Artigo de Revisão\Revision Article
Asma, polipose nasal e intolerância à aspirina – Uma tríade a recordar
Asthma, nasal polyposis and aspirin intolerance – A triad to remember
1 Interna Complementar de Pneumologia, Centro Hospitalar Vila Nova de Gaia, Serviço de Pneumologia, Rua Conceição Fernandes, 4434-502 V. N. Gaia
2 Assistente Hospitalar de Pneumologia, Centro Hospitalar Vila Nova de Gaia, Serviço de Pneumologia, Rua Conceição Fernandes, 4434-502 V. N. Gaia
3 Director do Serviço de Pneumologia, Centro Hospitalar Vila Nova de Gaia, Serviço de Pneumologia, Rua Conceição Fernandes, 4434-502 V. N. Gaia
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N. Gaia" "etiqueta" => "1" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Assistente Hospitalar de Pneumologia, Centro Hospitalar Vila Nova de Gaia, Serviço de Pneumologia, Rua Conceição Fernandes, 4434-502 V. N. Gaia" "etiqueta" => "2" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Director do Serviço de Pneumologia, Centro Hospitalar Vila Nova de Gaia, Serviço de Pneumologia, Rua Conceição Fernandes, 4434-502 V. N. Gaia" "etiqueta" => "3" "identificador" => "af0015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Asthma, nasal polyposis and aspirin intolerance – A triad to remember" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-03-03" "fechaAceptado" => "2006-06-30" "PalabrasClave" => array:1 [ "pt" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec568004" "palabras" => array:4 [ 0 => "Asma" 1 => "polipose nasal" 2 => "intolerância aspirina" 3 => "síndroma de Widal" ] ] 1 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec568005" "palabras" => array:4 [ 0 => "Asthma" 1 => "nasal polyposis" 2 => "aspirin intolerance" 3 => "Widal syndrome" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Apesar de reconhecida há mais de meio século, a tríade constituída por asma severa, polipose nasal e intolerância ao ácido acetilsalicílico a denominada <span class="elsevierStyleItalic"><span class="elsevierStyleBold">asma induzida pela aspirina ou sindrome de Widal</span></span> permanece francamente subdiagnosticada e insuficientemente tratada. De entre as principais razões para esta situação destacam-se o desconhecimento das suas características clínicas, a fisiopatologia e, por vezes, até a própria existência desta entidade.</p><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">O presente artigo pretende alertar a população médica para esta síndroma, ara as suas particularidades e para os cuidados específicos no seu tratamento, com vista a uma melhoria na prestação dos cuidados de saúde: O diagnóstico correcto é o primeiro passo no tratamento eficaz de qualquer patologia.</p><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006; XII (6): 709-714</span></p></span>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="as0010" class="elsevierStyleSection elsevierViewall"><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Despite more than a half-century of recognition, the triad characterised by severe asthma, nasal polyposis and acetylsalicylic acid intolerance known <span class="elsevierStyleItalic"><span class="elsevierStyleBold">as aspirin induced asthma or Widal’s triad</span></span> remains markedly underdiagnosed and mistreated. A number of reasons may contribute to this situation with the lack of awareness of its clinical characteristics, pathophysiology and even sometimes of its’ actual existence the main ones.</p><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">This review article aims to alert physicians to this entity and its particularities in an attempt to improve healthcare. A correct diagnosis is the first step in the effective treatment of a disease.</p><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Rev Port Pneumol 2006; XII (6): 709-714</span></p></span>" ] ] "lecturaRecomendada" => array:1 [ 0 => array:3 [ "vista" => "all" "titulo" => "<span class="elsevierStyleSectionTitle" id="st0025">Bibliografia</span>" "seccion" => array:1 [ 0 => array:2 [ "vista" => "all" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anaphylaxie et idiosyncrasie" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.F. Widal" 1 => "P. Abrami" 2 => "J. Lermoyez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "La Presse Médicale, Paris" "fecha" => "1922" "volumen" => "30" "paginaInicial" => "189" "paginaFinal" => "192" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis, Prevention and Treatment of Aspirin-Induced Asthma and Rhinitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Bochenek" 1 => "K. Banska" 2 => "Z. Szabo" 3 => "E. Nizankowska" 4 => "A. Szczeklik" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/mnfr.201500449" "Revista" => array:6 [ "tituloSerie" => "Current Drug Targets – Inflammation & Allergy" "fecha" => "2002" "volumen" => "1" "paginaInicial" => "1" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26337420" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.A. Settipane" 1 => "D.D. Stevenson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Allergy Clinical Immunology" "fecha" => "1989" "volumen" => "84" "numero" => "1" "paginaInicial" => "26" "paginaFinal" => "33" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aspirin and Asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K.S. Babu" 1 => "S.S. Salvi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2000" "volumen" => "118" "paginaInicial" => "1470" "paginaFinal" => "1476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11083703" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benefits from adding the 5-lipoxygenase inhibitor zileuton to conventional therapy in aspirin intolerant asthmatics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B. Dahlen" 1 => "E. Nizankowska" 2 => "A. Szczeliik" 3 => "G. Bochenek" 4 => "M. Kumlin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Respiratory Care Med" "fecha" => "1998" "volumen" => "157" "paginaInicial" => "11887" "paginaFinal" => "11896" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pivotal role of lipoxigenase products in the reaction of aspirin sensitive asthmatics to aspirin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Israel" 1 => "E.R. Fisher" 2 => "M.A. Rosenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm/148.6_Pt_1.1447" "Revista" => array:5 [ "tituloSerie" => "Am Rev Respiratory Dis" "fecha" => "1993" "volumen" => "148" "paginaInicial" => "1447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8256883" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long term effects of asthma desensitization – treatment of aspirin induced rhinosinusitis-asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.M. Sweet" 1 => "D.D. Stevenson" 2 => "D.A. Mathison" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Clin Immunol" "fecha" => "1990" "volumen" => "85" "paginaInicial" => "59" ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "pt" "url" => "/08732159/0000001200000006/v1_201509071353/S0873215915304566/v1_201509071353/pt/main.assets" "Apartado" => array:4 [ "identificador" => "43383" "tipo" => "SECCION" "pt" => array:2 [ "titulo" => "Artigos de Revisão/Revision Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "pt" ] "PDF" => "https://static.elsevier.es/multimedia/08732159/0000001200000006/v1_201509071353/S0873215915304566/v1_201509071353/pt/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0873215915304566?idApp=UINPBA00004E" ]
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ISSN: 08732159Original language: Portuguese
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