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Fonseca, Ana M. Arrobas" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Ana L." "apellidos" => "Fonseca" ] 1 => array:2 [ "nombre" => "Ana M." 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Mendes, Mariana Alves-Pereira, Nuno A.A. Castelo Branco" "autores" => array:4 [ 0 => array:2 [ "nombre" => "José Reis" "apellidos" => "Ferreira" ] 1 => array:2 [ "nombre" => "Carla P." "apellidos" => "Mendes" ] 2 => array:2 [ "nombre" => "Mariana" "apellidos" => "Alves-Pereira" ] 3 => array:2 [ "nombre" => "Nuno A.A." "apellidos" => "Castelo Branco" ] ] ] ] ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915304517?idApp=UINPBA00004E" "url" => "/08732159/0000001200000005/v1_201509071315/S0873215915304517/v1_201509071315/pt/main.assets" ] "pt" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artigo de Revisão / Revision Article</span>" "titulo" => "Cancro do pulmão na mulher: Uma entidade diferente?<a class="elsevierStyleCrossRef" href="#fn0005"><span class="elsevierStyleSup">1</span></a>" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "545" "paginaFinal" => "561" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Renato Sotto-Mayor" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Renato" "apellidos" => "Sotto-Mayor" "email" => array:1 [ 0 => "renato.sottomayor@hsm.min-saude.pt" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "af0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Chefe de Serviço de Pneumologia. Coordenador do Serviço de Pneumologia do Hospital de Santa Maria, Lisboa. Assistente Convidado da Faculdade de Medicina de Lisboa. Portugal." "etiqueta" => "2" "identificador" => "af0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Lung cancer in women: A different entity?" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-03-26" "fechaAceptado" => "2006-05-03" "PalabrasClave" => array:2 [ "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec567827" "palabras" => array:4 [ 0 => "Cancro do pulmão" 1 => "epidemiologia" 2 => "biologia molecular" 3 => "mulher" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec567826" "palabras" => array:4 [ 0 => "Lung cancer" 1 => "epidemiology" 2 => "molecular biology" 3 => "women" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Nos países desenvolvidos, o cancro do pulmão tem vindo a tornar-se uma verdadeira epidemia e uma das principais causas de morte por neoplasias malignas na mulher.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Embora controverso, é provável que a mulher apresente maior susceptibilidade para o cancro do pulmão do que o homem, estando a decorrer estudos de epidemiologia molecular e genética para a comprovar. Apontam-se especificidades no que se refere à biologia, à história natural, à histopatologia, à resposta à terapêutica e ao prognóstico do cancro do pulmão na mulher, factos ainda não completamente esclarecidos e, em alguns aspectos, não consensuais, havendo necessidade de se implementarem estudos prospectivos alargados para comparação dessas diferenças entre os dois sexos.</p><p id="sp1020" class="elsevierStyleSimplePara elsevierViewall">Até à data, na prática clínica, só existe uma área em que o determinante sexo poderá ser um factor a considerar no manejo terapêutico do cancro do pulmão, que diz respeito ao valor do gefitinib e do erlotinib na inibição dos receptores dos factores de crescimento epidermóide, em que estes produtos são claramente mais benéficos em mulheres não fumadoras.</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Dado o melhor prognóstico do cancro do pulmão nas mulheres, é recomendado que os futuros protocolos de investigação terapêutica incluam uma estratificação em função do sexo.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Na mulher, tal como no homem, a prevenção do cancro do pulmão é uma medida de saúde pública priori-tária, tendo como objectivo obrigatório a luta contra o tabaco, o seu factor etiológico <span class="elsevierStyleItalic">major</span>.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006; XII (5): 545-561</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Lung cancer is becoming a real epidemic in developed countries and one of the main causes of cancer death in women.</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Although it is controversial to state, it is probable that women are more susceptible to lung cancer than men. Molecular and genetic epidemiology studies are underway to prove this statement.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Several biological factors, such as family history, histopathology, response to treatment and the prognosis for lung cancer in women have a bearing on the case. While these are not completely clear or consensual, there is a need for wide-ranging prospective studies which compare the differences between males and females.