Involvement of central airways in vibroacoustic disease patients
Participação das vias aéreas centrais na doença vibroacústica
José Reis Ferreira1, Miguel B. Monteiro2, Fernanda Tavares3, Isabel Serrano4, Emanuel Monteiro5, Carla P. Mendes6, Mariana Alves-Pereira7, Nuno A.A. Castelo Branco8
1 Médico pneumologista/Pulmonologist. Unidade de Estudo Funcional Respiratório, Hospital da Força Aérea, Lisboa
2 Médico pneumologista/Pulmonologist. Unidade de Pneumologia, Centro Hospitalar de Cascais
3 Médica anatomopatologista/Anatomo-pathologist. Centro de Patologia Humana, Oeiras
4 Médica anatomopatologista/Anatomo-pathologist. Centro Hospitalar de Cascais
5 Técnico de anatomia/Anatomy technician. Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto
6 Médico pneumologista/Pulmonologist. Unidade de Estudo Funcional Respiratório, Hospital da Força Aérea, Lisboa
7 Mestre em engenharia biomédica/M.A.in Biomedical engeneering. Departamento de Ciências e Engenharia do Ambiente, Universidade Nova de Lisboa
8 Médico anatomopatologista/Anatomo-pathologist. Presidente do Conselho Científico/President of the Scientific Board, Centro da Performance Humana, Alverca
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"apellidos" => "Mendes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0030" ] ] ] 6 => array:3 [ "nombre" => "Mariana" "apellidos" => "Alves-Pereira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] ] ] 7 => array:4 [ "nombre" => "Nuno A.A." "apellidos" => "Castelo Branco" "email" => array:1 [ 0 => "vibroacoustic.disease@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">8</span>" "identificador" => "aff0040" ] ] ] ] "afiliaciones" => array:8 [ 0 => array:3 [ "entidad" => "Médico pneumologista/Pulmonologist. Unidade de Estudo Funcional Respiratório, Hospital da Força Aérea, Lisboa" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Médico pneumologista/Pulmonologist. Unidade de Pneumologia, Centro Hospitalar de Cascais" "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Médica anatomopatologista/Anatomo-pathologist. Centro de Patologia Humana, Oeiras" "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Médica anatomopatologista/Anatomo-pathologist. Centro Hospitalar de Cascais" "etiqueta" => "<span class="elsevierStyleSup">4</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Técnico de anatomia/Anatomy technician. Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto" "etiqueta" => "<span class="elsevierStyleSup">5</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Médico pneumologista/Pulmonologist. Unidade de Estudo Funcional Respiratório, Hospital da Força Aérea, Lisboa" "etiqueta" => "<span class="elsevierStyleSup">6</span>" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Mestre em engenharia biomédica/M.A.in Biomedical engeneering. Departamento de Ciências e Engenharia do Ambiente, Universidade Nova de Lisboa" "etiqueta" => "<span class="elsevierStyleSup">7</span>" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Médico anatomopatologista/Anatomo-pathologist. Presidente do Conselho Científico/President of the Scientific Board, Centro da Performance Humana, Alverca" "etiqueta" => "<span class="elsevierStyleSup">8</span>" "identificador" => "aff0040" ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Participação das vias aéreas centrais na doença vibroacústica" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2005-11-12" "fechaAceptado" => "2005-11-12" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key-words" "identificador" => "xpalclavsec158590" "palabras" => array:9 [ 0 => "Low frequency noise" 1 => "vibroacoustic disease" 2 => "vascular lesions" 3 => "displasia" 4 => "auto-imune disorders" 5 => "collagen disease" 6 => "ciliar structure" 7 => "apoptosis" 8 => "mecano-transduction" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec158589" "palabras" => array:9 [ 0 => "Ruído de baixa frequência" 1 => "doença vibroacústica" 2 => "lesões vasculares" 3 => "displasia" 4 => "doença auto-imune" 5 => "doença do colagénio" 6 => "estrutura ciliar" 7 => "apoptose" 8 => "mecano-transdução" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Introduction. Vibroacoustic disease (VAD) is the whole-body pathology caused by excessive exposure to LFN. For the past 25 years, it has been know that low frequency noise (LFN, <500 Hz, including infrasound) targets the respiratory system. In LFN-exposed rodents, the morphological changes of respiratory tract tissue partially explained some respiratory symptoms reported by VAD patients. However, many questions remain unanswered. Recently, some volunteer VAD patients underwent bronchoscopy in order to ascertain possible damage that could be associated with their respiratory complaints. Methods. Fourteen fully-informed and volunteer VAD patients were submitted to bronchoscopy, and biopsies were removed for analysis. Results. All patients exhibited small submucosal vascular-like lesions near the spurs, consisting of increased collagen and elastin fibres. Histology disclosed cilliary abnormalities, basal membrane hyperplasia, and thickening of vessel walls. In five patients, collagen bundles appeared degenerative and disrupted. No inflammatory process was ever identified, and no differences were seen between smokers and non-smokers. Discussion. Data is in accordance with what was observed in LFN-exposed animal models and also in 8 VAD patients who developed lung tumours. Collagen disruption and degeneration was also observed in electron microscopy images of the respiratory tract of LFN-exposed rodents. Thickened blood and lymphatic vessel walls have been consistently seen in images of VAD patients and of LFN-exposed rodents. During bronchoscopy performed by other reasons, this sort of structural aspects is not frequently seen. Taken together, it is strongly suggested that these findings could be VAD-specific.