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Reflexão sobre o posicionamento da Igreja católica" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "605" "paginaFinal" => "612" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Intensive medicine in the End-of-life Care. Considerations on the disposition of the Catholic church" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Filipe Monteiro" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Filipe" "apellidos" => "Monteiro" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915303664?idApp=UINPBA00004E" "url" => "/08732159/0000001300000004/v1_201509151514/S0873215915303664/v1_201509151514/pt/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0873215915303640" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30364-0" "estado" => "S350" "fechaPublicacion" => "2007-07-01" "aid" => "4" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2007;13:553-85" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2655 "formatos" => array:3 [ "EPUB" => 202 "HTML" => 1353 "PDF" => 1100 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original / Original Article</span>" "titulo" => "Timomas malignos – A experiência do IPO do Porto e revisão da literatura" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "553" "paginaFinal" => "585" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Malignant thymomas – The experience of the Portuguese Oncological Institute, Porto, and literature review" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Berta Sousa, António Araújo, Teresina Amaro, Isabel Azevedo, Marta Soares, Olga Sousa" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Berta" "apellidos" => "Sousa" ] 1 => array:2 [ "nombre" => "António" "apellidos" => "Araújo" ] 2 => array:2 [ "nombre" => "Teresina" "apellidos" => "Amaro" ] 3 => array:2 [ "nombre" => "Isabel" "apellidos" => "Azevedo" ] 4 => array:2 [ "nombre" => "Marta" "apellidos" => "Soares" ] 5 => array:2 [ "nombre" => "Olga" "apellidos" => "Sousa" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915303640?idApp=UINPBA00004E" "url" => "/08732159/0000001300000004/v1_201509151514/S0873215915303640/v1_201509151514/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão / Revision Article</span>" "titulo" => "Carcinoma do pulmão de pequenas células – Estado da arte e perspectivas futuras" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "587" "paginaFinal" => "604" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Fernando J. Barata, Ana Filipa Costa" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Fernando J." "apellidos" => "Barata" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Ana Filipa" "apellidos" => "Costa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Serviço de Pneumologia. Centro Hospitalar de Coimbra" "etiqueta" => "1" "identificador" => "af0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Small cell lung cancer – State of the art and future perspectives" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-10-31" "fechaAceptado" => "2007-03-26" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-Chave" "identificador" => "xpalclavsec570354" "palabras" => array:4 [ 0 => "Carcinoma pulmonar de pequenas células" 1 => "CPPC" 2 => "cancro do pulmão" 3 => "topotecano" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-Words" "identificador" => "xpalclavsec570353" "palabras" => array:4 [ 0 => "Small cell lung cancer" 1 => "lung cancer" 2 => "topotecan" 3 => "SCLC" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Em Portugal, o cancro do pulmão é a principal cau-sa de morte entre as neoplasias. Em 2006 são previstos mais de 3500 novos casos, dos quais 20% serão diagnosticados como carcinoma do pulmão de pequenas células (CPPC). Destes, 25% a 30% dos doentes serão estadiados como doença localizada ou regional. Para estes, a opção terapêutica passa pela combinação da radioterapia (50<span class="elsevierStyleHsp" style=""></span>Gy ou 60<span class="elsevierStyleHsp" style=""></span>Gy) diária e quimioterapia. A radioterapia hiperfraccionada, em consequência da sua toxicidade, está limitada a doentes seleccionados.