Artigo de Revisão / Revision Article
Abordagem terapêutica do carcinoma pulmonar de não pequenas células no idoso
Treatment of non-small cell lung cancer in elderly patients
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Mackay, Beatriz Guerra Vitral" "autores" => array:4 [ 0 => array:2 [ "nombre" => "João Cláudio Barroso" "apellidos" => "Pereira" ] 1 => array:2 [ "nombre" => "Amorita" "apellidos" => "Grijó" ] 2 => array:2 [ "nombre" => "Maria Cristina B." "apellidos" => "Mackay" ] 3 => array:2 [ "nombre" => "Beatriz Guerra" "apellidos" => "Vitral" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915303780?idApp=UINPBA00004E" "url" => "/08732159/0000001300000006/v1_201509151528/S0873215915303780/v1_201509151528/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão / Revision Article</span>" "titulo" => "Abordagem terapêutica do carcinoma pulmonar de não pequenas células no idoso" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "841" "paginaFinal" => "854" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Filipa Costa, Fernando J Barata" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Filipa" "apellidos" => "Costa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Fernando J" "apellidos" => "Barata" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Interna do Internato Complementar de Pneumologia, Quinta dos Vales, São Martinho do Bispo, 3046-853 Coimbra" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar Graduado de Pneumologia, Quinta dos Vales, São Martinho do Bispo, 3046-853 Coimbra" "etiqueta" => "2" "identificador" => "af0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Treatment of non-small cell lung cancer in elderly patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-04-10" "fechaAceptado" => "2007-06-01" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570448" "palabras" => array:3 [ 0 => "CPNPC" 1 => "idoso" 2 => "terapêutica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570447" "palabras" => array:3 [ 0 => "NSCLC" 1 => "elderly" 2 => "treatment" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">O cancro do pulmão é a primeira causa de morte por cancro. Dado o envelhecimento global da população, actualmente mais de 50% de todos os doentes com carcinoma pulmonar de não pequenas células (CPNPC) têm mais de 65 anos. Até há poucos anos, imperava o cepticismo no tratamento dos doentes neste grupo etário, prevalecendo a noção de que qualquer que fosse o tratamento instituído, o balanço entre o benefício e os efeitos secundários era desfavorável. A falência orgânica dependente da idade, as comorbilidades, a polimedicação e a fragilidade do idoso explicavam esta opinião geral. Nos últimos anos, mudou-se radicalmente esta atitude. Quando se decide na estratégia terapêutica destes doentes, é a idade biológica (baseada no <span class="elsevierStyleItalic">performance status</span> – PS e nas comorbilidades) e não a idade cronológica que deve ser tida em conta, e a não administração do tratamento <span class="elsevierStyleItalic">standard</span> ou a sua modificação só deverá ser feita perante uma razão válida. Isto aplica-se de igual forma à cirurgia, quimioterapia, radioterapia e às novas terapêuticas moleculares, as armas terapêuticas ao nosso dispor para combater esta patologia. Os estudos publicados recentemente e que se dedicaram especificamente à avaliação dos doentes idosos vieram comprovar que, se tratados de forma adequada, os doentes idosos com bom PS e sem comorbilidades <span class="elsevierStyleItalic">major</span> têm uma sobrevida e uma qualidade de vida semelhante à dos doentes mais jovens.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Dado o número crescente de doentes com cancro do pulmão em idade avançada, os autores fazem uma revisão bibliográfica da literatura existente sobre este tema.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIII (6): 841-854</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Lung cancer is the most common cause of cancer death. With the aging of the population, more than 50% of patients with non-small cell lung cancer (NSCLC) are older than 65 years. Until recently, there was some scepticism regarding treatment of patients in this age group, prevailing the notion that whatever treatment was given, the balance between the benefits and the side effects was unfavourable. The organ failure dependent of age, the comorbidities, the polimedication and the fragility of elderly people, were responsible for this generalized opinion. In the last few years, this nihilistic approach has changed radically. When deciding what treatment strategy should be used in these patients, the biological age (based on performance status: PS and comorbidities) rather than the chronological age should be taken into account, and the modification of standard treatment plans should only be made when there is a valid reason. This applies equally to surgery, chemotherapy, radiotherapy and the new targeted agents, the therapeutic weapons available to treat this disease. Recently published studies, that specifically analysed elderly patients, proved that if treated adequately, elderly patients with a good PS and without major comorbidities have the same survival rates and quality of life as younger patients.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">The rising number of elderly patients with lung cancer led the authors to do a review of the literature on this topic.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIII (6): 841-854</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:51 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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Proc Am Soc Clin Oncol 22:622S." ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001300000006/v1_201509151528/S0873215915303792/v1_201509151528/pt/main.assets" "Apartado" => array:4 [ "identificador" => "43356" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Artigos de revisão" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001300000006/v1_201509151528/S0873215915303792/v1_201509151528/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915303792?idApp=UINPBA00004E" ]
Article information
ISSN: 08732159Original language: Portuguese
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