</p>" ] "pt" => array:2 [ "titulo" => "Resumo" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Nos últimos vinte cinco anos constatou-se que o aparelho respiratório constitui um alvo do ruído de baixa frequência (RFB <500Hz, incluindo infra-sons). Denomina-se doença vibroacústica (VAD) a patologia sistémica causada pela exposição excessiva a RBF. Em ratos Wistar expostos a RBF, as alterações morfológicas observadas nos tecidos das vias aéreas centrais explicam, parcialmente, os sintomas apresentados pelos doentes com a VAD. Apesar disso, muitas perguntas permanecem por responder. Recentemente, voluntários com a doença vibroacústica submeteram-se a exames broncoscópicos para esclarecer e, se possível, demonstrar possíveis lesões das vias aéreas centrais que estariam associadas com as queixas respiratórias. Treze doentes voluntários, exaustivamente esclarecidos sobre este exame, submeteram-se a broncoscopias, durante as quais se colheram fragmentos para exame histológico e ultra-estrutural. Em todos os indivíduos se observaram lesões de tipo vascular na submucosa próximas das bifurcações das vias aéreas. Estas lesões caracterizavam-se por numerosos pequenos vasos com paredes espessadas, mergulhados em feixes de colagénio e algumas fibras de elastina. Em cinco indivíduos as lesões evidenciavam degenerescência e ruptura do colagénio. Histologicamente, na mucosa normal observaram-se alterações ciliares, hiperplasia da membrana basal e espessamento dos vasos sanguíneos. Em nenhum caso se observaram infiltrados celulares de natureza inflamatória. O estudo da ultra-estrutura revelou numerosos axonemas (de dois a oito) contidos numa membrana ciliar comum, algumas vesículas emanando dos cílios, imagens de apoptose com reforço do citosqueleto celular e das ligações intercelulares. Não se observaram diferenças entre fumadores e não fumadores. Estes dados estão de acordo com o que já fora observado nas vias aéreas centrais de oito doentes com carcinoma pavimento-celular do pulmão e também com as imagens observadas em ratos expostos a RBF. Em broncoscopias efectuadas em doentes sem a doença vibroacústica, não é normal observar-se este tipo de lesões vasculares. Assim, estas lesões vasculares das vias aéreas centrais podem ser específicas da doença vibroacústica.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Trabalho vencedor ex-aequo (Secção A).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliography" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:43 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vibroacoustic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N.A.A. Castelo Branco" 1 => "M. Alves-Pereira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1021/acsnano.5b00618" "Revista" => array:7 [ "tituloSerie" => "Noise & Health" "fecha" => "2004" "volumen" => "6" "numero" => "23" "paginaInicial" => "3" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25790372" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The clinical stages of vibroacoustic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "numero" => "3, Suppl" "paginaInicial" => "A32" "paginaFinal" => "A39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189154" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pericardium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B.D. Holt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Hurst's The Heart" "paginaInicial" => "2061" "paginaFinal" => "2082" "serieFecha" => "2001" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiography in 485 aeronautical workers exposed to different noise environments" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:13 [ 0 => "W. Marciniak" 1 => "E. Rodriguez" 2 => "K. Olsowska" 3 => "I. Botvin" 4 => "A. Araujo" 5 => "F. Pais" 6 => "C. Soares Ribeiro" 7 => "A. Bordalo" 8 => "J. Loureiro" 9 => "E. Prazeres de Sá" 10 => "D. Ferreira" 11 => "M.S.N.A.A. Castelo Branco" 12 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "numero" => "3, Suppl" "paginaInicial" => "A46" "paginaFinal" => "A53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189156" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurological aspects of vibroacoustic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.J.F. Martinho Pimenta" 1 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "numero" => "3, Suppl" "paginaInicial" => "A91" "paginaFinal" => "A95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189162" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of occupational exposure to low frequency noise on cognition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Gomes" 1 => "A.J.F. Martinho Pimenta" 2 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "numero" => "3, Suppl" "paginaInicial" => "A115" "paginaFinal" => "A118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189166" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loss of neurological control of breathing in vibroacoustic disease patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "J. Reis Ferreira" 1 => "E. Albuquerque" 2 => "J. Sousa" 3 => "C.P. Mendes" 4 => "M. Antunes" 5 => "M. Alves-Pereira" 6 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2004" "editorial" => "Proc. 11th Intern Cong Sound" "editorialLocalizacion" => "St. Petersburg, Russia" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of vibroacoustic disease – preliminary report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "J. Reis Ferreira" 1 => "C.P. Mendes" 2 => "M. Antunes" 3 => "A.J.F. Martinho Pimenta" 4 => "E. Monteiro" 5 => "M. Alves-Pereira" 6 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2003" "editorial" => "Proc 8th Intern Cong Noise as a Public Health Problem" "editorialLocalizacion" => "Rotterdam, Holland" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A unique case of vibroacoustic disease. A tribute to an extraordinary patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "numero" => "3, Suppl" "paginaInicial" => "A27" "paginaFinal" => "A31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189153" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "SEM and TEM study of rat respiratory epithelia exposed to low frequency noise" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N.A.A. Castelo Branco" 1 => "M. Alves-Pereira" 2 => "J. Martins dos Santos" 3 => "E. Monteiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "A.Mendez-Vilas" "paginaInicial" => "505" "paginaFinal" => "533" "serieVolumen" => "Vol. II" "serieTitulo" => "Science and Technology Education in Microscopy: An Overview" "serieFecha" => "2002" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory epithelia in Wistar rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.A.A. Castelo Branco" 1 => "E. Monteiro" 2 => "A. Costa e Silva" 3 => "J. Reis Ferreira" 4 => "M. Alves-Pereira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2003" "volumen" => "IX-5" "paginaInicial" => "381" "paginaFinal" => "388" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory epithelia in Wistar rats after 48 hours of continuous exposure to low frequency noise" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N.A.A. Castelo Branco" 1 => "P. Gomes-Ferreira" 2 => "E. Monteiro" 3 => "A. Costa e Silva" 4 => "J. Reis Ferreira" 5 => "M. Alves- Pereira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2003" "volumen" => "IX-6" "paginaInicial" => "470" "paginaFinal" => "473" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory epithelia in Wistar rats born in low frequency noise plus varying amounts of additional exposure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.A.A. Castelo Branco" 1 => "E. Monteiro" 2 => "A. Costa e Silva" 3 => "J. Reis Ferreira" 4 => "M. Alves-Pereira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2003" "volumen" => "IX-6" "paginaInicial" => "481" "paginaFinal" => "492" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The lung parenchyma in low frequency noise exposed rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.A.A. Castelo Branco" 1 => "E. Monteiro" 2 => "A. Costa e Silva" 3 => "J. Reis Ferreira" 4 => "M. Alves-Pereira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2004" "volumen" => "X-1" "paginaInicial" => "77" "paginaFinal" => "85" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of low frequency noise on rat tracheal epithelium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Sousa Pereira" 1 => "A. Águas" 2 => "N.R. Grande" 3 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AviatSpace Environ Med" "fecha" => "1999" "volumen" => "70" "numero" => "3, Suppl" "paginaInicial" => "A86" "paginaFinal" => "A90" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morphological changes in the rat lungparenchyma exposed to low frequency noise" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. Grande" 1 => "A.P. Águas" 2 => "A. Sousa Pereira" 3 => "E. Monteiro" 4 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "numero" => "3, Suppl" "paginaInicial" => "A70" "paginaFinal" => "A77" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189159" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of low frequency noise upon the reaction of pleural milky spots to mycobacterial infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.J.R. Oliveira" 1 => "A. Sousa Pereira" 2 => "A.P. Águas" 3 => "E. Monteiro" 4 => "N.R. Grande" 5 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "paginaInicial" => "A137" "paginaFinal" => "A140" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189171" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morphofunctional study of rat pleural mesothelial cells exposed to low frequency noise" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Sousa Pereira" 1 => "N.R. Grande" 2 => "M.S.N. Castelo Branco" 3 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "numero" => "3, Suppl" "paginaInicial" => "A78" "paginaFinal" => "A85" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189160" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of low-frequency and infrasonic noise on man" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G.C. Mohr" 1 => "J.N. Cole" 2 => "E. Guild" 3 => "H.E. Von Gierke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aerospace Med" "fecha" => "1965" "volumen" => "36" "paginaInicial" => "817" "paginaFinal" => "824" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14332329" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biological