Artigo Original/Original Article
Correlação entre hipoxemia moderada e função muscular esquelética periférica na doença pulmonar obstrutiva crónica – Estudo-piloto
Correlation between mild hypoxaemia and limb skeletal muscle function in chronic obstructive pulmonary disease – Pilot study
Sérgio Leite Rodrigues1,*, César Augusto Melo e Silva2, César Ferreira Amorim3, Terezinha Lima4, Fernanda Almeida Ribeiro5, Carlos Alberto de Assis Viegas6
1 Fisioterapeuta, Mestre em Ciências da Saúde, Universidade de Brasília – UnB / Physiotherapist, MsC, Health Sciences, Universidade de Brasília – UnB
2 Fisioterapeuta, Doutor em Ciências Médicas, Universidade de Brasília – UnB / Physiotherapist, Doctor of Medical Sciences, Universidade de Brasília – UnB
3 Engenheiro electrónico, Mestre em Engenharia Biomédica, Universidade do Vale do Paraíba – UNIVAP / Electronic Engineer, MsC, Biomedical Engineering, Universidade do Vale do Paraíba – UNIVAP
4 Médica, Mestre em Ciências da Saúde, Universidade de Brasília / Physician, MsC, Health Sciences, Universidade de Brasília
5 Fisioterapeuta, Especialista em Fisioterapia Pneumofuncional, Universidade de Brasília / Physiotherapist, Respiratory Physiotherapy specialist, Universidade de Brasília
6 Médico, Doutor da Universidade de Brasília – UnB, Universidade de Brasília – UnB / Physician, Doctor at the Universidade de Brasília – UnB, Universidade de Brasília – UnB
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] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Correlation between mild hypoxaemia and limb skeletal muscle function in chronic obstructive pulmonary disease – Pilot study" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-10-18" "fechaAceptado" => "2008-07-23" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570058" "palabras" => array:6 [ 0 => "Teste de caminhada de seis minutos" 1 => "força muscular" 2 => "hipoxemia" 3 => "DPOC" 4 => "reabilitação pulmonar" 5 => "electromiografia" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570059" "palabras" => array:6 [ 0 => "Six-minute walk test" 1 => "muscle strength" 2 => "hypoxaemia" 3 => "COPD" 4 => "pulmonary rehabilitation" 5 => "electromyography" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introdução:</span> A capacidade de exercício em portadores de DPOC depende da gravidade da limitação ao fluxo aéreo, do grau de hipoxemia e da função muscular esquelética. Nesses doentes, a atrofia e a fraqueza da musculatura periférica são consideradas consequências sistémicas da DPOC e estão associadas à redução da capacidade de exercício.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivos:</span> Investigar a possível correlação entre hipoxemia moderada e o comprometimento muscular periférico na DPOC.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Doentes e métodos:</span> Dez doentes encaminhados ao Programa de Reabilitação Pulmonar do Hospital Universitário de Brasília foram incluídos neste estudo. A função pulmonar foi avaliada por espirometria, gasometria arterial e avaliação funcional pelo teste de caminhada de seis minutos, sinal electromiográfico e força de deltóide e quadricípetes.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados:</span> As correlações entre PaO<span class="elsevierStyleInf">2</span> e a força quadricíptica (r<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,61 e p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,007) e a distância percorrida no TC6 (r<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,96 e p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,001) foram positivas e significativas. Houve correlação negativa e significativa entre PaO<span class="elsevierStyleInf">2</span> e a frequência mediana de quadricípetes (r<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>-0,42 e p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,04). Observámos também correlação significativa entre força de quadricípetes e o TC6 (r<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,67 e p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,001). Assim como houve correlação negativa e significativa entre a frequência mediana de quadricípetes, e o TC6 (r<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>-0,42 e p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,04). Não encontrámos correlação significativa entre a PaO<span class="elsevierStyleInf">2</span> e força ou frequência mediana do músculo deltóide.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusão:</span> A PaO<span class="elsevierStyleInf">2</span> tem correlação importante e significativa com variáveis de função muscular periférica. A hipoxemia moderada e a disfunção muscular periférica precoce possuem como principal impacto negativo a deterioração da capacidade funcional de portadores de DPOC.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (6): 769-785</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rationale:</span> Exercise capacity in COPD patients depends on the degree of airflow obstruction, the severity of the hypoxaemia and skeletal muscle function. Muscle atrophy and weakness are considered systemic consequences of COPD and are associated with reduced exercise capacity.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aims:</span> To investigate the correlation between mild hypoxaemia and muscular strength, muscular fatigue and functional capacity in COPD patients.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Methods:</span> Ten patients enrolled on a PRP at the Hospital Universitário de Brasília – HUB were included in this study. Lung function was evaluated by spirometry and arterial blood gas analysis. Functional evaluation was made using the 6MWT and using isometric contraction of deltoid and quadriceps muscles.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results:</span> There were positive correlations between PaO<span class="elsevierStyleInf">2,</span> quadriceps strength (r<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.61 and p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.007) and PaO<span class="elsevierStyleInf">2</span> and the 6MWT (r<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.96, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.001). There were negative correlations between PaO<span class="elsevierStyleInf">2</span> and median frequency of quadriceps (r<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>-0.42 and p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.04). We observed significant correlation between quadriceps strength and the 6MWT (r<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.67 and p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.001). There was negative correlation between median frequency of quadriceps and the 6MWT (r<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>-0.42 and p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.04). We did not observe any correlation between PaO<span class="elsevierStyleInf">2</span> and strength or median frequency of deltoid muscle.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusions:</span> PaO<span class="elsevierStyleInf">2</span> has important correlations with muscular function variables. The main negative impact of mild hypoxaemia and precocious limb muscular disability on COPD patients is decreased functional capacity.</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (6): 769-785</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia / Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease – GOLD Executive Summary" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.F. Rabe" 1 => "S. Hurd" 2 => "A. Anzueto" 3 => "P.J. Barnes" 4 => "S.A. 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Article information
ISSN: 08732159Original language: Portuguese
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| 2016 February | 3 | 5 | 8 |
| 2016 January | 9 | 4 | 13 |
| 2015 December | 4 | 1 | 5 |
| 2015 November | 3 | 2 | 5 |
| 2015 October | 2 | 3 | 5 |
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