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A case report" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Felizardo, A.C. Mendes, A. Fernandes, P. Campos, V. Magalhães, I. Correia, A. Pignatelli, C. Ferreira, R. Sotto-Mayor, A Bugalho de Almeida" "autores" => array:10 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Felizardo" ] 1 => array:2 [ "nombre" => "A.C." "apellidos" => "Mendes" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Fernandes" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Campos" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Magalhães" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "Correia" ] 6 => array:2 [ "nombre" => "A." "apellidos" => "Pignatelli" ] 7 => array:2 [ "nombre" => "C." "apellidos" => "Ferreira" ] 8 => array:2 [ "nombre" => "R." "apellidos" => "Sotto-Mayor" ] 9 => array:2 [ "nombre" => "A Bugalho" "apellidos" => "de Almeida" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302919?idApp=UINPBA00004E" "url" => "/08732159/0000001400000006/v1_201509151433/S0873215915302919/v1_201509151433/pt/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0873215915302889" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30288-9" "estado" => "S350" "fechaPublicacion" => "2008-11-01" "aid" => "6" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2008;14:803-27" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3013 "formatos" => array:3 [ "EPUB" => 237 "HTML" => 2041 "PDF" => 735 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original/Original Article</span>" "titulo" => "Avaliação económica do erlotinib, docetaxel, pemetrexedo e tratamento de suporte no tratamento de segunda ou terceira linhas de doentes com cancro do pulmão de não pequenas células" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "803" "paginaFinal" => "827" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "An economic analysis of erlotinib, docetaxel, pemetrexed and best supportive care as second or third line treatment of non-small cell lung cancer" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Araújo, B. Parente, R. Sotto-Mayor, E. Teixeira, T. Almodôvar, F. Barata, H. Queiroga, C. Pereira, H. Pereira, F. Negreiro, C. Silva" "autores" => array:11 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Araújo" ] 1 => array:2 [ "nombre" => "B." "apellidos" => "Parente" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Sotto-Mayor" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Teixeira" ] 4 => array:2 [ "nombre" => "T." "apellidos" => "Almodôvar" ] 5 => array:2 [ "nombre" => "F." "apellidos" => "Barata" ] 6 => array:2 [ "nombre" => "H." "apellidos" => "Queiroga" ] 7 => array:2 [ "nombre" => "C." "apellidos" => "Pereira" ] 8 => array:2 [ "nombre" => "H." "apellidos" => "Pereira" ] 9 => array:2 [ "nombre" => "F." "apellidos" => "Negreiro" ] 10 => array:2 [ "nombre" => "C." "apellidos" => "Silva" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302889?idApp=UINPBA00004E" "url" => "/08732159/0000001400000006/v1_201509151433/S0873215915302889/v1_201509151433/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original/Original Article</span>" "titulo" => "Análise comparativa entre tuberculose multirresistente e tuberculose extensivamente resistente – Epidemiologia e factores preditivos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "829" "paginaFinal" => "842" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Ana Sofia Vilariça, Carlos Gomes, Jaime Pina" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Ana" "apellidos" => "Sofia Vilariça" "email" => array:1 [ 0 => "anasofia.vilarica@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Carlos" "apellidos" => "Gomes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 2 => array:3 [ "nombre" => "Jaime" "apellidos" => "Pina" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "af0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Interna do Internato Complementar de Pneumologia, Serviço de Pneumologia III, Hospital de