action of intense wide-band noise on animals" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "V.I. Ponomarkov" 1 => "Tysik Ayu" 2 => "V.I. Kudryavtseva" 3 => "A.S. Barer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Problems of Space Biology NASA TT F-529" "fecha" => "1969" "volumen" => "7" "paginaInicial" => "307" "paginaFinal" => "309" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The influence of a company hearing conservation program on extra-auditory problems in workers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Safety Res" "fecha" => "1976" "volumen" => "8" "paginaInicial" => "146" "paginaFinal" => "162" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of infrasound on lung structure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V.I. Svigovyi" 1 => "V.V. Glinchikov" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gig Truda Prof Zabol" "fecha" => "1987" "volumen" => "1" "paginaInicial" => "34" "paginaFinal" => "37" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Noise and the respiratory system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Alves-Pereira" 1 => "J. Reis Ferreira" 2 => "J. Joanaz de Melo" 3 => "J. Motylewski" 4 => "E. Kotlicka" 5 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Port Pneumol" "fecha" => "2003" "volumen" => "IX-5" "paginaInicial" => "367" "paginaFinal" => "379" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extra-aural noise-induced pathology. A review and commentary" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Alves-Pereira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "paginaInicial" => "A7" "paginaFinal" => "A21" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189151" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pericardial features in vibroacoustic disease patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N.A.A. Castelo Branco" 1 => "J. Fragata" 2 => "E. Monteiro" 3 => "M. Alves-Pereira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2003" "editorial" => "Proc 8th Intern Cong Noise as a Public Health Problem" "editorialLocalizacion" => "Rotterdam, Holland" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The human pericardium in vibroacoustic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "N.A.A. Castelo Branco" 1 => "A.P. Águas" 2 => "A. Sousa Pereira" 3 => "E. Monteiro" 4 => "J.I.G. Fragata" 5 => "F. Tavares" 6 => "N.R. Grande" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "paginaInicial" => "A54" "paginaFinal" => "A62" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189157" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lymphatic lesions and vibroacoustic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Martins dos Santos" 1 => "N.R. Grande" 2 => "N.A.A. Castelo Branco" 3 => "C. Zagalo" 4 => "P. Oliveira" 5 => "M. Alves-Pereira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Lymphology" "fecha" => "2004" "volumen" => "12" "numero" => "40" "paginaInicial" => "17" "paginaFinal" => "20" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vascular lesions and vibroacoustic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Martins dos Santos" 1 => "N.R. Grande" 2 => "N.A.A. Castelo Branco" 3 => "C. Zagalo" 4 => "P. Oliveira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Anat" "fecha" => "2002" "volumen" => "6" "numero" => "1" "paginaInicial" => "17" "paginaFinal" => "21" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Echocardiography in noiseexposed flight crew" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Araújo" 1 => "F. Pais" 2 => "J.M.C. Lopo Tuna" 3 => "M. Alves-Pereira" 4 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2001" "editorial" => "Proc. Internoise" "editorialLocalizacion" => "The Hague, Holland" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vibroacoustic disease induced by long-term exposure to sonic booms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:14 [ 0 => "R. Torres" 1 => "G. Tirado" 2 => "A. Roman" 3 => "R. Ramirez" 4 => "H. Colon" 5 => "A. Araujo" 6 => "F. Pais" 7 => "W. Marciniak" 8 => "J. Nóbrega" 9 => "A. Bordalo e Sá" 10 => "J.M.C. Lopo Tuna" 11 => "M.S.N.A.A. Castelo Branco" 12 => "M. Alves-Pereira" 13 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2001" "editorial" => "Proc Internoise" "editorialLocalizacion" => "The Hague, Holland" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pleural involvement in systemic disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Aiello" 1 => "A. Chetta" 2 => "E. Marangio" 3 => "M. Zompatori" 4 => "D. Olivieri" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Curr. Drug Targets Inflamm Allergy" "fecha" => "2004" "volumen" => "3" "numero" => "4" "paginaInicial" => "441" "paginaFinal" => "447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15584892" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acceleration of lupus erythematosus-like processes by low frequency noise in the hybrid NZB/W mouse model" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.P. Águas" 1 => "N. Esaguy" 2 => "A.P. Castro" 3 => "N.R. Grande" 4 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "paginaInicial" => "A132" "paginaFinal" => "A136" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189170" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increase in CD8+ and CD4+ T lymphocytes in patients