecha" => "2006"
                          "volumen" => "54"
                          "numero" => "4"
                          "paginaInicial" => "305"
                          "paginaFinal" => "312"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17088695"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              10 => array:3 [
                "identificador" => "bb0055"
                "etiqueta" => "11&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Risk factors and prevalence of allergic rhinitis among Chilean children"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "L&#46; Caussade"
                              1 => "C&#46; Valdivia"
                              2 => "M&#46; Navarro"
                              3 => "B&#46; Perez"
                              4 => "S&#46; Aquevedo"
                              5 => "D&#46; Sanchez"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "/S0034-98872006000400008"
                        "Revista" => array:7 [
                          "tituloSerie" => "Rev Med Chil"
                          "fecha" => "2006"
                          "volumen" => "134"
                          "numero" => "4"
                          "paginaInicial" => "456"
                          "paginaFinal" => "464"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16758081"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              11 => array:3 [
                "identificador" => "bb0060"
                "etiqueta" => "12&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Environmental epidemiology of pediatric asthma and allergy"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "C&#46; Johnson"
                              1 => "D&#46; Ownby"
                              2 => "E&#46; Zoratti"
                              3 => "S&#46; Alford"
                              4 => "K&#46; Williams"
                              5 => "C&#46; Joseph"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Epidemiol Rev"
                          "fecha" => "2002"
                          "volumen" => "24"
                          "numero" => "2"
                          "paginaInicial" => "154"
                          "paginaFinal" => "175"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12762090"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              12 => array:3 [
                "identificador" => "bb0065"
                "etiqueta" => "13&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Genetics of asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "D&#46; Wiesch"
                              1 => "D&#46; Meyers"
                              2 => "E&#46; Bleeker"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1999"
                          "volumen" => "104"
                          "paginaInicial" => "895"
                          "paginaFinal" => "901"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10550729"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              13 => array:3 [
                "identificador" => "bb0070"
                "etiqueta" => "14&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of symptoms of childhood asthma&#44; allergic rhinoconjunctivitis and eczema in the Pacific&#58; The International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:9 [
                              0 => "S&#46; Foliaki"
                              1 => "I&#46; Annesi-Maesano"
                              2 => "R&#46; Daniel"
                              3 => "T&#46; Fakakovikaetau"
                              4 => "M&#46; Magatongia"
                              5 => "N&#46; Tuuau-Potoi"
                              6 => "L&#46; Waqatakirewa"
                              7 => "S&#46; Cheng"
                              8 => "N&#46; Pearce"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1398-9995.2007.01343.x"
                        "Revista" => array:7 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2007"
                          "volumen" => "62"
                          "numero" => "3"
                          "paginaInicial" => "259"
                          "paginaFinal" => "264"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17298342"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              14 => array:3 [
                "identificador" => "bb0075"
                "etiqueta" => "15&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Socioeconomic status and prevalence of allergic rhinitis and atopic eczema symptoms in young adolescents"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:7 [
                              0 => "M&#46; Mercer"
                              1 => "G&#46; Joubert"
                              2 => "R&#46; Ehrlich"
                              3 => "H&#46; Nelson"
                              4 => "M&#46; Poyser"
                              5 => "A&#46; Puterman"
                              6 => "E&#46; Weinberg"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1399-3038.2004.00125.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatr Allergy Immunol"
                          "fecha" => "2004"
                          "volumen" => "15"
                          "paginaInicial" => "234"
                          "paginaFinal" => "241"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15209956"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              15 => array:3 [
                "identificador" => "bb0080"
                "etiqueta" => "16&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "International study of asthma and allergies in childhood &#40;ISAAC&#41;&#58; rationale and methods"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:13 [
                              0 => "M&#46; Asher"
                              1 => "U&#46; Keil"
                              2 => "H&#46; Anderson"
                              3 => "R&#46; Beasley"
                              4 => "J&#46; Crane"
                              5 => "F&#46; Martinez"
                              6 => "E&#46; Mitchell"
                              7 => "N&#46; Pearce"
                              8 => "B&#46; Sibbald"
                              9 => "A&#46; Stewart"
                              10 => "D&#46; Strachan"
                              11 => "S&#46; Weiland"
                              12 => "H&#46; Williams"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "1995"
                          "volumen" => "8"
                          "paginaInicial" => "483"
                          "paginaFinal" => "491"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7789502"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              16 => array:3 [
                "identificador" => "bb0085"
                "etiqueta" => "17&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Standardization of spirometry&#58; 1994 update"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "American Thoracic Society"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.152.3.7663792"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Respir Crit Care Med"
                          "fecha" => "1995"
                          "volumen" => "152"
                          "paginaInicial" => "1107"
                          "paginaFinal" => "1136"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7663792"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              17 => array:3 [
                "identificador" => "bb0090"
                "etiqueta" => "18&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Program The global burden of asthma&#58; executive summary of the GINA Dissemination Committee Report"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "M&#46; Masoli"
                              1 => "D&#46; Fabian"
                              2 => "S&#46; Holt"
                              3 => "Beasley R&#46;"
                              4 => "Global Initiative for asthma &#40;GINA&#41;"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1398-9995.2004.00526.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2004"
                          "volumen" => "59"
                          "paginaInicial" => "469"
                          "paginaFinal" => "478"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15080825"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              18 => array:3 [
                "identificador" => "bb0095"
                "etiqueta" => "19&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Is the prevalence of adult asthma and allergic rhinitis still increasing&#63; Results of an Italian study"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:13 [
                              0 => "G&#46; Verlato"
                              1 => "A&#46; Corsico"
                              2 => "S&#46; Villani"
                              3 => "I&#46; Cerveri"
                              4 => "E&#46; Migliore"
                              5 => "S&#46; Accordini"
                              6 => "A&#46; Carolei"
                              7 => "P&#46; Piccioni"
                              8 => "M&#46; Bugiani"
                              9 => "V&#46; Lo Cascio"
                              10 => "A&#46; Marinoni"
                              11 => "A&#46; Poli"
                              12 => "R&#46; de Marco"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "2003"
                          "volumen" => "111"
                          "paginaInicial" => "1232"
                          "paginaFinal" => "1238"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12789222"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              19 => array:3 [
                "identificador" => "bb0100"
                "etiqueta" => "20&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The rising prevalence of asthma in young Melbourne adults is associated with improvement in treatment"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "R&#46; Woods"
                              1 => "E&#46; Walters"
                              2 => "C&#46; Wharton"
                              3 => "N&#46; Watson"
                              4 => "M&#46; Abramson"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/S1081-1206(10)62204-1"
                        "Revista" => array:6 [
                          "tituloSerie" => "Ann Allergy Asthma Immunol"
                          "fecha" => "2001"
                          "volumen" => "87"
                          "paginaInicial" => "117"
                          "paginaFinal" => "123"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11527242"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              20 => array:3 [
                "identificador" => "bb0105"
                "etiqueta" => "21&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The prevalence of asthma and allergies in Singapore&#59; data from two ISAAC surveys seven years apart"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "X&#46; Wang"
                              1 => "T&#46; Tan"
                              2 => "L&#46; Shek"
                              3 => "S&#46; Chng"
                              4 => "N&#46; Hia"
                              5 => "S&#46; Ma"
                              6 => "B&#46; Lee"
                              7 => "D&#46; Goh"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Arch Dis Child"
                          "fecha" => "2004"
                          "volumen" => "89"
                          "paginaInicial" => "423"
                          "paginaFinal" => "426"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15102631"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              21 => array:3 [
                "identificador" => "bb0110"
                "etiqueta" => "22&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Trends in prevalence of symptoms of asthma&#44; hay fever&#44; and eczema in 12-14 year olds in the British Isles&#44; 1995-2002&#58; questionnaire survey"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:9 [
                              0 => "H&#46; Anderson"
                              1 => "R&#46; Ruggles"
                              2 => "D&#46; Strachan"
                              3 => "J&#46; Austin"
                              4 => "M&#46; Burr"
                              5 => "D&#46; Jeffs"
                              6 => "P&#46; Stranding"
                              7 => "A&#46; Steriu"
                              8 => "R&#46; Goulding"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1136/bmj.38057.583727.47"
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "2004"
                          "volumen" => "328"
                          "paginaInicial" => "1052"
                          "paginaFinal" => "1053"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15028634"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              22 => array:3 [
                "identificador" => "bb0115"
                "etiqueta" => "23&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Is the increase in childhood asthma coming to an end&#63; Findings from three surveys of schoolchildren in Rome&#44; Italy"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:10 [
                              0 => "R&#46; Ronchetti"
                              1 => "M&#46; Villa"
                              2 => "M&#46; Barreto"
                              3 => "R&#46; Rota"
                              4 => "J&#46; Pagani"
                              5 => "S&#46; Martella"
                              6 => "C&#46; Falasca"
                              7 => "B&#46; Paggi"
                              8 => "F&#46; Guglielmi"
                              9 => "G&#46; Ciofetta"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2001"
                          "volumen" => "17"
                          "paginaInicial" => "881"
                          "paginaFinal" => "886"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11488320"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              23 => array:3 [
                "identificador" => "bb0120"