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">A combinação etopósido e cisplatina é sinérgica, bem tolerada. É o regimen <span class="elsevierStyleItalic">standard</span> quer na opção concomi-tante com a radioterapia, quer isoladamente na doença disseminada.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Apesar da quimiossensibilidade e radiosensibilidade, o prognóstico global do CPPC é pobre. Há um de-senvolvimento precoce de resistência associado a uma elevada predisposição para a recidiva.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">A terapêutica de segunda linha para o CPPC é um problema real e actual. Topotecano é hoje uma op-ção efectiva e bem tolerada no tratamento em segunda linha do CPPC. Há um aumento significativo da sobrevivência mediana <span class="elsevierStyleItalic">versus</span> a terapêutica sintomática. A sua eficácia é comparável ao clássi-co regimen CAV. Mostra boa tolerabilidade mes-mo quando administrado em doentes idosos, com PS<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2. Continua a ser bem tolerado e eficaz quando combinado com a radioterapia holocraniana cerebral ou quando administrado num esquema semanal.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Com novas classes de fármacos, como agentes anti-angiogénicos como o bevacizumab, inibidores da tirosina quinase e talidomida, decorrem ensaios avaliando a sua associação com a clássica quimioterapia em doentes com CPPC disseminada.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIII (4): 587-604</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Lung cancer is the leading cause of cancer related death in Portugal. Almost 3500 Portuguese are expected to be diagnosed with lung cancer in 2006; approximately 20% will have small cell lung cancer (SCLC). At presentation, 25% to 30% of patients will have local or regional disease, classified as limited stage disease. The concurrent chemovalidation therapy is the best choice. Once daily thoracic radiation therapy to doses in the range of 50<span class="elsevierStyleHsp" style=""></span>Gy to 60<span class="elsevierStyleHsp" style=""></span>Gy would reflect an accepted standard of care in daily practice. Because of the increase toxicity associated with hyper fractionated radiation, this approach is often limited to select patients. Etoposide plus cisplatin are synergistic, well tolerated and result in equal or superior survival compared with other regimens. This is the standard regimen for concomitant therapy in limited stage and for extensive disease SCLC.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Despite good chemo sensitivity and radio sensitivity, the prognosis of SCLC is very poor because of the early development of resistance and the associated high tendency to recurrence, making second line treatment of SCLC a problem of real medical relevance.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Topotecan now offers an effective and well tolerated mono-substance for second line therapy of recurrent SCLC. There has been a significant increase in median survival for patients with SCLC receiving topotecan plus symptomatic therapy <span class="elsevierStyleItalic">versus</span> symptomatic therapy. The efficacy of this drug is comparable to the efficacy of the three-drug combination CAV. The tolerability can be improved by means of toxicity-adapted dosing. In elderly and in patients with performance status 2, topotecan is also well tolerated and has good efficacy. Initial studies into weekly administration also demonstrate good efficacy. The combination of topotecan with cranial radiotherapy is well tolerated and effective in the treatment of cerebral metastases of SCLC. New classes of agents, such as antiangiogenic agents including bevacizumab, small molecule tyrosine kinase inhibitors and thalidomide are being evaluated with chemotherapy for patients with extensive stage SCLC.