Caso Clínico / Clinical Case
Vasculite e padrão de panbronquiolite difusa no lúpus eritematoso sistémico – Caso clínico
Vasculitis and diffuse panbronchiolitis-like in systemic lupus erythematosus – Case report
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Faculdade de Medicina da Universidade de Coimbra" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Pneumologista Eventual. Hospitais da Universidade de Coimbra" "etiqueta" => "2" "identificador" => "af0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Vasculitis and diffuse panbronchiolitis-like in systemic lupus erythematosus – Case report" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-11-18" "fechaAceptado" => "2006-12-19" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec567850" "palabras" => array:4 [ 0 => "LES" 1 => "bronquiolite" 2 => "vasculite" 3 => "panbronquiolite difusa" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec567851" "palabras" => array:4 [ 0 => "SLE" 1 => "bronchiolitis" 2 => "vasculitis" 3 => "diffuse pan-bronchiolitis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">O compromisso visceral pelo lúpus eritematoso sistémico (LES) estende-se para além do rim e da pele. Lesões pleuropulmonares são reconhecidas e as for-mas de destruição alveolar difusa e hemorragia alveolar são as mais difíceis de controlar. O compromisso pulmonar na evolução clínica do LES difere nas crianças e nos adultos, tanto nos padrões morfológicos como nas apresentações clínicas, dependendo da imunoincompe-tência do doente e do tratamento instituído.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Um rapaz de 16 anos apresentou um quadro clínico de astenia, cansaço e pequenos gânglios linfáticos cer-vicais bilaterais e não dolorosos, entendido como in-fecção pelo EBV, com serologia concordante (IgG e IgM de EBV e EBNA positivos). Os sintomas persistiram durante oito meses e progressivamente insta-lou-se eritema nasal e malar, discreto e descamativo e também febre persistente, dispneia e estertores basais à auscultação. Foram efectuadas biópsia de um gânglio linfático cervical e biópsia cirúrgica pulmonar.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Observouse hiperplasia folicular no gânglio linfático e ausência de células LMP1 (EBV) positivas. Na biópsia pulmonar eram evidentes fenómenos de bronquiolite e vasculite à custa de células macrofágicas identificadas pelo marcador CD68. Os macrófagos dissociavam as paredes vasculares e bronquiolares e também estavam presentes nos septos interalveolares peribroncovascu-lares e nos espaços alveolares, observando-se assim um padrão de panbronquiolite difusa e vasculite. Não se identificaram células LMP1 (EBV) positivas.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">O padrão pulmonar micronodular bilateral observado na TAC resolveu com corticoterapia. O diagnóstico de LES foi confirmado pela positividade dos anticorpos ANA, anti-dsDNA, anti-nDNA e anti-histonas.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Este é o primeiro caso divulgado na literatura médica de compromisso pulmonar sob a forma de vasculite e padão de panbronquiolite difusa como primeira ma-nifestação clínica do lúpus eritematosos sistémico.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIII (2): 267-274</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Visceral involvement in systemic lupus erythematosus (SLE) extends beyond renal and cutaneous management. Pleuro-pulmonary lesions have been recognised and diffuse alveolar damage and hemorrhage are the most difficult patterns to control. Pulmonary compromise in clinical evolution of SLE differs from children to adults, both in morphological patterns and in clinical presentation, depending on immunocompetence and the treatment prescribed.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">A 16-year-old boy presented asthenia, malaise and bilateral cervical painless adenopathies understood as EBV infection as serological EBV IgG, IgM and EBNA were positive. The symptoms persisted for eight months when discrete erythematous and desquamative nasal and malar rash expressed together with persistent fever, dispnoea and bibasilar crackles. Lymph node and pulmonary biopsi-ses were performed.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Lymph node presented follicular hyperplasia and LMP1 (EBV) immunostaining was negative. In lung biopsy bronchovascular lesions were consistent with vasculitis and bronchiolitis due to intense macrophage infiltration, validated with CD68 antibody and intra-alveolar macrophages were also present with septal compromise; LMP1 (EBV) positive cells were not visualized.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">The lung pattern seen in CAT as diffuse micronodules all over the lung parenchyme resolved after corticos-teroid therapy. The diagnosis of SLE was confirmed by ANA, anti-dsDNA, anti-nDNA and anti-histones positivity.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">To the best of our knowledge this is the first reported case of pulmonary SLE involvement with vasculitis and diffuse panbronchiolitis – like pattern as the first clinical sign of the disease.</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIII (2): 267-274</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:42 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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DeRemee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mayo Clin Proc" "fecha" => "1977" "volumen" => "52" "paginaInicial" => "477" "paginaFinal" => "485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18640" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bb0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A boy with consecutive development of SLE and Wegener granulomatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "O. Erdogan" 1 => "A. Oner" 2 => "G. Demircin" 3 => "M. Bulbul" 4 => "L. Memis" 5 => "C. Uner" 6 => "N. 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Article information
ISSN: 08732159Original language: Portuguese
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| 2021 April | 52 | 19 | 71 |
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| 2020 December | 19 | 12 | 31 |
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| 2019 December | 44 | 16 | 60 |
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| 2018 June | 40 | 19 | 59 |
| 2018 May | 42 | 23 | 65 |
| 2018 April | 38 | 32 | 70 |
| 2018 March | 48 | 24 | 72 |
| 2018 February | 29 | 8 | 37 |
| 2018 January | 45 | 16 | 61 |
| 2017 December | 57 | 19 | 76 |
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| 2017 June | 35 | 9 | 44 |
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| 2017 April | 11 | 3 | 14 |
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| 2016 December | 18 | 10 | 28 |
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| 2016 August | 2 | 1 | 3 |
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| 2016 May | 0 | 1 | 1 |
| 2016 April | 9 | 34 | 43 |
| 2016 March | 3 | 12 | 15 |
| 2016 February | 3 | 14 | 17 |
| 2016 January | 5 | 7 | 12 |
| 2015 December | 7 | 8 | 15 |
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