Pulido Valente, Centro Hospitalar Lisboa Norte, Lisboa, Alameda das Linhas de Torres, 117, 1769-001Lisboa / Pulmonology resident" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar Graduado de Pneumologia, Serviço de Pneumologia III, Hospital de Pulido Valente, Centro Hospitalar Lisboa Norte, Lisboa, Alameda das Linhas de Torres, 117, 1769-001Lisboa / Pulmonology consultant and specialist" "etiqueta" => "2" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Chefe de Serviço Hospitalar de Pneumologia e Director do Serviço de Pneumologia III do Hospital de Pulido Valente, Lisboa / Head, Hospital Pulmonology Service and Director, Hospital Pulmonology Service III, Pulido Valente Hospital, Lisbon" "etiqueta" => "3" "identificador" => "af0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Comparative analysis of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis – Epidemiology and predictive factors" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-09-09" "fechaAceptado" => "2008-10-01" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570067" "palabras" => array:4 [ 0 => "Tuberculose extensivamente resistente (TBXDR)" 1 => "tuberculose multirresistente (TBMR)" 2 => "epidemiologia" 3 => "valor preditivo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570066" "palabras" => array:4 [ 0 => "Extensively drug-resistant tuberculosis (XDR-TB)" 1 => "multidrug-resistant tuberculosis (MDRTB)" 2 => "epidemiology" 3 => "predictive value" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introdução:</span> A tuberculose extensivamente resistente (TBXDR) define-se como uma forma de tuberculose multirresistente (TBMR) com resistências adicionais às fluoroquinolonas e, pelo menos, a um dos antibacilares injectáveis seguintes: amicacina, canamicina e capreomicina. Foi classificada pela OMS como uma ameaça séria ao controlo da tuberculose, com consequências à escala mundial, assumindo os contornos de uma autêntica pandemia em algumas regiões do globo.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivo:</span> Comparar os doentes com TBXDR <span class="elsevierStyleItalic">versus</span> outros perfis de TBMR no que diz respeito às características demográficas e epidemiológicas, factores etiopatogénicos e evolução no internamento.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Material e métodos:</span> Doentes internados no Serviço de Pneumologia III do Hospital de Pulido Valente no período compreendido entre Abril de 1999 e Junho de 2007, com o diagnóstico de TBMR microbiologicamente confirmado. Foram analisadas as seguintes variáveis: sexo, distribuição etária, raça, formas de apresentação da TB, grupos de tratamento, perfil de resistência aos antibacilares, estatuto de imigrante, número e duração de tratamentos anteriores, classificação OMS, co-infecção VIH, alcoolismo e/ou toxicodependência, demora média do internamento e mortalidade intra-hospitalar. A análise estatística realizou-se no programa SPSS (Statistical Package for the Social Sciences), versão 15.0. Nas variáveis categoriais, as diferenças estatísticas entre os grupos foram avaliadas através do teste qui-quadrado e as variáveis numéricas através do teste <span class="elsevierStyleItalic">t</span>. Para a construção do modelo preditivo da presença de TBXDR (variável dependente) foi utilizada a análise de regressão logística, tendo sido incluídas as seguintes variáveis independentes: classificação OMS, coinfecção VIH, estatuto de imigrante, alcoolismo e/ou toxicodependência e número e duração de tratamentos anteriores.