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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">O estadiamento do cancro do pulm&#227;o &#40;CP&#41; permanece um desafio cl&#237;nico&#44; sendo fundamental para estabelecer o progn&#243;stico e a terap&#234;utica da doen&#231;a&#46; &#201; reconhecido que o tratamento cir&#250;rgico do cancro de pulm&#227;o de n&#227;o pequenas c&#233;lulas &#40;CPNPC&#41; constitui a &#250;nica estrat&#233;gia com potencial curativo&#46; Neste &#226;mbito&#44; pretende-se&#44; com o estadiamento&#44; seleccionar correctamente os doentes que beneficiar&#227;o de cirurgia&#44; evitando submeter doentes inoper&#225;veis a cirurgias desnecess&#225;rias e&#44; simultaneamente&#44; n&#227;o excluindo doentes com les&#245;es potencialmente ressec&#225;veis&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">O objectivo principal deste estudo foi comparar o estadiamento TNM cl&#237;nico &#40;TNMc&#41; com o estadiamento TNM anatomopatol&#243;gico &#40;TNMp&#41; e avaliar aspectos do diagn&#243;stico&#44; tratamento e sobrevida dos doentes&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Consistiu num estudo retrospectivo de doentes com CPNPC ou com les&#245;es altamente suspeitas&#44; submetidos a cirurgia&#44; seguidos na Consulta de Pneumologia Oncol&#243;gica do Hospital de S&#227;o Jo&#227;o&#44; de Janeiro de 1999 a Dezembro de 2003&#59; baseou-se na revis&#227;o de processos cl&#237;nicos e de relat&#243;rios anatomopatol&#243;gicos&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Foram inclu&#237;dos 60 doentes&#44; 73&#44;3&#37; do sexo masculino&#44; com mediana de idades de 59&#44;5 anos&#46; Os TNMc mais frequentes foram&#58; T1N0M0 em 41&#44;7&#37; e T2N0M0 em 36&#44;7&#37;&#46; Foi efectuada toracotomia com objectivo terap&#234;utico em 80&#37; dos doentes&#59; nos restantes 20&#37; esta foi tamb&#233;m diagn&#243;stica&#46; Em 6&#44;7&#37; dos casos&#44; a ressec&#231;&#227;o foi incompleta&#46; Quanto ao TNMp&#44; os mais frequentes foram&#58; T2N0p em 33&#44;3&#37;&#44; T2N1p em 15&#44;0&#37; e T2N2p em 13&#44;3&#37;&#46; Quando comparados&#44; verificou-se que a diferen&#231;a entre os estadiamentos foi significativa&#44; tendo ocorrido subida de est&#225;dio em 65&#44;0&#37; e descida em 6&#44;7&#37;&#59; apenas 28&#44;3&#37; mantiveram o mesmo est&#225;dio&#46; As principais altera&#231;&#245;es foram de T1N0c para T2N0p e de T2N0c para T2N1p&#46; A concord&#226;ncia global entre os dois m&#233;todos de estadiamento foi de 21&#44;7&#37;&#46; A sobrevida mediana global foi de 43 meses&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Em conclus&#227;o&#44; o estadiamento cl&#237;nico revelou-se menos rigoroso&#44; apesar de n&#227;o ter condicionado importante altera&#231;&#227;o na estrat&#233;gia terap&#234;utica nem na sobrevida&#46; No futuro&#44; ser&#225; necess&#225;rio considerar outros meios de estadiamento&#44; bem como factores biol&#243;gicos&#44; para al&#233;m dos anat&#243;micos actualmente usados&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 337-357</span></p></span>"
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        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Lung cancer &#40;LC&#41; staging remains a clinical challenge as it determines the disease&#8217;s prognosis and treatment&#46; Surgery is the best option for controlling non-small cell lung cancer &#40;NSCLC&#41; and the only potential cure&#46; In this setting&#44; lung cancer staging helps select patients who will benefit from surgery&#44; excluding inoperable patients and including patients with resectable lesions&#46; The aim of this study is to compare clinical staging &#40;TNMc&#41; with pathological staging &#40;TNMp&#41; and to evaluate diagnosis&#44; complementary treatment and survival of these patients&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">This is a retrospective study that included patients with non-small cell lung cancer or with highly suspicious lesions who had undergone surgery and were followed up in the Hospital de S&#227;o Jo&#227;o lung cancer unit between January 1999 and December 2003&#46; It is based on clinical files and pathology reports&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">73&#46;3&#37; of this group of 