                "etiqueta" => "24&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of asthma and allergy in schoolchildren in Belmont&#44; Australia&#58; three cross-sectional surveys over 20 years"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "B&#46; Toelle"
                              1 => "K&#46; Ng"
                              2 => "E&#46; Belusova"
                              3 => "M&#46; Salome"
                              4 => "K&#46; Peat"
                              5 => "B&#46; Marks"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1136/bmj.328.7436.386"
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "2004"
                          "volumen" => "328"
                          "paginaInicial" => "386"
                          "paginaFinal" => "387"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14962876"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              24 => array:3 [
                "identificador" => "bb0125"
                "etiqueta" => "25&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Swiss Study on Childhood Allergy and Respiratory symptoms&#59; Air Pollution &#40;SCARPOL&#41; team&#46; No further increase in asthma&#44; hay fever and atopic sensitisation in adolescents living in Switzerland"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:9 [
                              0 => "C&#46; Braun-Fahrlander"
                              1 => "M&#46; Gassner"
                              2 => "L&#46; Grize"
                              3 => "K&#46; Takken-Sahli"
                              4 => "U&#46; Neu"
                              5 => "T&#46; Stricker"
                              6 => "H&#46; Varonier"
                              7 => "B&#46; Wuthrich"
                              8 => "Sennhauser F&#46;"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2004"
                          "volumen" => "23"
                          "paginaInicial" => "407"
                          "paginaFinal" => "413"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15065830"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              25 => array:3 [
                "identificador" => "bb0130"
                "etiqueta" => "26&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increasing prevalence of allergic rhinitis but not asthma among children in Hong Kong from 1995 to 2001 &#40;Phase 3 International Study of Asthma and Allergies in Childhood&#41;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "L&#46; Lee"
                              1 => "W&#46; Wong"
                              2 => "L&#46; Lau"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatr Allergy Immunol"
                          "fecha" => "2004"
                          "volumen" => "15"
                          "paginaInicial" => "72"
                          "paginaFinal" => "78"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14998385"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              26 => array:3 [
                "identificador" => "bb0135"
                "etiqueta" => "27&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Stabilization of asthma prevalence among adolescents and increase among schoolchildren &#40;ISAAC phases I and III&#41; in Spain"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:12 [
                              0 => "L&#46; Garc&#237;a-Marcos"
                              1 => "A&#46; Blanco Quir&#243;s"
                              2 => "G&#46; Garcia Hern&#225;ndez"
                              3 => "F&#46; Guillan-Grima"
                              4 => "C&#46; Gonzalez D&#237;az"
                              5 => "I&#46; Ure&#328;a"
                              6 => "A&#46; Pena"
                              7 => "R&#46; Monge"
                              8 => "M&#46; Su&#225;rez-Varela"
                              9 => "A&#46; Varela"
                              10 => "P&#46; Cabanillas"
                              11 => "J&#46; Garrido"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1398-9995.2004.00562.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2004"
                          "volumen" => "59"
                          "paginaInicial" => "1301"
                          "paginaFinal" => "1307"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507099"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              27 => array:3 [
                "identificador" => "bb0140"
                "etiqueta" => "28&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Declining incidence of episodes of asthma&#58; a study of trends in new episodes presenting to general practitioners in the period 1989-98"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "M&#46; Flemming"
                              1 => "R&#46; Sunderland"
                              2 => "W&#46; Cross"
                              3 => "M&#46; Ross"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Thorax"
                          "fecha" => "2000"
                          "volumen" => "55"
                          "paginaInicial" => "657"
                          "paginaFinal" => "661"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10899241"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              28 => array:3 [
                "identificador" => "bb0145"
                "etiqueta" => "29&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Stabilization of an increasing trend in physician&#8211;diagnosed asthma prevalence in Saskatchewan&#44; 1991 to 1998"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "A&#46; Senthilselvan"
                              1 => "J&#46; Lawson"
                              2 => "C&#46; Rennie"
                              3 => "A&#46; Dosman"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2003"
                          "volumen" => "124"
                          "paginaInicial" => "438"
                          "paginaFinal" => "448"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12907527"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              29 => array:3 [
                "identificador" => "bb0150"
                "etiqueta" => "30&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Agreement between parental and self-completed questionnaires about asthma in teenagers"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "L&#46; Hedman"
                              1 => "B&#46; Lindgren"
                              2 => "M&#46; Perzanowski"
                              3 => "E&#46; Ronmark"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1399-3038.2005.00231.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatr Allergy Immunol"
                          "fecha" => "2005"
                          "volumen" => "16"
                          "paginaInicial" => "176"
                          "paginaFinal" => "181"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15787877"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              30 => array:3 [
                "identificador" => "bb0155"
                "etiqueta" => "31&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Signs of reversing trends in prevalence of asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "L&#46; von Hertzen"
                              1 => "T&#46; Haahtela"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1398-9995.2005.00769.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2005"
                          "volumen" => "60"
                          "paginaInicial" => "283"
                          "paginaFinal" => "292"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15679712"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              31 => array:3 [
                "identificador" => "bb0160"
                "etiqueta" => "32&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Changing prevalence of asthma in school children&#58; evidence for diagnostic changes in asthma in two surveys 13<span class="elsevierStyleHsp" style=""></span>yrs apart"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "W&#46; Nystad"
                              1 => "P&#46; Magnus"
                              2 => "A&#46; Gulsvik"
                              3 => "I&#46; Skarpaas"
                              4 => "K&#46; Carlsen"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "1997"
                          "volumen" => "10"
                          "paginaInicial" => "1046"
                          "paginaFinal" => "1051"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9163645"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              32 => array:3 [
                "identificador" => "bb0165"
                "etiqueta" => "33&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Apparent but not real increase in asthma prevalence during the 1990s"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "R&#46; Barraclough"
                              1 => "G&#46; Devereux"
                              2 => "D&#46; Hendrick"
                              3 => "S&#46; Stenton"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2002"
                          "volumen" => "20"
                          "paginaInicial" => "826"
                          "paginaFinal" => "833"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12412671"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              33 => array:3 [
                "identificador" => "bb0170"
                "etiqueta" => "34&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Secular trend in the occurrence of asthma among children and young adults&#58; critical appraisal of repeated cross sectional surveys"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "P&#46; Magnus"
                              1 => "J&#46; Jaakkola"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "1997"
                          "volumen" => "314"
                          "paginaInicial" => "1795"
                          "paginaFinal" => "1799"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9224081"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              34 => array:3 [
                "identificador" => "bb0175"
                "etiqueta" => "35&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increasing prevalence of asthma diagnosis and symptoms in children is confined to mild symptoms"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "G&#46; Kwong"
                              1 => "A&#46; Proctor"
                              2 => "C&#46; Billings"
                              3 => "R&#46; Duggan"
                              4 => "C&#46; Das"
                              5 => "K&#46; Whyte"
                              6 => "V&#46; Powell"
                              7 => "R&#46; Primhak"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Thorax"
                          "fecha" => "2001"
                          "volumen" => "56"
                          "paginaInicial" => "312"
                          "paginaFinal" => "314"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11254824"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              35 => array:3 [
                "identificador" => "bb0180"
                "etiqueta" => "36&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Asthma programme in Finland&#58; a community problem needs community solutions"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "T&#46; Haahtela"
                              1 => "T&#46; Klaukka"
                              2 => "K&#46; Koskela"
                              3 => "M&#46; Erhola"
                              4 => "L&#46; Laitinen"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Thorax"
                          "fecha" => "2001"
                          "volumen" => "56"
                          "paginaInicial" => "806"
                          "paginaFinal" => "814"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11562522"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              36 => array:3 [
                "identificador" => "bb0185"
                "etiqueta" => "37&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Intergenerational 20 year trend in the prevalence of asthma and hay fever in adults&#58; the Midspan family study surveys of parents and offspring"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:7 [
                              0 => "M&#46; Upton"
                              1 => "A&#46; McConnachie"
                              2 => "C&#46; Mc Sharry"
                              3 => "C&#46; Hart"
                              4 => "G&#46; Smith"
                              5 => "C&#46; Gillis"
                              6 => "G&#46; Watt"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "2000"
                          "volumen" => "321"
                          "paginaInicial" => "88"
                          "paginaFinal" => "92"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10884260"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              37 => array:3 [
                "identificador" => "bb0190"
                "etiqueta" => "38&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Incidence of occupational asthma and persistent asthma in young adults has increased in Finland"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "K&#46; Reijula"
                              1 => "T&#46; Haahtela"
                              2 => "T&#46; Klaukka"
                              3 => "J&#46; Rantanen"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "1996"
                          "volumen" => "110"
                          "paginaInicial" => "58"
                          "paginaFinal" => "61"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8681665"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              38 => array:3 [
                "identificador" => "bb0195"
                "etiqueta" => "39&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Childhood antecedents of allergic sensitization in young British adults"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "D&#46; Strachan"
                              1 => "L&#46; Harkins"
                              2 => "I&#46; Johnston"
                              3 => "H&#46; Anderson"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1997"
                          "volumen" => "99"