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">Until now, there has only been one area in which gender could impact on the therapeutic management of lung cancer: the role of gefitinib and erlotinib in inhibiting the epidermal growth factor receptors, since these products are clearly of more benefit to female non-smokers.</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">Given that women have a better lung cancer prognosis, it is recommended that future research protocols include stratification on gender.</p><p id="sp0155" class="elsevierStyleSimplePara elsevierViewall">Prevention of lung cancer in both women and men is a priority public health concern. A mandatory aim of this is the fight against smoking, the largest aetiological factor of lung cancer</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006; XII (5): 545-561</span></p></span>" ] ] "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="np0005">Texto apresentado em parte no “39.º Curso de Pneumologia para Pós-Graduados” (Universidade Católica, Lisboa, Março de 2006), na sessão “Cancro do pulmão na mulher”.</p>" "identificador" => "fn0005" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0020">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:66 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." 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Original language: Portuguese
Year/Month | Html | Total | |
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2024 November | 8 | 6 | 14 |
2024 October | 33 | 18 | 51 |
2024 September | 32 | 19 | 51 |
2024 August | 50 | 32 | 82 |
2024 July | 36 | 30 | 66 |
2024 June | 32 | 20 | 52 |
2024 May | 25 | 31 | 56 |
2024 April | 32 | 20 | 52 |
2024 March | 32 | 20 | 52 |
2024 February | 20 | 16 | 36 |
2024 January | 22 | 28 | 50 |
2023 December | 25 | 17 | 42 |
2023 November | 13 | 19 | 32 |
2023 October | 26 | 31 | 57 |
2023 September | 21 | 33 | 54 |
2023 August | 23 | 12 | 35 |
2023 July | 20 | 25 | 45 |
2023 June | 17 | 12 | 29 |
2023 May | 28 | 21 | 49 |
2023 April | 19 | 12 | 31 |
2023 March | 20 | 20 | 40 |
2023 February | 24 | 15 | 39 |
2023 January | 17 | 15 | 32 |
2022 December | 20 | 20 | 40 |
2022 November | 43 | 30 | 73 |
2022 October | 24 | 16 | 40 |
2022 September | 33 | 41 | 74 |
2022 August | 34 | 45 | 79 |
2022 July | 14 | 33 | 47 |
2022 June | 24 | 28 | 52 |
2022 May | 30 | 29 | 59 |
2022 April | 25 | 33 | 58 |
2022 March | 20 | 27 | 47 |
2022 February | 27 | 18 | 45 |
2022 January | 26 | 42 | 68 |
2021 December | 18 | 22 | 40 |
2021 November | 27 | 25 | 52 |
2021 October | 20 | 26 | 46 |
2021 September | 19 | 23 | 42 |
2021 August | 24 | 19 | 43 |
2021 July | 16 | 18 | 34 |
2021 June | 18 | 22 | 40 |
2021 May | 29 | 22 | 51 |
2021 April | 75 | 25 | 100 |
2021 March | 42 | 7 | 49 |
2021 February | 52 | 16 | 68 |
2021 January | 22 | 14 | 36 |
2020 December | 28 | 18 | 46 |
2020 November | 45 | 16 | 61 |
2020 October | 30 | 17 | 47 |
2020 September | 67 | 23 | 90 |
2020 August | 52 | 16 | 68 |
2020 July | 76 | 14 | 90 |
2020 June | 61 | 20 | 81 |
2020 May | 58 | 11 | 69 |
2020 April | 62 | 24 | 86 |
2020 March | 53 | 12 | 65 |
2020 February | 36 | 22 | 58 |
2020 January | 54 | 17 | 71 |
2019 December | 32 | 13 | 45 |
2019 November | 64 | 22 | 86 |
2019 October | 43 | 16 | 59 |
2019 September | 41 | 17 | 58 |
2019 August | 53 | 29 | 82 |
2019 July | 31 | 18 | 49 |
2019 June | 31 | 11 | 42 |
2019 May | 40 | 17 | 57 |
2019 April | 44 | 21 | 65 |
2019 March | 32 | 19 | 51 |
2019 February | 26 | 12 | 38 |
2019 January | 38 | 18 | 56 |
2018 December | 17 | 2 | 19 |
2018 November | 4 | 0 | 4 |
2018 October | 16 | 0 | 16 |
2018 September | 12 | 11 | 23 |
2018 August | 47 | 28 | 75 |
2018 July | 28 | 22 | 50 |
2018 June | 44 | 14 | 58 |
2018 May | 56 | 21 | 77 |
2018 April | 53 | 25 | 78 |
2018 March | 31 | 27 | 58 |
2018 February | 23 | 13 | 36 |
2018 January | 33 | 8 | 41 |
2017 December | 24 | 21 | 45 |
2017 November | 35 | 12 | 47 |
2017 October | 24 | 14 | 38 |
2017 September | 23 | 15 | 38 |
2017 August | 23 | 18 | 41 |
2017 July | 8 | 4 | 12 |
2017 June | 26 | 6 | 32 |
2017 May | 32 | 7 | 39 |
2017 April | 12 | 2 | 14 |
2017 March | 16 | 5 | 21 |
2017 February | 11 | 2 | 13 |
2017 January | 6 | 2 | 8 |
2016 December | 19 | 6 | 25 |
2016 November | 9 | 5 | 14 |
2016 October | 12 | 5 | 17 |
2016 September | 0 | 1 | 1 |
2016 August | 10 | 2 | 12 |
2016 July | 6 | 1 | 7 |
2016 June | 3 | 0 | 3 |
2016 May | 1 | 0 | 1 |
2016 April | 4 | 1 | 5 |
2016 March | 3 | 5 | 8 |
2016 February | 8 | 11 | 19 |
2016 January | 5 | 0 | 5 |
2015 December | 6 | 1 | 7 |
2015 November | 2 | 3 | 5 |
2015 October | 3 | 1 | 4 |