60 patients were male&#44; with median age 59&#46;2<span class="elsevierStyleHsp" style=""></span>years&#46; The most frequent TNMc stages were 41&#46;7&#37; T1N0M0 and 36&#46;7&#37; T2N0M0&#46; Thoracotomy for therapeutic purpose was performed in 80&#37; and thoracotomy for diagnostic purpose also in the remaining 20&#37;&#46; In 6&#46;7&#37; the resection was incomplete&#46; The most frequent TNMp stages were T2N0p in 33&#46;3&#37;&#44; T2N1p in 15&#46;0&#37; and T2N2p in 13&#46;3&#37;&#46; There was a significant difference between the two staging types&#44; with upstaging in 65&#46;0&#37;&#44; down staging in 67&#37; and only 28&#46;3&#37; keeping the same stage&#46; The most frequent differences were from T1N0c to T2N0p and from T2N0c to T2N1p&#46; The global agreement between both staging methods was 21&#46;7&#37;&#46; Median global survival was 43 months&#46;</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">In conclusion&#44; while clinical staging was less accurate&#44; it did not determine important changes in therapeutic strategy and survival&#46; For the future&#44; we should consider using other diagnostic tools and other biological factors to complement the anatomical information that we currently use&#46;</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 337-357</span></p></span>"
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Artigo Original\Original Article
Cancro do pulmão de não pequenas células – Comparação entre o estadiamento clínico e o patológico
Non small cell lung cancer – Comparison between clinical and pathological staging
G. Fernandes1,
Corresponding author
gabrielafer@netcabo.pt

Correspondência/Correspondence to: Gabriela Fernandes, Serviço de Pneumologia do Hospital de São João Alameda Professor Hernâni Monteiro 4202-451 Porto. Telefone: 225512214
, M. Sucena2, E. Lombardia2, A. Machado2, V. Hespanhol3,4, H. Queiroga3,5
1 Interna Complementar de Pneumologia / Complementary Pulmonology Intern, Serviço de Pneumologia do Hospital de São João. Faculdade de Medicina da Universidade do Porto
2 Assistente Hospitalar de Pneumologia / Hospital Assistant, Pulmonology Graduate, Serviço de Pneumologia do Hospital de São João. Faculdade de Medicina da Universidade do Porto
3 Assistente Hospitalar Graduado de Pneumologia / Hospital Assistant, Pulmonology Graduate, Serviço de Pneumologia do Hospital de São João. Faculdade de Medicina da Universidade do Porto
4 Professor Auxiliar de Medicina da Faculdade de Medicina / Assistant Professor of Medicine, Medical School, Serviço de Pneumologia do Hospital de São João. Faculdade de Medicina da Universidade do Porto
5 Professor Associado de Medicina da Faculdade de Medicina / Associate Professor of Medicine, Medical School, Serviço de Pneumologia do Hospital de São João. Faculdade de Medicina da Universidade do Porto
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        "titulo" => "Resumo"
        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">O estadiamento do cancro do pulm&#227;o &#40;CP&#41; permanece um desafio cl&#237;nico&#44; sendo fundamental para estabelecer o progn&#243;stico e a terap&#234;utica da doen&#231;a&#46; &#201; reconhecido que o tratamento cir&#250;rgico do cancro de pulm&#227;o de n&#227;o pequenas c&#233;lulas &#40;CPNPC&#41; constitui a &#250;nica estrat&#233;gia com potencial curativo&#46; Neste &#226;mbito&#44; pretende-se&#44; com o estadiamento&#44; seleccionar correctamente os doentes que beneficiar&#227;o de cirurgia&#44; evitando submeter doentes inoper&#225;veis a cirurgias desnecess&#225;rias e&#44; simultaneamente&#44; n&#227;o excluindo doentes com les&#245;es potencialmente ressec&#225;veis&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">O objectivo principal deste estudo foi comparar o estadiamento TNM cl&#237;nico &#40;TNMc&#41; com o estadiamento TNM anatomopatol&#243;gico &#40;TNMp&#41; e avaliar aspectos do diagn&#243;stico&#44; tratamento e sobrevida dos doentes&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Consistiu num estudo retrospectivo de doentes com CPNPC ou com les&#245;es altamente suspeitas&#44; submetidos a cirurgia&#44; seguidos na Consulta de Pneumologia Oncol&#243;gica do Hospital de S&#227;o Jo&#227;o&#44; de Janeiro de 1999 a Dezembro de 2003&#59; baseou-se na