Caso Clínico / Clinical Case
A tuberculose multirresistente e a rainha vermelha – A rapidez do diagnóstico é decisiva
Multi-drug resistant tuberculosis and the red queen – Diagnosis speed is crucial
Read
6083
Timeswas read the article
2122
Total PDF
3961
Total HTML
Share statistics
array:25 [ "pii" => "S0873215915303810" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30381-0" "estado" => "S350" "fechaPublicacion" => "2007-11-01" "aid" => "8" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "copyrightAnyo" => "2007" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2007;13:869-77" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2708 "formatos" => array:3 [ "EPUB" => 234 "HTML" => 1791 "PDF" => 683 ] ] "itemSiguiente" => array:19 [ "pii" => "S0873215915303779" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30377-9" "estado" => "S350" "fechaPublicacion" => "2007-11-01" "aid" => "4" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "Rev Port Pneumol. 2007;13:801-26" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2721 "formatos" => array:3 [ "EPUB" => 252 "HTML" => 1670 "PDF" => 799 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão / Revision Article</span>" "titulo" => "Fumador internado? – A intervenção apropriada" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "801" "paginaFinal" => "826" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "In-patient smoker? – Providing appropriate intervention" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Paula Pamplona" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Paula" "apellidos" => "Pamplona" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915303779?idApp=UINPBA00004E" "url" => "/08732159/0000001300000006/v1_201509151528/S0873215915303779/v1_201509151528/pt/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0873215915303767" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30376-7" "estado" => "S350" "fechaPublicacion" => "2007-11-01" "aid" => "3" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Rev Port Pneumol. 2007;13:789-99" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2688 "formatos" => array:3 [ "EPUB" => 210 "HTML" => 1844 "PDF" => 634 ] ] "pt" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original / Original Article</span>" "titulo" => "Tuberculose em profissionais de saúde de um serviço hospitalar" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "pt" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "789" "paginaFinal" => "799" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Tuberculosis in hospital department health care workers" ] ] "contieneResumen" => array:2 [ "pt" => true "en" => true ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sandra Saleiro, Ana Rosa Santos, Otília Vidal, Teresa Carvalho, José Torres Costa, José Agostinho Marques" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Sandra" "apellidos" => "Saleiro" ] 1 => array:2 [ "nombre" => "Ana Rosa" "apellidos" => "Santos" ] 2 => array:2 [ "nombre" => "Otília" "apellidos" => "Vidal" ] 3 => array:2 [ "nombre" => "Teresa" "apellidos" => "Carvalho" ] 4 => array:2 [ "nombre" => "José Torres" "apellidos" => "Costa" ] 5 => array:2 [ "nombre" => "José Agostinho" "apellidos" => "Marques" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915303767?idApp=UINPBA00004E" "url" => "/08732159/0000001300000006/v1_201509151528/S0873215915303767/v1_201509151528/pt/main.assets" ] "asociados" => array:1 [ 0 => array:19 [ "pii" => "S0873215915302269" "issn" => "08732159" "doi" => "10.1016/S0873-2159(15)30226-9" "estado" => "S350" "fechaPublicacion" => "2008-01-01" "aid" => "6" "copyright" => "Sociedade Portuguesa de Pneumologia/SPP" "documento" => "simple-article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "err" "cita" => "Rev Port Pneumol. 2008;14:165" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1955 "formatos" => array:3 [ "EPUB" => 199 "HTML" => 1105 "PDF" => 651 ] ] "pt" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Erratum</span>" "titulo" => "Erratum to "A tuberculose multirresistente e a rainha vermelha – A rapidez do diagnóstico é decisiva"" "tienePdf" => "pt" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "165" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Erratum to "Multi-drug resistant tuberculosis and the red queen – Diagnosis speed is crucial"" ] ] "contienePdf" => array:1 [ "pt" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "João Costeira, Jaime Pina" "autores" => array:2 [ 0 => array:2 [ "nombre" => "João" "apellidos" => "Costeira" ] 1 => array:2 [ "nombre" => "Jaime" "apellidos" => "Pina" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915302269?idApp=UINPBA00004E" "url" => "/08732159/0000001400000001/v1_201509151510/S0873215915302269/v1_201509151510/pt/main.assets" ] ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Caso Clínico / Clinical Case</span>" "titulo" => "A tuberculose multirresistente e a rainha vermelha – A rapidez do diagnóstico é decisiva" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "869" "paginaFinal" => "877" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "João Costeira, Jaime Pina" "autores" => array:2 [ 0 => array:4 [ "nombre" => "João" "apellidos" => "Costeira" "email" => array:1 [ 0 => "Joao.Costeira@hpv.min-saude.pt" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Jaime" "apellidos" => "Pina" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Assistente Hospitalar Graduado de Pneumologia, Hospital de Pulido Valente, EPE, Alameda das Linhas de Torres, 117 1769-001 Lisboa" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Chefe de Serviço Hospitalar de Pneumologia e Director do Serviço de Pneumologia 2 do Hospital de Pulido Valente, Lisboa" "etiqueta" => "2" "identificador" => "af0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Multi-drug resistant tuberculosis and the red queen – Diagnosis speed is crucial" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-07-02" "fechaAceptado" => "2007-09-12" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec570456" "palabras" => array:4 [ 0 => "Tuberculose multirresistente" 1 => "método genotípico" 2 => "sensibilidade" 3 => "especificidade" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec570455" "palabras" => array:4 [ 0 => "Multi-drug resistant tuberculosis" 1 => "genotypic method" 2 => "sensitivity" 3 => "specificity" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A tuberculose multirresistente é uma ameaça importante ao controlo da tuberculose.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Neste sentido, é fundamental o diagnóstico precoce da TBMR para adoptar as medidas mais adequadas. Os métodos de detecção da resistência aos antibacilares baseados na avaliação das determinantes genéticas (métodos genotípicos) têm a vantagem, em relação aos métodos clássicos (fenotípicos), de serem mais céleres, poderem ser aplicados directamente na amostra clínica e de identificarem simultaneamente o <span class="elsevierStyleItalic">Myco</span>-<span class="elsevierStyleItalic">bacterium tuberculosis complex</span>.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">A análise dos dados dos doentes internados no Serviço de Pneumologia 2 do Hospital de Pulido Valente mostrou uma significativa prevalência de TBMR (10,3%). Revelou, também, que em 34,1% dos doentes com TBMR a multirresistência não foi identificada, tendo sido a mortalidade nesses doentes de 31% <span class="elsevierStyleItalic">versus</span> 18,4% nos doentes com o perfil de resistências previamente conhecido. Estes valores são piores nos doentes com TBMR<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>SIDA, que têm uma mortalidade de 50% <span class="elsevierStyleItalic">versus</span> 15%, respectivamente.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Para uma rápida identificação das resistências nos doentes internados no Serviço de Pneumologia 2 do HPV, foi avaliado o teste INNO-LIPA Rif.TB para detecção da resistência à RMP como marcador de multirresistência. Os resultados do teste, efectuado em 113 amostras, mostraram elevadas taxas de sensibilidade (91,6%), especificidade (98%), valor preditivo positivo (84,6%) e valor preditivo negativo (99%).</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">A demora média para obter os resultados foi de 7,6 dias para o teste genotípico <span class="elsevierStyleItalic">versus</span> 23,4 dias para o teste fenotípico (BACTEC MGIT 960).</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Actualmente, o teste INNO-LIPA Rif. TB é aplicado em todos os doentes internados com tuberculose bacilífera sem perfil de resistências previamente conhecido, com bons resultados.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIII (6): 869-877</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">The multi-drug resistant Tuberculosis (MDRTB) is a huge menace to Tuberculosis control.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">The early detection of MDRTB is essential to best appropriate measures.