                          "numero" => "1<span class="elsevierStyleHsp" style=""></span>Pt<span class="elsevierStyleHsp" style=""></span>1"
                          "paginaInicial" => "6"
                          "paginaFinal" => "12"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9003205"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              39 => array:3 [
                "identificador" => "bb0200"
                "etiqueta" => "40&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Breast-feeding and the risk of bronchial asthma in childhood&#58; a systematic review with meta-analysis of prospective studies"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "M&#46; Gdalevich"
                              1 => "D&#46; Mimouni"
                              2 => "M&#46; Mimouni"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1067/mpd.2001.117006"
                        "Revista" => array:7 [
                          "tituloSerie" => "J Pediatr"
                          "fecha" => "2001"
                          "volumen" => "139"
                          "numero" => "2"
                          "paginaInicial" => "261"
                          "paginaFinal" => "266"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11487754"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              40 => array:3 [
                "identificador" => "bb0205"
                "etiqueta" => "41&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Environmental factors influencing the development and progression of pediatric asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "E&#46; von Mutius"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "2002"
                          "volumen" => "109"
                          "numero" => "suppl 6"
                          "paginaInicial" => "S525"
                          "paginaFinal" => "S532"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12063508"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              41 => array:3 [
                "identificador" => "bb0210"
                "etiqueta" => "42&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Maternal smoking during pregnancy increases the risk of recurrent wheezing during the first years of life &#40;BAMSE&#41;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "E&#46; Lanner"
                              1 => "M&#46; Wickman"
                              2 => "G&#46; Pershagen"
                              3 => "L&#46; Nordvall"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1186/1465-9921-7-3"
                        "Revista" => array:6 [
                          "tituloSerie" => "Respir Res"
                          "fecha" => "2006"
                          "volumen" => "7"
                          "numero" => "1"
                          "paginaInicial" => "3"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16396689"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              42 => array:3 [
                "identificador" => "bb0215"
                "etiqueta" => "43&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Breastfeeding and Risk of Atopic Dermatitis&#44; by Parental History of Allergy&#44; during the First 18 Months of Life"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "C&#46; Benn"
                              1 => "J&#46; Wohlfahrt"
                              2 => "P&#46; Aaby"
                              3 => "T&#46; Westergaard"
                              4 => "E&#46; Benfeldt"
                              5 => "K&#46; Michaelsen"
                              6 => "B&#46; Bj&#246;rkst&#233;n"
                              7 => "M&#46; Melbye"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1093/aje/kwh208"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Epidemiol"
                          "fecha" => "2004"
                          "volumen" => "160"
                          "paginaInicial" => "217"
                          "paginaFinal" => "223"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15257994"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              43 => array:3 [
                "identificador" => "bb0220"
                "etiqueta" => "44&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Connections among parent and child atopic illnesses"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "E&#46; Sarafino"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatr Allergy Immunol"
                          "fecha" => "2000"
                          "volumen" => "11"
                          "paginaInicial" => "80"
                          "paginaFinal" => "86"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10893009"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              44 => array:3 [
                "identificador" => "bb0225"
                "etiqueta" => "45&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "D&#46; Strachan"
                              1 => "B&#46; Butland"
                              2 => "H&#46; Anderson"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "1996"
                          "volumen" => "312"
                          "paginaInicial" => "1195"
                          "paginaFinal" => "1199"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8634562"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              45 => array:3 [
                "identificador" => "bb0230"
                "etiqueta" => "46&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Asthma from birth to age 23&#58; incidence and relation to prior and concurrent atopic disease"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "H&#46; Anderson"
                              1 => "A&#46; Pottier"
                              2 => "D&#46; Strachan"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Thorax"
                          "fecha" => "1992"
                          "volumen" => "47"
                          "paginaInicial" => "537"
                          "paginaFinal" => "542"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1412098"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              46 => array:3 [
                "identificador" => "bb0235"
                "etiqueta" => "47&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Longitudinal follow up of the changing gender ratio in asthma from childhood to adulthood&#58; role of delayed manifestation in girls"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "T&#46; Nicolai"
                              1 => "L&#46; Pereszlenyiova-Bliznakova"
                              2 => "S&#46; Illi"
                              3 => "D&#46; Reinhardt"
                              4 => "E&#46; von Mutius"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatr Allergy Immunol"
                          "fecha" => "2003"
                          "volumen" => "14"
                          "paginaInicial" => "280"
                          "paginaFinal" => "283"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12911505"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              47 => array:3 [
                "identificador" => "bb0240"
                "etiqueta" => "48&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of asthma in a Portuguese countryside town&#58; repercussions in absenteeism and self-concept"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "L&#46; Borrego"
                              1 => "M&#46; C&#233;sar"
                              2 => "P&#46; Leiria-Pinto"
                              3 => "J&#46; Rosado-Pinto"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergol et Immunopathol"
                          "fecha" => "2005"
                          "volumen" => "33"
                          "numero" => "2"
                          "paginaInicial" => "92"
                          "paginaFinal" => "99"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              48 => array:3 [
                "identificador" => "bb0245"
                "etiqueta" => "49&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Epidemiologia e Classifica&#231;&#227;o da asma na crian&#231;a"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "C&#46; Nunes"
                              1 => "S&#46; Ladeira"
                              2 => "Rosado-Pinto J&#46; Defini&#231;&#227;o"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:4 [
                          "titulo" => "A crian&#231;a asm&#225;tica no mundo da alergia"
                          "paginaInicial" => "35"
                          "paginaFinal" => "55"
                          "serieFecha" => "2003"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              49 => array:3 [
                "identificador" => "bb0250"
                "etiqueta" => "50&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Epidemiologic evidence for asthma and rhinitis comorbidity"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "B&#46; Leynaert"
                              1 => "F&#46; Neukirch"
                              2 => "P&#46; Demoly"
                              3 => "J&#46; Bousquet"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1067/mai.2000.108604"
                        "Revista" => array:7 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "2000"
                          "volumen" => "106"
                          "numero" => "Suppl&#46;5"
                          "paginaInicial" => "201"
                          "paginaFinal" => "205"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10932062"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              50 => array:3 [
                "identificador" => "bb0255"
                "etiqueta" => "51&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Rhinitis and asthma&#58; a continuum of disease&#63;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "A&#46; Vignola"
                              1 => "J&#46; Bousquet"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Clin Exp Allergy"
                          "fecha" => "2001"
                          "volumen" => "31"
                          "paginaInicial" => "674"
                          "paginaFinal" => "677"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11422125"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              51 => array:3 [
                "identificador" => "bb0260"
                "etiqueta" => "52&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "One airway&#44; one disease"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "J&#46; Grossman"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Chest"
                          "fecha" => "1997"
                          "volumen" => "111"
                          "numero" => "Suppl&#46; 2"
                          "paginaInicial" => "11S"
                          "paginaFinal" => "16S"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9042022"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              52 => array:3 [
                "identificador" => "bb0265"
                "etiqueta" => "53&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Allergic rhinobronchitis&#58; the asthma-allergic rhinitis link"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "F&#46; Simons"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1999"
                          "volumen" => "104"
                          "numero" => "3<span class="elsevierStyleHsp" style=""></span>Pt<span class="elsevierStyleHsp" style=""></span>1"
                          "paginaInicial" => "534"
                          "paginaFinal" => "540"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10482824"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              53 => array:3 [
                "identificador" => "bb0270"
                "etiqueta" => "54&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Evaluating the use of a Portable Spirometer in a Study of Pediatric Asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "S&#46; Mortimer"
                              1 => "A&#46; Fallot"
                              2 => "J&#46; Balmes"
                              3 => "I&#46; Tager"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "CHEST"
                          "fecha" => "2003"
                          "volumen" => "123"
                          "paginaInicial" => "1899"
                          "paginaFinal" => "1907"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12796166"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/08732159/0000001400000006/v1_201509151433/S0873215915302853/v1_201509151433/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9575"
    "tipo" => "SECCION"
    "pt" => array:2 [
      "titulo" => "Artigos originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "pt"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001400000006/v1_201509151433/S0873215915302853/v1_201509151433/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302853?idApp=UINPBA00004E"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Artigo Original/Original Article
Prevalência da asma e da rinite em adolescentes de 13 anos do Porto, Portugal
Prevalence of asthma and rhinitis in 13 year old adolescents in Porto, Portugal
Helena Falcão1,
Corresponding author
hfalcao@med.up.pt

Correspondência / Correspondence to: Helena Falcão, Serviço de Higiene e Epidemiologia da Faculdade de Medicina, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal, Phone: +351-225507597 / Fax: +351-225095618
, Elisabete Ramos2, Agostinho Marques3, Henrique Barros4
1 Investigadora, Serviço de Higiene e Epidemiologia, Faculdade de Medicina da Universidade do Porto / Researcher, Hygiene and Epidemiology Unit, School of Medicine, University of Porto.
2 Professora, Serviço de Higiene e Epidemiologia, Faculdade de Medicina da Universidade do Porto / Professor, Hygiene and Epidemiology Unit, School of Medicine, University of Porto.
3 Professor Catedrático, Serviço de Pneumologia, Faculdade de Medicina da Universidade do Porto / Cathedratic Professor, Pulmonology Unit, School of Medicine, University of Porto.
4 Professor Catedrático e Director do Serviço de Higiene e Epidemiologia, Faculdade de Medicina da Universidade do Porto / Cathedratic Professor and Head, Hygiene and Epidemiology Unit, School of Medicine, University of Porto.
