Correspondência/Correspondence to: António M S Chibante, Centro de Investigações Pneumológicas RJ, Rua Sorocaba, 477 sala 601 Rio de Janeiro, Brasil, Cep: 22.271-110 E
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Fernandes, M. Sucena, E. Lombardia, A. Machado, V. Hespanhol, H. Queiroga" "autores" => array:6 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Fernandes" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Sucena" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Lombardia" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Machado" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Hespanhol" ] 5 => array:2 [ "nombre" => "H." "apellidos" => "Queiroga" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915304384?idApp=UINPBA00004E" "url" => "/08732159/0000001200000004/v1_201509071300/S0873215915304384/v1_201509071300/pt/main.assets" ] "pt" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original\Original Article</span>" "titulo" => "Papel das citocinas proliferativas TGF-β e VEGF no derrame pleural pós-revascularização do miocárdio" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "359" "paginaFinal" => "367" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "António M.S. Chibante, Marcelo Alexandre C. Vaz, Francisco Vargas Suso" "autores" => array:3 [ 0 => array:4 [ "nombre" => "António M.S." "apellidos" => "Chibante" "email" => array:1 [ 0 => "chibante@domain.com.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "af0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cr0005" ] ] ] 1 => array:3 [ "nombre" => "Marcelo Alexandre C." "apellidos" => "Vaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] 2 => array:3 [ "nombre" => "Francisco Vargas" "apellidos" => "Suso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Serviço de Cardiopneumologia, Hospital Gaffrée-Guinle. Univesidade do Rio de Janeiro/Cardiopulmonology Unit, Hospital Gaffrée-Guinle. Universidade do Rio de Janeiro" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Serviço de Pneumologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo/Pulmonolgy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo" "etiqueta" => "2" "identificador" => "af0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "*" "correspondencia" => "<span class="elsevierStyleBold">Correspondência/Correspondence to:</span> António M S Chibante, Centro de Investigações Pneumológicas RJ, Rua Sorocaba, 477 sala 601 Rio de Janeiro, Brasil, Cep: 22.271-110 E" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "The proliferative cytokines TGF-β and VEGF in pleural effusions post-coronary artery bypass graft" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-11-11" "fechaAceptado" => "2006-04-26" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec567761" "palabras" => array:4 [ 0 => "Inflamação" 1 => "citocinas" 2 => "derrame pleural" 3 => "revascularização do miocárdio" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec567760" "palabras" => array:4 [ 0 => "Inflammation" 1 => "cytokines" 2 => "pleural effusions" 3 => "coronary artery bypass grafting" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A cirurgia de revascularização do miocárdio envolve o acometimento, tanto do pericárdio como da pleura, conduzindo ao favorecimento de processos inflamatórios responsáveis pelo desenvolvimento de derrames nestes compartimentos.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivo:</span> Estudar o comportamento das citocinas proliferativas TGF-β (factor beta de transformação do crescimento) e VEGF (factor de crescimento do endotélio vascular) nos líquidos de 16 transudatos e de 43 derrames pleurais de doentes submetidos a cirurgias de revascularização do miocárdio provenientes do Instituto de Coração e do Serviço de Pneumologia da Universidade do São Paulo nos intervalos de 2, 24 e 48 horas de pós-operatório.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados:</span> O derrame pleural pós-revascularização do miocárdio é um exsudato mobilizador de TGF-β e VEGF no pós-operatório imediato. Os níveis de TGF-β apresentam-se elevados nas primeiras 2 horas para caírem progressivamente até se aproximarem dos valores dos transudatos ao fim de 48 horas, enquanto o VEGF se inicia com níveis elevados já nas primeiras 2 horas com tendência a aumento pelo menos até 48 horas de pós-operatório.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusões:</span> O TGF-β parece comportar-se como elemento gatilho sobre a célula mesotelial pleural para a liberação de VEGF no desenvolvimento de derrame pleural nas cirurgias de revascularização do miocárdio.