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIII (4): 587-604</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia / Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:78 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The etiology and epidemiology of lung cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Schottenfeld" 1 => "J.G. 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Original language: Portuguese
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 10 | 2 | 12 |
2024 October | 34 | 25 | 59 |
2024 September | 44 | 30 | 74 |
2024 August | 36 | 31 | 67 |
2024 July | 44 | 30 | 74 |
2024 June | 49 | 18 | 67 |
2024 May | 39 | 35 | 74 |
2024 April | 35 | 25 | 60 |
2024 March | 49 | 21 | 70 |
2024 February | 52 | 23 | 75 |
2024 January | 65 | 27 | 92 |
2023 December | 36 | 14 | 50 |
2023 November | 30 | 17 | 47 |
2023 October | 20 | 42 | 62 |
2023 September | 20 | 32 | 52 |
2023 August | 23 | 24 | 47 |
2023 July | 44 | 30 | 74 |
2023 June | 27 | 10 | 37 |
2023 May | 72 | 19 | 91 |
2023 April | 24 | 20 | 44 |
2023 March | 36 | 20 | 56 |
2023 February | 32 | 23 | 55 |
2023 January | 27 | 15 | 42 |
2022 December | 21 | 18 | 39 |
2022 November | 65 | 29 | 94 |
2022 October | 23 | 20 | 43 |
2022 September | 22 | 26 | 48 |
2022 August | 37 | 35 | 72 |
2022 July | 19 | 36 | 55 |
2022 June | 23 | 24 | 47 |
2022 May | 41 | 25 | 66 |
2022 April | 35 | 31 | 66 |
2022 March | 25 | 29 | 54 |
2022 February | 23 | 25 | 48 |
2022 January | 28 | 36 | 64 |
2021 December | 23 | 29 | 52 |
2021 November | 26 | 29 | 55 |
2021 October | 27 | 30 | 57 |
2021 September | 20 | 26 | 46 |
2021 August | 22 | 29 | 51 |
2021 July | 18 | 23 | 41 |
2021 June | 14 | 19 | 33 |
2021 May | 27 | 26 | 53 |
2021 April | 47 | 29 | 76 |
2021 March | 21 | 16 | 37 |
2021 February | 45 | 11 | 56 |
2021 January | 37 | 12 | 49 |
2020 December | 29 | 9 | 38 |
2020 November | 49 | 16 | 65 |
2020 October | 31 | 15 | 46 |
2020 September | 55 | 26 | 81 |
2020 August | 43 | 14 | 57 |
2020 July | 93 | 21 | 114 |
2020 June | 66 | 29 | 95 |
2020 May | 66 | 19 | 85 |
2020 April | 71 | 9 | 80 |
2020 March | 62 | 15 | 77 |
2020 February | 46 | 71 | 117 |
2020 January | 60 | 41 | 101 |
2019 December | 45 | 22 | 67 |
2019 November | 66 | 25 | 91 |
2019 October | 61 | 27 | 88 |
2019 September | 47 | 27 | 74 |
2019 August | 54 | 39 | 93 |
2019 July | 42 | 30 | 72 |
2019 June | 28 | 35 | 63 |
2019 May | 37 | 36 | 73 |
2019 April | 37 | 47 | 84 |
2019 March | 44 | 23 | 67 |
2019 February | 44 | 28 | 72 |
2019 January | 56 | 16 | 72 |
2018 December | 18 | 12 | 30 |
2018 November | 5 | 0 | 5 |
2018 October | 5 | 0 | 5 |
2018 September | 17 | 7 | 24 |
2018 August | 41 | 21 | 62 |
2018 July | 33 | 27 | 60 |
2018 June | 29 | 34 | 63 |
2018 May | 40 | 44 | 84 |
2018 April | 34 | 39 | 73 |
2018 March | 29 | 31 | 60 |
2018 February | 22 | 7 | 29 |
2018 January | 32 | 18 | 50 |
2017 December | 29 | 14 | 43 |
2017 November | 35 | 29 | 64 |
2017 October | 37 | 22 | 59 |
2017 September | 34 | 16 | 50 |
2017 August | 25 | 14 | 39 |
2017 July | 22 | 11 | 33 |
2017 June | 20 | 16 | 36 |
2017 May | 33 | 13 | 46 |
2017 April | 6 | 30 | 36 |
2017 March | 13 | 54 | 67 |
2017 February | 9 | 4 | 13 |
2017 January | 12 | 8 | 20 |
2016 December | 11 | 6 | 17 |
2016 November | 15 | 12 | 27 |
2016 October | 10 | 9 | 19 |
2016 September | 4 | 5 | 9 |
2016 August | 2 | 4 | 6 |
2016 July | 4 | 4 | 8 |
2016 June | 4 | 0 | 4 |
2016 May | 3 | 4 | 7 |
2016 April | 4 | 1 | 5 |
2016 March | 5 | 6 | 11 |
2016 February | 7 | 11 | 18 |
2016 January | 5 | 4 | 9 |
2015 December | 7 | 5 | 12 |
2015 November | 3 | 2 | 5 |
2015 October | 3 | 1 | 4 |