Read
5795
Times
was read the article
2338
Total PDF
3457
Total HTML
Share statistics
 array:24 [
  "pii" => "S0873215915302853"
  "issn" => "08732159"
  "doi" => "10.1016/S0873-2159(15)30285-3"
  "estado" => "S350"
  "fechaPublicacion" => "2008-11-01"
  "aid" => "3"
  "copyright" => "Sociedade Portuguesa de Pneumologia&#47;SPP"
  "copyrightAnyo" => "2008"
  "documento" => "simple-article"
  "crossmark" => 0
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "Rev Port Pneumol. 2008;14:747-68"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 2847
    "formatos" => array:3 [
      "EPUB" => 237
      "HTML" => 1783
      "PDF" => 827
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0873215915302865"
    "issn" => "08732159"
    "doi" => "10.1016/S0873-2159(15)30286-5"
    "estado" => "S350"
    "fechaPublicacion" => "2008-11-01"
    "aid" => "4"
    "copyright" => "Sociedade Portuguesa de Pneumologia&#47;SPP"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2008;14:769-85"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2791
      "formatos" => array:3 [
        "EPUB" => 230
        "HTML" => 1800
        "PDF" => 761
      ]
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original&#47;Original Article</span>"
      "titulo" => "Correla&#231;&#227;o entre hipoxemia moderada e fun&#231;&#227;o muscular esquel&#233;tica perif&#233;rica na doen&#231;a pulmonar obstrutiva cr&#243;nica &#8211; Estudo-piloto"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "769"
          "paginaFinal" => "785"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Correlation between mild hypoxaemia and limb skeletal muscle function in chronic obstructive pulmonary disease &#8211; Pilot study"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#233;rgio Leite Rodrigues, C&#233;sar Augusto Melo e Silva, C&#233;sar Ferreira Amorim, Terezinha Lima, Fernanda Almeida Ribeiro, Carlos Alberto de Assis Viegas"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "S&#233;rgio"
              "apellidos" => "Leite Rodrigues"
            ]
            1 => array:2 [
              "nombre" => "C&#233;sar"
              "apellidos" => "Augusto Melo e Silva"
            ]
            2 => array:2 [
              "nombre" => "C&#233;sar"
              "apellidos" => "Ferreira Amorim"
            ]
            3 => array:2 [
              "nombre" => "Terezinha"
              "apellidos" => "Lima"
            ]
            4 => array:2 [
              "nombre" => "Fernanda"
              "apellidos" => "Almeida Ribeiro"
            ]
            5 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "Alberto de Assis Viegas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302865?idApp=UINPBA00004E"
    "url" => "/08732159/0000001400000006/v1_201509151433/S0873215915302865/v1_201509151433/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0873215915302841"
    "issn" => "08732159"
    "doi" => "10.1016/S0873-2159(15)30284-1"
    "estado" => "S350"
    "fechaPublicacion" => "2008-11-01"
    "aid" => "2"
    "copyright" => "Sociedade Portuguesa de Pneumologia&#47;SPP"
    "documento" => "simple-article"
    "crossmark" => 0
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "Rev Port Pneumol. 2008;14:727-46"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2176
      "formatos" => array:3 [
        "EPUB" => 228
        "HTML" => 1268
        "PDF" => 680
      ]
    ]
    "pt" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original&#47;Original Article</span>"
      "titulo" => "Estudo de polimorfismos gen&#233;ticos do HLA &#40;classes I e II&#41; e do TNF-&#945; em doentes com sarcoidose"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "pt"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "727"
          "paginaFinal" => "746"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "HLA class I and II and TNF-&#945; gene polymorphisms in sarcoidosis patients"
        ]
      ]
      "contieneResumen" => array:2 [
        "pt" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Ant&#243;nio Morais, Helena Alves, Bruno Lima, Lu&#237;s Delgado, Ricardo Gon&#231;alves, Sandra Tafulo"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Ant&#243;nio"
              "apellidos" => "Morais"
            ]
            1 => array:2 [
              "nombre" => "Helena"
              "apellidos" => "Alves"
            ]
            2 => array:2 [
              "nombre" => "Bruno"
              "apellidos" => "Lima"
            ]
            3 => array:2 [
              "nombre" => "Lu&#237;s"
              "apellidos" => "Delgado"
            ]
            4 => array:2 [
              "nombre" => "Ricardo"
              "apellidos" => "Gon&#231;alves"
            ]
            5 => array:2 [
              "nombre" => "Sandra"
              "apellidos" => "Tafulo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302841?idApp=UINPBA00004E"
    "url" => "/08732159/0000001400000006/v1_201509151433/S0873215915302841/v1_201509151433/pt/main.assets"
  ]
  "pt" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original&#47;Original Article</span>"
    "titulo" => "Preval&#234;ncia da asma e da rinite em adolescentes de 13 anos do Porto&#44; Portugal"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "747"
        "paginaFinal" => "768"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Helena Falc&#227;o, Elisabete Ramos, Agostinho Marques, Henrique Barros"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Helena"
            "apellidos" => "Falc&#227;o"
            "email" => array:1 [
              0 => "hfalcao&#64;med&#46;up&#46;pt"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "af0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cr0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Elisabete"
            "apellidos" => "Ramos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">2</span>"
                "identificador" => "af0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Agostinho"
            "apellidos" => "Marques"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">3</span>"
                "identificador" => "af0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Henrique"
            "apellidos" => "Barros"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">4</span>"
                "identificador" => "af0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Investigadora&#44; Servi&#231;o de Higiene e Epidemiologia&#44; Faculdade de Medicina da Universidade do Porto &#47; Researcher&#44; Hygiene and Epidemiology Unit&#44; School of Medicine&#44; University of Porto&#46;"
            "etiqueta" => "1"
            "identificador" => "af0005"
          ]
          1 => array:3 [
            "entidad" => "Professora&#44; Servi&#231;o de Higiene e Epidemiologia&#44; Faculdade de Medicina da Universidade do Porto &#47; Professor&#44; Hygiene and Epidemiology Unit&#44; School of Medicine&#44; University of Porto&#46;"
            "etiqueta" => "2"
            "identificador" => "af0010"
          ]
          2 => array:3 [
            "entidad" => "Professor Catedr&#225;tico&#44; Servi&#231;o de Pneumologia&#44; Faculdade de Medicina da Universidade do Porto &#47; Cathedratic Professor&#44; Pulmonology Unit&#44; School of Medicine&#44; University of Porto&#46;"
            "etiqueta" => "3"
            "identificador" => "af0015"
          ]
          3 => array:3 [
            "entidad" => "Professor Catedr&#225;tico e Director do Servi&#231;o de Higiene e Epidemiologia&#44; Faculdade de Medicina da Universidade do Porto &#47; Cathedratic Professor and Head&#44; Hygiene and Epidemiology Unit&#44; School of Medicine&#44; University of Porto&#46;"
            "etiqueta" => "4"
            "identificador" => "af0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cr0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "<span class="elsevierStyleBold">Correspond&#234;ncia</span> &#47; <span class="elsevierStyleItalic"><span class="elsevierStyleBold">Correspondence to&#58;</span></span> Helena Falc&#227;o&#44; Servi&#231;o de Higiene e Epidemiologia da Faculdade de Medicina&#44; Alameda Prof&#46; Hern&#226;ni Monteiro&#44; 4200-319 Porto&#44; Portugal&#44; Phone&#58; &#43;<span class="elsevierStyleHsp" style=""></span>351-225507597 &#47; Fax&#58; &#43;<span class="elsevierStyleHsp" style=""></span>351-225095618"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Prevalence of asthma and rhinitis in 13 year old adolescents in Porto&#44; Portugal"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2008-07-08"
    "fechaAceptado" => "2008-09-19"
    "PalabrasClave" => array:2 [
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras-chave"
          "identificador" => "xpalclavsec570057"
          "palabras" => array:6 [
            0 => "Adolescentes"
            1 => "asma"
            2 => "rinite"
            3 => "estudos transversais"
            4 => "preval&#234;ncia"
            5 => "tend&#234;ncia"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key-words"
          "identificador" => "xpalclavsec570056"
          "palabras" => array:6 [
            0 => "Adolescents"
            1 => "asthma"
            2 => "rhinitis"
            3 => "cross-sectional studies"
            4 => "prevalence"
            5 => "trends"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "pt" => array:2 [
        "titulo" => "Resumo"
        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introdu&#231;&#227;o&#58;</span> As preval&#234;ncias da asma e rinite t&#234;m aumentado nas &#250;ltimas d&#233;cadas&#44; mas nos &#250;ltimos anos tem sido referida a sua estabiliza&#231;&#227;o ou mesmo diminui&#231;&#227;o&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivo&#58;</span> O objectivo foi o de descrever a preval&#234;ncia de rinite&#44; asma ou sintomas do tipo da asma em adolescentes urbanos de 13 anos&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">M&#233;todos&#58;</span> Os participantes eleg&#237;veis foram todos os alunos das escolas p&#250;blicas e privadas do Porto&#44; nascidos em 1990&#59; 2161 &#40;77&#44;5&#37;&#41; concordaram em participar&#46; Atrav&#233;s de question&#225;rios autoaplicados&#44; a informa&#231;&#227;o recolhida contemplou aspectos sociais&#44; demogr&#225;ficos&#44; comportamentais&#44; hist&#243;ria cl&#237;nica de asma e doen&#231;as al&#233;rgicas do adolescente e fam&#237;lia&#46; Foi usada a vers&#227;o portuguesa do <span class="elsevierStyleItalic">International Study of Asthma and Allergies in Childhood&#8217;s</span> &#40;ISAAC&#41; e foram efectuadas espirometrias&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados&#58;</span> Nesta amostra de adolescentes urbanos de 13 anos&#44; a preval&#234;ncia da asma durante a vida foi de 12&#44;9&#37;&#44; 84&#44;4&#37; com diagn&#243;stico m&#233;dico&#46; A pieira durante a vida foi 18&#44;3&#37; e no &#250;ltimo ano de 9&#44;3&#37;&#46; A rinite foi relatada por 10&#44;1&#37;&#44; mas a preval&#234;ncia durante a vida de adolescentes com espirros&#44; rinorreia serosa ou obstru&#231;&#227;o nasal&#44; foi de 32&#44;0&#37;&#44; e no &#250;ltimo ano de 27&#44;4&#37;&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclus&#227;o&#58;</span> Verificou-se uma estabiliza&#231;&#227;o ou mesmo diminui&#231;&#227;o da preval&#234;ncia dos sintomas e diagn&#243;stico de asma e rinite nos adolescentes do Porto&#44; quando comparada com os resultados do ISAAC em 2002&#44; tal como noutras investiga&#231;&#245;es na Europa&#46; A asma e a rinite est&#227;o frequentemente presentes no mesmo doente e a tosse nocturna &#233; um importante sintoma que surge associado aos sintomas nasais&#46; A fun&#231;&#227;o pulmonar permitiu discriminar os adolescentes com queixas respirat&#243;rias&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;6&#41;&#58; 747-768</span></p></span>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Background&#58;</span> The prevalence of asthma and rhinitis has been increasing over the past few decades&#44; but the last few years have seen these rates stabilise or even decrease&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aim&#58;</span> The aim of our study was to describe the prevalence of rhinitis&#44; asthma or asthma-like symptoms in 13 year-old urban adolescents&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Methods&#58;</span> Eligible participants were all students at state and private schools in Porto born in 1990&#46; 2161 &#40;77&#46;5&#37;&#41; agreed to participate&#46; Information was obtained using self-administered questionnaires inquiring into social&#44; demographic&#44; behavioural and clinical history including asthma and allergic diseases in the adolescent and the family&#46; We used the Portuguese version of the International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41; questionnaire and we also performed spirometry tests&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results&#58;</span> In this sample of 13 year old urban adolescents the prevalence of asthma ever was 12&#46;9&#37;&#44; 84&#46;4&#37; with physician diagnosis&#46; Lifetime wheezing was reported by 18&#46;3&#37; and current wheezing by 9&#46;3&#37; of the adolescents&#46; Rhinitis was referred to by 10&#46;1&#37;&#44; but the prevalence of adolescents with sneezing ever&#44; or a runny&#47;blocked nose&#44; was 32&#46;0&#37; and the prevalence in the last 12 months was 27&#46;4&#37;&#46;</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusion&#58;</span> We concluded that there was stabilisation or even decrease in the prevalence of asthma and rhinitis symptoms and diagnosis in adolescents reported in Porto&#44; compared with the 2002 ISAAC study&#44; as observed in other surveys in Europe&#46; Asthma and rhinitis is frequently present in the same patient and nocturnal cough is an important symptom concomitant with nasal symptoms&#46; Measures of lung function permitted the discrimination of adolescents with respiratory complaints&#46;</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008&#59; XIV &#40;6&#41;&#58; 747-768</span></p></span>"
