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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Nos pa&#237;ses desenvolvidos&#44; o cancro do pulm&#227;o tem vindo a tornar-se uma verdadeira epidemia e uma das principais causas de morte por neoplasias malignas na mulher&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Embora controverso&#44; &#233; prov&#225;vel que a mulher apresente maior susceptibilidade para o cancro do pulm&#227;o do que o homem&#44; estando a decorrer estudos de epidemiologia molecular e gen&#233;tica para a comprovar&#46; Apontam-se especificidades no que se refere &#224; biologia&#44; &#224; hist&#243;ria natural&#44; &#224; histopatologia&#44; &#224; resposta &#224; terap&#234;utica e ao progn&#243;stico do cancro do pulm&#227;o na mulher&#44; factos ainda n&#227;o completamente esclarecidos e&#44; em alguns aspectos&#44; n&#227;o consensuais&#44; havendo necessidade de se implementarem estudos prospectivos alargados para compara&#231;&#227;o dessas diferen&#231;as entre os dois sexos&#46;</p><p id="sp1020" class="elsevierStyleSimplePara elsevierViewall">At&#233; &#224; data&#44; na pr&#225;tica cl&#237;nica&#44; s&#243; existe uma &#225;rea em que o determinante sexo poder&#225; ser um factor a considerar no manejo terap&#234;utico do cancro do pulm&#227;o&#44; que diz respeito ao valor do gefitinib e do erlotinib na inibi&#231;&#227;o dos receptores dos factores de crescimento epiderm&#243;ide&#44; em que estes produtos s&#227;o claramente mais ben&#233;ficos em mulheres n&#227;o fumadoras&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Dado o melhor progn&#243;stico do cancro do pulm&#227;o nas mulheres&#44; &#233; recomendado que os futuros protocolos de investiga&#231;&#227;o terap&#234;utica incluam uma estratifica&#231;&#227;o em fun&#231;&#227;o do sexo&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Na mulher&#44; tal como no homem&#44; a preven&#231;&#227;o do cancro do pulm&#227;o &#233; uma medida de sa&#250;de p&#250;blica priori-t&#225;ria&#44; tendo como objectivo obrigat&#243;rio a luta contra o tabaco&#44; o seu factor etiol&#243;gico <span class="elsevierStyleItalic">major</span>&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;5&#41;&#58; 545-561</span></p></span>"
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Artigo de Revisão / Revision Article
Cancro do pulmão na mulher: Uma entidade diferente?1
Lung cancer in women: A different entity?
Renato Sotto-Mayor2
2 Chefe de Serviço de Pneumologia. Coordenador do Serviço de Pneumologia do Hospital de Santa Maria, Lisboa. Assistente Convidado da Faculdade de Medicina de Lisboa. Portugal.
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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Nos pa&#237;ses desenvolvidos&#44; o cancro do pulm&#227;o tem vindo a tornar-se uma verdadeira epidemia e uma das principais causas de morte por neoplasias malignas na mulher&#46;</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Embora controverso&#44; &#233; prov&#225;vel que a mulher apresente maior susceptibilidade para o cancro do pulm&#227;o do que o homem&#44; estando a decorrer estudos de epidemiologia molecular e gen&#233;tica para a comprovar&#46; Apontam-se especificidades no que se refere &#224; biologia&#44; &#224; hist&#243;ria natural&#44; &#224; histopatologia&#44; &#224; resposta &#224; terap&#234;utica e ao progn&#243;stico do cancro do pulm&#227;o na mulher&#44; factos ainda n&#227;o completamente esclarecidos e&#44; em alguns aspectos&#44; n&#227;o consensuais&#44; havendo necessidade de se implementarem estudos prospectivos alargados para compara&#231;&#227;o dessas diferen&#231;as entre os dois sexos&#46;</p><p id="sp1020" class="elsevierStyleSimplePara elsevierViewall">At&#233; &#224; data&#44; na pr&#225;tica cl&#237;nica&#44; s&#243; existe uma &#225;rea em que o determinante sexo poder&#225; ser um factor a considerar no manejo terap&#234;utico do cancro do pulm&#227;o&#44; que diz respeito ao valor do gefitinib e do erlotinib na inibi&#231;&#227;o dos receptores dos factores de crescimento epiderm&#243;ide&#44; em que estes produtos s&#227;o claramente mais ben&#233;ficos em mulheres n&#227;o fumadoras&#46;</p><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Dado o melhor progn&#243;stico do cancro do pulm&#227;o nas mulheres&#44; &#233; recomendado que os futuros protocolos de investiga&#231;&#227;o terap&#234;utica incluam uma estratifica&#231;&#227;o em fun&#231;&#227;o do sexo&#46;</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Na mulher&#44; tal como no homem&#44; a preven&#231;&#227;o do cancro do pulm&#227;o &#233; uma medida de sa&#250;de p&#250;blica priori-t&#225;ria&#44; tendo como objectivo obrigat&#243;rio a luta contra o tabaco&#44; o seu factor etiol&#243;gico <span class="elsevierStyleItalic">major</span>&#46;</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;5&#41;&#58; 545-561</span></p></span>"
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        "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Lung cancer is becoming a real epidemic in developed countries and one of the main causes of cancer death in women&#46;</p><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Although it is controversial to state&#44; it is probable that women are more susceptible to lung cancer than men&#46; Molecular and genetic epidemiology studies are underway to prove this statement&#46;</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Several biological factors&#44; such as family history&#44; histopathology&#44; response to treatment and the prognosis for lung cancer in women have a bearing on the case&#46; While these are not completely clear or consensual&#44; there is a need for wide-ranging prospective studies which compare the differences between males and females&#46;</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">Until now&#44; there has only been one area in which gender could impact on the therapeutic management of lung cancer&#58; the role of gefitinib and erlotinib in inhibiting the epidermal growth factor receptors&#44; since these products are clearly of more benefit to female non-smokers&#46;</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">Given that women have a better lung cancer prognosis&#44; it is recommended that future research protocols include stratification on gender&#46;</p><p id="sp0155" class="elsevierStyleSimplePara elsevierViewall">Prevention of lung cancer in both women and men is a priority public health concern&#46; A mandatory aim of this is the fight against smoking&#44; the largest aetiological factor of lung cancer</p><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006&#59; XII &#40;5&#41;&#58; 545-561</span></p></span>"
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Article information
ISSN: 08732159
Original language: Portuguese
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Pulmonology

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