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">The detection methods for drug resistance based in evaluation of the genetic determinants (genotypic methods), instead of phenotypic methods, allows for faster results, the possibility of direct application in clinical samples and simultaneous identification of <span class="elsevierStyleItalic">Mycobacterium tuberculosis complex</span>.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">The inpatients data analysis in the “Serviço de Pneumologia 2 do Hospital Pulido Valente”, showed a high prevalence of MDRTB (10.3%). In 34.1% of the MDRTB patients the multi-drug resistance was not been identified, with a mortality ratio in this cases of 31% versus 18.4% in the subset of patients with resistance previously identified. Moreover the mortality ratio was worst in MDRTB/AIDS patients with 50% versus 15%, respectively.</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall">Targeting for rapid drug resistance detection, in hospitalized patients at “Serviço de Pneumologia 2 do Hospital Pulido Valente”, the test INNO-LIPA Rif.TB, to identify the rifampicin resistance as a marker of multi-drug resistance, was evaluated.</p><p id="sp0065" class="elsevierStyleSimplePara elsevierViewall">The test was performed in 113 samples and had a high ratio of sensitivity (91.6%), specificity (98%), positive predictive value (84, 6%) and negative predictive value (99%).</p><p id="sp0070" class="elsevierStyleSimplePara elsevierViewall">Time to obtain the results was 7.6<span class="elsevierStyleHsp" style=""></span>days for the genotypic test versus 23.4<span class="elsevierStyleHsp" style=""></span>days to the phenotypic test (BACTEC MGIT 960).</p><p id="sp0075" class="elsevierStyleSimplePara elsevierViewall">The INNO-LIPA Rif.TB test is, now, performed in every patient with smear-positive Tuberculosis with no previous knows resistance profile, with good outcome.</p><p id="sp0080" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2007; XIII (6): 869-877</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increase in resistance of tubercle bacilli to streptomycin, preliminary report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.P. Youmans" 1 => "E.H. Williston" 2 => "W.H. Feldman" 3 => "H.C. Hinshaw" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Mayo Cli" "fecha" => "1946" "volumen" => "21" "paginaInicial" => "126" "paginaFinal" => "127" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of drug-resistant tuberculosis on the survival of HIV-infected patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Sungkanuparh" 1 => "B. Eampokalap" 2 => "S. Chottanapund" 3 => "S. Thongyen" 4 => "W. Manosuthi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Dis" "fecha" => "2007" "volumen" => "11" "numero" => "3" "paginaInicial" => "325" "paginaFinal" => "330" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.A. Mitchison" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc. Lung Dis" "fecha" => "1998" "volumen" => "2" "paginaInicial" => "10" "paginaFinal" => "15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9562106" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of initial drug resistance on the response to short-course chemotherapy of pulmonary tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.A. Mitchison" 1 => "A.J. Nunn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/arrd.1986.133.3.423" "Revista" => array:7 [ "tituloSerie" => "Am Rev Respir Dis" "fecha" => "1986" "volumen" => "133" "numero" => "3" "paginaInicial" => "423" "paginaFinal" => "430" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2420242" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "WHO" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:5 [ "edicion" => "3" "titulo" => "Treatment of Tuberculosis. Guidelines for national programmes" "fecha" => "2003" "editorial" => "World Health Organization" "editorialLocalizacion" => "Geneva" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The emergence of drug-resistant tuberculosis in New York City" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "T.R. Frieden" 1 => "T. Sterling" 2 => "A. Pablos-Mendez" 3 => "J.O. Kilburn" 4 => "G.M. Cauthen" 5 => "S.W. Dooley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199302253280801" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1993" "volumen" => "328" "paginaInicial" => "521" "paginaFinal" => "526" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8381207" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Nosocomial