      ]
    ]
    "lecturaRecomendada" => array:1 [
      0 => array:3 [
        "vista" => "all"
        "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia &#47; Bibliography</span>"
        "seccion" => array:1 [
          0 => array:2 [
            "vista" => "all"
            "bibliografiaReferencia" => array:54 [
              0 => array:3 [
                "identificador" => "bb0005"
                "etiqueta" => "1&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Trends in prevalence of atopic diseases and allergic sensitization in children in Eastern Germany"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "J&#46; Heinrich"
                              1 => "B&#46; Hoelscher"
                              2 => "C&#46; Frye"
                              3 => "I&#46; Meyer"
                              4 => "M&#46; Wjst"
                              5 => "H&#46;E&#46; Wichmann"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2002"
                          "volumen" => "19"
                          "paginaInicial" => "1040"
                          "paginaFinal" => "1046"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12108854"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              1 => array:3 [
                "identificador" => "bb0010"
                "etiqueta" => "2&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Are asthma and allergies in children and adolescents increasing&#63; Results from ISAAC phase I and phase III surveys in M&#252;nster&#44; Germany"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:7 [
                              0 => "W&#46; Maziak"
                              1 => "T&#46; Behrens"
                              2 => "T&#46; Brasky"
                              3 => "H&#46; Duhme"
                              4 => "P&#46; Rzehak"
                              5 => "S&#46; Weiland"
                              6 => "U&#46; Keil"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2003"
                          "volumen" => "58"
                          "paginaInicial" => "572"
                          "paginaFinal" => "579"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12823113"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              2 => array:3 [
                "identificador" => "bb0015"
                "etiqueta" => "3&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Trends in prevalence of asthma and allergy in Finnish young men&#58; nationwide study"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "J&#46; Latvala"
                              1 => "L&#46; von Hertzen"
                              2 => "H&#46; Lindholm"
                              3 => "T&#46; Haahtela"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1136/bmj.38448.603924.AE"
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "2005"
                          "volumen" => "330"
                          "paginaInicial" => "1186"
                          "paginaFinal" => "1187"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15849204"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              3 => array:3 [
                "identificador" => "bb0020"
                "etiqueta" => "4&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Current controversies&#58; sinus disease and the lower airways"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "S&#46;G&#46; Campanella"
                              1 => "M&#46;I&#46; Asher"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Pediatr Pulmonol"
                          "fecha" => "2001"
                          "volumen" => "31"
                          "numero" => "2"
                          "paginaInicial" => "165"
                          "paginaFinal" => "172"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11180693"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              4 => array:3 [
                "identificador" => "bb0025"
                "etiqueta" => "5&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Allergic rhinitis and asthma comorbidity in a survey of young adults in Italy"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:10 [
                              0 => "M&#46; Bugiani"
                              1 => "A&#46; Carosso"
                              2 => "E&#46; Migliore"
                              3 => "P&#46; Piccioni"
                              4 => "A&#46; Corsico"
                              5 => "M&#46; Olivieri"
                              6 => "M&#46; Ferrari"
                              7 => "Pirina P&#46;"
                              8 => "de Marco R&#46;"
                              9 => "ISAYA &#40;ECRHS Italy&#41; Study Group"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1398-9995.2005.00659.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2005"
                          "volumen" => "60"
                          "paginaInicial" => "165"
                          "paginaFinal" => "170"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15647036"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              5 => array:3 [
                "identificador" => "bb0030"
                "etiqueta" => "6&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "World Health Organization&#46; Allergic rhinitis and its impact on asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "J&#46; Bousquet"
                              1 => "P&#46; van Cauwenberge"
                              2 => "N&#46; Khaltaev"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "In collaboration with the World Health Organization&#46; Executive summary of the workshop report&#46; Allergy"
                          "fecha" => "2002"
                          "volumen" => "57"
                          "paginaInicial" => "841"
                          "paginaFinal" => "855"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12169183"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              6 => array:3 [
                "identificador" => "bb0035"
                "etiqueta" => "7&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Risk factors for early&#44; persistent&#44; and late-onset wheezing in young children"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "F&#46; Rusconi"
                              1 => "C&#46; Galassi"
                              2 => "G&#46; Corbo"
                              3 => "F&#46; Forastiere"
                              4 => "A&#46; Biggeri"
                              5 => "G&#46; Ciccone"
                              6 => "E&#46; Renzoni"
                              7 => "SIDRIA Collaborative Group"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.160.5.9811002"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Respir Crit Care Med"
                          "fecha" => "1999"
                          "volumen" => "160"
                          "paginaInicial" => "1617"
                          "paginaFinal" => "1622"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10556130"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              7 => array:3 [
                "identificador" => "bb0040"
                "etiqueta" => "8&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Overview of comorbid associations of allergic rhinitis"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "S&#46; Spector"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1997"
                          "volumen" => "99"
                          "paginaInicial" => "S773"
                          "paginaFinal" => "S780"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9042070"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              8 => array:3 [
                "identificador" => "bb0045"
                "etiqueta" => "9&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Allergic rhinitis and asthma&#58; how important is the link&#63;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "J&#46; Corren"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1997"
                          "volumen" => "99"
                          "numero" => "2"
                          "paginaInicial" => "S781"
                          "paginaFinal" => "S786"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9042071"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              9 => array:3 [
                "identificador" => "bb0050"
                "etiqueta" => "10&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Asthma and wheezing symptoms in young people in six Western countries"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "A&#46; Hublet"
                              1 => "A&#46; Andersen"
                              2 => "E&#46; Godeau"
                              3 => "C&#46; Vereecken"
                              4 => "R&#46; Valimaa"
                              5 => "J&#46; Tynjala"
                              6 => "W&#46; Boyce"
                              7 => "L&#46; Maes"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Rev Epidemiol Sante Publique"
                          "fecha" => "2006"
                          "volumen" => "54"
                          "numero" => "4"
                          "paginaInicial" => "305"
                          "paginaFinal" => "312"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17088695"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              10 => array:3 [
                "identificador" => "bb0055"
                "etiqueta" => "11&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Risk factors and prevalence of allergic rhinitis among Chilean children"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "L&#46; Caussade"
                              1 => "C&#46; Valdivia"
                              2 => "M&#46; Navarro"
                              3 => "B&#46; Perez"
                              4 => "S&#46; Aquevedo"
                              5 => "D&#46; Sanchez"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "/S0034-98872006000400008"
                        "Revista" => array:7 [
                          "tituloSerie" => "Rev Med Chil"
                          "fecha" => "2006"
                          "volumen" => "134"
                          "numero" => "4"
                          "paginaInicial" => "456"
                          "paginaFinal" => "464"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16758081"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              11 => array:3 [
                "identificador" => "bb0060"
                "etiqueta" => "12&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Environmental epidemiology of pediatric asthma and allergy"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "C&#46; Johnson"
                              1 => "D&#46; Ownby"
                              2 => "E&#46; Zoratti"
                              3 => "S&#46; Alford"
                              4 => "K&#46; Williams"
                              5 => "C&#46; Joseph"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Epidemiol Rev"
                          "fecha" => "2002"
                          "volumen" => "24"
                          "numero" => "2"
                          "paginaInicial" => "154"
                          "paginaFinal" => "175"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12762090"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              12 => array:3 [
                "identificador" => "bb0065"
                "etiqueta" => "13&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Genetics of asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "D&#46; Wiesch"
                              1 => "D&#46; Meyers"
                              2 => "E&#46; Bleeker"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1999"
                          "volumen" => "104"
                          "paginaInicial" => "895"
                          "paginaFinal" => "901"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10550729"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              13 => array:3 [
                "identificador" => "bb0070"
                "etiqueta" => "14&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of symptoms of childhood asthma&#44; allergic rhinoconjunctivitis and eczema in the Pacific&#58; The International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:9 [
                              0 => "S&#46; Foliaki"
                              1 => "I&#46; Annesi-Maesano"
                              2 => "R&#46; Daniel"
                              3 => "T&#46; Fakakovikaetau"
                              4 => "M&#46; Magatongia"
                              5 => "N&#46; Tuuau-Potoi"
                              6 => "L&#46; Waqatakirewa"
                              7 => "S&#46; Cheng"
                              8 => "N&#46; Pearce"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1398-9995.2007.01343.x"
                        "Revista" => array:7 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2007"
                          "volumen" => "62"
                          "numero" => "3"
                          "paginaInicial" => "259"
                          "paginaFinal" => "264"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17298342"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              14 => array:3 [
                "identificador" => "bb0075"
