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Artigo de Revisão\Revision Article
Malformações arteriovenosas pulmonares – Associação a telangiectasia hemorrágica hereditária. Casos clínicos e rastreio familiar
Pulmonary arteriovenous malformations – Association with hereditary hemorrhagic telangiectasia. Clinical cases and family screening
Diva Ferreira1,
Corresponding author
divafferreira@sapo.pt

Correspondência: Diva de Fátima Gonçalves Ferreira, Rua Conceição Fernandes 4434-502 Vila Nova de Gaia.
, Joana Amado2, Raquel Duarte2, José Almeida2, Paulo Morgado3, Teresa Shiang4
1 Interna complementar de Pneumologia, Centro Hospitalar de Vila Nova de Gaia
2 Assistente Hospitalar de Pneumologia, Centro Hospitalar de Vila Nova de Gaia
3 Assistente Hospitalar de Radiologia, Centro Hospitalar de Vila Nova de Gaia
4 Assistente Graduada de Pneumologia, Centro Hospitalar de Vila Nova de Gaia
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      "en" => array:1 [
        "titulo" => "Pulmonary arteriovenous malformations &#8211; Association with hereditary hemorrhagic telangiectasia&#46; Clinical cases and family screening"
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            0 => "Malforma&#231;&#245;es arteriovenosas pulmonares"
            1 => "telangiectasia hemorr&#225;gica heredit&#225;ria"
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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">As malforma&#231;&#245;es arteriovenosas pulmonares s&#227;o raras e mais de metade dos casos surgem em associa&#231;&#227;o a telangiectasia hemorr&#225;gica heredit&#225;ria&#46;</p><p id="sp0110" class="elsevierStyleSimplePara elsevierViewall">Faz-se uma revis&#227;o te&#243;rica sobre a apresenta&#231;&#227;o cl&#237;nica&#44; abordagem diagn&#243;stica&#44; terap&#234;utica e progn&#243;stico destas malforma&#231;&#245;es vasculares&#46; Est&#227;o associadas a morbilidade e mortalidade consider&#225;veis&#44; pelo que se preconiza o seu tratamento&#44; assim como o rastreio dos familiares directos quando se identificam malforma&#231;&#245;es arteriovenosas pulmonares num doente com telangiectasia hemorr&#225;gica heredit&#225;ria&#46; Ainda n&#227;o existem estudos prospectivos que estabele&#231;am o melhor plano de estudo do doente e seus familiares&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Descrevem-se dois casos cl&#237;nicos de malforma&#231;&#245;es arteriovenosas pulmonares no contexto familiar de telangiectasia hemorr&#225;gica heredit&#225;ria&#46; A identifica&#231;&#227;o das doentes implicou o rastreio familiar que permitiu detectar malforma&#231;&#245;es arteriovenosas pulmonares em dois familiares e excluir o envolvimento pulmonar em quatro familiares com a doen&#231;a&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 383-399</span></p></span>"
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        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Pulmonary arteriovenous malformations are a rare disorder associated to hereditary hemorrhagic telangiectasia in over<span class="elsevierStyleHsp" style=""></span>50 &#37; of the cases&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Clinical presentation&#44; diagnostic work-up&#44; therapeutic options and prognosis are reviewed by the authors&#46; Pulmonary arteriovenous malformations are known to have considerable morbidity and mortality&#44; their treatment being advisable as well as their screening among family members&#44; especially if the index case is diagnosed with both pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia&#46; To this moment prospective studies establishing the best diagnostic work-up for the patients and their families are lacking&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">The authors report two pulmonary arteriovenous malformations cases in a family with hereditary hemorrhagic telangiectasia&#46; Patient&#8217;s diagnosis led to family screening which resulted in the identification of pulmonary arteriovenous malformations in two family members and pulmonary disease exclusion in four patients previously known to have hereditary hemorrhagic telangiectasia&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 383-399</span></p></span>"
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Article information
ISSN: 08732159
Original language: Portuguese
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