Artigo Original / Original Article
Hipertensão arterial pulmonar – Experiência do Centro Hospitalar de Vila Nova de Gaia
Pulmonary arterial hypertension – Experience of Centro Hospitalar de Vila Nova de Gaia
Ana Oliveira1, Daniela Ferreira1, António Caiado2, Susana Ferreira1, Paula Ferreira1, Lino Santos3, Manuel Gonçalves4, Teresa Shiang5
1 Interna Complementar de Pneumologia / Pulmonolgy resident
2 Assistente Hospitalar de Pneumologia / Pulmonolgy consultant
3 Assistente Hospitalar de Cardiologia / Cardiology consultant
4 Assistente Hospitalar Graduado de Medicina Interna / Internal Medicine specialist consultant
5 Assistente Hospitalar Graduada de Pneumologia / Pulmonolgy specialist consultant
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"tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "239" "paginaFinal" => "254" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Ana Oliveira, Daniela Ferreira, António Caiado, Susana Ferreira, Paula Ferreira, Lino Santos, Manuel Gonçalves, Teresa Shiang" "autores" => array:8 [ 0 => array:3 [ "nombre" => "Ana" "apellidos" => "Oliveira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Daniela" "apellidos" => "Ferreira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 2 => array:3 [ "nombre" => "António" "apellidos" => "Caiado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 3 => array:3 [ "nombre" => "Susana" "apellidos" => "Ferreira" "referencia" => array:1 [ 0 => array:2 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resident</span>" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar de Pneumologia / <span class="elsevierStyleItalic">Pulmonolgy consultant</span>" "etiqueta" => "2" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Assistente Hospitalar de Cardiologia / <span class="elsevierStyleItalic">Cardiology consultant</span>" "etiqueta" => "3" "identificador" => "af0015" ] 3 => array:3 [ "entidad" => "Assistente Hospitalar Graduado de Medicina Interna / <span class="elsevierStyleItalic">Internal Medicine specialist consultant</span>" "etiqueta" => "4" "identificador" => "af0020" ] 4 => array:3 [ "entidad" => "Assistente Hospitalar Graduada de Pneumologia / <span class="elsevierStyleItalic">Pulmonolgy specialist consultant</span>" "etiqueta" => "5" "identificador" => "af0025" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pulmonary arterial hypertension – Experience of Centro Hospitalar de Vila Nova de Gaia" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-10-04" "fechaAceptado" => "2007-01-02" "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introdução:</span> A hipertensão arterial pulmonar (HAP) é uma doença grave e progressiva potencialmente fatal em poucos anos. Até à década de 90, o único tratamento eficaz para esta entidade era o transplante pul-monar/cardiopulmonar. Nos últimos anos assistiu-se ao aparecimento de novos fármacos que vieram alte-rar o curso da doença.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivos:</span> Caracterização dos doentes com HAP observados no Centro Hospitalar de VN Gaia no período de 2000 a 2006. Alertar para esta entidade.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Material e métodos:</span> Análise retrospectiva de todos os doentes com HAP ou doença tromboembólica crónica em tratamento no CHVN Gaia.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados</span>: No referido período foram observados 11 doentes, 7 mulheres e 4 homens, com média etária de 43 anos. Cinco doentes com HAP idiopática, três com doença tromboembólica crónica, dois com HAP associada a comunicação interauricular e um com HAP associada a S. CREST. Ao diagnóstico, a maioria en-contravase em classe funcional NYHA/OMS III/IV, a pressão sistólica média da artéria pulmonar foi de 98<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>32<span class="elsevierStyleHsp" style=""></span>mmHg e a distância média percorrida na 6-MWT foi de 401<span class="elsevierStyleHsp" style=""></span>m. Terapêutica inicial: Três doentes iloprost por via inalatória; dois treprostinil subcutâneo; três bosentan <span class="elsevierStyleItalic">per os</span>; um sildenafil <span class="elsevierStyleItalic">per os</span> e dois doentes foram submetidos a cirurgia. O tempo médio de <span class="elsevierStyleItalic">follow-up</span> é de 28,1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>20.3 meses. Cinco doentes melhoraram, três mantiveram-se estáveis, um agravou e dois faleceram.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusão</span>: A HAP é uma doença grave que requer uma abordagem multidisciplinar com necessidade de terapêuticas complexas e dispendiosas. O diagnóstico em estádios precoces é essencial, de modo a permitir uma terapêutica atempada.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIII (2): 239-254</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introduction:</span> Pulmonary arterial hypertension (PAH) is a serious and progressive disease, potentially fatal in a few years. Until the 1990s the only effective treatment for this disease was pulmonary/cardiopulmo-nary transplant. Over the last few years several drugs have emerged that have modified the course of the disease.