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados:</span> Foram contabilizados 132 doentes com TBMR, dos quais 69 (52,3%) eram TBXDR. Observaram-se diferenças estatisticamente significativas nas seguintes variáveis: raça (a raça negra esteve associada a TBXDR em 74% dos casos <span class="elsevierStyleItalic">versus</span> 46% da raça caucasiana); classificação OMS (doentes com retratamento por insucesso terapêutico, interrupção do tratamento ou recidiva constituíram 69,5% dos casos de TBXDR <span class="elsevierStyleItalic">versus</span> 44,5 % dos casos não TBXDR); duração média dos tratamentos anteriores (4,2 meses para os casos de TBXDR <span class="elsevierStyleItalic">versus</span> 2,8 meses para os casos não TBXDR); coinfecção VIH/SIDA (doentes com coinfecção VIH constituíram 65,2% dos casos de TB XDR <span class="elsevierStyleItalic">versus</span> 42,9% dos casos não TBXDR) e mortalidade (33,3% nos doentes com TBXDR <span class="elsevierStyleItalic">versus</span> 14,3% nos doentes não TBXDR).</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusões:</span> As variáveis com valor preditivo para o diagnóstico de TBXDR <span class="elsevierStyleItalic">versus</span> não TBXDR foram: presença de infecção VIH (risco relativo [RR] para TBXDR de 2,5; intervalo de confiança [IC], 1,24 -5,05); maior duração média dos tratamentos anteriores ([RR] para TB XDR de 1,2; [IC], 1,11-2,30).</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (6): 829-842</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introduction:</span> Extensively drug-resistant tuberculosis (XDR-TB) is defined as a form of multidrug-resis-tant tuberculosis (MDR-TB) with additional resistance to fluoroquinolones and at least one of the injectable drugs used in tuberculosis treatment: amikacin, kanamycin and capreomycin. It was classified by WHO as a serious threat to tuberculosis (TB) control, with world-wide consequences, taking on the proportions of a real pandemic in some regions.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aim:</span> To compare patients with XDR-TB <span class="elsevierStyleItalic">versus</span> other MDR-TB profiles with regard to epidemiological and demographic characteristics, aetiopathogenic factors and inhospital outcomes.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Methods:</span> Patients admitted to Pulido Valente Hospital (Pulmonology Service III) in the period ranging from April 1999 to June 2007 with MDR-TB diagnosis microbiologically confirmed. The following variables were evaluated: gender, age, race, forms of TB presentation, treatment groups, resistance profile, immigrant status, number and duration of previous treatments, WHO classification, HIV co-infection, alcoholism and/or drug addiction, average length of hospital stay and inhospital mortality.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">Statistical analysis was performed using the SPSS (Statistical Package for the Social Sciences), version 15.0. In categorical variables, the statistical differences between groups were evaluated by the Chisquare test and numeric variables using the T-test. Logistical regression analysis was used to build the predictive model of XDR-TB existence (dependent variable), which included the following independent variables: WHO classification, HIV co-infection, immigrant status, alcoholism and/or drug addiction and number and duration of previous treatments.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results:</span> We recorded 132 patients with MDR-TB, of which 69 (52.3%) were XDR-TB. Statistically significant differences were observed in the following variables: race (black race was associated with XDRTB in 74% of cases <span class="elsevierStyleItalic">versus</span> 46% of the Caucasian race); WHO classification (patients with retreatment for therapeutic failure, stopping treatment or relapse were 69.5% of XDR-TB cases versus 44.5% of Not XDR-TB cases; average duration of previous treatments (4.2<span class="elsevierStyleHsp" style=""></span>months for XDR-TB cases <span class="elsevierStyleItalic">versus</span> 2.8<span class="elsevierStyleHsp" style=""></span>months for Not XDR-TB cases); HIV co-infection (patients with HIV co-infection constituted 65.2% of XDR-TB cases <span class="elsevierStyleItalic">versus</span> 42.9% of Not XDR-TB cases), mortality (33.3% in patients with XDR-TB <span class="elsevierStyleItalic">versus</span> 14.3% in Not XDR-TB patients).