transmission of multi-drug resistant tuberculosis among HIV-infected persons – Florida and New York, 1988-1991" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "MMWRMorb Mortal Wkly Rep" "fecha" => "1991" "volumen" => "40" "paginaInicial" => "585" "paginaFinal" => "591" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment outcomes by drug resistance and HIV status among tuberculosis patients in Ho Chi Minh City, Vietnam" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.T. Quy" 1 => "F.G. Cobelens" 2 => "N.T. Lan" 3 => "T.N. Buu" 4 => "C.S. Lambregts" 5 => "M.W. Borgdorff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2006" "volumen" => "10" "numero" => "1" "paginaInicial" => "45" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16466036" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome of pulmonary multidrug-resistant tuberculosis: a 6<span class="elsevierStyleHsp" style=""></span>yr follow-up study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:8 [ 0 => "C.Y. Chiang" 1 => "D.A. Enarson" 2 => "M.C. Yu" 3 => "K.J. Bai" 4 => "R.M. Huang" 5 => "C.J. Hsu" 6 => "J. Suo" 7 => "T.P. Lin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.06.00125705" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2006" "volumen" => "28" "paginaInicial" => "980" "paginaFinal" => "985" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16837502" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of drug-resistant tuberculosis on the survival of HIV-infected patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Sungkanuparh" 1 => "B. Eampokalap" 2 => "S. Chottanapund" 3 => "S. Thongyen" 4 => "W. Manosuthi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Dis" "fecha" => "2007" "volumen" => "11" "numero" => "3" "paginaInicial" => "325" "paginaFinal" => "330" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extensively drug-resistant tuberculosis (XDR-TB): recommendations for prevention and control" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "World Health Organization" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Wkly Epidemiol Rec" "fecha" => "2006" "volumen" => "81" "paginaInicial" => "430" "paginaFinal" => "432" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17096498" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extensively Drug-resistant Tuberculosis, Italy and Germany" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:11 [ 0 => "G.B. Migliori" 1 => "J. Ortmann" 2 => "E. Girardi" 3 => "G. Besozzi" 4 => "C. Lange" 5 => "D.M. Cirillo" 6 => "M. Ferrarese" 7 => "G. Iaco" 8 => "A. Gori" 9 => "M.C. Raviglione" 10 => "SMIRA/TBNET Study Group" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "CDC Emerging Infectious Diseases" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "780" "paginaFinal" => "782" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Menace That Threatens To Destabilize Tuberculosis Control" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.K. Sharma" 1 => "A. Mohan" 2 => "A. Multidrug-Resistant Tuberculosis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.130.1.261" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2006" "volumen" => "130" "paginaInicial" => "261" "paginaFinal" => "272" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16840411" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "125 years after Robert Koch’s discovery of the tubercule bacillus: the new XDR-TB threat. Is “science” enough to tackle the epidemic?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.B. Migliori" 1 => "R. Loddenkemper" 2 => "F. Blasi" 3 => "M.C. Raviglione" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00001307" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2007" "volumen" => "29" "paginaInicial" => "423" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17329486" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "N.R. Gandhi" 1 => "A. Moll" 2 => "A.W. Sturn" 3 => "R. Pawinski" 4 => "T. Govender" 5 => "U. Lallo" 6 => "K. Zeller" 7 => "J. Andrews" 8 => "G. Friendland" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(06)69573-1" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2006" "volumen" => "368" "paginaInicial" => "1575" "paginaFinal" => "1580" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17084757" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advances in the Diagnosis