revis&#227;o de processos cl&#237;nicos e de relat&#243;rios anatomopatol&#243;gicos&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Foram inclu&#237;dos 60 doentes&#44; 73&#44;3&#37; do sexo masculino&#44; com mediana de idades de 59&#44;5 anos&#46; Os TNMc mais frequentes foram&#58; T1N0M0 em 41&#44;7&#37; e T2N0M0 em 36&#44;7&#37;&#46; Foi efectuada toracotomia com objectivo terap&#234;utico em 80&#37; dos doentes&#59; nos restantes 20&#37; esta foi tamb&#233;m diagn&#243;stica&#46; Em 6&#44;7&#37; dos casos&#44; a ressec&#231;&#227;o foi incompleta&#46; Quanto ao TNMp&#44; os mais frequentes foram&#58; T2N0p em 33&#44;3&#37;&#44; T2N1p em 15&#44;0&#37; e T2N2p em 13&#44;3&#37;&#46; Quando comparados&#44; verificou-se que a diferen&#231;a entre os estadiamentos foi significativa&#44; tendo ocorrido subida de est&#225;dio em 65&#44;0&#37; e descida em 6&#44;7&#37;&#59; apenas 28&#44;3&#37; mantiveram o mesmo est&#225;dio&#46; As principais altera&#231;&#245;es foram de T1N0c para T2N0p e de T2N0c para T2N1p&#46; A concord&#226;ncia global entre os dois m&#233;todos de estadiamento foi de 21&#44;7&#37;&#46; A sobrevida mediana global foi de 43 meses&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Em conclus&#227;o&#44; o estadiamento cl&#237;nico revelou-se menos rigoroso&#44; apesar de n&#227;o ter condicionado importante altera&#231;&#227;o na estrat&#233;gia terap&#234;utica nem na sobrevida&#46; No futuro&#44; ser&#225; necess&#225;rio considerar outros meios de estadiamento&#44; bem como factores biol&#243;gicos&#44; para al&#233;m dos anat&#243;micos actualmente usados&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 337-357</span></p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Lung cancer &#40;LC&#41; staging remains a clinical challenge as it determines the disease&#8217;s prognosis and treatment&#46; Surgery is the best option for controlling non-small cell lung cancer &#40;NSCLC&#41; and the only potential cure&#46; In this setting&#44; lung cancer staging helps select patients who will benefit from surgery&#44; excluding inoperable patients and including patients with resectable lesions&#46; The aim of this study is to compare clinical staging &#40;TNMc&#41; with pathological staging &#40;TNMp&#41; and to evaluate diagnosis&#44; complementary treatment and survival of these patients&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">This is a retrospective study that included patients with non-small cell lung cancer or with highly suspicious lesions who had undergone surgery and were followed up in the Hospital de S&#227;o Jo&#227;o lung cancer unit between January 1999 and December 2003&#46; It is based on clinical files and pathology reports&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">73&#46;3&#37; of this group of 60 patients were male&#44; with median age 59&#46;2<span class="elsevierStyleHsp" style=""></span>years&#46; The most frequent TNMc stages were 41&#46;7&#37; T1N0M0 and 36&#46;7&#37; T2N0M0&#46; Thoracotomy for therapeutic purpose was performed in 80&#37; and thoracotomy for diagnostic purpose also in the remaining 20&#37;&#46; In 6&#46;7&#37; the resection was incomplete&#46; The most frequent TNMp stages were T2N0p in 33&#46;3&#37;&#44; T2N1p in 15&#46;0&#37; and T2N2p in 13&#46;3&#37;&#46; There was a significant difference between the two staging types&#44; with upstaging in 65&#46;0&#37;&#44; down staging in 67&#37; and only 28&#46;3&#37; keeping the same stage&#46; The most frequent differences were from T1N0c to T2N0p and from T2N0c to T2N1p&#46; The global agreement between both staging methods was 21&#46;7&#37;&#46; Median global survival was 43 months&#46;</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">In conclusion&#44; while clinical staging was less accurate&#44; it did not determine important changes in therapeutic strategy and survival&#46; For the future&#44; we should consider using other diagnostic tools and other biological factors to complement the anatomical information that we currently use&#46;</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 337-357</span></p></span>"
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Article information
ISSN: 08732159
Original language: Portuguese
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