</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusions:</span> The variables with predictive value for the diagnosis of XDR-TB <span class="elsevierStyleItalic">vs</span>. Not XDR-TB were presence of HIV co-infection (odds ratio [OR] for XDRTB 2.5; 95% confidence interval [CI], 1.24<span class="elsevierStyleHsp" style=""></span>-<span class="elsevierStyleHsp" style=""></span>5.05) and increased average duration of previous treatments ([OR] for XDR-TB 1.2; 95% [CI], 1.11 – 2.30).</p><p id="sp0065" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2008; XIV (6): 829-842</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia / Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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Original language: Portuguese
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 6 | 2 | 8 |
2024 October | 66 | 32 | 98 |
2024 September | 54 | 29 | 83 |
2024 August | 90 | 42 | 132 |
2024 July | 69 | 31 | 100 |
2024 June | 54 | 29 | 83 |
2024 May | 53 | 31 | 84 |
2024 April | 49 | 41 | 90 |
2024 March | 52 | 27 | 79 |
2024 February | 47 | 25 | 72 |
2024 January | 40 | 29 | 69 |
2023 December | 39 | 34 | 73 |
2023 November | 40 | 25 | 65 |
2023 October | 40 | 28 | 68 |
2023 September | 48 | 35 | 83 |
2023 August | 29 | 20 | 49 |
2023 July | 40 | 34 | 74 |
2023 June | 27 | 14 | 41 |
2023 May | 26 | 27 | 53 |
2023 April | 35 | 15 | 50 |
2023 March | 27 | 24 | 51 |
2023 February | 24 | 41 | 65 |
2023 January | 23 | 18 | 41 |
2022 December | 33 | 23 | 56 |
2022 November | 49 | 27 | 76 |
2022 October | 31 | 24 | 55 |
2022 September | 22 | 35 | 57 |
2022 August | 45 | 41 | 86 |
2022 July | 22 | 35 | 57 |
2022 June | 19 | 27 | 46 |
2022 May | 31 | 31 | 62 |
2022 April | 26 | 35 | 61 |
2022 March | 24 | 38 | 62 |
2022 February | 22 | 21 | 43 |
2022 January | 22 | 39 | 61 |
2021 December | 25 | 39 | 64 |
2021 November | 21 | 26 | 47 |
2021 October | 22 | 40 | 62 |
2021 September | 27 | 32 | 59 |
2021 August | 19 | 19 | 38 |
2021 July | 29 | 24 | 53 |
2021 June | 16 | 24 | 40 |
2021 May | 33 | 39 | 72 |
2021 April | 56 | 71 | 127 |
2021 March | 42 | 16 | 58 |
2021 February | 55 | 21 | 76 |
2021 January | 37 | 15 | 52 |
2020 December | 38 | 8 | 46 |
2020 November | 32 | 13 | 45 |
2020 October | 19 | 11 | 30 |
2020 September | 55 | 28 | 83 |
2020 August | 46 | 18 | 64 |
2020 July | 47 | 26 | 73 |
2020 June | 42 | 29 | 71 |
2020 May | 48 | 16 | 64 |
2020 April | 51 | 25 | 76 |
2020 March | 45 | 22 | 67 |
2020 February | 48 | 23 | 71 |
2020 January | 45 | 23 | 68 |
2019 December | 46 | 22 | 68 |
2019 November | 34 | 12 | 46 |
2019 October | 41 | 19 | 60 |
2019 September | 46 | 20 | 66 |
2019 August | 47 | 30 | 77 |
2019 July | 37 | 12 | 49 |
2019 June | 37 | 18 | 55 |
2019 May | 36 | 34 | 70 |
2019 April | 35 | 22 | 57 |
2019 March | 84 | 15 | 99 |
2019 February | 75 | 10 | 85 |
2019 January | 95 | 21 | 116 |
2018 December | 41 | 6 | 47 |
2018 November | 7 | 3 | 10 |
2018 October | 11 | 7 | 18 |
2018 September | 12 | 7 | 19 |
2018 August | 50 | 24 | 74 |
2018 July | 39 | 20 | 59 |
2018 June | 47 | 14 | 61 |
2018 May | 51 | 21 | 72 |
2018 April | 66 | 37 | 103 |
2018 March | 36 | 34 | 70 |
2018 February | 23 | 14 | 37 |
2018 January | 38 | 12 | 50 |
2017 December | 23 | 18 | 41 |
2017 November | 37 | 13 | 50 |
2017 October | 29 | 11 | 40 |
2017 September | 25 | 13 | 38 |
2017 August | 35 | 12 | 47 |
2017 July | 27 | 9 | 36 |
2017 June | 29 | 15 | 44 |
2017 May | 36 | 21 | 57 |
2017 April | 15 | 30 | 45 |
2017 March | 13 | 10 | 23 |
2017 February | 13 | 4 | 17 |
2017 January | 15 | 3 | 18 |
2016 December | 11 | 4 | 15 |
2016 November | 8 | 5 | 13 |
2016 October | 12 | 13 | 25 |
2016 September | 4 | 2 | 6 |
2016 August | 4 | 2 | 6 |
2016 July | 8 | 7 | 15 |
2016 June | 0 | 2 | 2 |
2016 May | 2 | 5 | 7 |
2016 April | 3 | 1 | 4 |
2016 March | 1 | 2 | 3 |
2016 February | 2 | 7 | 9 |
2016 January | 5 | 5 | 10 |
2015 December | 9 | 3 | 12 |
2015 November | 3 | 1 | 4 |
2015 October | 2 | 3 | 5 |