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aims:</span> To characterise patients with PAH followed at Centro Hospitalar de V.N.Gaia between 2000 and 2006. To raise awareness of this entity.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Material and methods:</span> Retrospective analysis of all patients with PAH or chronic thromboembolic pulmonary hypertension (CTEPH) followed at our Hospital.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results:</span> In this period 11 patients were observed, 7 women and 4 men, with a mean age of 43 y. Five patients had idiopathic PAH, three had CTEPH, two had PAH associated with interauricular communication and one had PAH associated with CREST Syndrome.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">At the time of diagnosis most patients were in NYHA/ /WHO Functional Class III/IV, mean systolic pulmonary artery pressure was 98<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>32<span class="elsevierStyleHsp" style=""></span>mmHg and mean distance walked in the 6-minute walk test was 401<span class="elsevierStyleHsp" style=""></span>m. Initial treatment: Three patients had inhaled iloprost, two subcutaneous treprostinil, three oral bosentan, one oral sildenafil and two patients under-went surgery. Mean follow-up time was 28.1<span class="elsevierStyleHsp" style=""></span>months. Five patients recovered, three are stable, one worsened and two died.</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusions</span>: PAH is a serious illness which requires a multidisciplinary approach with the need for complex and expensive therapies. Diagnosis in initial stages is essential for an effective treatment.</p><p id="sp0065" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIII (2): 239-254</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0015">Bibliografia / Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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Rubin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(98)02111-4" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1998" "volumen" => "352" "paginaInicial" => "719" "paginaFinal" => "725" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9729004" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Drug Therapy For Pulmonary Arterial Hyper-tension: What’s On The Menu Today?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "S. Mehta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2003" "volumen" => "124" "paginaInicial" => "2045" "paginaFinal" => "2049" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14665473" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and Management of Pulmonary Artery Hypertension: ACCP Evidence-Based Clinical Practice Guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "L.J. Rubin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2004" "volumen" => "126" "paginaInicial" => "1S" "paginaFinal" => "92S" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostanoids For Pulmonary Arterial Hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Galie" 1 => "A. Manes" 2 => "A. Branzi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Respir Med" "fecha" => "2003" "volumen" => "2" "paginaInicial" => "123" "paginaFinal" => "137" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14720012" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A Comparison Of Continuous Intravenous Epoprostenol (Prostacyclin) With Conventional Therapy For Primary Pulmonary Hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:2 [ 0 => "R.J. Barst" 1 => "L. Rubin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199602013340504" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1996" "volumen" => "334" "paginaInicial" => "296" "paginaFinal" => "301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8532025" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome in 91 Consecutive Patients with Pulmonary Arterial Hypertension Receiving Epoprostenol" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "K.P. Kuhn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200204-333OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2003" "volumen" => "167" "paginaInicial" => "580" "paginaFinal" => "586" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12446266" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival in Primary Pulmonary Hypertension – The Impact of Epoprostenol Therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "V. McLaughlin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2002" "volumen" => "106" "paginaInicial" => "1477" "paginaFinal" => "1482" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12234951" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "for The Aerosolized Iloprost Randomized (AIR) Study Group. Inhaled Iloprost For Severe Pulmonary Hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "H. Olschewski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa020204" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2002" "volumen" => "347" "paginaInicial" => "322" "paginaFinal" => "329" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12151469" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-Term Treatment Of Primary Pulmonary Hypertension With Aerosolized Iloprost, A Prostacyclin Analogue" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "M. 