                "etiqueta" => "15&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Socioeconomic status and prevalence of allergic rhinitis and atopic eczema symptoms in young adolescents"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:7 [
                              0 => "M&#46; Mercer"
                              1 => "G&#46; Joubert"
                              2 => "R&#46; Ehrlich"
                              3 => "H&#46; Nelson"
                              4 => "M&#46; Poyser"
                              5 => "A&#46; Puterman"
                              6 => "E&#46; Weinberg"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1399-3038.2004.00125.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatr Allergy Immunol"
                          "fecha" => "2004"
                          "volumen" => "15"
                          "paginaInicial" => "234"
                          "paginaFinal" => "241"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15209956"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              15 => array:3 [
                "identificador" => "bb0080"
                "etiqueta" => "16&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "International study of asthma and allergies in childhood &#40;ISAAC&#41;&#58; rationale and methods"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:13 [
                              0 => "M&#46; Asher"
                              1 => "U&#46; Keil"
                              2 => "H&#46; Anderson"
                              3 => "R&#46; Beasley"
                              4 => "J&#46; Crane"
                              5 => "F&#46; Martinez"
                              6 => "E&#46; Mitchell"
                              7 => "N&#46; Pearce"
                              8 => "B&#46; Sibbald"
                              9 => "A&#46; Stewart"
                              10 => "D&#46; Strachan"
                              11 => "S&#46; Weiland"
                              12 => "H&#46; Williams"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "1995"
                          "volumen" => "8"
                          "paginaInicial" => "483"
                          "paginaFinal" => "491"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7789502"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              16 => array:3 [
                "identificador" => "bb0085"
                "etiqueta" => "17&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Standardization of spirometry&#58; 1994 update"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "American Thoracic Society"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1164/ajrccm.152.3.7663792"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Respir Crit Care Med"
                          "fecha" => "1995"
                          "volumen" => "152"
                          "paginaInicial" => "1107"
                          "paginaFinal" => "1136"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7663792"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              17 => array:3 [
                "identificador" => "bb0090"
                "etiqueta" => "18&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Program The global burden of asthma&#58; executive summary of the GINA Dissemination Committee Report"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "M&#46; Masoli"
                              1 => "D&#46; Fabian"
                              2 => "S&#46; Holt"
                              3 => "Beasley R&#46;"
                              4 => "Global Initiative for asthma &#40;GINA&#41;"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1398-9995.2004.00526.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2004"
                          "volumen" => "59"
                          "paginaInicial" => "469"
                          "paginaFinal" => "478"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15080825"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              18 => array:3 [
                "identificador" => "bb0095"
                "etiqueta" => "19&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Is the prevalence of adult asthma and allergic rhinitis still increasing&#63; Results of an Italian study"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:13 [
                              0 => "G&#46; Verlato"
                              1 => "A&#46; Corsico"
                              2 => "S&#46; Villani"
                              3 => "I&#46; Cerveri"
                              4 => "E&#46; Migliore"
                              5 => "S&#46; Accordini"
                              6 => "A&#46; Carolei"
                              7 => "P&#46; Piccioni"
                              8 => "M&#46; Bugiani"
                              9 => "V&#46; Lo Cascio"
                              10 => "A&#46; Marinoni"
                              11 => "A&#46; Poli"
                              12 => "R&#46; de Marco"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "2003"
                          "volumen" => "111"
                          "paginaInicial" => "1232"
                          "paginaFinal" => "1238"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12789222"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              19 => array:3 [
                "identificador" => "bb0100"
                "etiqueta" => "20&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The rising prevalence of asthma in young Melbourne adults is associated with improvement in treatment"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "R&#46; Woods"
                              1 => "E&#46; Walters"
                              2 => "C&#46; Wharton"
                              3 => "N&#46; Watson"
                              4 => "M&#46; Abramson"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1016/S1081-1206(10)62204-1"
                        "Revista" => array:6 [
                          "tituloSerie" => "Ann Allergy Asthma Immunol"
                          "fecha" => "2001"
                          "volumen" => "87"
                          "paginaInicial" => "117"
                          "paginaFinal" => "123"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11527242"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              20 => array:3 [
                "identificador" => "bb0105"
                "etiqueta" => "21&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "The prevalence of asthma and allergies in Singapore&#59; data from two ISAAC surveys seven years apart"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "X&#46; Wang"
                              1 => "T&#46; Tan"
                              2 => "L&#46; Shek"
                              3 => "S&#46; Chng"
                              4 => "N&#46; Hia"
                              5 => "S&#46; Ma"
                              6 => "B&#46; Lee"
                              7 => "D&#46; Goh"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Arch Dis Child"
                          "fecha" => "2004"
                          "volumen" => "89"
                          "paginaInicial" => "423"
                          "paginaFinal" => "426"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15102631"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              21 => array:3 [
                "identificador" => "bb0110"
                "etiqueta" => "22&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Trends in prevalence of symptoms of asthma&#44; hay fever&#44; and eczema in 12-14 year olds in the British Isles&#44; 1995-2002&#58; questionnaire survey"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:9 [
                              0 => "H&#46; Anderson"
                              1 => "R&#46; Ruggles"
                              2 => "D&#46; Strachan"
                              3 => "J&#46; Austin"
                              4 => "M&#46; Burr"
                              5 => "D&#46; Jeffs"
                              6 => "P&#46; Stranding"
                              7 => "A&#46; Steriu"
                              8 => "R&#46; Goulding"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1136/bmj.38057.583727.47"
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "2004"
                          "volumen" => "328"
                          "paginaInicial" => "1052"
                          "paginaFinal" => "1053"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15028634"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              22 => array:3 [
                "identificador" => "bb0115"
                "etiqueta" => "23&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Is the increase in childhood asthma coming to an end&#63; Findings from three surveys of schoolchildren in Rome&#44; Italy"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:10 [
                              0 => "R&#46; Ronchetti"
                              1 => "M&#46; Villa"
                              2 => "M&#46; Barreto"
                              3 => "R&#46; Rota"
                              4 => "J&#46; Pagani"
                              5 => "S&#46; Martella"
                              6 => "C&#46; Falasca"
                              7 => "B&#46; Paggi"
                              8 => "F&#46; Guglielmi"
                              9 => "G&#46; Ciofetta"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2001"
                          "volumen" => "17"
                          "paginaInicial" => "881"
                          "paginaFinal" => "886"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11488320"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              23 => array:3 [
                "identificador" => "bb0120"
                "etiqueta" => "24&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of asthma and allergy in schoolchildren in Belmont&#44; Australia&#58; three cross-sectional surveys over 20 years"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:6 [
                              0 => "B&#46; Toelle"
                              1 => "K&#46; Ng"
                              2 => "E&#46; Belusova"
                              3 => "M&#46; Salome"
                              4 => "K&#46; Peat"
                              5 => "B&#46; Marks"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1136/bmj.328.7436.386"
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "2004"
                          "volumen" => "328"
                          "paginaInicial" => "386"
                          "paginaFinal" => "387"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14962876"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              24 => array:3 [
                "identificador" => "bb0125"
                "etiqueta" => "25&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Swiss Study on Childhood Allergy and Respiratory symptoms&#59; Air Pollution &#40;SCARPOL&#41; team&#46; No further increase in asthma&#44; hay fever and atopic sensitisation in adolescents living in Switzerland"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:9 [
                              0 => "C&#46; Braun-Fahrlander"
                              1 => "M&#46; Gassner"
                              2 => "L&#46; Grize"
                              3 => "K&#46; Takken-Sahli"
                              4 => "U&#46; Neu"
                              5 => "T&#46; Stricker"
                              6 => "H&#46; Varonier"
                              7 => "B&#46; Wuthrich"
                              8 => "Sennhauser F&#46;"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2004"
                          "volumen" => "23"
                          "paginaInicial" => "407"
                          "paginaFinal" => "413"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15065830"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              25 => array:3 [
                "identificador" => "bb0130"
                "etiqueta" => "26&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increasing prevalence of allergic rhinitis but not asthma among children in Hong Kong from 1995 to 2001 &#40;Phase 3 International Study of Asthma and Allergies in Childhood&#41;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "L&#46; Lee"
                              1 => "W&#46; Wong"
                              2 => "L&#46; Lau"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatr Allergy Immunol"
                          "fecha" => "2004"
                          "volumen" => "15"
                          "paginaInicial" => "72"
                          "paginaFinal" => "78"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14998385"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              26 => array:3 [
                "identificador" => "bb0135"
                "etiqueta" => "27&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Stabilization of asthma prevalence among adolescents and increase among schoolchildren &#40;ISAAC phases I and III&#41; in Spain"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:12 [
                              0 => "L&#46; Garc&#237;a-Marcos"
                              1 => "A&#46; Blanco Quir&#243;s"
                              2 => "G&#46; Garcia Hern&#225;ndez"
                              3 => "F&#46; Guillan-Grima"
                              4 => "C&#46; Gonzalez D&#237;az"
                              5 => "I&#46; Ure&#328;a"
                              6 => "A&#46; Pena"
                              7 => "R&#46; Monge"
                              8 => "M&#46; Su&#225;rez-Varela"