and Treatment of Tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Nahid" 1 => "M. Pai" 2 => "P. Hopewell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Proc Am Thorax Soc" "fecha" => "2006" "volumen" => "3" "paginaInicial" => "103" "paginaFinal" => "110" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Tortoli" 1 => "J.C. Palomino" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Chapter 14 New Diagnostic Methods" "paginaInicial" => "441" "paginaFinal" => "486" "serieFecha" => "2007" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Anandi Martin" 1 => "Françoise Portaels" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Chapter 19: Drug Resistance and Drug Resistance Detection, Tuberculosis" "paginaInicial" => "635" "paginaFinal" => "660" "serieFecha" => "2007" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Direct Detection of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> Complex DNA and Rifampin Resistance in Clinical Specimens from Tuberculosis Patients by Line Probe Assay" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Traore" 1 => "A. Deun" 2 => "I.C. Shamputa" 3 => "L. Rigouts" 4 => "F. Portaels" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/JCM.01332-06" "Revista" => array:6 [ "tituloSerie" => "Journal of Clinical Microbiology" "fecha" => "2006" "volumen" => "44" "paginaInicial" => "4384" "paginaFinal" => "4388" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17035487" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Direct Application of the INNO-LIPA Rif.TB Line-Probe Assay for Rapid Identification of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> Complex Strains and Detection Resistance in 360 Smear-Positive Respiratory Specimens from an Area of High Incidence of Multidrug-Resistant Tuberculosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Viveiros" 1 => "C. Leandro" 2 => "L. Rodrigues" 3 => "J. Almeida" 4 => "R. Bettencourt" 5 => "I. Couto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/JCM.43.9.4880-4884.2005" "Revista" => array:6 [ "tituloSerie" => "Journal of Clinical Microbiology" "fecha" => "2005" "volumen" => "43" "paginaInicial" => "4880" "paginaFinal" => "4884" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16145166" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bb0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A commercial line probe assay for the rapid detection of rifampicin resistance in <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Morgan" 1 => "S. Kalantri" 2 => "L. Flores" 3 => "M. Pai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2334-5-62" "Revista" => array:5 [ "tituloSerie" => "BMC infectious Diseases" "fecha" => "2005" "volumen" => "5" "paginaInicial" => "62" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16050959" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bb0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Viveiros" 1 => "C. Leandro" 2 => "L. Rodrigues" 3 => "J. Almeida" 4 => "R. Bettencourt" 5 => "I. Couto" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:5 [ "titulo" => "Diagnóstico da Tuberculose O Programa “Faster-Track” de Combate à Tuberculose Multirresistente na Grande Lisboa" "paginaInicial" => "83" "paginaFinal" => "99" "conferencia" => "Tuberculose-Impacto da Infecção pelo VIH 12.ª Reunião de Pneumologistas do Hospital Pulido Valente" "serieFecha" => "2005" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bb0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> and the host response" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.H.E. Kaufmann" 1 => "S.T. Cole" 2 => "V. Mizrahi" 3 => "E. Rubin" 4 => "C. Nathan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Exp Med" "fecha" => "2005" "volumen" => "6" "paginaInicial" => "1963" "paginaFinal" => "1967" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bb0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Pathogenesis of Tuberculosis, The First One Hundred (and Twenty-Three) Years" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N.W. Schluger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1165/rcmb.F293" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Cell Mol Biol" "fecha" => "2005" "volumen" => "32" "paginaInicial" => "251" "paginaFinal" => "256" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15778414" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bb0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A new evolutionary law" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Van