with vibroacoustic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.P. Castro" 1 => "A.P. Aguas" 2 => "N.R. Grande" 3 => "E. Monteiro" 4 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aviat Space Environ Med" "fecha" => "1999" "volumen" => "70" "paginaInicial" => "A141" "paginaFinal" => "A144" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10189172" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanochemical basis of cell and tissue regulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.E. Ingber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "NAE Bridge" "fecha" => "2004" "volumen" => "34" "numero" => "3" "paginaInicial" => "4" "paginaFinal" => "10" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanobiology and diseases of mechanotransduction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.E. Ingber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Med" "fecha" => "2003" "volumen" => "35" "paginaInicial" => "1" "paginaFinal" => "14" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanotransduction across the cell surface and through the cytoskeleton" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Wang" 1 => "J.P. Butler" 2 => "D.E. Ingber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Science (in Reports), New Series" "fecha" => "1993" "volumen" => "260" "numero" => "5111" "paginaInicial" => "1124" "paginaFinal" => "1127" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanical properties of individual focal adhesions probed with a magnetic microneedle" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "B.D. Matthews" 1 => "D.R. Overby" 2 => "F.J. Alenghat" 3 => "J. Karavitis" 4 => "Y. Numaguchi" 5 => "P.G. Allen" 6 => "D.E. Ingber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochem Biophys Res Comm" "fecha" => "2004" "volumen" => "313" "paginaInicial" => "758" "paginaFinal" => "764" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14697256" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global cytoskeletal control of mechanotransduction in kidney epithelial cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F.J. Alenghat" 1 => "S.M. Nauli" 2 => "R. Kolb" 3 => "J. Zhou" 4 => "D.E. Ingber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.yexcr.2004.08.003" "Revista" => array:6 [ "tituloSerie" => "Exp Cell Res" "fecha" => "2004" "volumen" => "301" "paginaInicial" => "23" "paginaFinal" => "30" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15501441" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Alves-Pereira" 1 => "J. Joanaz de Melo" 2 => "J. Motylewski" 3 => "E. Kotlicka" 4 => "N.A.A. Castelo Branco" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Vibroacoustic disease II: The biological and acoustical basis of low frequency noise induced pathology" "fecha" => "2003" "volumen" => "Vol25" "paginaInicial" => "73" "paginaFinal" => "79" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Electron microscopy of respiratory tract cilia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.J. Sanderson" 1 => "E.R. Dirksen" 2 => "P. Satir" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "Electron Microscopy of the Lung" "paginaInicial" => "54" "serieFecha" => "1990" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sister chromatid exchanges workers exposed to noise and vibration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.J. Silva" 1 => "A. Carothers" 2 => "N.A.A. Castelo Branco" 3 => "A. Dias" 4 => "M.G. Boavida" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Aviation, Space and Environmental Medicine" "fecha" => "1999" "volumen" => "70" "numero" => "3, Suppl" "paginaInicial" => "A40" "paginaFinal" => "A45" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased levels of sister chromatid exchanges in military aircraft pilots" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.J. Silva" 1 => "A. Carothers" 2 => "N.A.A. Castelo Branco" 3 => "A. Dias" 4 => "M.G. Boavida" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mut Res - Gen Tox & Environ Mutag" "fecha" => "1999" "volumen" => "44" "numero" => "1" "paginaInicial" => "129" "paginaFinal" => "134" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low frequency noise and whole-body vibration cause increased levels of sister chromatid exchange in splenocytes of exposed mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.J. Silva" 1 => "A. Dias" 2 => "P.J. Nogueira" 3 => "N.A.A. Castelo Branco" 4 => "M.G. Boavida" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Teratogenesis Carcinogenesis Mutagenesis" "fecha" => "2002" "volumen" => "22" "numero" => "3" "paginaInicial" => "195" "paginaFinal" => "203" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735115/0000001200000002/v1_201305151420/S2173511506703918/v1_201305151420/en/main.assets" "Apartado" => array:4 [ "identificador" => "9555" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Prémio Thomé Villar/Boehringer Ingelheim 2004" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735115/0000001200000002/v1_201305151420/S2173511506703918/v1_201305151420/en/main.pdf?idApp=UINPBA00004E&text.app=https://journalpulmonology.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173511506703918?idApp=UINPBA00004E" ]
| Year/Month | Html | Total | |
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| 2024 November | 6 | 6 | 12 |
| 2024 October | 31 | 47 | 78 |
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