                              9 => "A&#46; Varela"
                              10 => "P&#46; Cabanillas"
                              11 => "J&#46; Garrido"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1398-9995.2004.00562.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2004"
                          "volumen" => "59"
                          "paginaInicial" => "1301"
                          "paginaFinal" => "1307"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507099"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              27 => array:3 [
                "identificador" => "bb0140"
                "etiqueta" => "28&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Declining incidence of episodes of asthma&#58; a study of trends in new episodes presenting to general practitioners in the period 1989-98"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "M&#46; Flemming"
                              1 => "R&#46; Sunderland"
                              2 => "W&#46; Cross"
                              3 => "M&#46; Ross"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Thorax"
                          "fecha" => "2000"
                          "volumen" => "55"
                          "paginaInicial" => "657"
                          "paginaFinal" => "661"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10899241"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              28 => array:3 [
                "identificador" => "bb0145"
                "etiqueta" => "29&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Stabilization of an increasing trend in physician&#8211;diagnosed asthma prevalence in Saskatchewan&#44; 1991 to 1998"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "A&#46; Senthilselvan"
                              1 => "J&#46; Lawson"
                              2 => "C&#46; Rennie"
                              3 => "A&#46; Dosman"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "2003"
                          "volumen" => "124"
                          "paginaInicial" => "438"
                          "paginaFinal" => "448"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12907527"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              29 => array:3 [
                "identificador" => "bb0150"
                "etiqueta" => "30&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Agreement between parental and self-completed questionnaires about asthma in teenagers"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "L&#46; Hedman"
                              1 => "B&#46; Lindgren"
                              2 => "M&#46; Perzanowski"
                              3 => "E&#46; Ronmark"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1399-3038.2005.00231.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatr Allergy Immunol"
                          "fecha" => "2005"
                          "volumen" => "16"
                          "paginaInicial" => "176"
                          "paginaFinal" => "181"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15787877"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              30 => array:3 [
                "identificador" => "bb0155"
                "etiqueta" => "31&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Signs of reversing trends in prevalence of asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "L&#46; von Hertzen"
                              1 => "T&#46; Haahtela"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1111/j.1398-9995.2005.00769.x"
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergy"
                          "fecha" => "2005"
                          "volumen" => "60"
                          "paginaInicial" => "283"
                          "paginaFinal" => "292"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15679712"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              31 => array:3 [
                "identificador" => "bb0160"
                "etiqueta" => "32&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Changing prevalence of asthma in school children&#58; evidence for diagnostic changes in asthma in two surveys 13<span class="elsevierStyleHsp" style=""></span>yrs apart"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "W&#46; Nystad"
                              1 => "P&#46; Magnus"
                              2 => "A&#46; Gulsvik"
                              3 => "I&#46; Skarpaas"
                              4 => "K&#46; Carlsen"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "1997"
                          "volumen" => "10"
                          "paginaInicial" => "1046"
                          "paginaFinal" => "1051"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9163645"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              32 => array:3 [
                "identificador" => "bb0165"
                "etiqueta" => "33&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Apparent but not real increase in asthma prevalence during the 1990s"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "R&#46; Barraclough"
                              1 => "G&#46; Devereux"
                              2 => "D&#46; Hendrick"
                              3 => "S&#46; Stenton"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Eur Respir J"
                          "fecha" => "2002"
                          "volumen" => "20"
                          "paginaInicial" => "826"
                          "paginaFinal" => "833"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12412671"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              33 => array:3 [
                "identificador" => "bb0170"
                "etiqueta" => "34&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Secular trend in the occurrence of asthma among children and young adults&#58; critical appraisal of repeated cross sectional surveys"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "P&#46; Magnus"
                              1 => "J&#46; Jaakkola"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "1997"
                          "volumen" => "314"
                          "paginaInicial" => "1795"
                          "paginaFinal" => "1799"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9224081"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              34 => array:3 [
                "identificador" => "bb0175"
                "etiqueta" => "35&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Increasing prevalence of asthma diagnosis and symptoms in children is confined to mild symptoms"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "G&#46; Kwong"
                              1 => "A&#46; Proctor"
                              2 => "C&#46; Billings"
                              3 => "R&#46; Duggan"
                              4 => "C&#46; Das"
                              5 => "K&#46; Whyte"
                              6 => "V&#46; Powell"
                              7 => "R&#46; Primhak"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Thorax"
                          "fecha" => "2001"
                          "volumen" => "56"
                          "paginaInicial" => "312"
                          "paginaFinal" => "314"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11254824"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              35 => array:3 [
                "identificador" => "bb0180"
                "etiqueta" => "36&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Asthma programme in Finland&#58; a community problem needs community solutions"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "T&#46; Haahtela"
                              1 => "T&#46; Klaukka"
                              2 => "K&#46; Koskela"
                              3 => "M&#46; Erhola"
                              4 => "L&#46; Laitinen"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Thorax"
                          "fecha" => "2001"
                          "volumen" => "56"
                          "paginaInicial" => "806"
                          "paginaFinal" => "814"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11562522"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              36 => array:3 [
                "identificador" => "bb0185"
                "etiqueta" => "37&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Intergenerational 20 year trend in the prevalence of asthma and hay fever in adults&#58; the Midspan family study surveys of parents and offspring"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:7 [
                              0 => "M&#46; Upton"
                              1 => "A&#46; McConnachie"
                              2 => "C&#46; Mc Sharry"
                              3 => "C&#46; Hart"
                              4 => "G&#46; Smith"
                              5 => "C&#46; Gillis"
                              6 => "G&#46; Watt"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "2000"
                          "volumen" => "321"
                          "paginaInicial" => "88"
                          "paginaFinal" => "92"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10884260"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              37 => array:3 [
                "identificador" => "bb0190"
                "etiqueta" => "38&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Incidence of occupational asthma and persistent asthma in young adults has increased in Finland"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "K&#46; Reijula"
                              1 => "T&#46; Haahtela"
                              2 => "T&#46; Klaukka"
                              3 => "J&#46; Rantanen"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Chest"
                          "fecha" => "1996"
                          "volumen" => "110"
                          "paginaInicial" => "58"
                          "paginaFinal" => "61"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8681665"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              38 => array:3 [
                "identificador" => "bb0195"
                "etiqueta" => "39&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Childhood antecedents of allergic sensitization in young British adults"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "D&#46; Strachan"
                              1 => "L&#46; Harkins"
                              2 => "I&#46; Johnston"
                              3 => "H&#46; Anderson"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1997"
                          "volumen" => "99"
                          "numero" => "1<span class="elsevierStyleHsp" style=""></span>Pt<span class="elsevierStyleHsp" style=""></span>1"
                          "paginaInicial" => "6"
                          "paginaFinal" => "12"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9003205"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              39 => array:3 [
                "identificador" => "bb0200"
                "etiqueta" => "40&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Breast-feeding and the risk of bronchial asthma in childhood&#58; a systematic review with meta-analysis of prospective studies"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "M&#46; Gdalevich"
                              1 => "D&#46; Mimouni"
                              2 => "M&#46; Mimouni"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1067/mpd.2001.117006"
                        "Revista" => array:7 [
                          "tituloSerie" => "J Pediatr"
                          "fecha" => "2001"
                          "volumen" => "139"
                          "numero" => "2"
                          "paginaInicial" => "261"
                          "paginaFinal" => "266"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11487754"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              40 => array:3 [
                "identificador" => "bb0205"
                "etiqueta" => "41&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Environmental factors influencing the development and progression of pediatric asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "E&#46; von Mutius"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "2002"
                          "volumen" => "109"
                          "numero" => "suppl 6"
                          "paginaInicial" => "S525"
                          "paginaFinal" => "S532"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12063508"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              41 => array:3 [
                "identificador" => "bb0210"
                "etiqueta" => "42&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Maternal smoking during pregnancy increases the risk of recurrent wheezing during the first years of life &#40;BAMSE&#41;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "E&#46; Lanner"
                              1 => "M&#46; Wickman"
                              2 => "G&#46; Pershagen"
                              3 => "L&#46; Nordvall"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1186/1465-9921-7-3"
                        "Revista" => array:6 [
                          "tituloSerie" => "Respir Res"
                          "fecha" => "2006"
                          "volumen" => "7"
                          "numero" => "1"
                          "paginaInicial" => "3"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16396689"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              42 => array:3 [