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006; XII (4): 359-367</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Coronary artery bypass graft (CABG) surgeries can impact on the pericardium and pleural space, leading to inflammation which can cause effusion.</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aim:</span> To study the role of the proliferative cytokines TGF-β and VEGF in the fluids of 16 transudates and 43 pleural effusions of patients who underwent CABG at the Heart Unit and Pulmonology Unit of the University Hospital of São Paulo. Levels of cytokines were assessed 2, 24 and 48 hours post-surgery.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results:</span> The pleural effusion after CABG is an exsudative mobilizer of TGF-β and VEGF cytokines immediately after surgery. The TGF-β concentrations were elevated 2 hours after surgery but started to fall soon after, reaching transudate levels after 48 hours. VEGF levels were high in the first 2 hours post surgery and tended to maintain the same concentrations for at least 48 hours after surgery.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusions:</span> Based on the results obtained, TGF-β is a cytokine that seems to work as a trigger, leading the pleural mesothelial cell to express VEGF a cause of pleural effusion in CABG surgeries.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006; XII (4): 359-367</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia/Bibliography</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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Original language: Portuguese
Year/Month | Html | Total | |
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2024 November | 8 | 5 | 13 |
2024 October | 56 | 29 | 85 |
2024 September | 53 | 28 | 81 |
2024 August | 58 | 27 | 85 |
2024 July | 50 | 28 | 78 |
2024 June | 27 | 22 | 49 |
2024 May | 31 | 33 | 64 |
2024 April | 41 | 20 | 61 |
2024 March | 29 | 21 | 50 |
2024 February | 33 | 21 | 54 |
2024 January | 26 | 26 | 52 |
2023 December | 30 | 21 | 51 |
2023 November | 38 | 18 | 56 |
2023 October | 21 | 30 | 51 |
2023 September | 40 | 32 | 72 |
2023 August | 28 | 16 | 44 |
2023 July | 22 | 24 | 46 |
2023 June | 24 | 9 | 33 |
2023 May | 42 | 23 | 65 |
2023 April | 31 | 12 | 43 |
2023 March | 28 | 19 | 47 |
2023 February | 21 | 17 | 38 |
2023 January | 28 | 13 | 41 |
2022 December | 29 | 13 | 42 |
2022 November | 31 | 23 | 54 |
2022 October | 35 | 17 | 52 |
2022 September | 25 | 13 | 38 |
2022 August | 24 | 42 | 66 |
2022 July | 28 | 31 | 59 |
2022 June | 18 | 28 | 46 |
2022 May | 30 | 27 | 57 |
2022 April | 27 | 26 | 53 |
2022 March | 16 | 28 | 44 |
2022 February | 21 | 20 | 41 |
2022 January | 22 | 31 | 53 |
2021 December | 13 | 26 | 39 |
2021 November | 26 | 18 | 44 |
2021 October | 16 | 28 | 44 |
2021 September | 25 | 26 | 51 |
2021 August | 17 | 17 | 34 |
2021 July | 20 | 27 | 47 |
2021 June | 22 | 28 | 50 |
2021 May | 16 | 28 | 44 |
2021 April | 51 | 43 | 94 |
2021 March | 28 | 12 | 40 |
2021 February | 34 | 17 | 51 |
2021 January | 22 | 13 | 35 |
2020 December | 19 | 5 | 24 |
2020 November | 33 | 25 | 58 |
2020 October | 34 | 16 | 50 |
2020 September | 36 | 22 | 58 |
2020 August | 35 | 18 | 53 |
2020 July | 37 | 14 | 51 |
2020 June | 24 | 26 | 50 |
2020 May | 29 | 14 | 43 |
2020 April | 34 | 15 | 49 |
2020 March | 19 | 16 | 35 |
2020 February | 30 | 11 | 41 |
2020 January | 26 | 17 | 43 |
2019 December | 26 | 17 | 43 |
2019 November | 40 | 12 | 52 |
2019 October | 30 | 16 | 46 |
2019 September | 41 | 13 | 54 |
2019 August | 38 | 19 | 57 |
2019 July | 26 | 11 | 37 |
2019 June | 22 | 18 | 40 |
2019 May | 23 | 17 | 40 |
2019 April | 23 | 30 | 53 |
2019 March | 36 | 19 | 55 |
2019 February | 35 | 15 | 50 |
2019 January | 41 | 18 | 59 |
2018 December | 17 | 18 | 35 |
2018 November | 1 | 0 | 1 |
2018 October | 1 | 0 | 1 |
2018 September | 10 | 5 | 15 |
2018 August | 37 | 17 | 54 |
2018 July | 30 | 22 | 52 |
2018 June | 41 | 17 | 58 |
2018 May | 35 | 16 | 51 |
2018 April | 44 | 26 | 70 |
2018 March | 32 | 26 | 58 |
2018 February | 22 | 12 | 34 |
2018 January | 25 | 17 | 42 |
2017 December | 28 | 16 | 44 |
2017 November | 48 | 10 | 58 |
2017 October | 30 | 21 | 51 |
2017 September | 36 | 19 | 55 |
2017 August | 21 | 16 | 37 |
2017 July | 22 | 11 | 33 |
2017 June | 33 | 9 | 42 |
2017 May | 34 | 11 | 45 |
2017 April | 13 | 28 | 41 |
2017 March | 18 | 8 | 26 |
2017 February | 10 | 5 | 15 |
2017 January | 9 | 4 | 13 |
2016 December | 15 | 6 | 21 |
2016 November | 9 | 12 | 21 |
2016 October | 10 | 14 | 24 |
2016 September | 3 | 3 | 6 |
2016 August | 3 | 1 | 4 |
2016 July | 3 | 4 | 7 |
2016 June | 0 | 5 | 5 |
2016 April | 3 | 14 | 17 |
2016 March | 2 | 8 | 10 |
2016 February | 7 | 10 | 17 |
2016 January | 6 | 6 | 12 |
2015 December | 6 | 1 | 7 |
2015 November | 1 | 2 | 3 |
2015 October | 4 | 2 | 6 |