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Tapson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.129.3.683" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2006" "volumen" => "129" "paginaInicial" => "683" "paginaFinal" => "688" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16537868" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Continuous Subcutaneous Infusion Of Treprostinil, A Prostacyclin Analogue, In Patients With Pulmonary Arterial Hypertension: A Double-Blind, Randomized, Placebo-Con-trolled Trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "G. 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Gomberg-Maitland" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjcard.2005.06.083" "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2005" "volumen" => "96" "paginaInicial" => "1334" "paginaFinal" => "1336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16253609" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001300000002/v1_201509071322/S0873215915303469/v1_201509071322/pt/main.assets" "Apartado" => array:4 [ "identificador" => "43382" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Artigos Originais/Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001300000002/v1_201509071322/S0873215915303469/v1_201509071322/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915303469?idApp=UINPBA00004E" ]
Article information
ISSN: 08732159Original language: Portuguese
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| 2023 October | 12 | 29 | 41 |
| 2023 September | 26 | 35 | 61 |
| 2023 August | 20 | 29 | 49 |
| 2023 July | 18 | 29 | 47 |
| 2023 June | 22 | 15 | 37 |
| 2023 May | 15 | 30 | 45 |
| 2023 April | 25 | 13 | 38 |
| 2023 March | 30 | 25 | 55 |
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| 2022 December | 23 | 20 | 43 |
| 2022 November | 31 | 28 | 59 |
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| 2022 August | 35 | 45 | 80 |
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| 2022 May | 33 | 31 | 64 |
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| 2022 March | 28 | 24 | 52 |
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| 2022 January | 25 | 38 | 63 |
| 2021 December | 25 | 29 | 54 |
| 2021 November | 15 | 35 | 50 |
| 2021 October | 25 | 32 | 57 |
| 2021 September | 21 | 21 | 42 |
| 2021 August | 15 | 29 | 44 |
| 2021 July | 19 | 19 | 38 |
| 2021 June | 17 | 19 | 36 |
| 2021 May | 20 | 21 | 41 |
| 2021 April | 33 | 48 | 81 |
| 2021 March | 27 | 21 | 48 |
| 2021 February | 32 | 17 | 49 |
| 2021 January | 25 | 9 | 34 |
| 2020 December | 19 | 17 | 36 |
| 2020 November | 44 | 23 | 67 |
| 2020 October | 18 | 14 | 32 |
| 2020 September | 41 | 33 | 74 |
| 2020 August | 46 | 17 | 63 |
| 2020 July | 48 | 19 | 67 |
| 2020 June | 33 | 19 | 52 |
| 2020 May | 64 | 17 | 81 |
| 2020 April | 44 | 12 | 56 |
| 2020 March | 41 | 18 | 59 |
| 2020 February | 30 | 15 | 45 |
| 2020 January | 40 | 10 | 50 |
| 2019 December | 38 | 12 | 50 |
| 2019 November | 42 | 11 | 53 |
| 2019 October | 55 | 20 | 75 |
| 2019 September | 39 | 20 | 59 |
| 2019 August | 52 | 25 | 77 |
| 2019 July | 35 | 10 | 45 |
| 2019 June | 40 | 14 | 54 |
| 2019 May | 48 | 25 | 73 |
| 2019 April | 38 | 19 | 57 |
| 2019 March | 44 | 18 | 62 |
| 2019 February | 53 | 20 | 73 |
| 2019 January | 51 | 14 | 65 |
| 2018 December | 18 | 14 | 32 |
| 2018 November | 9 | 9 | 18 |
| 2018 October | 3 | 0 | 3 |
| 2018 September | 10 | 4 | 14 |
| 2018 August | 47 | 25 | 72 |
| 2018 July | 37 | 22 | 59 |
| 2018 June | 39 | 22 | 61 |
| 2018 May | 52 | 14 | 66 |
| 2018 April | 39 | 37 | 76 |
| 2018 March | 43 | 26 | 69 |
| 2018 February | 31 | 14 | 45 |
| 2018 January | 22 | 15 | 37 |
| 2017 December | 50 | 14 | 64 |
| 2017 November | 34 | 10 | 44 |
| 2017 October | 28 | 12 | 40 |
| 2017 September | 42 | 13 | 55 |
| 2017 August | 39 | 21 | 60 |
| 2017 July | 19 | 16 | 35 |
| 2017 June | 29 | 18 | 47 |
| 2017 May | 39 | 7 | 46 |
| 2017 April | 9 | 3 | 12 |
| 2017 March | 19 | 18 | 37 |
| 2017 February | 14 | 7 | 21 |
| 2017 January | 16 | 4 | 20 |
| 2016 December | 13 | 10 | 23 |
| 2016 November | 10 | 9 | 19 |
| 2016 October | 14 | 8 | 22 |
| 2016 September | 5 | 7 | 12 |
| 2016 August | 5 | 4 | 9 |
| 2016 July | 3 | 2 | 5 |
| 2016 May | 0 | 9 | 9 |
| 2016 April | 2 | 7 | 9 |
| 2016 March | 7 | 16 | 23 |
| 2016 February | 5 | 13 | 18 |
| 2016 January | 5 | 2 | 7 |
| 2015 December | 7 | 2 | 9 |
| 2015 November | 3 | 1 | 4 |
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