                "identificador" => "bb0215"
                "etiqueta" => "43&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Breastfeeding and Risk of Atopic Dermatitis&#44; by Parental History of Allergy&#44; during the First 18 Months of Life"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:8 [
                              0 => "C&#46; Benn"
                              1 => "J&#46; Wohlfahrt"
                              2 => "P&#46; Aaby"
                              3 => "T&#46; Westergaard"
                              4 => "E&#46; Benfeldt"
                              5 => "K&#46; Michaelsen"
                              6 => "B&#46; Bj&#246;rkst&#233;n"
                              7 => "M&#46; Melbye"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1093/aje/kwh208"
                        "Revista" => array:6 [
                          "tituloSerie" => "Am J Epidemiol"
                          "fecha" => "2004"
                          "volumen" => "160"
                          "paginaInicial" => "217"
                          "paginaFinal" => "223"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15257994"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              43 => array:3 [
                "identificador" => "bb0220"
                "etiqueta" => "44&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Connections among parent and child atopic illnesses"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "E&#46; Sarafino"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatr Allergy Immunol"
                          "fecha" => "2000"
                          "volumen" => "11"
                          "paginaInicial" => "80"
                          "paginaFinal" => "86"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10893009"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              44 => array:3 [
                "identificador" => "bb0225"
                "etiqueta" => "45&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "D&#46; Strachan"
                              1 => "B&#46; Butland"
                              2 => "H&#46; Anderson"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "BMJ"
                          "fecha" => "1996"
                          "volumen" => "312"
                          "paginaInicial" => "1195"
                          "paginaFinal" => "1199"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8634562"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              45 => array:3 [
                "identificador" => "bb0230"
                "etiqueta" => "46&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Asthma from birth to age 23&#58; incidence and relation to prior and concurrent atopic disease"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "H&#46; Anderson"
                              1 => "A&#46; Pottier"
                              2 => "D&#46; Strachan"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Thorax"
                          "fecha" => "1992"
                          "volumen" => "47"
                          "paginaInicial" => "537"
                          "paginaFinal" => "542"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1412098"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              46 => array:3 [
                "identificador" => "bb0235"
                "etiqueta" => "47&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Longitudinal follow up of the changing gender ratio in asthma from childhood to adulthood&#58; role of delayed manifestation in girls"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:5 [
                              0 => "T&#46; Nicolai"
                              1 => "L&#46; Pereszlenyiova-Bliznakova"
                              2 => "S&#46; Illi"
                              3 => "D&#46; Reinhardt"
                              4 => "E&#46; von Mutius"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Pediatr Allergy Immunol"
                          "fecha" => "2003"
                          "volumen" => "14"
                          "paginaInicial" => "280"
                          "paginaFinal" => "283"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12911505"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              47 => array:3 [
                "identificador" => "bb0240"
                "etiqueta" => "48&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Prevalence of asthma in a Portuguese countryside town&#58; repercussions in absenteeism and self-concept"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "L&#46; Borrego"
                              1 => "M&#46; C&#233;sar"
                              2 => "P&#46; Leiria-Pinto"
                              3 => "J&#46; Rosado-Pinto"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Allergol et Immunopathol"
                          "fecha" => "2005"
                          "volumen" => "33"
                          "numero" => "2"
                          "paginaInicial" => "92"
                          "paginaFinal" => "99"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              48 => array:3 [
                "identificador" => "bb0245"
                "etiqueta" => "49&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Epidemiologia e Classifica&#231;&#227;o da asma na crian&#231;a"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:3 [
                              0 => "C&#46; Nunes"
                              1 => "S&#46; Ladeira"
                              2 => "Rosado-Pinto J&#46; Defini&#231;&#227;o"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "LibroEditado" => array:4 [
                          "titulo" => "A crian&#231;a asm&#225;tica no mundo da alergia"
                          "paginaInicial" => "35"
                          "paginaFinal" => "55"
                          "serieFecha" => "2003"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              49 => array:3 [
                "identificador" => "bb0250"
                "etiqueta" => "50&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Epidemiologic evidence for asthma and rhinitis comorbidity"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "B&#46; Leynaert"
                              1 => "F&#46; Neukirch"
                              2 => "P&#46; Demoly"
                              3 => "J&#46; Bousquet"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:2 [
                        "doi" => "10.1067/mai.2000.108604"
                        "Revista" => array:7 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "2000"
                          "volumen" => "106"
                          "numero" => "Suppl&#46;5"
                          "paginaInicial" => "201"
                          "paginaFinal" => "205"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10932062"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              50 => array:3 [
                "identificador" => "bb0255"
                "etiqueta" => "51&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Rhinitis and asthma&#58; a continuum of disease&#63;"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:2 [
                              0 => "A&#46; Vignola"
                              1 => "J&#46; Bousquet"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "Clin Exp Allergy"
                          "fecha" => "2001"
                          "volumen" => "31"
                          "paginaInicial" => "674"
                          "paginaFinal" => "677"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11422125"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              51 => array:3 [
                "identificador" => "bb0260"
                "etiqueta" => "52&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "One airway&#44; one disease"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "J&#46; Grossman"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "Chest"
                          "fecha" => "1997"
                          "volumen" => "111"
                          "numero" => "Suppl&#46; 2"
                          "paginaInicial" => "11S"
                          "paginaFinal" => "16S"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9042022"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              52 => array:3 [
                "identificador" => "bb0265"
                "etiqueta" => "53&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Allergic rhinobronchitis&#58; the asthma-allergic rhinitis link"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:1 [
                              0 => "F&#46; Simons"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:7 [
                          "tituloSerie" => "J Allergy Clin Immunol"
                          "fecha" => "1999"
                          "volumen" => "104"
                          "numero" => "3<span class="elsevierStyleHsp" style=""></span>Pt<span class="elsevierStyleHsp" style=""></span>1"
                          "paginaInicial" => "534"
                          "paginaFinal" => "540"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10482824"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
              53 => array:3 [
                "identificador" => "bb0270"
                "etiqueta" => "54&#46;"
                "referencia" => array:1 [
                  0 => array:2 [
                    "contribucion" => array:1 [
                      0 => array:2 [
                        "titulo" => "Evaluating the use of a Portable Spirometer in a Study of Pediatric Asthma"
                        "autores" => array:1 [
                          0 => array:2 [
                            "etal" => false
                            "autores" => array:4 [
                              0 => "S&#46; Mortimer"
                              1 => "A&#46; Fallot"
                              2 => "J&#46; Balmes"
                              3 => "I&#46; Tager"
                            ]
                          ]
                        ]
                      ]
                    ]
                    "host" => array:1 [
                      0 => array:1 [
                        "Revista" => array:6 [
                          "tituloSerie" => "CHEST"
                          "fecha" => "2003"
                          "volumen" => "123"
                          "paginaInicial" => "1899"
                          "paginaFinal" => "1907"
                          "link" => array:1 [
                            0 => array:2 [
                              "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12796166"
                              "web" => "Medline"
                            ]
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/08732159/0000001400000006/v1_201509151433/S0873215915302853/v1_201509151433/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9575"
    "tipo" => "SECCION"
    "pt" => array:2 [
      "titulo" => "Artigos originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "pt"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001400000006/v1_201509151433/S0873215915302853/v1_201509151433/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302853?idApp=UINPBA00004E"
]
Article information
ISSN: 08732159
Original language: Portuguese
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 4 1 5
2024 October 33 32 65
2024 September 56 21 77
2024 August 52 33 85
2024 July 52 34 86
2024 June 33 57 90
2024 May 18 36 54
2024 April 31 25 56
2024 March 23 30 53
2024 February 33 26 59
2024 January 29 28 57
2023 December 12 16 28
2023 November 27 22 49
2023 October 24 27 51
2023 September 19 31 50
2023 August 37 17 54
2023 July 16 33 49
2023 June 17 20 37
2023 May 27 22 49
2023 April 12 22 34
2023 March 20 21 41
2023 February 33 34 67
2023 January 26 10 36
2022 December 21 25 46
2022 November 31 40 71
2022 October 24 32 56
2022 September 22 38 60
2022 August 28 57 85
2022 July 33 37 70
2022 June 16 29 45
2022 May 29 37 66
2022 April 26 34 60
2022 March 13 30 43
2022 February 22 26 48
2022 January 27 43 70
2021 December 22 36 58
2021 November 27 37 64
2021 October 24 37 61
2021 September 21 33 54
2021 August 25 12 37
2021 July 24 28 52
2021 June 29 22 51
2021 May 33 26 59
2021 April 44 37 81
2021 March 37 17 54
2021 February 44 16 60
2021 January 27 9 36
2020 December 30 7 37
2020 November 25 14 39
2020 October 23 15 38
2020 September 53 32 85
2020 August 34 19 53
2020 July 49 17 66
2020 June 30 15 45
2020 May 47 20 67
2020 April 41 13 54
2020 March 39 17 56
2020 February 36 33 69
2020 January 31 19 50
2019 December 46 23 69
2019 November 59 26 85
2019 October 38 21 59
2019 September 49 23 72
2019 August 65 20 85
2019 July 84 25 109
2019 June 65 19 84
2019 May 69 33 102
2019 April 77 27 104
2019 March 67 12 79
2019 February 74 13 87
2019 January 89 19 108
2018 December 71 10 81
2018 November 13 0 13
2018 October 27 11 38
2018 September 12 9 21
2018 August 40 31 71
2018 July 39 30 69
2018 June 48 16 64
2018 May 73 32 105
2018 April 55 44 99
2018 March 75 32 107
2018 February 32 16 48
2018 January 58 16 74
2017 December 55 18 73
2017 November 45 17 62
2017 October 24 21 45
2017 September 34 16 50
2017 August 31 15 46
2017 July 25 18 43
2017 June 35 23 58
2017 May 39 20 59
2017 April 9 12 21
2017 March 13 58 71
2017 February 18 1 19
2017 January 15 3 18
2016 December 13 5 18
2016 November 8 6 14
2016 October 11 7 18
2016 September 3 2 5
2016 August 2 1 3
2016 July 6 4 10
2016 May 0 4 4
2016 April 1 1 2
2016 March 1 4 5
2016 February 5 4 9
2016 January 6 6 12
2015 December 7 2 9
2015 November 3 3 6
2015 October 2 2 4
Show all

Follow this link to access the full text of the article

Pulmonology

Are you a health professional able to prescribe or dispense drugs?