Valen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Evolutionary Theory" "fecha" => "1973" "volumen" => "1" "paginaInicial" => "1" "paginaFinal" => "30" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bb0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Carrol" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "titulo" => "Through the looking glass and what Alice found there" "fecha" => "1872" "editorial" => "MacMillan" "editorialLocalizacion" => "London" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001300000006/v1_201509151528/S0873215915303810/v1_201509151528/pt/main.assets" "Apartado" => array:4 [ "identificador" => "9575" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Artigos originais" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001300000006/v1_201509151528/S0873215915303810/v1_201509151528/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915303810?idApp=UINPBA00004E" ]
Article information
ISSN: 08732159Original language: Portuguese
The statistics are updated each day
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 6 | 10 |
| 2024 October | 35 | 38 | 73 |
| 2024 September | 30 | 26 | 56 |
| 2024 August | 39 | 34 | 73 |
| 2024 July | 32 | 32 | 64 |
| 2024 June | 22 | 22 | 44 |
| 2024 May | 23 | 29 | 52 |
| 2024 April | 28 | 31 | 59 |
| 2024 March | 32 | 23 | 55 |
| 2024 February | 27 | 24 | 51 |
| 2024 January | 15 | 20 | 35 |
| 2023 December | 27 | 26 | 53 |
| 2023 November | 17 | 27 | 44 |
| 2023 October | 23 | 28 | 51 |
| 2023 September | 22 | 29 | 51 |
| 2023 August | 12 | 18 | 30 |
| 2023 July | 24 | 31 | 55 |
| 2023 June | 13 | 14 | 27 |
| 2023 May | 35 | 27 | 62 |
| 2023 April | 23 | 17 | 40 |
| 2023 March | 21 | 27 | 48 |
| 2023 February | 26 | 24 | 50 |
| 2023 January | 16 | 15 | 31 |
| 2022 December | 27 | 24 | 51 |
| 2022 November | 51 | 42 | 93 |
| 2022 October | 30 | 19 | 49 |
| 2022 September | 51 | 44 | 95 |
| 2022 August | 55 | 31 | 86 |
| 2022 July | 55 | 30 | 85 |
| 2022 June | 73 | 29 | 102 |
| 2022 May | 44 | 36 | 80 |
| 2022 April | 24 | 30 | 54 |
| 2022 March | 36 | 31 | 67 |
| 2022 February | 23 | 23 | 46 |
| 2022 January | 37 | 37 | 74 |
| 2021 December | 18 | 25 | 43 |
| 2021 November | 35 | 25 | 60 |
| 2021 October | 33 | 33 | 66 |
| 2021 September | 16 | 22 | 38 |
| 2021 August | 32 | 22 | 54 |
| 2021 July | 25 | 23 | 48 |
| 2021 June | 28 | 23 | 51 |
| 2021 May | 41 | 33 | 74 |
| 2021 April | 86 | 57 | 143 |
| 2021 March | 31 | 24 | 55 |
| 2021 February | 59 | 14 | 73 |
| 2021 January | 38 | 13 | 51 |
| 2020 December | 20 | 11 | 31 |
| 2020 November | 59 | 14 | 73 |
| 2020 October | 26 | 10 | 36 |
| 2020 September | 65 | 27 | 92 |
| 2020 August | 79 | 18 | 97 |
| 2020 July | 97 | 13 | 110 |
| 2020 June | 96 | 33 | 129 |
| 2020 May | 91 | 25 | 116 |
| 2020 April | 60 | 7 | 67 |
| 2020 March | 61 | 19 | 80 |
| 2020 February | 60 | 17 | 77 |
| 2020 January | 57 | 16 | 73 |
| 2019 December | 65 | 18 | 83 |
| 2019 November | 67 | 10 | 77 |
| 2019 October | 86 | 19 | 105 |
| 2019 September | 63 | 20 | 83 |
| 2019 August | 87 | 17 | 104 |
| 2019 July | 68 | 14 | 82 |
| 2019 June | 69 | 22 | 91 |
| 2019 May | 72 | 27 | 99 |
| 2019 April | 64 | 21 | 85 |
| 2019 March | 71 | 17 | 88 |
| 2019 February | 63 | 21 | 84 |
| 2019 January | 77 | 23 | 100 |
| 2018 December | 29 | 11 | 40 |
| 2018 November | 17 | 7 | 24 |
| 2018 October | 18 | 0 | 18 |
| 2018 September | 14 | 7 | 21 |
| 2018 August | 41 | 18 | 59 |
| 2018 July | 36 | 26 | 62 |
| 2018 June | 42 | 12 | 54 |
| 2018 May | 73 | 24 | 97 |
| 2018 April | 46 | 26 | 72 |
| 2018 March | 50 | 26 | 76 |
| 2018 February | 33 | 13 | 46 |
| 2018 January | 35 | 11 | 46 |
| 2017 December | 43 | 28 | 71 |
| 2017 November | 25 | 14 | 39 |
| 2017 October | 33 | 6 | 39 |
| 2017 September | 32 | 11 | 43 |
| 2017 August | 32 | 24 | 56 |
| 2017 July | 31 | 17 | 48 |
| 2017 June | 26 | 28 | 54 |
| 2017 May | 47 | 14 | 61 |
| 2017 April | 13 | 5 | 18 |
| 2017 March | 19 | 31 | 50 |
| 2017 February | 17 | 3 | 20 |
| 2017 January | 10 | 2 | 12 |
| 2016 December | 15 | 6 | 21 |
| 2016 November | 11 | 5 | 16 |
| 2016 October | 16 | 9 | 25 |
| 2016 September | 3 | 1 | 4 |
| 2016 August | 6 | 2 | 8 |
| 2016 July | 5 | 6 | 11 |
| 2016 June | 1 | 4 | 5 |
| 2016 May | 0 | 5 | 5 |
| 2016 April | 2 | 2 | 4 |
| 2016 March | 2 | 5 | 7 |
| 2016 February | 4 | 8 | 12 |
| 2016 January | 6 | 3 | 9 |
| 2015 December | 6 | 3 | 9 |
| 2015 November | 1 | 1 | 2 |
| 2015 October | 4 | 1 | 5 |
Show all
