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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A cirurgia de revasculariza&#231;&#227;o do mioc&#225;rdio envolve o acometimento&#44; tanto do peric&#225;rdio como da pleura&#44; conduzindo ao favorecimento de processos inflamat&#243;rios respons&#225;veis pelo desenvolvimento de derrames nestes compartimentos&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivo&#58;</span> Estudar o comportamento das citocinas proliferativas TGF-&#946; &#40;factor beta de transforma&#231;&#227;o do crescimento&#41; e VEGF &#40;factor de crescimento do endot&#233;lio vascular&#41; nos l&#237;quidos de 16 transudatos e de 43 derrames pleurais de doentes submetidos a cirurgias de revasculariza&#231;&#227;o do mioc&#225;rdio provenientes do Instituto de Cora&#231;&#227;o e do Servi&#231;o de Pneumologia da Universidade do S&#227;o Paulo nos intervalos de 2&#44; 24 e 48 horas de p&#243;s-operat&#243;rio&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados&#58;</span> O derrame pleural p&#243;s-revasculariza&#231;&#227;o do mioc&#225;rdio &#233; um exsudato mobilizador de TGF-&#946; e VEGF no p&#243;s-operat&#243;rio imediato&#46; Os n&#237;veis de TGF-&#946; apresentam-se elevados nas primeiras 2 horas para ca&#237;rem progressivamente at&#233; se aproximarem dos valores dos transudatos ao fim de 48 horas&#44; enquanto o VEGF se inicia com n&#237;veis elevados j&#225; nas primeiras 2 horas com tend&#234;ncia a aumento pelo menos at&#233; 48 horas de p&#243;s-operat&#243;rio&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclus&#245;es&#58;</span> O TGF-&#946; parece comportar-se como elemento gatilho sobre a c&#233;lula mesotelial pleural para a libera&#231;&#227;o de VEGF no desenvolvimento de derrame pleural nas cirurgias de revasculariza&#231;&#227;o do mioc&#225;rdio&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 359-367</span></p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Coronary artery bypass graft &#40;CABG&#41; surgeries can impact on the pericardium and pleural space&#44; leading to inflammation which can cause effusion&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aim&#58;</span> To study the role of the proliferative cytokines TGF-&#946; and VEGF in the fluids of 16 transudates and 43 pleural effusions of patients who underwent CABG at the Heart Unit and Pulmonology Unit of the University Hospital of S&#227;o Paulo&#46; Levels of cytokines were assessed 2&#44; 24 and 48 hours post-surgery&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results&#58;</span> The pleural effusion after CABG is an exsudative mobilizer of TGF-&#946; and VEGF cytokines immediately after surgery&#46; The TGF-&#946; concentrations were elevated 2 hours after surgery but started to fall soon after&#44; reaching transudate levels after 48 hours&#46; VEGF levels were high in the first 2 hours post surgery and tended to maintain the same concentrations for at least 48 hours after surgery&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusions&#58;</span> Based on the results obtained&#44; TGF-&#946; is a cytokine that seems to work as a trigger&#44; leading the pleural mesothelial cell to express VEGF a cause of pleural effusion in CABG surgeries&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 359-367</span></p></span>"
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Artigo Original\Original Article
Papel das citocinas proliferativas TGF-β e VEGF no derrame pleural pós-revascularização do miocárdio
The proliferative cytokines TGF-β and VEGF in pleural effusions post-coronary artery bypass graft
António M.S. Chibante1,
Corresponding author
chibante@domain.com.br

Correspondência/Correspondence to: António M S Chibante, Centro de Investigações Pneumológicas RJ, Rua Sorocaba, 477 sala 601 Rio de Janeiro, Brasil, Cep: 22.271-110 E
, Marcelo Alexandre C. Vaz2, Francisco Vargas Suso2
1 Serviço de Cardiopneumologia, Hospital Gaffrée-Guinle. Univesidade do Rio de Janeiro/Cardiopulmonology Unit, Hospital Gaffrée-Guinle. Universidade do Rio de Janeiro
2 Serviço de Pneumologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo/Pulmonolgy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">A cirurgia de revasculariza&#231;&#227;o do mioc&#225;rdio envolve o acometimento&#44; tanto do peric&#225;rdio como da pleura&#44; conduzindo ao favorecimento de processos inflamat&#243;rios respons&#225;veis pelo desenvolvimento de derrames nestes compartimentos&#46;</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Objectivo&#58;</span> Estudar o comportamento das citocinas proliferativas TGF-&#946; &#40;factor beta de transforma&#231;&#227;o do crescimento&#41; e VEGF &#40;factor de crescimento do endot&#233;lio vascular&#41; nos l&#237;quidos de 16 transudatos e de 43 derrames pleurais de doentes submetidos a cirurgias de revasculariza&#231;&#227;o do mioc&#225;rdio provenientes do Instituto de Cora&#231;&#227;o e do Servi&#231;o de Pneumologia da Universidade do S&#227;o Paulo nos intervalos de 2&#44; 24 e 48 horas de p&#243;s-operat&#243;rio&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Resultados&#58;</span> O derrame pleural p&#243;s-revasculariza&#231;&#227;o do mioc&#225;rdio &#233; um exsudato mobilizador de TGF-&#946; e VEGF no p&#243;s-operat&#243;rio imediato&#46; Os n&#237;veis de TGF-&#946; apresentam-se elevados nas primeiras 2 horas para ca&#237;rem progressivamente at&#233; se aproximarem dos valores dos transudatos ao fim de 48 horas&#44; enquanto o VEGF se inicia com n&#237;veis elevados j&#225; nas primeiras 2 horas com tend&#234;ncia a aumento pelo menos at&#233; 48 horas de p&#243;s-operat&#243;rio&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclus&#245;es&#58;</span> O TGF-&#946; parece comportar-se como elemento gatilho sobre a c&#233;lula mesotelial pleural para a libera&#231;&#227;o de VEGF no desenvolvimento de derrame pleural nas cirurgias de revasculariza&#231;&#227;o do mioc&#225;rdio&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 359-367</span></p></span>"
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        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Coronary artery bypass graft &#40;CABG&#41; surgeries can impact on the pericardium and pleural space&#44; leading to inflammation which can cause effusion&#46;</p><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Aim&#58;</span> To study the role of the proliferative cytokines TGF-&#946; and VEGF in the fluids of 16 transudates and 43 pleural effusions of patients who underwent CABG at the Heart Unit and Pulmonology Unit of the University Hospital of S&#227;o Paulo&#46; Levels of cytokines were assessed 2&#44; 24 and 48 hours post-surgery&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results&#58;</span> The pleural effusion after CABG is an exsudative mobilizer of TGF-&#946; and VEGF cytokines immediately after surgery&#46; The TGF-&#946; concentrations were elevated 2 hours after surgery but started to fall soon after&#44; reaching transudate levels after 48 hours&#46; VEGF levels were high in the first 2 hours post surgery and tended to maintain the same concentrations for at least 48 hours after surgery&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusions&#58;</span> Based on the results obtained&#44; TGF-&#946; is a cytokine that seems to work as a trigger&#44; leading the pleural mesothelial cell to express VEGF a cause of pleural effusion in CABG surgeries&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;4&#41;&#58; 359-367</span></p></span>"
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Pulmonology

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